Affinity DataKi: 10nM IC50: 2.25E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one
derivatives were tested as potential E. coli TrxR inhibitors by standard
DTNB ...More data for this Ligand-Target Pair
Affinity DataKi: 40nM IC50: 2.10E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one
derivatives were tested as potential E. coli TrxR inhibitors by standard
DTNB ...More data for this Ligand-Target Pair
Affinity DataKi: 50nM IC50: 2.00E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one
derivatives were tested as potential E. coli TrxR inhibitors by standard
DTNB ...More data for this Ligand-Target Pair
TargetThioredoxin reductase(Plasmodium falciparum (isolate 3D7))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataKi: 200nMAssay Description:Binding affinity to Plasmodium falciparum TrxR in presence of thioredoxinMore data for this Ligand-Target Pair
TargetThioredoxin reductase(Plasmodium falciparum (isolate 3D7))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataKi: 200nMAssay Description:Binding affinity to Plasmodium falciparum TrxR in presence of NADPHMore data for this Ligand-Target Pair
Affinity DataKi: 250nM IC50: 3.00E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one
derivatives were tested as potential E. coli TrxR inhibitors by standard
DTNB ...More data for this Ligand-Target Pair
Affinity DataKi: 250nM IC50: 6.00E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one
derivatives were tested as potential E. coli TrxR inhibitors by standard
DTNB ...More data for this Ligand-Target Pair
Affinity DataKi: 280nMAssay Description:Irreversible inhibition of thioredoxin reductase (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 300nM IC50: 6.00E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one
derivatives were tested as potential E. coli TrxR inhibitors by standard
DTNB ...More data for this Ligand-Target Pair
Affinity DataKi: 390nMAssay Description:Inhibition of Entamoeba histolytica thioredoxin reductaseMore data for this Ligand-Target Pair
Affinity DataKi: 550nM IC50: 7.00E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one
derivatives were tested as potential E. coli TrxR inhibitors by standard
DTNB ...More data for this Ligand-Target Pair
TargetThioredoxin reductase(Plasmodium falciparum (isolate 3D7))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataKi: 650nMAssay Description:Binding affinity to Plasmodium falciparum TrxR in presence of thioredoxinMore data for this Ligand-Target Pair
Affinity DataKi: 680nMAssay Description:Inhibition of Entamoeba histolytica thioredoxin reductaseMore data for this Ligand-Target Pair
Affinity DataKi: 690nMAssay Description:Inhibition of Entamoeba histolytica thioredoxin reductaseMore data for this Ligand-Target Pair
Affinity DataKi: 730nMAssay Description:Inhibition of Entamoeba histolytica thioredoxin reductaseMore data for this Ligand-Target Pair
Affinity DataKi: 1.00E+3nM IC50: 1.50E+4nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one
derivatives were tested as potential E. coli TrxR inhibitors by standard
DTNB ...More data for this Ligand-Target Pair
TargetThioredoxin reductase(Plasmodium falciparum (isolate 3D7))
University Of Michigan
Curated by ChEMBL
University Of Michigan
Curated by ChEMBL
Affinity DataKi: 1.00E+3nMAssay Description:Binding affinity to Plasmodium falciparum TrxR in presence of NADPHMore data for this Ligand-Target Pair
Affinity DataKi: 1.05E+3nMAssay Description:Inhibition of Entamoeba histolytica thioredoxin reductaseMore data for this Ligand-Target Pair
Affinity DataKi: 1.20E+3nM IC50: 7.50E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one
derivatives were tested as potential E. coli TrxR inhibitors by standard
DTNB ...More data for this Ligand-Target Pair
Affinity DataKi: 1.50E+3nM IC50: 3.00E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one
derivatives were tested as potential E. coli TrxR inhibitors by standard
DTNB ...More data for this Ligand-Target Pair
Affinity DataKi: 1.90E+3nMAssay Description:Mixed-type inhibition of rat liver cytosolic TrxR1 by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 2.07E+3nMAssay Description:Inhibition of Entamoeba histolytica thioredoxin reductaseMore data for this Ligand-Target Pair
Affinity DataKi: 2.82E+3nMAssay Description:Inhibition of Entamoeba histolytica thioredoxin reductaseMore data for this Ligand-Target Pair
Affinity DataKi: 2.88E+3nMAssay Description:Inhibition of Entamoeba histolytica thioredoxin reductaseMore data for this Ligand-Target Pair
Affinity DataKi: 3.16E+3nMAssay Description:Inhibition of Entamoeba histolytica thioredoxin reductaseMore data for this Ligand-Target Pair
Affinity DataKi: 3.30E+3nMAssay Description:Inhibition of Entamoeba histolytica thioredoxin reductaseMore data for this Ligand-Target Pair
Affinity DataKi: 3.56E+3nMAssay Description:Inhibition of Entamoeba histolytica thioredoxin reductaseMore data for this Ligand-Target Pair
Affinity DataKi: 4.66E+3nMAssay Description:Inhibition of Entamoeba histolytica thioredoxin reductaseMore data for this Ligand-Target Pair
Affinity DataKi: 5.68E+3nMAssay Description:Inhibition of Entamoeba histolytica thioredoxin reductaseMore data for this Ligand-Target Pair
Affinity DataKi: 6.23E+3nMAssay Description:Inhibition of Entamoeba histolytica thioredoxin reductaseMore data for this Ligand-Target Pair
Affinity DataKi: 8.10E+3nMAssay Description:Mixed-type inhibition of rat liver cytosolic TrxR1 at protein-substrate complex by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 1.09E+4nMAssay Description:Inhibition of Entamoeba histolytica thioredoxin reductaseMore data for this Ligand-Target Pair
Affinity DataKi: 1.61E+4nMAssay Description:Inhibition of Entamoeba histolytica thioredoxin reductaseMore data for this Ligand-Target Pair
Affinity DataKi: 2.70E+4nMAssay Description:Inhibition of Entamoeba histolytica thioredoxin reductaseMore data for this Ligand-Target Pair
Affinity DataKi: 3.37E+5nMAssay Description:Inhibition of Entamoeba histolytica thioredoxin reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.854nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.03nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.52nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.16nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.99nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.35nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.05nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Affinity DataIC50: 6.78nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Affinity DataIC50: 6.90nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Affinity DataIC50: 7.16nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Affinity DataIC50: 7.33nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Affinity DataIC50: 7.60nMAssay Description:Small molecule inhibition of recombinant thioredoxin reductase 1 (TrxR1) and gluthathione reductase (GR) was examined in 96-well plate format. 30 nM ...More data for this Ligand-Target Pair
Affinity DataIC50: 9.20nMAssay Description:Inhibition of TrxR1 (unknown origin) assessed as reduction in DTNB to TNB by colorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9.20nMAssay Description:Inhibition of TrxR1 (unknown origin) assessed as reduction in DTNB to TNB by colorimetric assayMore data for this Ligand-Target Pair