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Found 747 Enz. Inhib. hit(s) with Target = 'Glutamate receptor ionotropic, NMDA 2A'
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50038046(2-((S)-9-Bromo-2,3-dioxo-2,3,6,7-tetrahydro-1H,5H-...)
Affinity DataKi:  0.960nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50591723(CHEMBL5185347)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50038055(((S)-9-Bromo-2,3-dioxo-2,3,6,7-tetrahydro-1H,5H-py...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50038047(2-(9-Bromo-2,3-dioxo-2,3,6,7-tetrahydro-1H,5H-pyri...)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50591722(CHEMBL5208012)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50284815(2-((S)-9-Chloro-6-methyl-2,3-dioxo-2,3,6,7-tetrahy...)
Affinity DataKi:  3.10nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50591721(CHEMBL5208606)
Affinity DataKi:  3.30nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50284813(((S)-9-Chloro-6-methyl-2,3-dioxo-2,3,6,7-tetrahydr...)
Affinity DataKi:  4.40nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50284817((9-Chloro-2,3-dioxo-2,3,6,7-tetrahydro-1H,5H-pyrid...)
Affinity DataKi:  5.10nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50284818(2-(9-Chloro-2,3-dioxo-2,3,6,7-tetrahydro-1H,5H-pyr...)
Affinity DataKi:  6.60nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50591724(CHEMBL129149)
Affinity DataKi:  9.60nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50038043((9-Bromo-2,3-dioxo-2,3,6,7-tetrahydro-1H,5H-pyrido...)
Affinity DataKi:  9.90nMAssay Description:Displacement of [3H]DCKA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Rattus norvegicus (Rat))
University Of Copenhagen

LigandPNGBDBM213889(5,7-Dichlorokynurenic acid (5,7-DCKA))
Affinity DataKi:  65nM ΔG°:  -41.0kJ/mole IC50:  92nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50038163((6,7-Dichloro-2,3-dioxo-3,4-dihydro-2H-quinoxalin-...)
Affinity DataKi:  110nMAssay Description:Displacement of [3H]glycine from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Rattus norvegicus (Rat))
University Of Copenhagen

LigandPNGBDBM213888(1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]-quinox...)
Affinity DataKi:  560nM ΔG°:  -35.7kJ/mole IC50:  770nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50601783(CHEMBL5184678)
Affinity DataKi:  590nMAssay Description:Binding affinity to NMDAR (unknown origin) assessed as inhibition constant by [3H]MK-801 binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50044140(2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone | ...)
Affinity DataKi:  1.90E+3nMAssay Description:Binding affinity to NMDA receptor (unknown origin)More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50281275((6,7-Dimethyl-2,3-dioxo-3,4-dihydro-2H-quinoxalin-...)
Affinity DataKi:  5.28E+3nMAssay Description:Displacement of [3H]glycine from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50281273((6,7-Dimethyl-2,3-dioxo-3,4-dihydro-2H-quinoxalin-...)
Affinity DataKi:  1.38E+4nMAssay Description:Displacement of [3H]glycine from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50591744(CHEMBL5195778)
Affinity DataKi:  4.10E+4nMAssay Description:Binding affinity to NMDA receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50591743(CHEMBL1375097)
Affinity DataKi:  5.30E+4nMAssay Description:Binding affinity to NMDA receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50591740(CHEMBL5179605)
Affinity DataKi:  5.50E+4nMAssay Description:Binding affinity to NMDA receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50591741(CHEMBL5187440)
Affinity DataKi:  5.60E+4nMAssay Description:Binding affinity to NMDA receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50591742(CHEMBL5199355)
Affinity DataKi:  6.90E+4nMAssay Description:Binding affinity to NMDA receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50591731(CHEMBL5174264)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity to NMDA receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50591732(CHEMBL5198336)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity to NMDA receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50591733(CHEMBL5190991)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity to NMDA receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50591734(CHEMBL5208673)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity to NMDA receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50591739(CHEMBL5186117)
Affinity DataKi: >1.00E+5nMAssay Description:Binding affinity to NMDA receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50591726(CHEMBL450325)
Affinity DataIC50:  2.60nMAssay Description:Displacement of [3H]L-689560 from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50591725(CHEMBL61720)
Affinity DataIC50:  4.40nMAssay Description:Displacement of [3H]L-689560 from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50069483(CHEMBL356281 | N-(7-Bromo-2,3-dioxo-1,2,3,4-tetrah...)
Affinity DataIC50:  10nMAssay Description:Displacement of [3H]MDL from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50069459(CHEMBL413125 | Thiophene-3-carboxylic acid (7-brom...)
Affinity DataIC50:  10nMAssay Description:Displacement of [3H]MDL from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50069465(CHEMBL343863 | Thiophene-2-carboxylic acid (7-brom...)
Affinity DataIC50:  10nMAssay Description:Displacement of [3H]MDL from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM393276(5-(3,4- difluorobenzenesulfon- amidomethyl)-6- met...)
Affinity DataIC50:  16.2nMAssay Description:Cell Culture and plating: HEK293 cells expressing NR1/NR2A (Chantest, Cleveland, Ohio) were grown to 70-80% confluency as an adherent monolayer in st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM393246(5-(3-chloro-4- fluorobenzenesulfon- amidomethyl)-6...)
Affinity DataIC50:  19.6nMAssay Description:Cell Culture and plating: HEK293 cells expressing NR1/NR2A (Chantest, Cleveland, Ohio) were grown to 70-80% confluency as an adherent monolayer in st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50344263((+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]he...)
Affinity DataIC50:  29nMAssay Description:Antagonist activity at NR2A transfected in oocytesMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM86494(EAA-090 | Perzinfotel | WAY-126090)
Affinity DataIC50:  30nMAssay Description:Binding affinity to NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50171881((E)-(R)-2-Amino-4-methyl-5-phosphono-pent-3-enoic ...)
Affinity DataIC50:  35nMAssay Description:Inhibition of [3H]CPP binding to rat N-methyl-D-aspartic acid receptor 2AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM393274(5-(3- chlorobenzenesulfon- midomethyl)-6- methyl-N...)
Affinity DataIC50:  39.5nMAssay Description:Cell Culture and plating: HEK293 cells expressing NR1/NR2A (Chantest, Cleveland, Ohio) were grown to 70-80% confluency as an adherent monolayer in st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM393080(5-(3-chloro-4- fluorobenzenesulfon- amidomethyl)-N...)
Affinity DataIC50:  61nMAssay Description:Cell Culture and plating: HEK293 cells expressing NR1/NR2A (Chantest, Cleveland, Ohio) were grown to 70-80% confluency as an adherent monolayer in st...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM17657((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Affinity DataIC50:  70nMAssay Description:Binding affinity to NMDA receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM393273(5-(3-chloro-4- fluorobenzenesulfon- amidomethyl)-6...)
Affinity DataIC50:  87.8nMAssay Description:Cell Culture and plating: HEK293 cells expressing NR1/NR2A (Chantest, Cleveland, Ohio) were grown to 70-80% confluency as an adherent monolayer in st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM50591726(CHEMBL450325)
Affinity DataIC50:  90nMAssay Description:Displacement of [3H]NMDA from NMDA receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50004927(4-Phosphonomethyl-piperidine-2-carboxylic acid | 4...)
Affinity DataIC50:  95nMAssay Description:Inhibition of [3H]CPP binding to rat N-methyl-D-aspartic acid receptor 2AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50132483(CHEMBL108043 | Pentyl-(1-phenethyloxy-4,5-dihydro-...)
Affinity DataIC50: <100nMAssay Description:Inhibitory activity against N-methyl-D-aspartate glutamate receptor 2A in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM393074(5-(3-chloro-4- fluorobenzenesulfon- amidomethyl)-N...)
Affinity DataIC50:  108nMAssay Description:Cell Culture and plating: HEK293 cells expressing NR1/NR2A (Chantest, Cleveland, Ohio) were grown to 70-80% confluency as an adherent monolayer in st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM393097(6-(3-chloro-4- fluorobenzenesulfon- amidomethyl)-N...)
Affinity DataIC50:  108nMAssay Description:Cell Culture and plating: HEK293 cells expressing NR1/NR2A (Chantest, Cleveland, Ohio) were grown to 70-80% confluency as an adherent monolayer in st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutamate receptor ionotropic, NMDA 2A(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50010893((R)-2-Amino-4-oxo-5-phosphono-pentanoic acid | 2-A...)
Affinity DataIC50:  110nMAssay Description:Inhibition of [3H]CPP binding to rat N-methyl-D-aspartic acid receptor 2AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2A(Homo sapiens (Human))
Central South University

Curated by ChEMBL
LigandPNGBDBM393275(5-(4- fluorobenzenesulfon- amidomethyl)-6- methyl-...)
Affinity DataIC50:  137nMAssay Description:Cell Culture and plating: HEK293 cells expressing NR1/NR2A (Chantest, Cleveland, Ohio) were grown to 70-80% confluency as an adherent monolayer in st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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