Compile Data Set for Download or QSAR
maximum 50k data
Found 26 Enz. Inhib. hit(s) with Target = 'Dual specificity mitogen-activated protein kinase kinase 1/RAF proto-oncogene serine/threonine-protein kinase'
LigandPNGBDBM50095232(6-Methoxy-7-(3-morpholin-4-yl-propoxy)-4-(4-phenox...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50095235(6-Methoxy-7-(2-morpholin-4-yl-ethoxy)-4-(4-phenoxy...)
Affinity DataIC50:  8nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50095226(6,7-Dimethoxy-4-(4-phenoxy-phenylamino)-quinoline-...)
Affinity DataIC50:  9nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50095236(6-Methoxy-4-(4-phenoxy-phenylamino)-quinoline-3-ca...)
Affinity DataIC50:  18nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50095229(7-(3-Morpholin-4-yl-propoxy)-4-(4-phenoxy-phenylam...)
Affinity DataIC50:  28nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50095230(5,7-Dimethoxy-4-(4-phenoxy-phenylamino)-quinoline-...)
Affinity DataIC50:  60nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50095234(7-Methoxy-4-(4-phenoxy-phenylamino)-quinoline-3-ca...)
Affinity DataIC50:  90nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50095239(6,7-Dimethoxy-4-(3-phenoxy-phenylamino)-quinoline-...)
Affinity DataIC50:  95nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50095231(5-Methoxy-4-(4-phenoxy-phenylamino)-quinoline-3-ca...)
Affinity DataIC50:  98nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50095233(4-(4-Phenoxy-phenylamino)-quinoline-3-carbonitrile...)
Affinity DataIC50:  125nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50072147((2Z,3Z)-2,3-bis(amino(2-aminophenylthio)methylene)...)
Affinity DataIC50:  290nMAssay Description:Inhibition of EGF-stimulated Elk1-luciferase reporter assay in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of EGF-stimulated Elk1-luciferase reporter assay in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50474839(CHEMBL180308)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of EGF-stimulated Elk1-luciferase reporter assay in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50095240(6,7,8-Trimethoxy-4-(4-phenoxy-phenylamino)-quinoli...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50095238(6,7-Dimethoxy-4-(2-phenoxy-phenylamino)-quinoline-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50095228(8-Methoxy-4-(4-phenoxy-phenylamino)-quinoline-3-ca...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50095237(5,8-Dimethoxy-4-(4-phenoxy-phenylamino)-quinoline-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ERK-phosphorylation by Raf-MEK-ERK in coupled ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50474842(CHEMBL365404)
Affinity DataIC50:  1.05E+4nMAssay Description:Inhibition of EGF-stimulated Elk1-luciferase reporter assay in HeLa cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50474841(CHEMBL184940)
Affinity DataIC50:  1.12E+4nMAssay Description:Inhibition of EGF-stimulated Elk1-luciferase reporter assay in HeLa cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50474837(CHEMBL361195)
Affinity DataIC50:  1.23E+4nMAssay Description:Inhibition of EGF-stimulated Elk1-luciferase reporter assay in HeLa cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50474838(CHEMBL182656)
Affinity DataIC50:  1.42E+4nMAssay Description:Inhibition of EGF-stimulated Elk1-luciferase reporter assay in HeLa cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50474836(CHEMBL359722)
Affinity DataIC50:  1.62E+4nMAssay Description:Inhibition of EGF-stimulated Elk1-luciferase reporter assay in HeLa cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50474843(CHEMBL181589)
Affinity DataIC50:  1.94E+4nMAssay Description:Inhibition of EGF-stimulated Elk1-luciferase reporter assay in HeLa cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50474840(CHEMBL185291)
Affinity DataIC50:  2.06E+4nMAssay Description:Inhibition of EGF-stimulated Elk1-luciferase reporter assay in HeLa cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50474835(CHEMBL182807)
Affinity DataIC50:  2.53E+4nMAssay Description:Inhibition of EGF-stimulated Elk1-luciferase reporter assay in HeLa cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50095227((6,7-Dimethoxy-quinazolin-4-yl)-(4-phenoxy-phenyl)...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of ERK phosphorylation in coupled Raf-MEK-ERK ELISA (Weakly active)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed