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Found 100 Enz. Inhib. hit(s) with Target = 'Thyroid peroxidase'
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM217355(4-benzyl-2-hydroxybenzenecarbohydroxamic acid (HX2...)
Affinity DataIC50:  63nMAssay Description:The halogenation activities of LPO (EC 1.11.1.7) and TPO (EC 1.11.1.8) were determined using a modified method of that described previously [Ferrari ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM92467(2-Thioxanthine, TX2)
Affinity DataIC50:  590nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM50567713(CHEMBL4859908)
Affinity DataIC50:  640nMAssay Description:Inhibition of C-terminal hexaHis-tagged TPO (unknown origin) expressed in Trichoplusia ni insect cells using 3-iodo tyrosine as substrate preincubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM50567712(CHEMBL4869433)
Affinity DataIC50:  700nMAssay Description:Inhibition of C-terminal hexaHis-tagged TPO (unknown origin) expressed in Trichoplusia ni insect cells using 3-iodo tyrosine as substrate preincubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM50567715(CHEMBL4855931)
Affinity DataIC50:  710nMAssay Description:Inhibition of C-terminal hexaHis-tagged TPO (unknown origin) expressed in Trichoplusia ni insect cells using 3-iodo tyrosine as substrate preincubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM50595667(CHEMBL5181350)
Affinity DataIC50:  770nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM312172(Alternative Preparation | US10016430, Example 3 | ...)
Affinity DataIC50:  890nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM50133595(CHEMBL3633460)
Affinity DataIC50:  990nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM50567722(CHEMBL4862053)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of C-terminal hexaHis-tagged TPO (unknown origin) expressed in Trichoplusia ni insect cells using 3-iodo tyrosine as substrate preincubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM50567718(CHEMBL4863015)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of C-terminal hexaHis-tagged TPO (unknown origin) expressed in Trichoplusia ni insect cells using 3-iodo tyrosine as substrate preincubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM50567717(CHEMBL4853722)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of C-terminal hexaHis-tagged TPO (unknown origin) expressed in Trichoplusia ni insect cells using 3-iodo tyrosine as substrate preincubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM312173(1-{2-[(1S)-1-Aminoethyl]-4-chlorobenzyl}-2-thioxo-...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM50595666(CHEMBL5200126)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM312244(1-[2-(Aminomethyl)-4-chlorobenzyl]-2-thioxo-1,2,3,...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM50595661(CHEMBL5197968)
Affinity DataIC50:  1.39E+3nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM50595663(CHEMBL5175091)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM50595660(CHEMBL5185576)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM217354(2-(3,5-bistrifluoromethylbenzylamino)-6-oxo-1H-pyr...)
Affinity DataIC50:  1.59E+3nMAssay Description:The halogenation activities of LPO (EC 1.11.1.7) and TPO (EC 1.11.1.8) were determined using a modified method of that described previously [Ferrari ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM217356(2-(benzylamino)-6-oxo-3H-pyrimidine-5-carbohydroxa...)
Affinity DataIC50:  1.59E+3nMAssay Description:The halogenation activities of LPO (EC 1.11.1.7) and TPO (EC 1.11.1.8) were determined using a modified method of that described previously [Ferrari ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM50567723(CHEMBL4860429)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of C-terminal hexaHis-tagged TPO (unknown origin) expressed in Trichoplusia ni insect cells using 3-iodo tyrosine as substrate preincubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM50567719(CHEMBL4871587)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of C-terminal hexaHis-tagged TPO (unknown origin) expressed in Trichoplusia ni insect cells using 3-iodo tyrosine as substrate preincubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM50595665(CHEMBL5186129)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM50567721(CHEMBL4878518)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of C-terminal hexaHis-tagged TPO (unknown origin) expressed in Trichoplusia ni insect cells using 3-iodo tyrosine as substrate preincubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM50015089(2,N-Dihydroxy-benzamide | CHEMBL309339 | N,2-dihyd...)
Affinity DataIC50:  2.00E+3nMAssay Description:The halogenation activities of LPO (EC 1.11.1.7) and TPO (EC 1.11.1.8) were determined using a modified method of that described previously [Ferrari ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM50567714(CHEMBL4855030)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of C-terminal hexaHis-tagged TPO (unknown origin) expressed in Trichoplusia ni insect cells using 3-iodo tyrosine as substrate preincubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM312245(1-{4-Chloro-2-[(methylamino)methyl]benzyl}-2-thiox...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM357629(7-benzyl-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine ...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of TPO (unknown origin) using 3-iodo tyrosine as substrate incubated for 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM50567716(CHEMBL4846080)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of C-terminal hexaHis-tagged TPO (unknown origin) expressed in Trichoplusia ni insect cells using 3-iodo tyrosine as substrate preincubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM92469(2-Thioxanthine, TX4)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM50133597(CHEBI:8502 | Propacil | Propylthiouracil | Prothyr...)
Affinity DataIC50:  3.38E+3nMAssay Description:Inhibition of TPO (unknown origin) using Amplex Red as substrate assessed as formation of resorufin measured every 20 secs by spectrophotometric anal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM50595662(CHEMBL5197383)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM50507390(CHEMBL4482878 | US10981879, Example 3)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of human TPO assessed as reduction in H2O2 catalyzed 3,5-iodo tyrosine formation from 3-iodotyrosine and potassium iodide preincubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM50595659(CHEMBL5181827)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM50595664(CHEMBL5207346)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM312172(Alternative Preparation | US10016430, Example 3 | ...)
Affinity DataIC50:  4.30E+3nMAssay Description:To detect thyroid peroxidase (TPO) inhibitory activity, the production of hypoiodous acid (HOI) was quantified. HOI was detected by reacting it with ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM312172(Alternative Preparation | US10016430, Example 3 | ...)
Affinity DataIC50:  4.30E+3nMAssay Description:MPO: The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM312172(Alternative Preparation | US10016430, Example 3 | ...)
Affinity DataIC50:  4.30E+3nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM312157(1-{2-[(1R)-1-Aminopropyl]-4-chlorobenzyl}-2-thioxo...)
Affinity DataIC50:  4.40E+3nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM312157(1-{2-[(1R)-1-Aminopropyl]-4-chlorobenzyl}-2-thioxo...)
Affinity DataIC50:  4.40E+3nMAssay Description:MPO: The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM312157(1-{2-[(1R)-1-Aminopropyl]-4-chlorobenzyl}-2-thioxo...)
Affinity DataIC50:  4.40E+3nMAssay Description:To detect thyroid peroxidase (TPO) inhibitory activity, the production of hypoiodous acid (HOI) was quantified. HOI was detected by reacting it with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM50543850(CHEMBL4645343)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of thyroid peroxidase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM50543852(CHEMBL4633000)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibition of thyroid peroxidase (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM50554044(CHEMBL4792720)
Affinity DataIC50:  6.30E+3nMAssay Description:Inhibition of TPO (unknown origin) using 3-iodo tyrosine as substrate incubated for 10 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM50567720(CHEMBL4855956)
Affinity DataIC50:  6.70E+3nMAssay Description:Inhibition of C-terminal hexaHis-tagged TPO (unknown origin) expressed in Trichoplusia ni insect cells using 3-iodo tyrosine as substrate preincubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM312261(1-{2-[(Propan-2-ylamino)methyl]benzyl}-2-thioxo-1,...)
Affinity DataIC50:  8.10E+3nMAssay Description:Inhibition of human recombinant TPO (1 to 839 residues) expressed in baculovirus-infected insect cells measured after 15 mins in presence of H2O2 by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM312171(1-[2-(1-Aminoethyl)-4-chlorobenzyl]-2-thioxo-1,2,3...)
Affinity DataIC50:  8.80E+3nMAssay Description:To detect thyroid peroxidase (TPO) inhibitory activity, the production of hypoiodous acid (HOI) was quantified. HOI was detected by reacting it with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM312171(1-[2-(1-Aminoethyl)-4-chlorobenzyl]-2-thioxo-1,2,3...)
Affinity DataIC50:  8.80E+3nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM312171(1-[2-(1-Aminoethyl)-4-chlorobenzyl]-2-thioxo-1,2,3...)
Affinity DataIC50:  8.80E+3nMAssay Description:MPO: The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM312176(1-{4-Chloro-2-[1-(methylamino)ethyl]benzyl}-2-thio...)
Affinity DataIC50:  8.90E+3nMAssay Description:To detect thyroid peroxidase (TPO) inhibitory activity, the production of hypoiodous acid (HOI) was quantified. HOI was detected by reacting it with ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThyroid peroxidase(Homo sapiens (Human))
University Of Otago Christchurch

LigandPNGBDBM312176(1-{4-Chloro-2-[1-(methylamino)ethyl]benzyl}-2-thio...)
Affinity DataIC50:  8.90E+3nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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