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Found 91 Enz. Inhib. hit(s) with Target = 'UDP-glucuronosyltransferase 1A1'
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM50044561(CHEMBL3222137)
Affinity DataKi:  1.54E+3nMAssay Description:Substrate inhibition of human UGT1A1-mediated T-5224 acyl O-glucuronide formation after 10 to 60 mins in presence of UDP-glucuronic acid by HPLC meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM50044561(CHEMBL3222137)
Affinity DataKi:  4.67E+3nMAssay Description:Substrate inhibition of human UGT1A1-mediated T-5224 hydroxyl O-glucuronide formation after 10 to 60 mins in presence of UDP-glucuronic acid by HPLC ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM50088502(CHEBI:5970 | CHEMBL3527329)
Affinity DataKi:  8.50E+3nMAssay Description:Substrate inhibition of human recombinant UGT1A1 assessed as IRI-O-5-monoglucuronide formation incubated for 5 mins prior to UDPGA addition measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM50088502(CHEBI:5970 | CHEMBL3527329)
Affinity DataKi:  1.41E+4nMAssay Description:Substrate inhibition of human recombinant UGT1A1 assessed as IRI-O-4'-monoglucuronide formation incubated for 5 mins prior to UDPGA addition measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A10(Homo sapiens (Human))
The University Of British Columbia

Curated by ChEMBL
LigandPNGBDBM13066(2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid...)
Affinity DataKi:  2.80E+4nMAssay Description:Inhibition of 4-methylumbelliferone glucuronidation by human recombinant UGT1A10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM23411(5,6,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-...)
Affinity DataKi:  4.13E+4nMAssay Description:Drug metabolism assessed as human recombinant UGT1A1-mediated formation of scutellarein-7-O-glucuronide after 25 mins by HPLC/UV analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM13066(2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid...)
Affinity DataKi:  5.20E+4nMAssay Description:Inhibition of 4-methylumbelliferone glucuronidation by human recombinant UGT1A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM50242284(CHEMBL487805 | scutellarin)
Affinity DataKi:  9.66E+4nMAssay Description:Drug metabolism assessed as human recombinant UGT1A1-mediated formation of scutellarein-6,7-diglucuronide after 25 mins by HPLC/UV analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A10(Homo sapiens (Human))
The University Of British Columbia

Curated by ChEMBL
LigandPNGBDBM50088511(CHEBI:87620 | Epiestriol | Epioestriol)
Affinity DataKi:  9.81E+4nMAssay Description:Inhibition of recombinant human C-terminal His-tagged UGT1A10 after 15 to 60 mins by Michaelis-Menten equation analysis in presence of UDPGAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A10(Homo sapiens (Human))
The University Of British Columbia

Curated by ChEMBL
LigandPNGBDBM50088502(CHEBI:5970 | CHEMBL3527329)
Affinity DataKi:  1.21E+5nMAssay Description:Substrate inhibition of human recombinant UGT1A10 assessed as IRI-O-4'-monoglucuronide formation incubated for 5 mins prior to UDPGA addition measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A10(Homo sapiens (Human))
The University Of British Columbia

Curated by ChEMBL
LigandPNGBDBM50242284(CHEMBL487805 | scutellarin)
Affinity DataKi:  2.08E+5nMAssay Description:Drug metabolism assessed as human recombinant UGT1A10-mediated formation of scutellarein-6,7-diglucuronide after 25 mins by HPLC/UV analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM50206509(4-Dipropylsulfamoyl-benzoic acid | 4-Dipropylsulfa...)
Affinity DataKi:  2.21E+5nMAssay Description:Inhibition of 4-methylumbelliferone glucuronidation by human recombinant UGT1A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A10(Homo sapiens (Human))
The University Of British Columbia

Curated by ChEMBL
LigandPNGBDBM50206509(4-Dipropylsulfamoyl-benzoic acid | 4-Dipropylsulfa...)
Affinity DataKi:  2.31E+5nMAssay Description:Inhibition of 4-methylumbelliferone glucuronidation by human recombinant UGT1A10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A10(Homo sapiens (Human))
The University Of British Columbia

Curated by ChEMBL
LigandPNGBDBM50358252(CHEMBL1922235)
Affinity DataKi:  2.35E+5nMAssay Description:Inhibition of human recombinant UGT1A10 after 10 mins in presence of UDPGAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A10(Homo sapiens (Human))
The University Of British Columbia

