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Found 82 Enz. Inhib. hit(s) with Target = 'Protein tyrosine phosphatase type IVA 3'
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM396097(US10308663, JMS-631-053)
Affinity DataIC50:  18nMAssay Description:The in vitro biochemical evaluation of all compounds was carried out using recombinant human PTP4A3, overexpressed as a His6-tag fusion protein in E....More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM396097(US10308663, JMS-631-053)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant human His6-tagged PRL-3 expressed in Escherichia coli using DiFMUP as substrate incubated for 30 mins by fluorescence based...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50535759(CHEMBL4471843)
Affinity DataIC50:  30nMAssay Description:Inhibition of recombinant human His-6-tagged PTP4A3 expressed in Escherichia coli assessed as reduction in hydrolysis using DIFMUP as substrate incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM396097(US10308663, JMS-631-053)
Affinity DataIC50:  35nMAssay Description:Inhibition of recombinant human His-6-tagged PTP4A3 expressed in Escherichia coli assessed as reduction in hydrolysis using DIFMUP as substrate incub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM396097(US10308663, JMS-631-053)
Affinity DataIC50:  84nMAssay Description:Inhibition of recombinant human PTP4A3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50571230(CHEMBL4862721)
Affinity DataIC50:  107nMAssay Description:Inhibition of recombinant human PTP4A3More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50059084(CHEMBL3393171 | US10308663, Thienopyridone (5))
Affinity DataIC50:  128nMAssay Description:Inhibition of full length human fusion His6 tagged PRL3 expressed in Escherichia coli using TAMRA-Thr-Ala-Asp-Ile-Tyr(PO3H2)-Glu-NH2 substrate by imm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50059084(CHEMBL3393171 | US10308663, Thienopyridone (5))
Affinity DataIC50:  130nMAssay Description:Inhibition of recombinant human His-6-tagged PTP4A3 expressed in Escherichia coli assessed as increase in polarization using TAMRAThr-Ala-Asp-Ile-Tyr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50059084(CHEMBL3393171 | US10308663, Thienopyridone (5))
Affinity DataIC50:  132nMAssay Description:The in vitro biochemical evaluation of all compounds was carried out using recombinant human PTP4A3, overexpressed as a His6-tag fusion protein in E....More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50571225(CHEMBL4862502)
Affinity DataIC50:  206nMAssay Description:Inhibition of recombinant human PTP4A3More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50059084(CHEMBL3393171 | US10308663, Thienopyridone (5))
Affinity DataIC50:  240nMAssay Description:Inhibition of PRL3 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM45440(4-[5-(4-amidinophenoxy)pentoxy]benzamidine;2-hydro...)
Affinity DataIC50:  300nMAssay Description:Inhibition of PTP4A3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50059084(CHEMBL3393171 | US10308663, Thienopyridone (5))
Affinity DataIC50:  460nMAssay Description:Inhibition of full-length human heart His6-tagged PRL-3 expressed in Escherichia coli using DiFMUP as substrate incubated for 35 mins by fluorescence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50436447(CHEMBL2397162)
Affinity DataIC50:  800nMAssay Description:Inhibition of human His6-tagged full length PRL3 assessed as inhibition of DiFMUP dephosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50184288(5-(2-(2-bromobenzyloxy)-5-bromobenzylidene)-2-thio...)
Affinity DataIC50:  900nMAssay Description:Inhibition of human recombinant PRL-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50184297(5-(5-(benzo[b]thiophen-3-yl)-2-(benzyloxy)benzylid...)
Affinity DataIC50:  900nMAssay Description:Inhibition of human recombinant PRL-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50184288(5-(2-(2-bromobenzyloxy)-5-bromobenzylidene)-2-thio...)
Affinity DataIC50:  900nMAssay Description:Inhibition of PRL-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50184288(5-(2-(2-bromobenzyloxy)-5-bromobenzylidene)-2-thio...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human His6-tagged full length PRL3 assessed as inhibition of DiFMUP dephosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50571229(CHEMBL4852178)
Affinity DataIC50:  1.16E+3nMAssay Description:Inhibition of recombinant human PTP4A3More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50184287(5-(5-(benzofuran-3-yl)-2-(benzyloxy)benzylidene)-2...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of human recombinant PRL-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50184285(5-(2-(4-bromobenzyloxy)benzylidene)-2-thioxothiazo...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of human recombinant PRL-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50184298(5-(4-Benzyloxy-biphenyl-3-ylmethylene)-2-thioxo-th...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human recombinant PRL-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50184296(5-((3-(2-chloro-6-fluorobenzyloxy)naphthalen-2-yl)...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human recombinant PRL-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50184293(5-[1-[3-(biphenyl-4-ylmethoxy)-naphthalen-2-yl]-me...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of human recombinant PRL-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50571226(CHEMBL4864481)
Affinity DataIC50:  1.92E+3nMAssay Description:Inhibition of recombinant human PTP4A3More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50184291(5-((3-(benzyloxy)naphthalen-2-yl)methylene)-2-thio...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human recombinant PRL-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50184290(5-(2-(2-chlorobenzyloxy)-5-bromobenzylidene)-2-thi...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of human recombinant PRL-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50184294(5-(2-(benzyloxy)-5-bromobenzylidene)-2-thioxothiaz...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human recombinant PRL-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50184292(5-((3-(3,5-dimethoxybenzyloxy)naphthalen-2-yl)meth...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of human recombinant PRL-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM11318(1,3,8-trihydroxy-6-methyl-9,10-dihydroanthracene-9...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of PRL3 after 1 hr by DiFMUP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50184289(5-[1-(4-benzyloxy-4'-dimethylamino-biphenyl-3-yl)-...)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of human recombinant PRL-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50184286(5-(2-(benzyloxy)-5-bromobenzyl)-2-thioxothiazolidi...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of human recombinant PRL-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50312665(CHEMBL1088572 | Sodium 2-(2-Fluorophenyl)-6,7-meth...)
Affinity DataIC50:  4.93E+3nMAssay Description:Inhibition of human PTP4A3 by enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50571227(CHEMBL4854258)
Affinity DataIC50:  4.98E+3nMAssay Description:Inhibition of recombinant human PTP4A3More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50571228(CHEMBL4856668)
Affinity DataIC50:  6.59E+3nMAssay Description:Inhibition of recombinant human PTP4A3More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50184295((Z)-5-(5-bromo-2-hydroxybenzylidene)-2-thioxothiaz...)
Affinity DataIC50:  9.50E+3nMAssay Description:Inhibition of human recombinant PRL-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50391711(CHEMBL2146958)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of PRL3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50237949(2-(5-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)...)
Affinity DataIC50:  1.33E+4nMAssay Description:Inhibition of recombinant human PTP4A3 expressed in Escherichia coli BL21 (DE3) assessed as reduction in hydrolysis using DIFMUP as substrate incubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50237949(2-(5-((4-oxo-2-thioxothiazolidin-5-ylidene)methyl)...)
Affinity DataIC50:  1.33E+4nMAssay Description:Inhibition of human PRL3 expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50569365(CHEMBL4867742)
Affinity DataIC50:  1.52E+4nMAssay Description:Inhibition of PRL-3 (unknown origin) using DiFMUP as substrate incubated for 1 hrMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50237952(3-(2-((1-(3-chlorophenyl)-2,5-dioxoimidazolidin-4-...)
Affinity DataIC50:  1.54E+4nMAssay Description:Inhibition of human PRL3 expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50535760(CHEMBL4466901)
Affinity DataIC50:  1.54E+4nMAssay Description:Inhibition of recombinant human PTP4A3 expressed in Escherichia coli BL21 (DE3) assessed as reduction in hydrolysis using DIFMUP as substrate incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50237948((E)-2-(2-(5-(4-chlorophenyl)furan-2-yl)vinyl)-6-me...)
Affinity DataIC50:  1.83E+4nMAssay Description:Inhibition of human PRL3 expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50237948((E)-2-(2-(5-(4-chlorophenyl)furan-2-yl)vinyl)-6-me...)
Affinity DataIC50:  1.83E+4nMAssay Description:Inhibition of recombinant human PTP4A3 expressed in Escherichia coli BL21 (DE3) assessed as reduction in hydrolysis using DIFMUP as substrate incubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50569366(CHEMBL4858539)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibition of PRL-3 (unknown origin) using DiFMUP as substrate incubated for 1 hrMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50323199(5,7-dihydroxy-8-(5-(5-hydroxy-7-methoxy-4-oxo-4H-c...)
Affinity DataIC50:  2.58E+4nMAssay Description:Inhibition of human brain PRL-3 (1 to 168 residues) expressed in Escherichia coli BL21(DE3) cells using DiFMUP as substrate incubated for 1 hr by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50569362(CHEMBL1699070)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of PRL-3 (unknown origin) using DiFMUP as substrate incubated for 1 hrMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50569367(CHEMBL4850661)
Affinity DataIC50:  2.67E+4nMAssay Description:Inhibition of PRL-3 (unknown origin) using DiFMUP as substrate incubated for 1 hrMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50391714(CHEMBL2146957)
Affinity DataIC50:  2.76E+4nMAssay Description:Inhibition of PRL3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein tyrosine phosphatase type IVA 3(Homo sapiens (Human))
University Of Virginia Patent Foundation

US Patent
LigandPNGBDBM50237950(3-benzylsulfanyl-6-[1-(4-hydroxy-3-methoxy-phenyl)...)
Affinity DataIC50:  2.77E+4nMAssay Description:Inhibition of human PRL3 expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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