Compile Data Set for Download or QSAR
maximum 50k data
Found 50 Enz. Inhib. hit(s) with Target = 'Trans-sialidase'
TargetTrans-sialidase(Trypanosoma cruzi)
University Of British Columbia

LigandPNGBDBM84698(Quinolinone derivative, 9)
Affinity DataKi:  400nM ΔG°:  -37.7kJ/mole IC50:  600nMpH: 7.6 T: 2°CAssay Description:Inhibition assay using trans-sialidase, a membrane-associated protein.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of British Columbia

LigandPNGBDBM50174833(CHEMBL199442 | N-(3-(3-(3,4-dihydroxyphenyl)acrylo...)
Affinity DataKi:  3.70E+3nM ΔG°:  -32.0kJ/mole IC50:  2.50E+3nMpH: 7.6 T: 2°CAssay Description:Inhibition assay using trans-sialidase, a membrane-associated protein.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of British Columbia

LigandPNGBDBM50174837(4'-(p-toluenesulfonamide)-3,4-dihydroxy chalcone |...)
Affinity DataKi:  4.60E+3nM ΔG°:  -31.5kJ/mole IC50:  900nMpH: 7.6 T: 2°CAssay Description:Inhibition assay using trans-sialidase, a membrane-associated protein.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50467188(CHEMBL4295254)
Affinity DataKi:  1.40E+5nMAssay Description:Non-competitive inhibition of recombinant HisA-tagged Trypanosoma cruzi trans-sialidase expressed in Escherichia coli BL21 (DE3) using varying levels...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50467190(CHEMBL4284599)
Affinity DataKi:  1.90E+5nMAssay Description:Non-competitive inhibition of recombinant HisA-tagged Trypanosoma cruzi trans-sialidase expressed in Escherichia coli BL21 (DE3) using varying levels...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50467187(CHEMBL4279251)
Affinity DataKi:  4.30E+5nMAssay Description:Non-competitive inhibition of recombinant HisA-tagged Trypanosoma cruzi trans-sialidase expressed in Escherichia coli BL21 (DE3) using varying levels...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of British Columbia

LigandPNGBDBM50118216((4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl di...)
Affinity DataKi:  7.30E+6nMAssay Description:Inhibition of Trypanosoma cruzi trans-SialidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50118216((4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl di...)
Affinity DataKi:  7.30E+6nMAssay Description:Inhibition of Trypanosoma cruzi trans-sialidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Bath

Curated by ChEMBL
LigandPNGBDBM4706((2R,3R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-...)
Affinity DataKi:  1.23E+7nMAssay Description:Inhibition of recombinant Trypanosoma cruzi trans-sialidase expressed in Escherichia coli BL21 (DE3) using MuNANA as substrate after 10 mins in prese...More data for this Ligand-Target Pair
TargetTrans-sialidase(Trypanosoma cruzi)
University Of British Columbia

LigandPNGBDBM4706((2R,3R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-...)
Affinity DataKi:  1.23E+7nMAssay Description:Inhibition of Trypanosoma cruzi trans-SialidaseMore data for this Ligand-Target Pair
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Bath

Curated by ChEMBL
LigandPNGBDBM84698(Quinolinone derivative, 9)
Affinity DataIC50:  600nMAssay Description:Inhibition of Trypanosoma cruzi trans-sialidase using Trifluoromethylumbelliferyl alpha-sialoside as substrate by UV/visible spectrophotometerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50174837(4'-(p-toluenesulfonamide)-3,4-dihydroxy chalcone |...)
Affinity DataIC50:  900nMAssay Description:Inhibition of Trypanosoma cruzi trans-sialidase using CF3MuSA as substrate by UV/visible spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of British Columbia

LigandPNGBDBM84697(Quinolinone derivative, 8)
Affinity DataIC50:  3.00E+4nMpH: 7.6 T: 2°CAssay Description:Inhibition assay using trans-sialidase, a membrane-associated protein.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of British Columbia

LigandPNGBDBM50174834(CHEMBL382280 | N-(3-(3-(4-hydroxyphenyl)acryloyl)p...)
Affinity DataIC50:  3.70E+4nMpH: 7.6 T: 2°CAssay Description:Inhibition assay using trans-sialidase, a membrane-associated protein.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of British Columbia

LigandPNGBDBM50174835(4'-(4-toluenesulfonamido)-4-hydroxychalcone | 4'-(...)
Affinity DataIC50:  7.30E+4nMpH: 7.6 T: 2°CAssay Description:Inhibition assay using trans-sialidase, a membrane-associated protein.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of British Columbia

