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Found 125 Enz. Inhib. hit(s) with Target = 'Tumor necrosis factor receptor superfamily member 1A'
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123310(1,3-Diethyl-5-(1-methyl-1H-indol-3-ylmethylene)-2-...)
Affinity DataIC50:  130nMAssay Description:Inhibition of TNF-alpha binding to TNFRc1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123291(3-Ethyl-5-[1-[5-(2-methyl-5-trifluoromethyl-2H-pyr...)
Affinity DataIC50:  140nMAssay Description:Inhibition of TNF-alpha binding to TNFRc1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123283(2-Allyl-6,8-dimethoxy-9-methyl-imidazo[1,5-a]indol...)
Affinity DataIC50:  210nMAssay Description:Inhibition of TNF-alpha binding to TNFRc1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123293(2-Allyl-6,8-dimethoxy-9-methyl-1-thioxo-1,2-dihydr...)
Affinity DataIC50:  210nMAssay Description:Inhibition of TNF-alpha binding to TNFRc1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123285(2-Ethyl-8-methoxy-6-methoxymethoxy-3-thioxo-2,3-di...)
Affinity DataIC50:  280nMAssay Description:Inhibition of TNF-alpha binding to TNFRc1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123288(2-Allyl-6,8-dimethoxy-3-thioxo-2,3-dihydro-imidazo...)
Affinity DataIC50:  280nMAssay Description:Inhibition of TNF-alpha binding to TNFRc1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123289(3-{5-[3-Ethyl-4-oxo-2-thioxo-thiazolidin-(5Z)-ylid...)
Affinity DataIC50:  300nMAssay Description:Inhibition of TNF-alpha binding to TNFRc1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123298(2-Ethyl-8-methoxy-6-(pyridin-2-ylmethoxy)-3-thioxo...)
Affinity DataIC50:  310nMAssay Description:Inhibition of TNF-alpha binding to TNFRc1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123308(3-Ethyl-2-thioxo-5-[1-[5-(2-trifluoromethyl-phenyl...)
Affinity DataIC50:  320nMAssay Description:Inhibition of TNF-alpha binding to TNFRc1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123287((2-Ethyl-8-methoxy-1-oxo-3-thioxo-2,3-dihydro-1H-i...)
Affinity DataIC50:  390nMAssay Description:Inhibition of TNF-alpha binding to TNFRc1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123284(5-(5-Benzyloxy-1H-indol-3-ylmethylene)-1,3-diethyl...)
Affinity DataIC50:  400nMAssay Description:Inhibition of TNF-alpha binding to TNFRc1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123307(1,3-Diethyl-5-(7-methyl-1H-indol-3-ylmethylene)-2-...)
Affinity DataIC50:  600nMAssay Description:Inhibition of TNF-alpha binding to TNFRc1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123297(2-Allyl-6,8-dimethoxy-1-thioxo-1,2-dihydro-imidazo...)
Affinity DataIC50:  610nMAssay Description:Inhibition of TNF-alpha binding to TNFRc1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123302(6,8-Dimethoxy-2-(3-morpholin-4-yl-propyl)-3-thioxo...)
Affinity DataIC50:  670nMAssay Description:Inhibition of TNF-alpha binding to TNFRc1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50457655(CHEMBL4213787)
Affinity DataIC50:  770nMAssay Description:Inhibition of TNFR in TLR null HEK-blue cells assessed as decrease in TNFalpha-stimulated NF-kappaB activation-mediated SEAP production after 24 hrs ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123294(2-Allyl-6,7,8-trimethoxy-3-thioxo-2,3-dihydro-imid...)
Affinity DataIC50:  780nMAssay Description:Inhibition of TNF-alpha binding to TNFRc1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123286(5-(1H-Indol-3-ylmethylene)-2-thioxo-1,3-di-o-tolyl...)
Affinity DataIC50:  790nMAssay Description:Inhibition of TNF-alpha binding to TNFRc1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123313(2-Ethyl-6,8-dimethoxy-3-thioxo-2,3-dihydro-imidazo...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of TNF-alpha binding to TNFRc1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123305(1,3-Diethyl-5-(1H-indol-3-ylmethylene)-2-thioxo-di...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of TNF-alpha binding to TNFRc1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141477(CHEMBL39656 | {2,6-Dimethoxy-4-[(E)-3-(2-methoxy-5...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of TNF-alpha-induced VCAM-1 expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141481((E)-3-(5-Benzo[b]thiophen-2-yl-2,4-dimethoxy-pheny...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of TNF-alpha-induced VCAM-1 expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141488((E)-1-(2,2-Dihydroxy-benzo[1,3]dioxol-5-yl)-3-(3,4...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of TNF-alpha-induced VCAM-1 expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141495(CHEMBL37662 | [4-Benzo[b]thiophen-2-yl-5-methoxy-2...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of TNF-alpha-induced VCAM-1 expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141507(CHEMBL37663 | {4-[(E)-3-(5-Benzo[b]thiophen-2-yl-2...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of TNF-alpha-induced VCAM-1 expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141536(CHEMBL39896 | {4-[(E)-3-(3,4-Dimethoxy-5-thiophen-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of TNF-alpha-induced VCAM-1 expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141529((E)-1-[3,5-Dimethoxy-4-(4-methoxy-benzyloxy)-pheny...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of TNF-alpha-induced VCAM-1 expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141548((E)-3-(5-Bromo-2-methoxy-phenyl)-1-(3,4,5-trimetho...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of TNF-alpha-induced VCAM-1 expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123296(2-Allyl-6,8-dimethoxy-9-methyl-3-thioxo-2,3-dihydr...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of TNF-alpha binding to TNFRc1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123281(2-Allyl-6-methoxy-3-thioxo-2,3-dihydro-imidazo[1,5...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of TNF-alpha binding to TNFRc1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123295(5-[1-(1H-Indol-3-yl)-meth-(E)-ylidene]-2-thioxo-1-...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of TNF-alpha binding to TNFRc1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123309(6,8-Dimethoxy-2-phenethyl-3-thioxo-2,3-dihydro-imi...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of TNF-alpha binding to TNFRc1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50255012(5-((4-(methylsulfonyl)benzylamino)methyl)-3,4-difl...)
Affinity DataIC50:  2.00E+3nMAssay Description:Binding affinity to TRAK-A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141549((E)-3-(5-Bromo-2,4-dimethoxy-phenyl)-1-(3,4,5-trim...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of TNF-alpha-induced VCAM-1 expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141544((E)-3-[2-Methoxy-5-(4-methyl-thiophen-2-yl)-phenyl...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of TNF-alpha-induced VCAM-1 expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141538((E)-3-(2,4-Dimethoxy-5-thiophen-2-yl-phenyl)-1-(2,...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of TNF-alpha-induced VCAM-1 expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141534((E)-3-(5-Benzo[b]thiophen-2-yl-2-methoxy-phenyl)-1...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of TNF-alpha-induced VCAM-1 expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141527((E)-1-[4-(3,4-Dimethoxy-benzyloxy)-3-methoxy-pheny...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of TNF-alpha-induced VCAM-1 expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141525((E)-1-(2,5-Dimethoxy-phenyl)-3-(2-methoxy-5-thioph...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of TNF-alpha-induced VCAM-1 expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141524((E)-1-[4-(3,4-Dimethoxy-benzyloxy)-3,5-dimethoxy-p...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of TNF-alpha-induced VCAM-1 expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141526((E)-3-[2-Methoxy-5-(5-methyl-thiophen-2-yl)-phenyl...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of TNF-alpha-induced VCAM-1 expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141516((E)-1-(3,5-Dimethoxy-phenyl)-3-(2-methoxy-5-thioph...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of TNF-alpha-induced VCAM-1 expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141508((E)-1-(3,4-Dimethoxy-phenyl)-3-[2-methoxy-5-(5-met...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of TNF-alpha-induced VCAM-1 expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141497((E)-3-(3,4-Difluoro-phenyl)-1-(2-methoxy-4-thiophe...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of TNF-alpha-induced VCAM-1 expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141496((E)-3-(5-Benzo[b]thiophen-2-yl-2-methoxy-phenyl)-1...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of TNF-alpha-induced VCAM-1 expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141494((E)-1-[3,5-Dimethoxy-4-(3-methoxy-benzo[1,4]dioxin...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of TNF-alpha-induced VCAM-1 expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141487((E)-3-(3-Bromo-4,5-dimethoxy-phenyl)-1-(2,4,5-trim...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of TNF-alpha-induced VCAM-1 expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50141484((E)-1-(3,4-Dimethoxy-phenyl)-3-[2-methoxy-5-(4-met...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of TNF-alpha-induced VCAM-1 expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123312(1,3-Diethyl-2-thioxo-5-[5-(2-trifluoromethyl-pheny...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of TNF-alpha binding to TNFRc1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123301(2-Allyl-8-methoxy-3-thioxo-2,3-dihydro-imidazo[1,5...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of TNF-alpha binding to TNFRc1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor receptor superfamily member 1A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50123304(3-[5-(1,3-Diethyl-4,6-dioxo-2-thioxo-tetrahydro-py...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of TNF-alpha binding to TNFRc1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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