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Found 956 Enz. Inhib. hit(s) with Target = 'Sphingosine 1-phosphate receptor 4'
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM22202(S1P | [32P]S1P | [33P]S1P | sphingosine-1-phosphat...)
Affinity DataKi:  2.70nM ΔG°:  -45.5kJ/molepH: 7.5 T: 2°CAssay Description:Ki Values were determined by competition of [32P]-S1P binding to stably transfected CHO (S1P1,2,4) or RH7777 (S1P3,5) cells expressing the indicated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM22202(S1P | [32P]S1P | [33P]S1P | sphingosine-1-phosphat...)
Affinity DataKi:  21nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM23165(CHEMBL366208 | FTY720-phosphate, (S)-2 | [(2S)-2-a...)
Affinity DataKi:  23nM ΔG°:  -40.5kJ/molepH: 7.5 T: 2°CAssay Description:Ki Values were determined by competition of [32P]-S1P binding to stably transfected CHO (S1P1,2,4) or RH7777 (S1P3,5) cells expressing the indicated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM22202(S1P | [32P]S1P | [33P]S1P | sphingosine-1-phosphat...)
Affinity DataKi:  27nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM22202(S1P | [32P]S1P | [33P]S1P | sphingosine-1-phosphat...)
Affinity DataKi:  28nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50250631(CHEMBL4093489)
Affinity DataKi:  29nMAssay Description:Displacement of [33P]-S1P from human S1P4 receptor expressed in CHO-K1 cells after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM22202(S1P | [32P]S1P | [33P]S1P | sphingosine-1-phosphat...)
Affinity DataKi:  32nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM22202(S1P | [32P]S1P | [33P]S1P | sphingosine-1-phosphat...)
Affinity DataKi:  32nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM22202(S1P | [32P]S1P | [33P]S1P | sphingosine-1-phosphat...)
Affinity DataKi:  33nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM23163(CHEMBL114606 | FTY720-phosphate, rac-2 | {2-amino-...)
Affinity DataKi:  37nM ΔG°:  -39.4kJ/molepH: 7.5 T: 2°CAssay Description:Ki Values were determined by competition of [32P]-S1P binding to stably transfected CHO (S1P1,2,4) or RH7777 (S1P3,5) cells expressing the indicated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM22202(S1P | [32P]S1P | [33P]S1P | sphingosine-1-phosphat...)
Affinity DataKi:  64nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM23164(CHEMBL190006 | FTY720-phosphate, (R)-2 | [(2R)-2-a...)
Affinity DataKi:  105nM ΔG°:  -37.0kJ/molepH: 7.5 T: 2°CAssay Description:Ki Values were determined by competition of [32P]-S1P binding to stably transfected CHO (S1P1,2,4) or RH7777 (S1P3,5) cells expressing the indicated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50494302(CHEMBL3086532)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of S1P4 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50277186((R)-2-amino-2-(4-(4-(octyloxy)phenyl)-1H-imidazol-...)
Affinity DataIC50:  1.10nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50249294((R)-2-amino-2-(4-(4-(5-phenylpentyloxy)phenyl)-1H-...)
Affinity DataIC50:  1.23nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50147714(CHEMBL432067 | Phosphoric acid mono-[2-amino-4-(4-...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50277185((S)-2-amino-3-(2-fluoro-4-(octyloxy)phenylamino)-2...)
Affinity DataIC50:  1.80nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50277187((R)-2-amino-2-(4-(3-fluoro-4-(octyloxy)phenyl)-1H-...)
Affinity DataIC50:  1.90nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM23165(CHEMBL366208 | FTY720-phosphate, (S)-2 | [(2S)-2-a...)
Affinity DataIC50:  2.20nMAssay Description:Agonist activity at human S1P4 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50:  2.40nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50:  2.90nMAssay Description:Displacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50315559((S)-2-amino-3-(4-(2-(biphenyl-4-yl)ethoxy)-3-(trif...)
Affinity DataIC50:  3.40nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50277149((S)-2-amino-3-(3-fluoro-4-(octyloxy)phenylamino)-2...)
Affinity DataIC50:  3.5nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50249114((S)-2-amino-2-methyl-3-oxo-3-(4-(5-phenylpentyloxy...)
Affinity DataIC50:  3.60nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50277148((S)-2-amino-2-methyl-3-(4-(octyloxy)phenylamino)-3...)
Affinity DataIC50:  4nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50249240((S)-2-amino-3-(4-(2-(biphenyl-4-yl)ethoxy)phenylam...)
Affinity DataIC50:  4.17nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50315562((R)-2-amino-2-(4-(4-(biphenyl-4-ylmethoxy)-3-(trif...)
Affinity DataIC50:  4.40nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50249266((R)-2-amino-2-(4-(4-(biphenyl-4-ylmethoxy)phenyl)-...)
Affinity DataIC50:  4.87nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50249266((R)-2-amino-2-(4-(4-(biphenyl-4-ylmethoxy)phenyl)-...)
Affinity DataIC50:  4.90nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50249263((S)-2-amino-3-(4-(3-(biphenyl-4-yl)propoxy)phenyla...)
Affinity DataIC50:  5.24nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50249154((S)-2-amino-3-(4-(biphenyl-4-ylmethoxy)phenylamino...)
Affinity DataIC50:  6.15nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50315561((R)-2-amino-2-(4-(4-(2-(biphenyl-4-yl)ethoxy)-3-(t...)
Affinity DataIC50:  6.5nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50249153((S)-2-amino-3-(4-(4-cyclohexylbutoxy)phenylamino)-...)
Affinity DataIC50:  8.30nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50152322(CHEMBL184879 | {2-[5-(4-Nonyl-phenyl)-pyrrolidin-2...)
Affinity DataIC50:  8.40nMAssay Description:Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50152322(CHEMBL184879 | {2-[5-(4-Nonyl-phenyl)-pyrrolidin-2...)
Affinity DataIC50:  8.40nMAssay Description:Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50249240((S)-2-amino-3-(4-(2-(biphenyl-4-yl)ethoxy)phenylam...)
Affinity DataIC50:  10.3nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50249113((S)-2-amino-2-methyl-3-oxo-3-(4-(4-phenylbutoxy)ph...)
Affinity DataIC50:  10.3nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50249293((R)-2-amino-2-(4-(4-(4-phenylbutoxy)phenyl)-1H-imi...)
Affinity DataIC50:  11.7nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50315550((S)-2-amino-3-(4-(3-(biphenyl-4-yl)propanoyl)pheny...)
Affinity DataIC50:  13.1nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM23163(CHEMBL114606 | FTY720-phosphate, rac-2 | {2-amino-...)
Affinity DataIC50:  15nMAssay Description:Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50148399(CHEMBL117130 | Phosphoric acid mono-[1-amino-1-hyd...)
Affinity DataIC50:  15nMAssay Description:Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50152337(2-amino-2-({[dihydroxy(oxido)--phosphanyl]oxy}meth...)
Affinity DataIC50:  15nMAssay Description:Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM23163(CHEMBL114606 | FTY720-phosphate, rac-2 | {2-amino-...)
Affinity DataIC50:  15nMAssay Description:Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50147703(CHEMBL115554 | CHEMBL115713 | [(1S,3R)-3-Amino-1-h...)
Affinity DataIC50:  16nMAssay Description:Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50147703(CHEMBL115554 | CHEMBL115713 | [(1S,3R)-3-Amino-1-h...)
Affinity DataIC50:  16nMAssay Description:Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50344797(5-(2,5-dichlorophenyl)-N-(4-(hydroxymethyl)-2,6-di...)
Affinity DataIC50:  21nMAssay Description:Antagonist activity at S1P4 receptor in human U2OS cells expressing EDG6-linked GAL4-VP16 transcription factor via TEV protease site/beta-arrestin/TE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Affinity DataIC50:  23nMAssay Description:Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50147713(CHEMBL113344 | [3-Amino-1-hydroxy-5-(4-octyl-pheny...)
Affinity DataIC50:  23nMAssay Description:Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50148391(CHEMBL325193 | {3-[2-(4-Octyl-phenyl)-ethylamino]-...)
Affinity DataIC50:  24nMAssay Description:Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Mitsubishi Pharma

LigandPNGBDBM50249264((S)-2-amino-3-(4-(4-(biphenyl-4-yl)butoxy)phenylam...)
Affinity DataIC50:  24.8nMAssay Description:Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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