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Found 3 Enz. Inhib. hit(s) with Target = 'Isoform PDE2A1 of cGMP-dependent 3',5'-cyclic phosphodiesterase (PDE2A1)'
LigandPNGBDBM253042(US9493447, 1001)
Affinity DataIC50:  545nMpH: 7.5 T: 2°CAssay Description:The PDE assay medium consisted of (final concentrations); 50 mM Tris-HCL, pH 7.5; 8.3 mM MgCl2; 1.7 mM EGTA; 0.5 mg/mL bovine serum albumin; and subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM236643(US9388139, 12)
Affinity DataIC50: >5.00E+4nMAssay Description:PDE activity was measured using the IMAP fluorescence polarization assay (Molecular Devices) in which binding of hydrolyzed cyclic nucleotide substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM236643(US9388139, 12)
Affinity DataIC50: >5.00E+4nMAssay Description:PDE activity was measured using the IMAP fluorescence polarization assay (Molecular Devices) in which binding of hydrolyzed cyclic nucleotide substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent