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Found 1647 Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 3'
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50202406((+)-(1R,2R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]h...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]LY341495 from human recombinant mGluR3 in RGT cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50202406((+)-(1R,2R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]h...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]LY341495 from human recombinant mGluR3 in RGT cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50244204(CHEMBL4071962)
Affinity DataKi:  0.470nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu3 receptor expressed in HEK cell membranes after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50244219(CHEMBL4081453)
Affinity DataKi:  0.927nMAssay Description:Binding affinity against 5-hydroxytryptamine 1A receptor from bovine hippocampus, used [3H]8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu3 receptor expressed in hamster AV12 cell membranes co-expressing rat EAAT1 incubated for 90...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50244218(CHEMBL4068189)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu3 receptor expressed in HEK cell membranes after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50244206(CHEMBL4091203)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu3 receptor expressed in HEK cell membranes after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50244202(CHEMBL4091735)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu3 receptor expressed in HEK cell membranes after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50244203(CHEMBL4095567)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu3 receptor expressed in HEK cell membranes after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50558766(CHEMBL4751065)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu3 receptor expressed in hamster AV12 cell membranes co-expressing rat EAAT1 incubated for 90...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50204261(CHEMBL3969063)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]-LY459477 from human mGlu3 receptor expressed in hamster AV12 cell membranes co-expressing human EAAT1 after 90 mins by liquid sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50151453((1R,2R,3R,5R,6R)-2-Amino-3-(3,4-difluoro-benzyloxy...)
Affinity DataKi:  3nMAssay Description:Binding affinity towards metabotropic glutamate receptor 3 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50138784((1R,2S,3R)-2-((S)-Amino-carboxy-methyl)-3-hydroxy-...)
Affinity DataKi:  3nMAssay Description:Binding affinity of the compound towards metabotropic glutamate receptor 3 was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)
Affinity DataKi:  3.04nMAssay Description:Binding affinity towards metabotropic glutamate receptor 3 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50094843((+)-2-Amino-6-fluoro-4-oxo-bicyclo[3.1.0]hexane-2,...)
Affinity DataKi:  3.62nMAssay Description:Tested for binding affinity against Metabotropic glutamate receptor 3 in CHO cells using [3H]-7 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50151438((1R,2R,3R,5R,6R)-2-Amino-3-benzhydryloxy-6-fluoro-...)
Affinity DataKi:  3.93nMAssay Description:Binding affinity towards metabotropic glutamate receptor 3 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50279772(2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-cy...)
Affinity DataKi:  4.11nMAssay Description:Tested for binding affinity against Metabotropic glutamate receptor 3 in CHO cells using [3H]-7 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50244221(CHEMBL4063336)
Affinity DataKi:  4.30nMAssay Description:Binding affinity against 5-hydroxytryptamine 1A receptor from bovine hippocampus, used [3H]8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50151435((1R,2R,3R,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy...)
Affinity DataKi:  4.46nMAssay Description:Binding affinity towards metabotropic glutamate receptor 3 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50558768(CHEMBL4759992)
Affinity DataKi:  4.5nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu3 receptor expressed in hamster AV12 cell membranes co-expressing rat EAAT1 incubated for 90...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50151435((1R,2R,3R,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy...)
Affinity DataKi:  4.5nMAssay Description:Binding affinity to mGLUR3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50089890(4-Amino-2-oxa-bicyclo[3.1.0]hexane-4,6-dicarboxyli...)
Affinity DataKi:  4.60nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 3 (mGluR-3).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50244188(CHEMBL4061162)
Affinity DataKi:  4.60nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu3 receptor expressed in HEK cell membranes after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50074750((1R,4S,5S,6S)-4-amino-2-thia-bicyclo[3.1.0]hexane-...)
Affinity DataKi:  4.70nMAssay Description:Displacement of [3H]LY341495 from human recombinant mGluR3 in RGT cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50151447((1R,2R,3R,5R,6R)-2-Amino-3-(4-chloro-benzyloxy)-6-...)
Affinity DataKi:  4.77nMAssay Description:Binding affinity towards metabotropic glutamate receptor 3 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50151473((1R,2R,3R,5R,6R)-2-Amino-6-fluoro-3-(naphthalen-2-...)
Affinity DataKi:  5.43nMAssay Description:Binding affinity towards metabotropic glutamate receptor 3 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50074749((1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1.0]hexane-4...)
Affinity DataKi:  5.80nMAssay Description:Ability to displace [3H]-LY-341,495 from recombinant human Metabotropic glutamate receptor 3 expressed in RGT cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50074749((1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1.0]hexane-4...)
Affinity DataKi:  5.80nMAssay Description:Displacement of [3H]LY341495 from human recombinant mGluR3 in RGT cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50244207(CHEMBL4090293)
Affinity DataKi:  5.80nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu3 receptor expressed in HEK cell membranes after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50074749((1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1.0]hexane-4...)
Affinity DataKi:  5.80nMAssay Description:Ability to displace [3H]-LY-341,495 from recombinant human Metabotropic glutamate receptor 3 expressed in RGT cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50558774(CHEMBL4780402)
Affinity DataKi:  5.90nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu3 receptor expressed in hamster AV12 cell membranes co-expressing rat EAAT1 incubated for 90...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50244210(CHEMBL4095995)
Affinity DataKi:  6.80nMAssay Description:Compound was tested for antagonistic activity against D2 receptor from rat striatum, used [3H]raclopride as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50558775(CHEMBL4776989)
Affinity DataKi:  6.80nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu3 receptor expressed in hamster AV12 cell membranes co-expressing rat EAAT1 incubated for 90...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50089897(4-Amino-2-thia-bicyclo[3.1.0]hexane-4,6-dicarboxyl...)
Affinity DataKi:  7.60nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 3 (mGluR-3).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50558769(CHEMBL4746125)
Affinity DataKi:  7.70nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu3 receptor expressed in hamster AV12 cell membranes co-expressing rat EAAT1 incubated for 90...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50244201(CHEMBL4070866)
Affinity DataKi:  9.30nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu3 receptor expressed in HEK cell membranes after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50558772(CHEMBL4748699)
Affinity DataKi:  9.40nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu3 receptor expressed in hamster AV12 cell membranes co-expressing rat EAAT1 incubated for 90...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)
Affinity DataKi:  14nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 3 (mGluR-3).More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50151446((1R,2R,3R,5R,6R)-2-Amino-3-benzyloxy-6-fluoro-bicy...)
Affinity DataKi:  15.9nMAssay Description:Binding affinity towards metabotropic glutamate receptor 3 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50558771(CHEMBL4760856)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu3 receptor expressed in hamster AV12 cell membranes co-expressing rat EAAT1 incubated for 90...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50558779(CHEMBL4759209)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu3 receptor expressed in hamster AV12 cell membranes co-expressing rat EAAT1 incubated for 90...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50244194(CHEMBL4099470)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu3 receptor expressed in HEK cell membranes after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50558776(CHEMBL4784701)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu3 receptor expressed in hamster AV12 cell membranes co-expressing rat EAAT1 incubated for 90...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50558773(CHEMBL4757159)
Affinity DataKi:  26nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu3 receptor expressed in hamster AV12 cell membranes co-expressing rat EAAT1 incubated for 90...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50558781(CHEMBL4781638)
Affinity DataKi:  26nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu3 receptor expressed in hamster AV12 cell membranes co-expressing rat EAAT1 incubated for 90...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50244205(CHEMBL4098939)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu3 receptor expressed in HEK cell membranes after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50558770(CHEMBL4756556)
Affinity DataKi:  36nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu3 receptor expressed in hamster AV12 cell membranes co-expressing rat EAAT1 incubated for 90...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50056272((1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dic...)
Affinity DataKi:  38nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 3 (mGluR-3).More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50094842((+)-2-Amino-6-fluoro-bicyclo[3.1.0]hexane-2,6-dica...)
Affinity DataKi:  41.7nMAssay Description:Tested for binding affinity against Metabotropic glutamate receptor 3 in CHO cells using [3H]-7 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50121539(CHEMBL3616856)
Affinity DataKi:  43nMAssay Description:Displacement of [3H]-459477 from human recombinant mGlu3 receptor expressed in AV12 cells after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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