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Found 30 Enz. Inhib. hit(s) with Target = 'Low-density lipoprotein receptor'
TargetLow-density lipoprotein receptor-related protein 6(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50135174(CHEMBL3747431)
Affinity DataIC50:  3.00E+3nMAssay Description:Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow-density lipoprotein receptor-related protein 6(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50145410(CHEMBL3764819)
Affinity DataIC50:  3.38E+3nMAssay Description:Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow-density lipoprotein receptor-related protein 6(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50145403(CHEMBL3764323)
Affinity DataIC50:  3.74E+3nMAssay Description:Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow-density lipoprotein receptor-related protein 6(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50145379(CHEMBL3765769)
Affinity DataIC50:  3.77E+3nMAssay Description:Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow-density lipoprotein receptor-related protein 6(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50145384(CHEMBL3764205)
Affinity DataIC50:  4.06E+3nMAssay Description:Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow-density lipoprotein receptor-related protein 6(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50145382(CHEMBL3765415)
Affinity DataIC50:  4.33E+3nMAssay Description:Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow-density lipoprotein receptor-related protein 6(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50145409(CHEMBL3765394)
Affinity DataIC50:  4.61E+3nMAssay Description:Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow-density lipoprotein receptor-related protein 6(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50145380(CHEMBL3765591)
Affinity DataIC50:  4.71E+3nMAssay Description:Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow-density lipoprotein receptor-related protein 6(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50145381(CHEMBL3763214)
Affinity DataIC50:  4.87E+3nMAssay Description:Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow-density lipoprotein receptor-related protein 6(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50145377(CHEMBL3764713)
Affinity DataIC50:  5.23E+3nMAssay Description:Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow-density lipoprotein receptor-related protein 6(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50145383(CHEMBL3763953)
Affinity DataIC50:  5.50E+3nMAssay Description:Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow-density lipoprotein receptor-related protein 6(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50145378(CHEMBL3764972)
Affinity DataIC50:  6.16E+3nMAssay Description:Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow-density lipoprotein receptor-related protein 6(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50135174(CHEMBL3747431)
Affinity DataIC50:  6.38E+3nMAssay Description:Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow-density lipoprotein receptor(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50052689(CHEMBL115205 | N-[5-(4-Cyclohexyl-butyrylamino)-2-...)
Affinity DataEC50:  4.00E+3nMAssay Description:Concentration at which one-half of the maximum Low density lipoprotein receptor is upregulated in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow-density lipoprotein receptor(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50052691(CHEMBL114199 | N-[5-(4-Cyclohexyl-butyryl)-2-methy...)
Affinity DataEC50:  2.00E+3nMAssay Description:Concentration at which one-half the maximum Low density lipoprotein receptor upregulation is observed in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow-density lipoprotein receptor(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50052692(5-(3-Cyclohexyl-propionylamino)-N-(4-hydroxy-pheny...)
Affinity DataEC50:  7.00E+3nMAssay Description:Concentration at which one-half of the maximum Low density lipoprotein receptor is upregulated in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow-density lipoprotein receptor(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50052690(Acetic acid 4-[5-(3-cyclohexyl-propionylamino)-2-m...)
Affinity DataEC50:  2.50E+3nMAssay Description:Concentration at which one-half of the maximum Low density lipoprotein receptor is upregulated in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow-density lipoprotein receptor(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50052687(CHEMBL114705 | N-[5-(3-Cyclohexyl-propionylamino)-...)
Affinity DataEC50:  1.20E+3nMAssay Description:Concentration at which one-half of the maximum Low density lipoprotein receptor is upregulated in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow-density lipoprotein receptor(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50052686(CHEMBL115992 | N-{3-[(Benzo[1,3]dioxol-5-ylmethyl)...)
Affinity DataEC50:  600nMAssay Description:Concentration at which one-half of the maximum Low density lipoprotein receptor is upregulated in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow-density lipoprotein receptor(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50052688(CHEMBL419042 | N-[5-(3-Cyclohexyl-propionylamino)-...)
Affinity DataEC50:  2.00E+3nMAssay Description:Concentration at which one-half of the maximum Low density lipoprotein receptor is upregulated in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow-density lipoprotein receptor(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50052684(CHEMBL112106 | N-[5-(3-Cyclohexyl-propionylamino)-...)
Affinity DataEC50:  7.60E+3nMAssay Description:Concentration at which one-half of the maximum Low density lipoprotein receptor is upregulated in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow-density lipoprotein receptor(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50052685(4-Amino-N-[5-(3-cyclohexyl-propionylamino)-2-methy...)
Affinity DataEC50:  3.80E+3nMAssay Description:Concentration at which one-half of the maximum Low density lipoprotein receptor is upregulated in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow-density lipoprotein receptor(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50052680(CHEMBL419763 | N-[5-(3-Cyclohexyl-propionylamino)-...)
Affinity DataEC50:  1.70E+3nMAssay Description:Concentration at which one-half of the maximum Low density lipoprotein receptor is upregulated in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow-density lipoprotein receptor(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50052683(CHEMBL112449 | N-[3-((Z)-2-Cyano-2-pyridin-3-yl-vi...)
Affinity DataEC50:  1.00E+3nMAssay Description:Concentration at which one-half of the maximum Low density lipoprotein receptor is upregulated in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow-density lipoprotein receptor(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50052682(3-Cyclohexyl-N-[3-(5-hydroxy-1H-benzoimidazol-2-yl...)
Affinity DataEC50:  700nMAssay Description:Concentration at which one-half of the maximum Low density lipoprotein receptor is upregulated in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow-density lipoprotein receptor(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50052681(CHEMBL114890 | N-[3-((Z)-2-Benzo[1,3]dioxol-5-yl-2...)
Affinity DataEC50:  700nMAssay Description:Concentration at which one-half of the maximum Low density lipoprotein receptor is upregulated in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow-density lipoprotein receptor(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50052679(CHEMBL112537 | N-[5-(3-Cyclohexyl-propionylamino)-...)
Affinity DataEC50:  2.00E+3nMAssay Description:Concentration at which one-half of the maximum Low density lipoprotein receptor is upregulated in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow-density lipoprotein receptor(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50052678(3-Cyclohexyl-N-[4-methyl-3-(5-methyl-1H-benzoimida...)
Affinity DataEC50:  1.30E+3nMAssay Description:Concentration at which one-half of the maximum Low density lipoprotein receptor is upregulated in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow-density lipoprotein receptor(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50052676(CHEMBL115304 | N-[3-(1H-Benzoimidazol-2-yl)-4-meth...)
Affinity DataEC50:  1.30E+3nMAssay Description:Concentration at which one-half of the maximum Low density lipoprotein receptor is upregulated in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLow-density lipoprotein receptor(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50052677(CHEMBL115779 | N-(2-Cyclohexyl-ethyl)-3-(4-hydroxy...)
Affinity DataEC50:  2.00E+3nMAssay Description:Concentration at which one-half of the maximum Low density lipoprotein receptor is upregulated in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed