Compile Data Set for Download or QSAR
maximum 50k data
Found 275 Enz. Inhib. hit(s) with Target = 'Integrin alpha-V/beta-8'
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50530090(CHEMBL4443665)
Affinity DataIC50:  0.0600nMAssay Description:Inhibition of LAP binding to human integrin alphavbeta8 receptor after 1 hr by solid-phase binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50530090(CHEMBL4443665)
Affinity DataIC50:  0.0600nMAssay Description:Inhibition of LAP binding to human integrin alphavbeta8 receptor after 1 hr by solid-phase binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM279573((3S)-3-(3,5-dibromophenyl)-3-[[2-[[5-[(5-hydroxy-1...)
Affinity DataIC50:  0.200nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP protein (R&D Systems, Inc, 246-LP) diluted to 0.5 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM279573((3S)-3-(3,5-dibromophenyl)-3-[[2-[[5-[(5-hydroxy-1...)
Affinity DataIC50:  0.200nMAssay Description:Recombinant human LAP protein (R&D Systems, Inc, 246-LP) diluted to 0.5 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50497716(CHEMBL3319237)
Affinity DataIC50:  0.200nMAssay Description:Antagonist activity at alphavbeta8 integrin receptor (unknown origin) by cell-free ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM279560((3S)-3-(3,5-dibromophenyl)-3-(2-(3-hydroxy-5-((5-h...)
Affinity DataIC50:  0.300nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP protein (R&D Systems, Inc, 246-LP) diluted to 0.5 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM279568((3S)-3-[3-bromo-5-(trifluoromethyl)phenyl]-3-[[2-[...)
Affinity DataIC50:  0.300nMAssay Description:Recombinant human LAP protein (R&D Systems, Inc, 246-LP) diluted to 0.5 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM279575((3S)-3-[3-chloro-5-(trifluoromethoxy)phenyl)-3-(2-...)
Affinity DataIC50:  0.300nMAssay Description:Recombinant human LAP protein (R&D Systems, Inc, 246-LP) diluted to 0.5 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM279569((3S)-3-[3,5-bis(trifluoromethyl)phenyl)-3-(2-(3-hy...)
Affinity DataIC50:  0.300nMAssay Description:Recombinant human LAP protein (R&D Systems, Inc, 246-LP) diluted to 0.5 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM279562((3S)-3-[3-chloro-5-(difluoromethyl)phenyl)-3-(2-(3...)
Affinity DataIC50:  0.300nMAssay Description:Recombinant human LAP protein (R&D Systems, Inc, 246-LP) diluted to 0.5 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM279560((3S)-3-(3,5-dibromophenyl)-3-(2-(3-hydroxy-5-((5-h...)
Affinity DataIC50:  0.300nMAssay Description:Recombinant human LAP protein (R&D Systems, Inc, 246-LP) diluted to 0.5 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM279576((3S)-3-(3-bromo-5-(trifluoromethoxy)phenyl)-3-(2-(...)
Affinity DataIC50:  0.300nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP protein (R&D Systems, Inc, 246-LP) diluted to 0.5 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM279575((3S)-3-[3-chloro-5-(trifluoromethoxy)phenyl)-3-(2-...)
Affinity DataIC50:  0.300nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP protein (R&D Systems, Inc, 246-LP) diluted to 0.5 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM279568((3S)-3-[3-bromo-5-(trifluoromethyl)phenyl]-3-[[2-[...)
Affinity DataIC50:  0.300nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP protein (R&D Systems, Inc, 246-LP) diluted to 0.5 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM279569((3S)-3-[3,5-bis(trifluoromethyl)phenyl)-3-(2-(3-hy...)
Affinity DataIC50:  0.300nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP protein (R&D Systems, Inc, 246-LP) diluted to 0.5 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM279576((3S)-3-(3-bromo-5-(trifluoromethoxy)phenyl)-3-(2-(...)
Affinity DataIC50:  0.300nMAssay Description:Recombinant human LAP protein (R&D Systems, Inc, 246-LP) diluted to 0.5 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM279562((3S)-3-[3-chloro-5-(difluoromethyl)phenyl)-3-(2-(3...)
Affinity DataIC50:  0.300nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP protein (R&D Systems, Inc, 246-LP) diluted to 0.5 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM279566((3S)-3-[3-chloro-5-(trifluoromethyl)phenyl]3-[[2-[...)
Affinity DataIC50:  0.400nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP protein (R&D Systems, Inc, 246-LP) diluted to 0.5 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM279566((3S)-3-[3-chloro-5-(trifluoromethyl)phenyl]3-[[2-[...)
Affinity DataIC50:  0.400nMAssay Description:Recombinant human LAP protein (R&D Systems, Inc, 246-LP) diluted to 0.5 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM279563((3S)-3-[3-bromo-5-(difluoromethyl)phenyl)-3-(2-(3-...)
Affinity DataIC50:  0.400nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP protein (R&D Systems, Inc, 246-LP) diluted to 0.5 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM279567((3S)-3-(3-bromo-5-chloro-phenyl)-3-[[2-[[5-[(5-hyd...)
Affinity DataIC50:  0.400nMAssay Description:Recombinant human LAP protein (R&D Systems, Inc, 246-LP) diluted to 0.5 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM279563((3S)-3-[3-bromo-5-(difluoromethyl)phenyl)-3-(2-(3-...)
Affinity DataIC50:  0.400nMAssay Description:Recombinant human LAP protein (R&D Systems, Inc, 246-LP) diluted to 0.5 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM279567((3S)-3-(3-bromo-5-chloro-phenyl)-3-[[2-[[5-[(5-hyd...)
Affinity DataIC50:  0.400nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP protein (R&D Systems, Inc, 246-LP) diluted to 0.5 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM279565((3S)-3-[3-bromo-5-chloro-phenyl)-3-(2-(3-hydroxy-5...)
Affinity DataIC50:  0.5nMAssay Description:Recombinant human LAP protein (R&D Systems, Inc, 246-LP) diluted to 0.5 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM279561((3S)-3-(3-bromo-5-(trifluoromethyl)phenyl)-3-(2-(3...)
Affinity DataIC50:  0.5nMAssay Description:Recombinant human LAP protein (R&D Systems, Inc, 246-LP) diluted to 0.5 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM279565((3S)-3-[3-bromo-5-chloro-phenyl)-3-(2-(3-hydroxy-5...)
Affinity DataIC50:  0.5nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP protein (R&D Systems, Inc, 246-LP) diluted to 0.5 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM279561((3S)-3-(3-bromo-5-(trifluoromethyl)phenyl)-3-(2-(3...)
Affinity DataIC50:  0.5nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP protein (R&D Systems, Inc, 246-LP) diluted to 0.5 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM279570((3S)-3-[3-bromo-5-methyl-phenyl)-3-(2-(3-hydroxy-5...)
Affinity DataIC50:  0.600nMAssay Description:Recombinant human LAP protein (R&D Systems, Inc, 246-LP) diluted to 0.5 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM279570((3S)-3-[3-bromo-5-methyl-phenyl)-3-(2-(3-hydroxy-5...)
Affinity DataIC50:  0.600nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP protein (R&D Systems, Inc, 246-LP) diluted to 0.5 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM279564((3S)-3-[3-chloro-5-(trifluoromethyl)phenyl)-3-(2-(...)
Affinity DataIC50:  0.600nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP protein (R&D Systems, Inc, 246-LP) diluted to 0.5 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM279564((3S)-3-[3-chloro-5-(trifluoromethyl)phenyl)-3-(2-(...)
Affinity DataIC50:  0.600nMAssay Description:Recombinant human LAP protein (R&D Systems, Inc, 246-LP) diluted to 0.5 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50209461((3S)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-(2-(3-...)
Affinity DataIC50:  0.650nMAssay Description:Antagonist activity at human recombinant alphavbeta8 integrin receptor expressed in HEK293 cells after 4 hrs using p-nitrophenyl phosphate by colorim...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM279571((3S)-3-[3-chloro-5-methyl-phenyl)-3-(2-(3-hydroxy-...)
Affinity DataIC50:  0.700nMAssay Description:Recombinant human LAP protein (R&D Systems, Inc, 246-LP) diluted to 0.5 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM279571((3S)-3-[3-chloro-5-methyl-phenyl)-3-(2-(3-hydroxy-...)
Affinity DataIC50:  0.700nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP protein (R&D Systems, Inc, 246-LP) diluted to 0.5 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM279572((3S)-3-[3-bromo-5-fluoro-phenyl)-3-(2-(3-hydroxy-5...)
Affinity DataIC50:  1nMAssay Description:Recombinant human LAP protein (R&D Systems, Inc, 246-LP) diluted to 0.5 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM279572((3S)-3-[3-bromo-5-fluoro-phenyl)-3-(2-(3-hydroxy-5...)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP protein (R&D Systems, Inc, 246-LP) diluted to 0.5 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM279574((3S)-3-[3,5-dichloro-phenyl)-3-(2-(3-hydroxy-5-((5...)
Affinity DataIC50:  1.10nMpH: 7.4 T: 2°CAssay Description:Recombinant human LAP protein (R&D Systems, Inc, 246-LP) diluted to 0.5 μg/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM279574((3S)-3-[3,5-dichloro-phenyl)-3-(2-(3-hydroxy-5-((5...)
Affinity DataIC50:  1.10nMAssay Description:Recombinant human LAP protein (R&D Systems, Inc, 246-LP) diluted to 0.5 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50497714(Glpg-0187 | Glpg0187)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of ligand binding to integrin alphavbeta8 (unknown origin) expressed in baculovirus expression system after 2 hrs by solid-phase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50497714(Glpg-0187 | Glpg0187)
Affinity DataIC50:  1.20nMAssay Description:Antagonist activity at alphavbeta8 integrin receptor (unknown origin) by cell-free ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50530119(CHEMBL4449438)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of LAP binding to human integrin alphavbeta8 receptor after 1 hr by solid-phase binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50530119(CHEMBL4449438)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of LAP binding to human integrin alphavbeta8 receptor after 1 hr by solid-phase binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50530088(CHEMBL4520646)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of LAP binding to human integrin alphavbeta8 receptor after 1 hr by solid-phase binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50530088(CHEMBL4520646)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of LAP binding to human integrin alphavbeta8 receptor after 1 hr by solid-phase binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50209457((3S)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-(2-(3-...)
Affinity DataIC50:  1.70nMAssay Description:Antagonist activity at human recombinant alphavbeta8 integrin receptor expressed in HEK293 cells after 4 hrs using p-nitrophenyl phosphate by colorim...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50530098(CHEMBL4584228)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of LAP binding to human integrin alphavbeta8 receptor after 1 hr by solid-phase binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50530098(CHEMBL4584228)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of LAP binding to human integrin alphavbeta8 receptor after 1 hr by solid-phase binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM432094(US10577330, Comparison Compound C3)
Affinity DataIC50:  2nMAssay Description:Recombinant human LAP protein (R&D Systems, Inc, 246-LP) diluted to 0.5 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50464106(CHEMBL4237498)
Affinity DataIC50:  2.5nMAssay Description:Antagonist activity at human integrin alphaVbeta8 expressed in human K562 cells assessed as reduction in cell adhesion to GST-LAP after 30 mins by BC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-8(Homo sapiens (Human))
Technische Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM432092(US10577330, Comparison Compound C1)
Affinity DataIC50:  3nMAssay Description:Recombinant human LAP protein (R&D Systems, Inc, 246-LP) diluted to 0.5 g/mL in TBS+ buffer (25 mM Tris pH 7.4, 137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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