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Found 2004 Enz. Inhib. hit(s) with Target = 'Fatty acid synthase'
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM24567((2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-...)
Affinity DataKi:  280nMAssay Description:Antagonist activity at recombinant FASN thioesterase domain by fluorigenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetFatty acid synthase [2202-2509](Homo sapiens (Human))
Burnham Institute For Medical Research

LigandPNGBDBM24988(1-(3-hexyl-4-oxooxetan-2-yl)tridecan-2-yl 2-formam...)
Affinity DataKi:  300nM ΔG°:  -38.7kJ/molepH: 7.5 T: 2°CAssay Description:The reaction mixture consisted of FAS thioesterase domain (FASTE) in buffer, which was preincubated with test compounds for 30 min. The reaction was ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50124408(CHEMBL2165266)
Affinity DataKi:  380nMAssay Description:Inhibition of fatty acid synthase KE domain (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase [2202-2509](Homo sapiens (Human))
Burnham Institute For Medical Research

LigandPNGBDBM24984((5E)-1-(3,5-dimethylphenyl)-5-[(5-phenylfuran-2-yl...)
Affinity DataKi:  380nM ΔG°:  -38.1kJ/molepH: 7.5 T: 2°CAssay Description:The reaction mixture consisted of FAS thioesterase domain (FASTE) in buffer, which was preincubated with test compounds for 30 min. The reaction was ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM24984((5E)-1-(3,5-dimethylphenyl)-5-[(5-phenylfuran-2-yl...)
Affinity DataKi:  380nMAssay Description:Antagonist activity at human recombinant FASN thioesterase domain by fluorigenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase [2202-2509](Homo sapiens (Human))
Burnham Institute For Medical Research

LigandPNGBDBM24987((5E)-1-benzyl-5-{[5-(2-chlorophenyl)furan-2-yl]met...)
Affinity DataKi:  850nM ΔG°:  -36.0kJ/molepH: 7.5 T: 2°CAssay Description:The reaction mixture consisted of FAS thioesterase domain (FASTE) in buffer, which was preincubated with test compounds for 30 min. The reaction was ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase [2202-2509](Homo sapiens (Human))
Burnham Institute For Medical Research

LigandPNGBDBM24986((5E)-1-(3-bromophenyl)-5-{[5-(2-nitrophenyl)furan-...)
Affinity DataKi:  880nM ΔG°:  -36.0kJ/molepH: 7.5 T: 2°CAssay Description:The reaction mixture consisted of FAS thioesterase domain (FASTE) in buffer, which was preincubated with test compounds for 30 min. The reaction was ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase [2202-2509](Homo sapiens (Human))
Burnham Institute For Medical Research

LigandPNGBDBM24985((5E)-5-{[5-(4-fluorophenyl)furan-2-yl]methylidene}...)
Affinity DataKi:  910nM ΔG°:  -35.9kJ/molepH: 7.5 T: 2°CAssay Description:The reaction mixture consisted of FAS thioesterase domain (FASTE) in buffer, which was preincubated with test compounds for 30 min. The reaction was ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50070208(A-65006 | AG-1749 | CHEBI:6375 | Lansoprazole | Pr...)
Affinity DataKi:  1.70E+3nMAssay Description:Inhibition of human FASN enoyl reductase activity using crotonyl CoA as substrate assessed as inhibition of substrate hydrolysis measured every 1 min...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50394664(CHEMBL2165413)
Affinity DataKi:  2.50E+3nMAssay Description:Antagonist activity at recombinant FASN thioesterase domain by fluorigenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50241343((RS)-6-methoxy-2-((4-methoxy-3,5-dimethylpyridin-2...)
Affinity DataKi:  3.40E+3nMAssay Description:Inhibition of purified recombinant FASN TE activity (unknown origin) using 4-MUH as substrate preincubated for 30 mins before substrate addition meas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50241342(5-(difluoromethoxy)-2-((3,4-dimethoxypyridin-2-yl)...)
Affinity DataKi:  4.10E+3nMAssay Description:Inhibition of purified recombinant FASN TE activity (unknown origin) using 4-MUH as substrate preincubated for 30 mins before substrate addition meas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50070208(A-65006 | AG-1749 | CHEBI:6375 | Lansoprazole | Pr...)
Affinity DataKi:  5.30E+3nMAssay Description:Inhibition of purified recombinant FASN TE activity (unknown origin) using 4-MUH as substrate preincubated for 30 mins before substrate addition meas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50070209(Aciphex | CHEBI:8768 | LY-307640 | Rabeprazole)
Affinity DataKi:  5.90E+3nMAssay Description:Inhibition of purified recombinant FASN TE activity (unknown origin) using 4-MUH as substrate preincubated for 30 mins before substrate addition meas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50142501((+/-)-2-amino-4-(((2S,3S,4R,5R)-5-(6-amino-9H-puri...)
Affinity DataKi:  3.00E+4nMAssay Description:Inhibition constant against Escherichia coli cyclopropane fatty acid synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50142502(2-Amino-4-[(2S,3S,4R,5R)-5-(6-amino-purin-9-yl)-3,...)
Affinity DataKi:  3.00E+4nMAssay Description:Inhibition constant against Escherichia coli cyclopropane fatty acid synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50142502(2-Amino-4-[(2S,3S,4R,5R)-5-(6-amino-purin-9-yl)-3,...)
Affinity DataKi:  5.00E+4nMAssay Description:Inhibition constant against Escherichia coli cyclopropane fatty acid synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50142502(2-Amino-4-[(2S,3S,4R,5R)-5-(6-amino-purin-9-yl)-3,...)
Affinity DataKi:  5.00E+4nMAssay Description:Inhibition constant against Escherichia coli cyclopropane fatty acid synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50142505(2-Amino-4-[(2S,3S,4R,5R)-5-(6-amino-purin-9-yl)-3,...)
Affinity DataKi:  1.00E+5nMAssay Description:Inhibition constant against Escherichia coli cyclopropane fatty acid synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50009672(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)
Affinity DataKi:  1.50E+5nMAssay Description:Inhibition constant against Escherichia coli cyclopropane fatty acid synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50142506((2R,3R,4S,5S)-2-(6-Amino-purin-9-yl)-5-methanesulf...)
Affinity DataKi:  2.20E+5nMAssay Description:Inhibition constant against Escherichia coli cyclopropane fatty acid synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50142504((2R,3R,4S,5S)-2-(6-Amino-purin-9-yl)-5-methanesulf...)
Affinity DataKi:  5.00E+5nMAssay Description:Inhibition constant against Escherichia coli cyclopropane fatty acid synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM22111((2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-5-[(methyl...)
Affinity DataKi:  1.50E+6nMAssay Description:Inhibition constant against Escherichia coli cyclopropane fatty acid synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50366942(CHEMBL540135)
Affinity DataKi:  2.50E+6nMAssay Description:Inhibition constant against Escherichia coli cyclopropane fatty acid synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50291713(((S)-3-Amino-3-carboxy-propyl)-dimethyl-sulfonium ...)
Affinity DataKi:  1.40E+8nMAssay Description:Inhibition constant against Escherichia coli cyclopropane fatty acid synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50142500((2S)-2-amino-4-(methylsulfanyl)butanoic acid | (S)...)
Affinity DataKi: >1.50E+8nMAssay Description:Inhibition constant against Escherichia coli cyclopropane fatty acid synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50124410(CHEMBL3623457)
Affinity DataIC50:  3nMAssay Description:Inhibition of fatty acid synthase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM128366(US8802864, 132)
Affinity DataIC50:  3nMpH: 7.0Assay Description:Assay #1:Inhibition of FAS activity can be measured based on the detection of residual NADPH substrate after the FAS assay is quenched. This assay is...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM244437(US10226449, cpd 46 | US9428502, 46)
Affinity DataIC50:  5nMAssay Description:FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM244437(US10226449, cpd 46 | US9428502, 46)
Affinity DataIC50:  5nMT: 2°CAssay Description:The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FAS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM128362(US8802864, 42)
Affinity DataIC50:  5nMpH: 7.0Assay Description:Assay #1:Inhibition of FAS activity can be measured based on the detection of residual NADPH substrate after the FAS assay is quenched. This assay is...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50391838(CHEMBL2147033)
Affinity DataIC50:  6nMAssay Description:Inhibition of fatty acid synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM244398(US10226449, cpd 7 | US9428502, 7)
Affinity DataIC50:  6nMAssay Description:FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM244404(US10226449, cpd 13 | US9428502, 13)
Affinity DataIC50:  6nMAssay Description:FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50124413(CHEMBL3623460)
Affinity DataIC50:  6nMAssay Description:Inhibition of fatty acid synthase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM244398(US10226449, cpd 7 | US9428502, 7)
Affinity DataIC50:  6nMT: 2°CAssay Description:The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FAS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM244404(US10226449, cpd 13 | US9428502, 13)
Affinity DataIC50:  6nMT: 2°CAssay Description:The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FAS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM128359(US8802864, 14)
Affinity DataIC50:  6nMpH: 7.0Assay Description:Assay #1:Inhibition of FAS activity can be measured based on the detection of residual NADPH substrate after the FAS assay is quenched. This assay is...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM244435(US10226449, cpd 44 | US9428502, 44)
Affinity DataIC50:  7nMAssay Description:FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM244438(US10226449, cpd 47 | US9428502, 47)
Affinity DataIC50:  7nMAssay Description:FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM244435(US10226449, cpd 44 | US9428502, 44)
Affinity DataIC50:  7nMT: 2°CAssay Description:The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FAS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM244438(US10226449, cpd 47 | US9428502, 47)
Affinity DataIC50:  7nMT: 2°CAssay Description:The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FAS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM119133((S)-4-(4-(Benzofuran-5-yl)phenyl)-3-((1-(cycloprop...)
Affinity DataIC50:  7.70nMAssay Description:Inhibition of FAS by GSK2194069 was measured by an endpoint assay for thiols using a fluorescent maleimide.More data for this Ligand-Target Pair
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM50124411(CHEMBL3623458)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of fatty acid synthase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM244581(US10226449, cpd 190 | US9428502, 190)
Affinity DataIC50:  8nMAssay Description:FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM244581(US10226449, cpd 190 | US9428502, 190)
Affinity DataIC50:  8nMT: 2°CAssay Description:The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FAS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM244743(US10226449, cpd 353 | US9428502, 353)
Affinity DataIC50:  9nMAssay Description:FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM244769(US10226449, cpd 381 | US9428502, 381)
Affinity DataIC50:  9nMAssay Description:FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM244575(US10226449, cpd 184 | US9428502, 184)
Affinity DataIC50:  9nMAssay Description:FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFatty acid synthase(Homo sapiens (Human))
Wayne State University

Curated by ChEMBL
LigandPNGBDBM244632(US10226449, cpd 241 | US9428502, 241)
Affinity DataIC50:  9nMAssay Description:FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) release...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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