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Found 262 Enz. Inhib. hit(s) with Target = 'Rhodopsin kinase GRK1'
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50049820(4-Amino-5-carboxamide-7-(D-ribofuranosyl)pyrrolo[2...)
Affinity DataKi:  180nMAssay Description:Inhibition of rhodopsin kinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50566949(CHEMBL4877302)
Affinity DataIC50:  52nMAssay Description:Inhibition of human GRK1 using casein as substrate in presence of [gamma33P]ATP by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  57.8nMAssay Description:Inhibition of human GRK1 using casein as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50173307(CHEMBL3809796 | US10023564, Example 8)
Affinity DataIC50:  70nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  78.1nMAssay Description:Inhibition of human GRK1 using casein as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50173307(CHEMBL3809796 | US10023564, Example 8)
Affinity DataIC50:  100nMAssay Description:Inhibition of GRK1 (unknown origin) using tubulin as substrate by SDS-PAGE methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Bos taurus)
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50265871(3-(2-(1-(2-(dimethylamino)acetyl)-6-methoxy-4,4-di...)
Affinity DataIC50:  130nMAssay Description:Displacement of BODIPY TR-ADP from bovine GRK1 (1 to 535 residues) preincubated for 10 mins followed by compound addition and measured after 10 to 15...More data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50566946(CHEMBL4854871)
Affinity DataIC50:  190nMAssay Description:Inhibition of human GRK1 using casein as substrate in presence of [gamma33P]ATP by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50257340(CHEMBL4072828)
Affinity DataIC50:  270nMAssay Description:Inhibition of recombinant human GST-tagged GRK1 expressed in baculovirus infected fall armyworm Sf9 cells after 60 mins by LanthaScreen eu kinase bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)
Affinity DataIC50:  340nMAssay Description:Inhibition of GRK1-mediated bovine tubulin phosphorylation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50566947(CHEMBL4847703)
Affinity DataIC50:  450nMAssay Description:Inhibition of human GRK1 using casein as substrate in presence of [gamma33P]ATP by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Bos taurus)
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50529469(CHEMBL4456539)
Affinity DataIC50:  760nMAssay Description:Inhibition of bovine GRK1 using tubulin as substrate measured after 4 hrs by [gamma-32P]-ATP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Bos taurus)
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50529470(CHEMBL4475305)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of bovine GRK1 using tubulin as substrate measured after 4 hrs by [gamma-32P]-ATP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM283996(E22 | US10023564, Example 22)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of GRK1 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50257350(CHEMBL1738877)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of recombinant human GST-tagged GRK1 expressed in baculovirus infected fall armyworm Sf9 cells after 60 mins by LanthaScreen eu kinase bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50257350(CHEMBL1738877)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of GRK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM283996(E22 | US10023564, Example 22)
Affinity DataIC50:  3.50E+3nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50173310(CHEMBL3808660 | US10023564, Example 1)
Affinity DataIC50:  3.90E+3nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50173310(CHEMBL3808660 | US10023564, Example 1)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of GRK1 (unknown origin) using tubulin as substrate by SDS-PAGE methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Bos taurus)
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM3149(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of bovine C-terminal truncated GRK1 (535 residues) assessed as decrease in phosphorylation of urea-washed bovine rod outer segments preinc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50173313(CHEMBL1738878)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of GRK1 (unknown origin) using tubulin as substrate by SDS-PAGE methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Bos taurus)
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50173313(CHEMBL1738878)
Affinity DataIC50:  9.10E+3nMAssay Description:Inhibition of bovine GRK1 (1 to 535 residues) after 5 mins after 5 mins in presence of ATP by phosphorimaging assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50135286(CHEMBL3745885)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human GRK1 using casein as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50554258(CHEMBL4744858)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human GRK1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50554257(CHEMBL4742990)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human GRK1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50519662(CHEMBL4438748)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant full length human GRK1 using KKKKERLLDDRHD as substrate after 40 mins in presence of [gamma-33ATP] by radiometric scintilla...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50173315(CHEMBL3809100 | US10023564, Example 4)
Affinity DataIC50:  1.19E+4nMAssay Description:Inhibition of GRK1 (unknown origin) using tubulin as substrate by SDS-PAGE methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50173315(CHEMBL3809100 | US10023564, Example 4)
Affinity DataIC50:  1.19E+4nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRhodopsin kinase GRK1(Bos taurus)
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM27791(2-{[2-({4-chloro-2-methoxy-5-[(1-propylpiperidin-4...)
Affinity DataIC50:  1.30E+4nMAssay Description:Displacement of BODIPY TR-ADP from bovine GRK1 (1 to 535 residues) preincubated for 10 mins followed by compound addition and measured after 10 to 15...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM284001(E27 | US10023564, Example 27)
Affinity DataIC50:  1.40E+4nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM284001(E27 | US10023564, Example 27)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of GRK1 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50173325(CHEMBL3809965 | US10023564, Example 5)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of GRK1 (unknown origin) using tubulin as substrate by SDS-PAGE methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50173325(CHEMBL3809965 | US10023564, Example 5)
Affinity DataIC50:  1.63E+4nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50461321(CHEMBL4227138)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of GRK1 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM283998(E24 | US10023564, Example 24)
Affinity DataIC50:  1.80E+4nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM284006(E32 | US10023564, Example 32)
Affinity DataIC50:  2.10E+4nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRhodopsin kinase GRK1(Bos taurus)
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50260129(CHEMBL4098656)
Affinity DataIC50:  2.45E+4nMAssay Description:Inhibition of bovine GRK1 (1 to 535 residues) after 5 mins after 5 mins in presence of ATP by phosphorimaging assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Bos taurus)
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50260147(CHEMBL4063014)
Affinity DataIC50:  2.58E+4nMAssay Description:Binding affinity towards serotonin transporter determined using [3H]paroxetine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM284006(E32 | US10023564, Example 32)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of GRK1 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM283998(E24 | US10023564, Example 24)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of GRK1 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50257351(CHEMBL4095595)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of recombinant human GST-tagged GRK1 expressed in baculovirus infected fall armyworm Sf9 cells after 60 mins by LanthaScreen eu kinase bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50257328(CHEMBL4082775)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of recombinant human GST-tagged GRK1 expressed in baculovirus infected fall armyworm Sf9 cells after 60 mins by LanthaScreen eu kinase bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50257344(CHEMBL4065690)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of recombinant human GST-tagged GRK1 expressed in baculovirus infected fall armyworm Sf9 cells after 60 mins by LanthaScreen eu kinase bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50257365(CHEMBL4083276)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of recombinant human GST-tagged GRK1 expressed in baculovirus infected fall armyworm Sf9 cells after 60 mins by LanthaScreen eu kinase bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Bos taurus)
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50260130(CHEMBL4090923)
Affinity DataIC50:  3.20E+4nMAssay Description:Inhibitory concentration against human alpha-L-fucosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Bos taurus)
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50257350(CHEMBL1738877)
Affinity DataIC50:  5.21E+4nMAssay Description:Inhibitory concentration against alpha-galactosidase of coffee beanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Bos taurus)
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50260137(CHEMBL4062790)
Affinity DataIC50:  6.00E+4nMAssay Description:Inhibition of bovine GRK1 (1 to 535 residues) after 5 mins after 5 mins in presence of ATP by phosphorimaging assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM283997(E23 | US10023564, Example 23)
Affinity DataIC50:  6.70E+4nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50173314(CHEMBL3808840 | US10023564, Example 16)
Affinity DataIC50:  7.10E+4nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50173314(CHEMBL3808840 | US10023564, Example 16)
Affinity DataIC50:  7.10E+4nMAssay Description:Inhibition of GRK1 (unknown origin) using tubulin as substrate by SDS-PAGE methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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