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Found 7 Enz. Inhib. hit(s) with Target = 'Histone-lysine N-methyltransferase KMT5C'
TargetHistone-lysine N-methyltransferase KMT5C(Homo sapiens (Human))
Abbvie

LigandPNGBDBM223981(6,7-Dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthala...)
Affinity DataIC50:  144nMpH: 8.0 T: 2°CAssay Description:Experiments were performed in triplicate at room temperature with 1 h incubation of 10 μl reaction mixture in buffer of 20 mM Tris-HCl, pH 8.0, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase KMT5C(Homo sapiens (Human))
Abbvie

LigandPNGBDBM223980(6,7-Dichloro-N-cyclopentylquinolin-4-amine (2))
Affinity DataIC50:  1.20E+3nMpH: 8.0 T: 2°CAssay Description:Experiments were performed in triplicate at room temperature with 1 h incubation of 10 μl reaction mixture in buffer of 20 mM Tris-HCl, pH 8.0, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase KMT5C(Homo sapiens (Human))
Abbvie

LigandPNGBDBM223979(7-Chloro-N-cyclopentylquinolin-4-amine (1))
Affinity DataIC50:  4.80E+3nMpH: 8.0 T: 2°CAssay Description:Experiments were performed in triplicate at room temperature with 1 h incubation of 10 μl reaction mixture in buffer of 20 mM Tris-HCl, pH 8.0, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase KMT5C(Homo sapiens (Human))
Abbvie

LigandPNGBDBM50009672(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of SUV420H2 (unknown origin) by HMT assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase KMT5C(Homo sapiens (Human))
Abbvie

LigandPNGBDBM223982((6,7-Dichloro-4-(cyclopentylamino)phthalazin-1-yl)...)
Affinity DataIC50: >1.00E+4nMpH: 8.0 T: 2°CAssay Description:Experiments were performed in triplicate at room temperature with 1 h incubation of 10 μl reaction mixture in buffer of 20 mM Tris-HCl, pH 8.0, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase KMT5C(Homo sapiens (Human))
Abbvie

LigandPNGBDBM50063670(CHEMBL3397332)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of SUV420H2 (unknown origin) by HMT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase KMT5C(Homo sapiens (Human))
Abbvie

LigandPNGBDBM50051117(CHEMBL3318285)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of SUV420H2 (unknown origin) assessed as incorporation of tritium-labeled methyl group to lysine or arginine residues of peptide substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed