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Found 5411 Enz. Inhib. hit(s) with Target = 'Melanin-concentrating hormone receptor 1'
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50295693(CHEMBL557629)
Affinity DataKi:  0.0340nMAssay Description:Displacement of [35S] 4-(1-(3,4-difluorophenyl)-2-(ethyl(3-(6-fluoro-3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)propyl)amino)-2-oxoethyl)-3-oxopip...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Mus musculus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50295693(CHEMBL557629)
Affinity DataKi:  0.0520nMAssay Description:Displacement of [35S] 4-(1-(3,4-difluorophenyl)-2-(ethyl(3-(6-fluoro-3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)propyl)amino)-2-oxoethyl)-3-oxopip...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM85951(hAc-MCH(6-16)-NH2)
Affinity DataKi:  0.160nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM85788(MCH | hMCH)
Affinity DataKi:  0.170nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50169371(1-[4-(3'-Cyano-biphenyl-4-yl)-1-cyclopropylmethyl-...)
Affinity DataKi:  0.170nMAssay Description:Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50295690((+/-)-2-(3,4-difluorophenyl)-N-ethyl-N-(3-(6-fluor...)
Affinity DataKi:  0.180nMAssay Description:Binding affinity to human MCH1R expressed in CHO cells by scintillation counting per mg of proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM85790(Salmon MCH)
Affinity DataKi:  0.200nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(RAT)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50152456((S)-3-{3-[4-(3-Acetylamino-phenyl)-piperidin-1-yl]...)
Affinity DataKi:  0.25nMAssay Description:Displacement of [3H]SNAP 7941 from rat MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(RAT)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50152456((S)-3-{3-[4-(3-Acetylamino-phenyl)-piperidin-1-yl]...)
Affinity DataKi:  0.25nMAssay Description:Displacement of [3H]T226296 from rat recombinant MCH1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1 [E4Q,A5T](Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM258794(US9499482, 213)
Affinity DataKi:  0.300nMpH: 7.4Assay Description:An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMelanin-concentrating hormone receptor 1(RAT)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50120625(CHEMBL3618330)
Affinity DataKi:  0.300nMAssay Description:Displacement of [125I][Phe13,Tyr19]-MCH from rat MCHR1 by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM85789([Phe13,Tyr19]MCH)
Affinity DataKi:  0.300nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50169377(1-[4-(3'-Cyano-biphenyl-4-yl)-1-propyl-piperidin-4...)
Affinity DataKi:  0.310nMAssay Description:Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(RAT)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50241083(6-(4-chlorophenyl)-3-(3-methoxy-4-(2-(pyrrolidin-1...)
Affinity DataKi:  0.340nMAssay Description:Antagonist activity at rat MCHR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM85976(N-Me-Nle8)
Affinity DataKi:  0.340nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1 [E4Q,A5T](Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM258797(US9499482, 216)
Affinity DataKi:  0.400nMpH: 7.4Assay Description:An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMelanin-concentrating hormone receptor 1 [E4Q,A5T](Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM258817(US9499482, 252)
Affinity DataKi:  0.400nMpH: 7.4Assay Description:An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMelanin-concentrating hormone receptor 1 [E4Q,A5T](Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM258754(US9499482, 153)
Affinity DataKi:  0.400nMpH: 7.4Assay Description:An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMelanin-concentrating hormone receptor 1(RAT)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50120624(CHEMBL3618324)
Affinity DataKi:  0.400nMAssay Description:Displacement of [125I][Phe13,Tyr19]-MCH from rat MCHR1 by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50120625(CHEMBL3618330)
Affinity DataKi:  0.400nMAssay Description:Displacement of [125I][Phe13,Tyr19]-MCH from human MCHR1 expressed in HEK293 cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1 [E4Q,A5T](Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM258758(US9499482, 157)
Affinity DataKi:  0.400nMpH: 7.4Assay Description:An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMelanin-concentrating hormone receptor 1 [E4Q,A5T](Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM258763(US9499482, 163)
Affinity DataKi:  0.400nMpH: 7.4Assay Description:An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMelanin-concentrating hormone receptor 1 [E4Q,A5T](Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM258766(US9499482, 166)
Affinity DataKi:  0.400nMpH: 7.4Assay Description:An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMelanin-concentrating hormone receptor 1 [E4Q,A5T](Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM258778(US9499482, 184)
Affinity DataKi:  0.400nMpH: 7.4Assay Description:An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMelanin-concentrating hormone receptor 1 [E4Q,A5T](Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM258767(US9499482, 167)
Affinity DataKi:  0.400nMpH: 7.4Assay Description:An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMelanin-concentrating hormone receptor 1 [E4Q,A5T](Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM258795(US9499482, 214)
Affinity DataKi:  0.400nMpH: 7.4Assay Description:An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50169374(1-[4-(3'-Cyano-biphenyl-4-yl)-1-(2-methoxy-ethyl)-...)
Affinity DataKi:  0.410nMAssay Description:Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50295690((+/-)-2-(3,4-difluorophenyl)-N-ethyl-N-(3-(6-fluor...)
Affinity DataKi:  0.420nMAssay Description:Displacement of [35S] 4-(1-(3,4-difluorophenyl)-2-(ethyl(3-(6-fluoro-3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)propyl)amino)-2-oxoethyl)-3-oxopip...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50169390(1-[4-(3'-Cyano-biphenyl-4-yl)-1-isopropyl-piperidi...)
Affinity DataKi:  0.450nMAssay Description:Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1 [E4Q,A5T](Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM258709(US9499482, 108)
Affinity DataKi:  0.5nMpH: 7.4Assay Description:An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMelanin-concentrating hormone receptor 1 [E4Q,A5T](Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM258793(US9499482, 212)
Affinity DataKi:  0.5nMpH: 7.4Assay Description:An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMelanin-concentrating hormone receptor 1 [E4Q,A5T](Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM258713(US9499482, 112)
Affinity DataKi:  0.5nMpH: 7.4Assay Description:An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMelanin-concentrating hormone receptor 1 [E4Q,A5T](Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM258715(US9499482, 114)
Affinity DataKi:  0.5nMpH: 7.4Assay Description:An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMelanin-concentrating hormone receptor 1 [E4Q,A5T](Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM258752(US9499482, 151)
Affinity DataKi:  0.5nMpH: 7.4Assay Description:An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMelanin-concentrating hormone receptor 1 [E4Q,A5T](Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM258755(US9499482, 154)
Affinity DataKi:  0.5nMpH: 7.4Assay Description:An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50371874(CHEMBL257733)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to MCHR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Mus musculus)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50295690((+/-)-2-(3,4-difluorophenyl)-N-ethyl-N-(3-(6-fluor...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [35S] 4-(1-(3,4-difluorophenyl)-2-(ethyl(3-(6-fluoro-3H-spiro[isobenzofuran-1,4'-piperidine]-1'-yl)propyl)amino)-2-oxoethyl)-3-oxopip...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(RAT)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50120635(CHEMBL3618325)
Affinity DataKi:  0.5nMAssay Description:Displacement of [125I][Phe13,Tyr19]-MCH from rat MCHR1 by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50120624(CHEMBL3618324)
Affinity DataKi:  0.5nMAssay Description:Displacement of [125I][Phe13,Tyr19]-MCH from human MCHR1 expressed in HEK293 cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1 [E4Q,A5T](Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM258756(US9499482, 155)
Affinity DataKi:  0.5nMpH: 7.4Assay Description:An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMelanin-concentrating hormone receptor 1 [E4Q,A5T](Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM258762(US9499482, 161)
Affinity DataKi:  0.5nMpH: 7.4Assay Description:An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMelanin-concentrating hormone receptor 1 [E4Q,A5T](Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM258764(US9499482, 164)
Affinity DataKi:  0.5nMpH: 7.4Assay Description:An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMelanin-concentrating hormone receptor 1 [E4Q,A5T](Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM258769(US9499482, 169)
Affinity DataKi:  0.5nMpH: 7.4Assay Description:An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMelanin-concentrating hormone receptor 1 [E4Q,A5T](Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM258711(US9499482, 110)
Affinity DataKi:  0.5nMpH: 7.4Assay Description:An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM85956(N-Me-Arg11)
Affinity DataKi:  0.550nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1 [E4Q,A5T](Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM258747(US9499482, 146)
Affinity DataKi:  0.600nMpH: 7.4Assay Description:An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50383522(CHEMBL2032049)
Affinity DataKi:  0.600nMAssay Description:Binding affinity to human MCHR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50188823(3-(6-(3-(dimethylamino)pyrrolidin-1-yl)pyridin-3-y...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity to human MCH1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(RAT)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50219036(CHEMBL388440 | N-{3-[1-(3-{[hydroxy(diphenyl)acety...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]SNAP 7941 from rat MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1 [E4Q,A5T](Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM258825(US9499482, 260)
Affinity DataKi:  0.600nMpH: 7.4Assay Description:An in vitro binding assay was used to determine the compound Ki value or ability to antagonize binding of a peptide agonist to the human melanin conc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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