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Found 347 Enz. Inhib. hit(s) with Target = 'Excitatory amino acid transporter 3'
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM17657((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Affinity DataKi:  51nMAssay Description:Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50102484(2-(2-Amino-3-hydroxy-butyrylamino)-2-hydroxy-succi...)
Affinity DataKi:  600nMAssay Description:Inhibitory activity against EAAC1 (EAAT3) in absence of L-glutamic acid.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50252046((2S,4S)-2-amino-4-(benzyloxymethyl)pentanedioic ac...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM86711(3-[3-Methyl-4-(4-chlorophenyl)benzoylamino]alanine...)
Affinity DataKi:  1.45E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM86714(WAY 212922 | WAY-212922)
Affinity DataKi:  1.84E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50252051((2S,4R)-2-amino-4-(3-(methylamino)-3-oxopropyl)pen...)
Affinity DataKi: >3.00E+3nMAssay Description:Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50251951((2S,4S)-2-amino-4-(hydroxymethyl)pentanedioic acid...)
Affinity DataKi:  3.00E+3nMAssay Description:Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50252047((2S,4S)-4-(2-Hydroxy-2-oxoethyl)glutamic Acid | (2...)
Affinity DataKi: >3.00E+3nMAssay Description:Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50252049((1S,3R)-1-aminopentane-1,3,5-tricarboxylic acid | ...)
Affinity DataKi: >3.00E+3nMAssay Description:Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50252048((2S,4R)-2-amino-4-(3-methoxy-3-oxopropyl)pentanedi...)
Affinity DataKi:  3.00E+3nMAssay Description:Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50252050((2S,4R)-2-amino-4-(3-amino-3-oxopropyl)pentanedioi...)
Affinity DataKi: >3.00E+3nMAssay Description:Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50252662((2S,4R)-4-(3-Propylamino-3-oxopropyl)glutamic acid...)
Affinity DataKi: >3.00E+3nMAssay Description:Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50251893((2S,4R)-2-amino-4-(3-(benzylamino)-3-oxopropyl)pen...)
Affinity DataKi:  3.00E+3nMAssay Description:Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50251894((2S,4R)-4-(2,2-Diphenylethylamino-3-oxopropyl)glut...)
Affinity DataKi:  3.00E+3nMAssay Description:Inhibition of [3H]D-Asp uptake at human EAAT3 in HEK293 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM86712(CAS_868359-05-1 | N-[4-(2-BROMO-4,5-DIFLUOROPHENOX...)
Affinity DataKi:  3.79E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50102484(2-(2-Amino-3-hydroxy-butyrylamino)-2-hydroxy-succi...)
Affinity DataKi:  4.90E+3nMAssay Description:Inhibitory activity against EAAC1 (EAAT3) in presence of 20 uM L-glutamic acidMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM86713(WAY 213394 | WAY-213394)
Affinity DataKi:  6.56E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50031704((2S,4R)-2-Amino-4-methyl-pentanedioic acid | (2S,4...)
Affinity DataKi:  6.60E+3nMAssay Description:Binding affinity to human EAAT3 expressed in HEK293 cells in FMP (FLPR) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50197103((2S,1'R,2'S)-2-(2'-Carboxycyclobutyl)glycine | CHE...)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of human EAAT3 expressed in HEK293 cells by FLIPR membrane potential assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM86316(WAY-855)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50102486(2-Phenyl-4,5-dihydro-oxazole-4,5-dicarboxylic acid...)
Affinity DataKi:  1.40E+4nMAssay Description:Inhibitory activity against EAAC1 (EAAT3) in absence of L-glutamic acid in mammalian cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50088230((2S,4R)-4-propylglutamic acid | 2-Amino-4-propyl-p...)
Affinity DataKi:  3.20E+4nMAssay Description:Binding affinity to human EAAT3 expressed in HEK293 cells in FMP (FLPR) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50178684((2S,4R)-4-ethylglutamic acid | CHEMBL372124)
Affinity DataKi:  3.80E+4nMAssay Description:Binding affinity to human EAAT3 expressed in HEK293 cells in FMP (FLPR) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50102486(2-Phenyl-4,5-dihydro-oxazole-4,5-dicarboxylic acid...)
Affinity DataKi:  4.20E+4nMAssay Description:Inhibitory activity against EAAC1 (EAAT3) in presence of 20 uM L-glutamic acid in mammalian cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50180145((1R,4S,5R,6S)-3-azabicyclo[3.3.0]octane-4,6-dicarb...)
Affinity DataKi:  4.60E+4nMAssay Description:Activity against human EAAT3 transfected in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50197104((2S,1'R,2'R)-2-(2'-Carboxycyclobutyl)glycine | CHE...)
Affinity DataKi:  4.90E+4nMAssay Description:Inhibition of human EAAT3 expressed in HEK293 cells by FLIPR membrane potential assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50178683((2S,4S)-4-isopropylglutamic acid | CHEMBL199564)
Affinity DataKi:  5.10E+4nMAssay Description:Binding affinity to human EAAT3 expressed in HEK293 cells in FMP (FLPR) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50197105((2S,1'S,2'R)-2-(2'-Carboxycyclobutyl)glycine | CHE...)
Affinity DataKi:  5.20E+4nMAssay Description:Inhibition of human EAAT3 expressed in HEK293 cells by FLIPR membrane potential assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50178688((2S,4R)-4-benzylglutamic acid | CHEMBL198618)
Affinity DataKi:  6.60E+4nMAssay Description:Binding affinity to human EAAT3 expressed in HEK293 cells in FMP (FLPR) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50102487(2-Phenyl-oxazole-4,5-dicarboxylic acid | CHEMBL841...)
Affinity DataKi:  7.50E+4nMAssay Description:Inhibitory activity against EAAC1 (EAAT3) in absence of L-glutamic acid.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50178685((2S,4R)-4-butylglutamic acid | CHEMBL381004)
Affinity DataKi:  8.00E+4nMAssay Description:Binding affinity to human EAAT3 expressed in HEK293 cells in FMP (FLPR) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50178686((2S,4R)-4-isopentylglutamic acid | CHEMBL197176)
Affinity DataKi:  8.10E+4nMAssay Description:Binding affinity to human EAAT3 expressed in HEK293 cells in FMP (FLPR) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50088220((2S,4R)-4-pentylglutamic acid | 2-Amino-4-pentyl-p...)
Affinity DataKi:  9.80E+4nMAssay Description:Binding affinity to human EAAT3 expressed in HEK293 cells in FMP (FLPR) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50178687((2S,4R)-4-isobutylglutamic acid | CHEMBL199617)
Affinity DataKi:  3.00E+5nMAssay Description:Binding affinity to human EAAT3 expressed in HEK293 cells in FMP (FLPR) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50180146((3S,5S)-2-aza-bicyclo[2.2.1]heptane-3,5-dicarboxyl...)
Affinity DataKi: >4.00E+5nMAssay Description:Activity against human EAAT3 transfected in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50102487(2-Phenyl-oxazole-4,5-dicarboxylic acid | CHEMBL841...)
Affinity DataKi:  5.30E+5nMAssay Description:Inhibitory activity against EAAC1 (EAAT3) in presence of 20 uM L-glutamic acid.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50410463(CHEMBL2113115)
Affinity DataIC50:  50nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50366609(CHEMBL4177507)
Affinity DataIC50:  55nMAssay Description:Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50366609(CHEMBL4177507)
Affinity DataIC50:  55nMAssay Description:Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50366614(CHEMBL4176482)
Affinity DataIC50:  93nMAssay Description:Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50366614(CHEMBL4176482)
Affinity DataIC50:  94nMAssay Description:Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50366616(CHEMBL4176427)
Affinity DataIC50:  105nMAssay Description:Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50366616(CHEMBL4176427)
Affinity DataIC50:  110nMAssay Description:Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50327884((2S,3S)-2-amino-3-(3-(4-(trifluoromethyl)benzamido...)
Affinity DataIC50:  117nMAssay Description:Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50327884((2S,3S)-2-amino-3-(3-(4-(trifluoromethyl)benzamido...)
Affinity DataIC50:  120nMAssay Description:Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50366626(CHEMBL4165811)
Affinity DataIC50:  129nMAssay Description:Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50366626(CHEMBL4165811)
Affinity DataIC50:  130nMAssay Description:Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50410457(CHEMBL2113112)
Affinity DataIC50:  140nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50410455(CHEMBL2113116)
Affinity DataIC50:  200nMAssay Description:Inhibitory concentration against glutamate uptake in HEK cells expressing human Excitatory amino acid transporter 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Universite Blaise Pascal

Curated by ChEMBL
LigandPNGBDBM50366648(CHEMBL4173045)
Affinity DataIC50:  288nMAssay Description:Inhibition of human EAAT3 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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