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Found 23 Enz. Inhib. hit(s) with Target = 'Receptor-type tyrosine-protein kinase FLT3 [R834Q]'
TargetReceptor-type tyrosine-protein kinase FLT3 [R834Q](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM247371(US9447092, 1)
Affinity DataKd:  110nMAssay Description:The kinase selectivity was assessed by profiling Example 1 in a 442-kinase panel (386 non-mutant kinases) at a concentration of 1 μM using the K...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3 [R834Q](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM621165(Exemplary Synthetic Procedure #38 | US20230303563...)
Affinity DataKd:  0.390nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetReceptor-type tyrosine-protein kinase FLT3 [R834Q](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM538658(NCGC 00249373 | US11254667, Compound I-17 | US1154...)
Affinity DataKd:  3.40nMAssay Description:Table 7 For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetReceptor-type tyrosine-protein kinase FLT3 [R834Q](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM185149(1-[2-[5-[(3-methyloxetan-3-yl)methoxy]benzimidazol...)
Affinity DataKd:  1.30nMAssay Description:Table 7 For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3 [R834Q](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM538619(NCGC 00371479 | US11254667, Compound I-22 | US1154...)
Affinity DataKd:  0.420nMAssay Description:Table 7 For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phas...More data for this Ligand-Target Pair
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TargetReceptor-type tyrosine-protein kinase FLT3 [R834Q](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM538621(NCGC 00371481 | US11254667, Compound I-24 | US1154...)
Affinity DataKd:  0.300nMAssay Description:Table 7 For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phas...More data for this Ligand-Target Pair
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TargetReceptor-type tyrosine-protein kinase FLT3 [R834Q](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM621080(N-(6-(6-(1-methyl- cyclopropyl)imidazo- [1,2-a]pyr...)
Affinity DataKd:  0.800nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
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TargetReceptor-type tyrosine-protein kinase FLT3 [R834Q](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM621098(6-(6-(difluorometh- oxy)imidazo[1,2-a]- pyridin-3-...)
Affinity DataKd:  0.150nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetReceptor-type tyrosine-protein kinase FLT3 [R834Q](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM621166(N-((3S,4S)-4-fluoro- pyrrolidin-3-yl)-6-(6-(1- met...)
Affinity DataKd:  0.540nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetReceptor-type tyrosine-protein kinase FLT3 [R834Q](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM621167(1-(4-(3-(6-(((3S,4S)-4- fluoropyrrolidin-3-yl)- am...)
Affinity DataKd:  0.970nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetReceptor-type tyrosine-protein kinase FLT3 [R834Q](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM621168(6-(6-(1-cyclopropyl-1H- pyrazol-4-yl)imidazo- [1,2...)
Affinity DataKd:  1.30nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetReceptor-type tyrosine-protein kinase FLT3 [R834Q](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM621115(US20230303563, Compound 117)
Affinity DataKd:  0.0610nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
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TargetReceptor-type tyrosine-protein kinase FLT3 [R834Q](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM621116(2-(3-(6-(((3S,4S)-4- fluoropyrrolidin-3- yl)amino)...)
Affinity DataKd:  0.390nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
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In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3 [R834Q](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM621117(2-(3-(6-(((3S,4S)-4- fluoropiperidin-3- yl)amino)p...)
Affinity DataKd:  0.330nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetReceptor-type tyrosine-protein kinase FLT3 [R834Q](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM621123(US20230303563, Compound 165)
Affinity DataKd:  0.890nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
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TargetReceptor-type tyrosine-protein kinase FLT3 [R834Q](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM621125((R)-N-(6-(6- (difluoromethyl)imidazo[1,2- a]pyridi...)
Affinity DataKd:  0.900nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetReceptor-type tyrosine-protein kinase FLT3 [R834Q](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM621126(6-(6- (difluoromethyl)imidazo[1,2- a]pyridin-3-yl)...)
Affinity DataKd:  0.0360nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetReceptor-type tyrosine-protein kinase FLT3 [R834Q](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM621169(6-(6- (difluoromethyl)imidazo[1,2- a]pyridin-3-yl)...)
Affinity DataKd:  0.200nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetReceptor-type tyrosine-protein kinase FLT3 [R834Q](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM621130(N-(6-(6- (difluoromethyl)imidazo[1,2- a]pyridin-3-...)
Affinity DataKd:  0.340nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3 [R834Q](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM621136(3,5-difluoro-N-((3S,4S)-4- fluoropyrrolidin-3-yl)-...)
Affinity DataKd:  8.5nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetReceptor-type tyrosine-protein kinase FLT3 [R834Q](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM621137(3,5-difluoro-N-((3S,4S)-4- fluoropiperidin-3-yl)-6...)
Affinity DataKd:  1.5nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetReceptor-type tyrosine-protein kinase FLT3 [R834Q](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM621161(N-((3S,4S)-4- fluoropyrrolidin-3-yl)-6-(7- isoprop...)
Affinity DataKd:  1.20nMAssay Description:Table 33 and 34: Kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phase and in...More data for this Ligand-Target Pair
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TargetReceptor-type tyrosine-protein kinase FLT3 [R834Q](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)
Affinity DataKd:  12nMAssay Description:Table 7 For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phas...More data for this Ligand-Target Pair