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Found 227 Enz. Inhib. hit(s) with Target = 'Thioredoxin reductase 1, cytoplasmic'
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
University Of Padova

Curated by ChEMBL
LigandPNGBDBM50333880(CHEMBL1614664 | Hypericin | Pseudohypericin)
Affinity DataKi:  1.90E+3nMAssay Description:Mixed-type inhibition of rat liver cytosolic TrxR1 by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
University Of Padova

Curated by ChEMBL
LigandPNGBDBM50333880(CHEMBL1614664 | Hypericin | Pseudohypericin)
Affinity DataKi:  8.10E+3nMAssay Description:Mixed-type inhibition of rat liver cytosolic TrxR1 at protein-substrate complex by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM501863(US11028067, Example 4)
Affinity DataIC50:  0.854nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522169(US11161815, Example 25)
Affinity DataIC50:  1.03nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522162(US11161815, Example 18)
Affinity DataIC50:  1.52nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM531217(US11208384, Example 1)
Affinity DataIC50:  3.16nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM501865(US11028067, Example 6)
Affinity DataIC50:  3.99nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522165(US11161815, Example 21)
Affinity DataIC50:  4.35nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522166(US11161815, Example 22)
Affinity DataIC50:  5.05nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM501860(US11028067, Example 1 | US11028067, Example 8)
Affinity DataIC50:  5.5nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522173(US11161815, Example 29)
Affinity DataIC50:  6.78nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM501866(US11028067, Example 7)
Affinity DataIC50:  6.90nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522164(US11161815, Example 20)
Affinity DataIC50:  7.16nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522171(US11161815, Example 27)
Affinity DataIC50:  7.33nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522163(US11161815, Example 19)
Affinity DataIC50:  7.60nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM50576853(CHEMBL4859206)
Affinity DataIC50:  9.20nMAssay Description:Inhibition of TrxR1 (unknown origin) assessed as reduction in DTNB to TNB by colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM50576853(CHEMBL4859206)
Affinity DataIC50:  9.20nMAssay Description:Inhibition of TrxR1 (unknown origin) assessed as reduction in DTNB to TNB by colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM501864(US11028067, Example 5)
Affinity DataIC50:  10.8nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522156(US11161815, Example 12)
Affinity DataIC50:  12.3nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM50576851(CHEMBL1876217)
Affinity DataIC50:  13nMAssay Description:Inhibition of TrxR1 (unknown origin) assessed as reduction in DTNB to TNB by colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM50576851(CHEMBL1876217)
Affinity DataIC50:  13nMAssay Description:Inhibition of TrxR1 (unknown origin) assessed as reduction in DTNB to TNB by colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522167(US11161815, Example 23)
Affinity DataIC50:  14.5nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM50576852(CHEMBL4849098)
Affinity DataIC50:  18nMAssay Description:Inhibition of TrxR1 (unknown origin) assessed as reduction in DTNB to TNB by colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM50576852(CHEMBL4849098)
Affinity DataIC50:  18nMAssay Description:Inhibition of TrxR1 (unknown origin) assessed as reduction in DTNB to TNB by colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522145(US11161815, Example 1)
Affinity DataIC50:  18.2nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522170(US11161815, Example 26)
Affinity DataIC50:  18.8nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522172(US11161815, Example 28)
Affinity DataIC50:  20.3nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522168(US11161815, Example 24)
Affinity DataIC50:  25.3nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM501860(US11028067, Example 1 | US11028067, Example 8)
Affinity DataIC50:  26.8nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM524190(US11168069, Example 3)
Affinity DataIC50:  39.1nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522148(US11161815, Example 4)
Affinity DataIC50:  39.2nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  43nMAssay Description:Inhibition of TrxR1 (unknown origin) assessed as reduction in DTNB to TNB by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522150(US11161815, Example 6)
Affinity DataIC50:  56nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM501861(US11028067, Example 2)
Affinity DataIC50:  56.9nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522160(US11161815, Example 16)
Affinity DataIC50:  60.6nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522174(US11161815, Example 30)
Affinity DataIC50:  66.9nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522176(US11161815, Example 32)
Affinity DataIC50:  76.5nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM524188(US11168069, Example 1)
Affinity DataIC50:  93nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522158(US11161815, Example 14)
Affinity DataIC50:  96.9nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522161(US11161815, Example 17)
Affinity DataIC50:  103nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522159(US11161815, Example 15)
Affinity DataIC50:  122nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522154(US11161815, Example 10)
Affinity DataIC50:  124nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
University Of Padova

Curated by ChEMBL
LigandPNGBDBM50385274(CHEMBL2035489)
Affinity DataIC50:  130nMAssay Description:Inhibition of TrxR1 in rat liver homogenate preincubated for 5 mins measured by DNTB assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522175(US11161815, Example 31)
Affinity DataIC50:  131nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522157(US11161815, Example 13)
Affinity DataIC50:  160nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522149(US11161815, Example 5)
Affinity DataIC50:  181nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM522152(US11161815, Example 8)
Affinity DataIC50:  188nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
University Of Padova

Curated by ChEMBL
LigandPNGBDBM50551265(CHEMBL4792536)
Affinity DataIC50:  190nMAssay Description:Inhibition of recombinant rat TrxR1 using DTNB as substrate preincubated for 15 mins followed by substrate addition and measured for 20 mins by color...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM50547497(CHEMBL4757091)
Affinity DataIC50:  200nMAssay Description:Inhibition of TrxR in human BEL-7402/5-FU cells by colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Oblique Therapeutics

US Patent
LigandPNGBDBM50547498(CHEMBL4755909)
Affinity DataIC50:  200nMAssay Description:Inhibition of TrxR in human BEL-7402/5-FU cells by colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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