Found 26 Enz. Inhib. hit(s) with Target = 'Dual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase'
TargetDual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 2.40nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 28nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 95nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 98nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 125nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 290nMAssay Description:Inhibition of EGF-stimulated Elk1-luciferase reporter assay in HeLa cellsMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of EGF-stimulated Elk1-luciferase reporter assay in HeLa cellsMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of EGF-stimulated Elk1-luciferase reporter assay in HeLa cellsMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 1.05E+4nMAssay Description:Inhibition of EGF-stimulated Elk1-luciferase reporter assay in HeLa cellsMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 1.12E+4nMAssay Description:Inhibition of EGF-stimulated Elk1-luciferase reporter assay in HeLa cellsMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 1.23E+4nMAssay Description:Inhibition of EGF-stimulated Elk1-luciferase reporter assay in HeLa cellsMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 1.42E+4nMAssay Description:Inhibition of EGF-stimulated Elk1-luciferase reporter assay in HeLa cellsMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 1.62E+4nMAssay Description:Inhibition of EGF-stimulated Elk1-luciferase reporter assay in HeLa cellsMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 1.94E+4nMAssay Description:Inhibition of EGF-stimulated Elk1-luciferase reporter assay in HeLa cellsMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 2.06E+4nMAssay Description:Inhibition of EGF-stimulated Elk1-luciferase reporter assay in HeLa cellsMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 2.53E+4nMAssay Description:Inhibition of EGF-stimulated Elk1-luciferase reporter assay in HeLa cellsMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of ERK phosphorylation in coupled Raf-MEK-ERK ELISA (Weakly active)More data for this Ligand-Target Pair