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Found 12 Enz. Inhib. hit(s) with Target = 'Lysosomal acid lipase/cholesteryl ester hydrolase'
TargetLysosomal acid lipase/cholesteryl ester hydrolase(Homo sapiens (Human))
Weill Cornell Medical College

Curated by ChEMBL
LigandPNGBDBM50318690(4-Piperidinyl-1,2,5-thiadiazolyl-3-morpholine carb...)
Affinity DataIC50:  68nMAssay Description:Inhibition of human LAL after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid lipase/cholesteryl ester hydrolase(Homo sapiens (Human))
Weill Cornell Medical College

Curated by ChEMBL
LigandPNGBDBM50318691(4-(Piperidin-1-yl)-1,2,5-thiadiazol-3-yl piperidin...)
Affinity DataIC50:  152nMAssay Description:Inhibition of human LAL after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid lipase/cholesteryl ester hydrolase(Homo sapiens (Human))
Weill Cornell Medical College

Curated by ChEMBL
LigandPNGBDBM50318686(4-(Azepan-1-yl)-1,2,5-thiadiazol-3-yl morpholine-4...)
Affinity DataIC50:  189nMAssay Description:Inhibition of human LAL after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid lipase/cholesteryl ester hydrolase(Homo sapiens (Human))
Weill Cornell Medical College

Curated by ChEMBL
LigandPNGBDBM50318687(4-(Azepan-1-yl)-1,2,5-thiadiazol-3-yl piperidine-1...)
Affinity DataIC50:  300nMAssay Description:Inhibition of human LAL after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid lipase/cholesteryl ester hydrolase(Homo sapiens (Human))
Weill Cornell Medical College

Curated by ChEMBL
LigandPNGBDBM50318689(4-Morpholino-1,2,5-thiadiazol-3-yl piperidine-1-ca...)
Affinity DataIC50:  424nMAssay Description:Inhibition of human LAL after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid lipase/cholesteryl ester hydrolase(Homo sapiens (Human))
Weill Cornell Medical College

Curated by ChEMBL
LigandPNGBDBM50318692(4-(Pyrrolidin-1-yl)-1,2,5-thiadiazol-3-yl morpholi...)
Affinity DataIC50:  473nMAssay Description:Inhibition of human LAL after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid lipase/cholesteryl ester hydrolase(Homo sapiens (Human))
Weill Cornell Medical College

Curated by ChEMBL
LigandPNGBDBM50318688(3-N-Morpholinocarbamate-4-morpholino-1,2,5-thiadia...)
Affinity DataIC50:  492nMAssay Description:Inhibition of human LAL after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid lipase/cholesteryl ester hydrolase(Homo sapiens (Human))
Weill Cornell Medical College

Curated by ChEMBL
LigandPNGBDBM50318693(4-(Pyrrolidin-1-yl)-1,2,5-thiadiazol-3-yl Piperidi...)
Affinity DataIC50:  496nMAssay Description:Inhibition of human LAL after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid lipase/cholesteryl ester hydrolase(Homo sapiens (Human))
Weill Cornell Medical College

Curated by ChEMBL
LigandPNGBDBM50287473(3,3,4,4,4-Pentafluoro-1-((2S,4aS,8aS)-4a-methyl-de...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of ancreatic cholesterol esterase using using p-nitrophenylacetate or cholesteryl [1-14C]-oleate as substratesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetLysosomal acid lipase/cholesteryl ester hydrolase(Homo sapiens (Human))
Weill Cornell Medical College

Curated by ChEMBL
LigandPNGBDBM50287472(1-((S)-10,13-Dimethyl-17-octyl-hexadecahydro-cyclo...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of ancreatic cholesterol esterase using using p-nitrophenylacetate or cholesteryl [1-14C]-oleate as substratesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetLysosomal acid lipase/cholesteryl ester hydrolase(Homo sapiens (Human))
Weill Cornell Medical College

Curated by ChEMBL
LigandPNGBDBM50287471(1-(4-tert-Butyl-cyclohexyl)-3,3,4,4,4-pentafluoro-...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of ancreatic cholesterol esterase using using p-nitrophenylacetate or cholesteryl [1-14C]-oleate as substratesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetLysosomal acid lipase/cholesteryl ester hydrolase(Homo sapiens (Human))
Weill Cornell Medical College

Curated by ChEMBL
LigandPNGBDBM50287474(3,3-Difluoro-1-((2S,4aS,8aS)-4a-methyl-decahydro-n...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of ancreatic cholesterol esterase using using p-nitrophenylacetate or cholesteryl [1-14C]-oleate as substratesMore data for this Ligand-Target Pair
In DepthDetails Article