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Found 3341 Enz. Inhib. hit(s) with Target = 'Prolyl endopeptidase'
TargetProlyl endopeptidase(Rattus norvegicus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50155838((S)-1-((S)-1-(4-phenylbutanoyl)pyrrolidine-2-carbo...)
Affinity DataKi:  0.0200nMAssay Description:Inhibition of POP in Han/Wistar rat brain using Suc-Gly-Pro-AMC substrate incubated for 60 minsMore data for this Ligand-Target Pair
TargetProlyl endopeptidase(Sus scrofa)
University Of Kuopio

Curated by ChEMBL
LigandPNGBDBM50155838((S)-1-((S)-1-(4-phenylbutanoyl)pyrrolidine-2-carbo...)
Affinity DataKi:  0.0200nMAssay Description:Inhibitory activity against prolyl oligopeptidase of porcine brain homogenateMore data for this Ligand-Target Pair
TargetProlyl endopeptidase(Sus scrofa)
University Of Kuopio

Curated by ChEMBL
LigandPNGBDBM50155838((S)-1-((S)-1-(4-phenylbutanoyl)pyrrolidine-2-carbo...)
Affinity DataKi:  0.0230nMAssay Description:Inhibition of pig POPMore data for this Ligand-Target Pair
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Helsinki

Curated by ChEMBL
LigandPNGBDBM50155838((S)-1-((S)-1-(4-phenylbutanoyl)pyrrolidine-2-carbo...)
Affinity DataKi:  0.0230nMAssay Description:Inhibition of prolyl oligopeptidase (unknown origin)More data for this Ligand-Target Pair
TargetProlyl endopeptidase(Sus scrofa)
University Of Kuopio

Curated by ChEMBL
LigandPNGBDBM50155839((S)-1-[(R)-2-(4-Phenyl-butyryl)-cyclopent-2-enecar...)
Affinity DataKi:  0.0300nMAssay Description:Inhibitory activity against prolyl oligopeptidase of porcine brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Sus scrofa)
University Of Kuopio

Curated by ChEMBL
LigandPNGBDBM50051495((S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...)
Affinity DataKi:  0.0600nMAssay Description:Inhibitory activity against prolyl oligopeptidase of porcine brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Sus scrofa)
University Of Kuopio

Curated by ChEMBL
LigandPNGBDBM50051495((S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of poricne brain POP in expressed in Escherichia coli TOP10 competent cells pre-incubated for 2 hrs before Z-Gly-Pro-AMC substrate additio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Sus scrofa)
University Of Kuopio

Curated by ChEMBL
LigandPNGBDBM50155838((S)-1-((S)-1-(4-phenylbutanoyl)pyrrolidine-2-carbo...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of porcine prolyl oligopeptidase using Z-Gly-Pro-AMC as substrate after 60 mins by double-reciprocal plot analysisMore data for this Ligand-Target Pair
TargetProlyl endopeptidase(Sus scrofa)
University Of Kuopio

Curated by ChEMBL
LigandPNGBDBM50155836((R)-5-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...)
Affinity DataKi:  0.150nMAssay Description:Inhibitory activity against prolyl oligopeptidase of porcine brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Bos taurus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50038879((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Affinity DataKi:  0.210nMAssay Description:Inhibition of bovine brain POPMore data for this Ligand-Target Pair
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Helsinki

Curated by ChEMBL
LigandPNGBDBM50135635(2-[2-(Isothiazole-3-carbonyl)-pyrrolidine-1-carbon...)
Affinity DataKi:  0.260nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Helsinki

Curated by ChEMBL
LigandPNGBDBM50135633((S)-2-[(S)-2-(5-Benzyloxymethyl-isoxazole-3-carbon...)
Affinity DataKi:  0.280nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Helsinki

Curated by ChEMBL
LigandPNGBDBM50135637(1-{(S)-2-[(S)-2-(5-Benzyloxymethyl-isoxazole-3-car...)
Affinity DataKi:  0.340nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Mus musculus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50038879((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Affinity DataKi:  0.350nMAssay Description:Inhibition of mouse brain POPMore data for this Ligand-Target Pair
TargetProlyl endopeptidase(Bos taurus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50038879((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Affinity DataKi:  0.350nMAssay Description:Inhibition of POP in bovine serum using Z-Gly-Pro-NH-Mec fluorimetric substrateMore data for this Ligand-Target Pair
TargetProlyl endopeptidase(Sus scrofa)
University Of Kuopio

Curated by ChEMBL
LigandPNGBDBM50170682((S)-1-((S)-1-(3-((S)-2-(cyclopentanecarbonyl)pyrro...)
Affinity DataKi:  0.360nMAssay Description:Inhibition of pig brain POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Helsinki

Curated by ChEMBL
LigandPNGBDBM50038879((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of recombinant human POP assessed as affinity constant of second step of inhibition pre-incubated for 2 hrs before addition of ZGP-pNA sub...More data for this Ligand-Target Pair
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Helsinki

Curated by ChEMBL
LigandPNGBDBM50135634((S)-2-[(S)-2-(5-Trimethylsilanyl-isoxazole-3-carbo...)
Affinity DataKi:  0.450nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Flavobacterium meningosepticum)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50038879((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of Flavobacterium meningosepticum POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Helsinki

Curated by ChEMBL
LigandPNGBDBM50431227(CHEMBL2333024)
Affinity DataKi:  0.730nMAssay Description:Competitive inhibition of human PREP using Suc-GP-AMC as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Helsinki

Curated by ChEMBL
LigandPNGBDBM50180679(CHEMBL3817958)
Affinity DataKi:  0.75nMAssay Description:Inhibition of human POP by tight binding based Morrison equation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Helsinki

Curated by ChEMBL
LigandPNGBDBM50155838((S)-1-((S)-1-(4-phenylbutanoyl)pyrrolidine-2-carbo...)
Affinity DataKi:  0.920nMAssay Description:Inhibition of human POP by tight binding based Morrison equation analysisMore data for this Ligand-Target Pair
TargetProlyl endopeptidase(Rattus norvegicus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50038881(CHEMBL294803 | Y-29794 | [2-(8-Dimethylamino-octyl...)
Affinity DataKi:  0.950nMAssay Description:Inhibition of POP in rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Helsinki

Curated by ChEMBL
LigandPNGBDBM50155838((S)-1-((S)-1-(4-phenylbutanoyl)pyrrolidine-2-carbo...)
Affinity DataKi:  0.950nMAssay Description:Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate additionMore data for this Ligand-Target Pair
TargetProlyl endopeptidase(Rattus norvegicus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50005864(CHEMBL3236270)
Affinity DataKi:  0.950nMAssay Description:Competitive inhibition of rat brain prolyl oligopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Helsinki

Curated by ChEMBL
LigandPNGBDBM50051539((S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolid...)
Affinity DataKi:  0.970nMAssay Description:Inhibition of prolyl oligopeptidase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Helsinki

Curated by ChEMBL
LigandPNGBDBM50038879((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Affinity DataKi:  1nMAssay Description:Inhibition of recombinant human POP pre-incubated for 30 mins before addition of ZGP-pNA substrate by absorbance assayMore data for this Ligand-Target Pair
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Helsinki

Curated by ChEMBL
LigandPNGBDBM50180679(CHEMBL3817958)
Affinity DataKi:  1nMAssay Description:Inhibition of human POP expressed in Escherichia coli BL21 pre-incubated for 30 mins before ZGP-pNA substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316818(((2S,3aS,7aS)-1-((1R,2R)-2-phenylcyclopropanecarbo...)
Affinity DataKi:  1.30nMAssay Description:inhibition of rat cortex POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase FAP(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50326392((2S)-1-({(2S,4S)-4-[2-(1,3-Dihydro-2H-isoindol-2-y...)
Affinity DataKi:  1.30nMAssay Description:Competitive inhibition of human recombinant FAP expressed in Hi5 insect cells by Lineweaver-Burke plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Helsinki

Curated by ChEMBL
LigandPNGBDBM50316818(((2S,3aS,7aS)-1-((1R,2R)-2-phenylcyclopropanecarbo...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Helsinki

Curated by ChEMBL
LigandPNGBDBM50316818(((2S,3aS,7aS)-1-((1R,2R)-2-phenylcyclopropanecarbo...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human POP using Z-Gly-Pro-7-AMC substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Helsinki

Curated by ChEMBL
LigandPNGBDBM50200728((R)-1-(4-oxo-4-phenylbutanoyl)pyrrolidin-2-ylboron...)
Affinity DataKi:  1.70nMAssay Description:Inhibitory constant against POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Helsinki

Curated by ChEMBL
LigandPNGBDBM50135630((S)-2-[(S)-2-(5-Phenyl-isoxazole-3-carbonyl)-pyrro...)
Affinity DataKi:  1.87nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Helsinki

Curated by ChEMBL
LigandPNGBDBM50135630((S)-2-[(S)-2-(5-Phenyl-isoxazole-3-carbonyl)-pyrro...)
Affinity DataKi:  1.90nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Helsinki

Curated by ChEMBL
LigandPNGBDBM50200729((R)-1-(2-(2,5-dichlorobenzamido)acetyl)pyrrolidin-...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of recombinant POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Helsinki

Curated by ChEMBL
LigandPNGBDBM50200729((R)-1-(2-(2,5-dichlorobenzamido)acetyl)pyrrolidin-...)
Affinity DataKi:  2.20nMAssay Description:Inhibitory constant against POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Helsinki

Curated by ChEMBL
LigandPNGBDBM50200726((R)-1-(2-(cyclopentanecarboxamido)acetyl)pyrrolidi...)
Affinity DataKi:  2.30nMAssay Description:Inhibitory constant against POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Mus musculus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50279827(2-((S)-2-Formyl-pyrrolidine-1-carbonyl)-2,3-dihydr...)
Affinity DataKi:  2.40nM Kon:  0.000300M-1s-1 Koff:  1.40E+5s-1Assay Description:Compound was evaluated for the enzyme kinetic data (kon) for binding inhibition against Prolyl Endopeptidase (PEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetProlyl endopeptidase(Mus musculus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316840((R)-benzyl 2-((S)-2-formylpyrrolidine-1-carbonyl)i...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of mouse brain POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Helsinki

Curated by ChEMBL
LigandPNGBDBM50200721((R)-1-(2-(cyclohexanecarboxamido)acetyl)pyrrolidin...)
Affinity DataKi:  2.70nMAssay Description:Inhibitory constant against POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Helsinki

Curated by ChEMBL
LigandPNGBDBM50200723((R)-1-(2-(1-oxoisoindolin-2-yl)acetyl)pyrrolidin-2...)
Affinity DataKi:  2.80nMAssay Description:Inhibitory constant against POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Mus musculus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50279826((1S,2S)-2-((S)-2-Formyl-pyrrolidine-1-carbonyl)-cy...)
Affinity DataKi:  3nM Kon:  0.000700M-1s-1 Koff:  2.30E+5s-1Assay Description:Compound was evaluated for the enzyme kinetic data (kon) for binding inhibition against Prolyl Endopeptidase (PEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetProlyl endopeptidase FAP(Mus musculus (Mouse))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50434188(CHEMBL2385281 | US9346814, Cmpd No 2 Example 3)
Affinity DataKi:  3nMAssay Description:Inhibition of mouse recombinant FAP expressed in HEK293 cells using Ala-Pro-p-nitroanilide as substrate incubated for 15 mins prior to substrate addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Mus musculus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50279825((1R,2S)-2-((S)-2-Formyl-pyrrolidine-1-carbonyl)-cy...)
Affinity DataKi:  3nMAssay Description:Compound was evaluated for binding inhibition against Prolyl Endopeptidase (PEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetProlyl endopeptidase(Mus musculus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50279825((1R,2S)-2-((S)-2-Formyl-pyrrolidine-1-carbonyl)-cy...)
Affinity DataKi:  3nM Kon:  0.00200M-1s-1 Koff:  7.00E+5s-1Assay Description:Compound was evaluated for the enzyme kinetic data (kon) for binding inhibition against Prolyl Endopeptidase (PEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetProlyl endopeptidase(Mus musculus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50279826((1S,2S)-2-((S)-2-Formyl-pyrrolidine-1-carbonyl)-cy...)
Affinity DataKi:  3nMAssay Description:Inhibition of mouse brain POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Helsinki

Curated by ChEMBL
LigandPNGBDBM50135633((S)-2-[(S)-2-(5-Benzyloxymethyl-isoxazole-3-carbon...)
Affinity DataKi:  3.30nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Helsinki

Curated by ChEMBL
LigandPNGBDBM50135633((S)-2-[(S)-2-(5-Benzyloxymethyl-isoxazole-3-carbon...)
Affinity DataKi:  3.30nMAssay Description:Inhibition of PKD2 ( assessed as residual activity at 1 uM ) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Bos taurus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316839((S)-benzyl 2-((S)-2-formylpyrrolidine-1-carbonyl)-...)
Affinity DataKi:  3.40nMAssay Description:Inhibition of bovine brain POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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