Curated by ChEMBL
LigandPNGBDBM50088505(CHEMBL3542370)
Affinity DataKi:  2.42E+5nMAssay Description:Drug metabolism assessed as human recombinant UGT1A10-mediated formation of scutellarein-6,7-diglucuronide after 25 mins by HPLC/UV analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM13934(Atazanavir | BMS 232632 | CGP 73547 | CHEMBL1163 |...)
Affinity DataIC50:  300nMAssay Description:Inhibition of recombinant human UGT1A1 using bilirubin as substrate preincubated for 5 mins followed by substrate addition and measured after 40 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM13934(Atazanavir | BMS 232632 | CGP 73547 | CHEMBL1163 |...)
Affinity DataIC50:  300nMAssay Description:Inhibition of human recombinant UGT1A1 using bilirubin as substrate incubated for 40 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM13934(Atazanavir | BMS 232632 | CGP 73547 | CHEMBL1163 |...)
Affinity DataIC50:  600nMAssay Description:Inhibition of UGT1A1 in human liver microsomes using beta-estradiol as substrate preincubated for 5 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM13934(Atazanavir | BMS 232632 | CGP 73547 | CHEMBL1163 |...)
Affinity DataIC50:  600nMAssay Description:Inhibition of UGT1A1 in human liver microsomes using beta-estradiol as substrate incubated for 40 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM50068270((E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-y...)
Affinity DataIC50:  970nMAssay Description:Induction of UGT1A1 (unknown origin) assessed as increase in intracellular acidic autophagy vesicles formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM50599144(CHEMBL5179012)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human recombinant UGT1A1 using bilirubin as substrate incubated for 40 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM50460863(CHEMBL4227228)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human UGT1A1 expressed in baculovirus infected insect cells using bilirubin as substrate measured after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM50576021(CHEMBL4573938)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of UGT1A1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM50553286(CHEMBL4794465)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of human UGT1A1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM50458163(CHEMBL4209316)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of human UGT1A1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM50600733(CHEMBL5182534)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human UGT1A1More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM50088504(A-84538 | ABBOTT-84538 | CHEBI:45409 | Norvir | Ri...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in estradiol 3-glucuronidation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM50599144(CHEMBL5179012)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of UGT1A1 in human liver microsomes using beta-estradiol as substrate incubated for 40 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM50523559(CHEMBL4573907)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of UGT1A1 in human liver microsomes using beta-estradiol as substrate preincubated for 5 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM50523559(CHEMBL4573907)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of recombinant human UGT1A1 using bilirubin as substrate preincubated for 5 mins followed by substrate addition and measured after 40 mins...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM50088504(A-84538 | ABBOTT-84538 | CHEBI:45409 | Norvir | Ri...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in bilirubin glucuronidation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM13934(Atazanavir | BMS 232632 | CGP 73547 | CHEMBL1163 |...)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of UGT1A1 in rat liver microsomes using beta-estradiol as substrate preincubated for 5 mins followed by substrate addition and measured af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM50101979(2,6-Dihydroxyanthraquinone | 2,6-dihydroxy-9,10-an...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in bilirubin glucuronidation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM372346(Method A: (R)-4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13a...)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of UGT1A1(unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM50101979(2,6-Dihydroxyanthraquinone | 2,6-dihydroxy-9,10-an...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in estradiol 3-glucuronidation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM31768(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)
Affinity DataIC50:  4.10E+3nMAssay Description:Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM13934(Atazanavir | BMS 232632 | CGP 73547 | CHEMBL1163 |...)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of recombinant rat UGT1A1 using beta-estradiol as substrate preincubated for 5 mins followed by substrate addition and measured after 40 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM50009001(5,6,7-Trihydroxyflavone | 5,6,7-trihydroxy-2-pheny...)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in estradiol 3-glucuronidation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM50301375(3,3',5,5'-tetraiodo-L-thyronine | 3,5,3',5'-tetrai...)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in bilirubin glucuronidation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM50301375(3,3',5,5'-tetraiodo-L-thyronine | 3,5,3',5'-tetrai...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in estradiol 3-glucuronidation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM50550263(CHEMBL4748750)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of UGT1A1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM50009001(5,6,7-Trihydroxyflavone | 5,6,7-trihydroxy-2-pheny...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in bilirubin glucuronidation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM23420(7,4′-Dihydroxy-isoflavone (3a) | 7-hydroxy-3...)
Affinity DataIC50:  7.30E+3nMAssay Description:Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in bilirubin glucuronidation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM50561654(CHEMBL4785914)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of UGT1A1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM25759(CHEMBL723 | Carvedilol | Coreg | Dilatrend | Eucar...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in estradiol 3-glucuronidation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50523559(CHEMBL4573907)
Affinity DataIC50:  1.26E+4nMAssay Description:Inhibition of recombinant rat UGT1A1 using beta-estradiol as substrate preincubated for 5 mins followed by substrate addition and measured after 40 m...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM85507(CAS_4394-00-7 | NSC_4488 | Niflumic acid | Niflumi...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in estradiol 3-glucuronidation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM8610(1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imi...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of human recombinant UGT1A1 expressed in HEK293 cells assessed as reduction in estradiol 3-glucuronidation by LC-MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50523559(CHEMBL4573907)
Affinity DataIC50:  1.95E+4nMAssay Description:Inhibition of UGT1A1 in rat liver microsomes using beta-estradiol as substrate preincubated for 5 mins followed by substrate addition and measured af...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetUDP-glucuronosyltransferase 1A1(Homo sapiens (Human))
Toyama Chemical

Curated by ChEMBL
LigandPNGBDBM50001839(CHEMBL428647 | PACLITAXEL | taxol)
Affinity DataIC50:  2.00E+4nMAssay Description:Refer to Fisher et al., Drug Metab. Dispos., 28:560-566.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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