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Found 668 Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 11/12/13/14'
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of P38 mitogen activated protein kinase (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM19429(4-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]pyridine | S...)
Affinity DataKi:  600nMAssay Description:Inhibition of P38 mitogen activated protein kinase (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM15240(4-[1-methyl-2-(piperidin-4-yl)-4-[3-(trifluorometh...)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50219316(CHEMBL545353)
Affinity DataIC50:  0.150nMAssay Description:Inhibition of Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50222627(CHEMBL356125)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50222624(CHEMBL357598)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50473625(CHEMBL69319)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of p38-related TNF alpha release by human monocyte cell line (THP-1)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50474810(CHEMBL92082)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of LPS-stimulated p38-related TNF-alpha production in human peripheral blood mononuclear cells (PBMC)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50222629(CHEMBL142187)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50222628(CHEMBL142697)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50122391(5-(2-Chloro-phenyl)-1-(2,6-dichloro-phenyl)-7-(pip...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50122995((S)-3-(2-(1-methoxypropan-2-ylamino)pyridin-4-yl)-...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of LPS-induced p38-related TNF-alpha production in human peripheral blood mononuclear cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50476040(CHEMBL219796)
Affinity DataIC50:  0.510nMAssay Description:Inhibition of p38More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50122389(5-(2-Chloro-4-fluoro-phenyl)-1-(2,6-dichloro-pheny...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50122996(2-Phenyl-3-[2-((S)-1-phenyl-ethylamino)-pyrimidin-...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of LPS-induced p38-related TNF-alpha production in human peripheral blood mononuclear cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50219323(CHEMBL161276)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50194461(7-amino-5-(2,4-difluorophenyl)-1-(2,6-difluorophen...)
Affinity DataIC50:  0.690nMAssay Description:Inhibition of p38More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50222105(CHEMBL92814)
Affinity DataIC50:  0.700nMAssay Description:Anti human TNF-alpha activity determined through TNF-alpha release was measured in the supernatants by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50492380(CHEMBL2402001)
Affinity DataIC50:  0.720nMAssay Description:Inhibition of p38 MAPK-mediated TNFalpha production in LPS-induced human whole blood preincubated for 5 mins prior to LPS-treatment measured after 6 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50209771(3,4-dihydroquinolin-2(1H)-one | CHEMBL388582 | Dih...)
Affinity DataIC50:  0.740nMAssay Description:Inhibition of mitogen-activated protein kinase p38 at 2 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50222626(CHEMBL142289)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50222619(CHEMBL343682)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50474810(CHEMBL92082)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of LPS-stimulated p38-related IL1-beta production in human peripheral blood mononuclear cells (PBMC)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50357902(CHEMBL1738839)
Affinity DataIC50:  0.820nMAssay Description:Inhibition of MAPK p38 (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50215268(CHEMBL325211)
Affinity DataIC50:  0.910nMAssay Description:Inhibition of TNF-alpha production by lipopolysaccharide-stimulated human peripheral blood mononuclear cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50222622(CHEMBL358108)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50222621(CHEMBL142463)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50222096(CHEMBL92648)
Affinity DataIC50:  1.20nMAssay Description:Anti human TNF-alpha activity determined through TNF-alpha release was measured in the supernatants by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50460012(CHEMBL4227523)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of MAPK p38 in human THP1 cells assessed as reduction in LPS-induced TNFalpha production preincubated for 60 mins followed by LPS addition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50222108(CHEMBL93028)
Affinity DataIC50:  1.30nMAssay Description:Anti human TNF-alpha activity determined through TNF-alpha release was measured in the supernatants by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50222620(CHEMBL356754)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50219315(CHEMBL161477)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50222094(CHEMBL96305)
Affinity DataIC50:  1.5nMAssay Description:Anti human TNF-alpha activity determined through TNF-alpha release was measured in the supernatants by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50067495(2-(4-Fluoro-phenyl)-4-(3-methoxy-benzyloxy)-3-pyri...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of TNF-alpha production by lipopolysaccharide-stimulated human peripheral blood mononuclear cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50476039(CHEMBL219869)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of p38More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50476037(CHEMBL218968)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of p38More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50222107(CHEMBL93650)
Affinity DataIC50:  1.60nMAssay Description:Anti human TNF-alpha activity determined through TNF-alpha release was measured in the supernatants by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50222625(CHEMBL142050)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of p38 MAP kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50492375(CHEMBL2401997)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of p38 MAPK-mediated TNFalpha production in LPS-induced human whole blood preincubated for 5 mins prior to LPS-treatment measured after 6 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50219322(CHEMBL348754)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50222098(CHEMBL93161)
Affinity DataIC50:  2nMAssay Description:Anti human TNF-alpha activity determined through TNF-alpha release was measured in the supernatants by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50452152(CHEMBL4217462)
Affinity DataIC50:  2nMAssay Description:Inhibition of P38 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50474826(CHEMBL330282)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against LPS-stimulated TNF-alpha production in human monocytic cells (THP-1)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50122997(2-Phenyl-3-[2-((S)-1-phenyl-ethylamino)-pyridin-4-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of LPS-induced p38-related TNF-alpha production in human peripheral blood mononuclear cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50341356(6-(2,4-Difluorophenoxy)-8-methyl-2-((S)-1-methyl-2...)
Affinity DataIC50:  2nMAssay Description:Inhibition of MAPK p38 (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50452151(CHEMBL4208527)
Affinity DataIC50:  2nMAssay Description:Inhibition of P38 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50473629(CHEMBL70053 | RPR-238677)
Affinity DataIC50:  2nMAssay Description:Inhibition of p38-related TNF alpha release by human monocyte cell line (THP-1)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50215161(CHEMBL324468)
Affinity DataIC50:  2nMAssay Description:Inhibition of TNF-alpha production by lipopolysaccharide-stimulated human peripheral blood mononuclear cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50123004(2-Phenyl-3-[2-((R)-1-phenyl-ethylamino)-pyrimidin-...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of LPS-induced p38-related TNF-alpha production in human peripheral blood mononuclear cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boston University

Curated by ChEMBL
LigandPNGBDBM50219317(CHEMBL349524)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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