LigandPNGBDBM50266507(3-(benzo[d]thiazol-2-yl)-4-(2,5-dimethylphenyl)but...)
Affinity DataIC50:  1.20E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of British Columbia

LigandPNGBDBM50266479(3-(benzo[d]thiazol-2-yl)-4-(3-fluorophenyl)but-3-e...)
Affinity DataIC50:  1.20E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of British Columbia

LigandPNGBDBM50266386(3-(benzo[d]thiazol-2-yl)-4-(2-isopropoxyphenyl)but...)
Affinity DataIC50:  1.50E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of British Columbia

LigandPNGBDBM50266509(3-(benzo[d]thiazol-2-yl)-4-(3-(trifluoromethyl)phe...)
Affinity DataIC50:  1.50E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of British Columbia

LigandPNGBDBM50266506(3-(benzo[d]thiazol-2-yl)-4-(2-ethoxyphenyl)but-3-e...)
Affinity DataIC50:  1.60E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of British Columbia

LigandPNGBDBM50266478(3-(benzo[d]thiazol-2-yl)-4-(3,4-dimethoxyphenyl)bu...)
Affinity DataIC50:  1.80E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50467188(CHEMBL4295254)
Affinity DataIC50:  2.10E+5nMAssay Description:Inhibition of recombinant HisA-tagged Trypanosoma cruzi trans-sialidase expressed in Escherichia coli BL21 (DE3) using MuNANA as substrate pretreated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of British Columbia

LigandPNGBDBM50266444(2-(4,5-dimethyl-3-(propoxycarbonyl)thiophen-2-ylca...)
Affinity DataIC50:  2.10E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50467190(CHEMBL4284599)
Affinity DataIC50:  2.30E+5nMAssay Description:Inhibition of recombinant HisA-tagged Trypanosoma cruzi trans-sialidase expressed in Escherichia coli BL21 (DE3) using MuNANA as substrate pretreated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of British Columbia

LigandPNGBDBM50266334(2-(2-acetyl-5-tert-butylthiophen-3-ylcarbamoyl)ben...)
Affinity DataIC50:  2.70E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50467196(CHEMBL4283535)
Affinity DataIC50:  2.70E+5nMAssay Description:Inhibition of recombinant HisA-tagged Trypanosoma cruzi trans-sialidase expressed in Escherichia coli BL21 (DE3) using MuNANA as substrate pretreated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of British Columbia

LigandPNGBDBM50266335((5-(2-(benzo[d][1,3]dioxol-5-ylamino)-2-oxoethylth...)
Affinity DataIC50:  2.80E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50467192(CHEMBL4280072)
Affinity DataIC50:  2.90E+5nMAssay Description:Inhibition of recombinant HisA-tagged Trypanosoma cruzi trans-sialidase expressed in Escherichia coli BL21 (DE3) using MuNANA as substrate pretreated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of British Columbia

LigandPNGBDBM50266510(2-(2-acetylthiophen-3-ylcarbamoyl)benzoate | cid_2...)
Affinity DataIC50:  2.90E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of British Columbia

LigandPNGBDBM50266386(3-(benzo[d]thiazol-2-yl)-4-(2-isopropoxyphenyl)but...)
Affinity DataIC50:  2.90E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by TIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of British Columbia

LigandPNGBDBM50266477(3-(benzo[d]thiazol-2-yl)-4-(3-methoxyphenyl)but-3-...)
Affinity DataIC50:  3.10E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by MuNANA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of British Columbia

LigandPNGBDBM50266506(3-(benzo[d]thiazol-2-yl)-4-(2-ethoxyphenyl)but-3-e...)
Affinity DataIC50:  4.20E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by TIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of British Columbia

LigandPNGBDBM4733(5-Acetylamino-6-aminopyridine-2-carboxylic acid | ...)
Affinity DataIC50:  4.40E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-SialidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50467187(CHEMBL4279251)
Affinity DataIC50:  4.70E+5nMAssay Description:Inhibition of recombinant HisA-tagged Trypanosoma cruzi trans-sialidase expressed in Escherichia coli BL21 (DE3) using MuNANA as substrate pretreated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50467194(CHEMBL4294788)
Affinity DataIC50:  5.10E+5nMAssay Description:Inhibition of recombinant HisA-tagged Trypanosoma cruzi trans-sialidase expressed in Escherichia coli BL21 (DE3) using MuNANA as substrate pretreated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of British Columbia

LigandPNGBDBM50266508(3-(benzo[d]thiazol-2-yl)-4-(3-hydroxyphenyl)but-3-...)
Affinity DataIC50:  5.20E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-Sialidase by TIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of British Columbia

LigandPNGBDBM50266705(4-acetamido-3-(hydroxymethyl)benzoate)
Affinity DataIC50:  5.40E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-SialidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of British Columbia

LigandPNGBDBM50377984(Cephulac Syrup | Cholac | Chronulac | Constilac | ...)
Affinity DataIC50:  5.70E+5nMAssay Description:Inhibition of Trypanosoma cruzi trans-SialidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50467195(CHEMBL4286891)
Affinity DataIC50:  6.30E+5nMAssay Description:Inhibition of recombinant HisA-tagged Trypanosoma cruzi trans-sialidase expressed in Escherichia coli BL21 (DE3) using MuNANA as substrate pretreated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50467191(CHEMBL4287976)
Affinity DataIC50:  7.10E+5nMAssay Description:Inhibition of recombinant HisA-tagged Trypanosoma cruzi trans-sialidase expressed in Escherichia coli BL21 (DE3) using MuNANA as substrate pretreated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of British Columbia

LigandPNGBDBM50266707((3S,4S,5R)-4-acetamido-3,5-dihydroxycyclohex-1-eny...)
Affinity DataIC50:  1.50E+6nMAssay Description:Inhibition of Trypanosoma cruzi trans-SialidaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50467197(CHEMBL4289914)
Affinity DataIC50:  2.35E+6nMAssay Description:Inhibition of recombinant HisA-tagged Trypanosoma cruzi trans-sialidase expressed in Escherichia coli BL21 (DE3) using MuNANA as substrate pretreated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of British Columbia

LigandPNGBDBM50266703(ethyl (3S,4R,5R)-4-acetamido-3-hydroxy-5-(2-hydrox...)
Affinity DataIC50:  5.00E+6nMAssay Description:Inhibition of Trypanosoma cruzi trans-SialidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50467189(CHEMBL4291378)
Affinity DataIC50:  5.58E+6nMAssay Description:Inhibition of recombinant HisA-tagged Trypanosoma cruzi trans-sialidase expressed in Escherichia coli BL21 (DE3) using MuNANA as substrate pretreated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrans-sialidase(Trypanosoma cruzi)
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50467193(CHEMBL4289944)
Affinity DataIC50: >7.50E+6nMAssay Description:Inhibition of recombinant HisA-tagged Trypanosoma cruzi trans-sialidase expressed in Escherichia coli BL21 (DE3) using MuNANA as substrate pretreated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase [3-643](Trypanosoma cruzi)
Universidade Federal Do Rio De Janeiro

LigandPNGBDBM217357(NeuSGal | methyl-S-(5-acetamide-3,5-dideoxy-D-glyc...)
Affinity DataKd:  4.56E+5nMT: 2°CAssay Description:Solutions of TS, TSY342H, and TSD247A in 20 mM Tris-HCl were exchanged with deuterated PBS using four cycles of concentration with Amicon Ultra (50,0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrans-sialidase [3-643,Y342H](Trypanosoma cruzi)
Universidade Federal Do Rio De Janeiro

LigandPNGBDBM217358(α2,3'-sialyllactose | 3-SL)
Affinity DataKd:  2.34E+5nMT: 2°CAssay Description:Solutions of TS, TSY342H, and TSD247A in 20 mM Tris-HCl were exchanged with deuterated PBS using four cycles of concentration with Amicon Ultra (50,0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrans-sialidase [3-643](Trypanosoma cruzi)
Universidade Federal Do Rio De Janeiro

LigandPNGBDBM50048093(CHEBI:610092 | CHEMBL503075 | Lactoside | Methyl B...)
Affinity DataKd:  1.50E+4nMT: 2°CAssay Description:Solutions of TS, TSY342H, and TSD247A in 20 mM Tris-HCl were exchanged with deuterated PBS using four cycles of concentration with Amicon Ultra (50,0...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrans-sialidase [3-643,D247A](Trypanosoma cruzi)
Universidade Federal Do Rio De Janeiro

LigandPNGBDBM217358(α2,3'-sialyllactose | 3-SL)
Affinity DataKd:  1.07E+5nMT: 2°CAssay Description:Solutions of TS, TSY342H, and TSD247A in 20 mM Tris-HCl were exchanged with deuterated PBS using four cycles of concentration with Amicon Ultra (50,0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrans-sialidase [3-643,Y342H](Trypanosoma cruzi)
Universidade Federal Do Rio De Janeiro

LigandPNGBDBM50048093(CHEBI:610092 | CHEMBL503075 | Lactoside | Methyl B...)
Affinity DataKd:  5.20E+4nMT: 2°CAssay Description:Solutions of TS, TSY342H, and TSD247A in 20 mM Tris-HCl were exchanged with deuterated PBS using four cycles of concentration with Amicon Ultra (50,0...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed