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Found 5 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase BTK/Lck'
TargetTyrosine-protein kinase BTK/Lck(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM194087(US20230364079, Example Tirabrutinib | US9199997, 9...)
Affinity DataIC50:  375nMT: 2°CAssay Description:The measurement of Btk enzyme inhibitory activity was performed using the following reagents: Z'-LYTE Kinase Assay Kit-Tyr 1 (containing Tyr 1 peptid...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK/Lck(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM275489(US9879013, 11(3))
Affinity DataIC50:  1.90E+4nMAssay Description:The Btk enzyme inhibitory activity was measured, based on the protocol provided by the manufacturer, using Btk (Invitrogen Corporation) and the ZR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK/Lck(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM275463(US9879013, 8)
Affinity DataIC50:  8.00E+4nMAssay Description:The Btk enzyme inhibitory activity was measured, based on the protocol provided by the manufacturer, using Btk (Invitrogen Corporation) and the ZR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK/Lck(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM194087(US20230364079, Example Tirabrutinib | US9199997, 9...)
Affinity DataIC50:  1.14E+5nMAssay Description:The Btk enzyme inhibitory activity was measured, based on the protocol provided by the manufacturer, using Btk (Invitrogen Corporation) and the ZR...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK/Lck(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM275473(US9879013, 8(14))
Affinity DataIC50:  2.20E+5nMAssay Description:The Btk enzyme inhibitory activity was measured, based on the protocol provided by the manufacturer, using Btk (Invitrogen Corporation) and the ZR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent