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Found 47 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein phosphatase non-receptor type 12'
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50544111(CHEMBL4638054)
Affinity DataKi:  1.00E+3nMAssay Description:Competitive inhibition of PTP-PEST (unknown origin) assessed as inhibition constant using varying level of pNPP as substrate by Lineweaver-Burk plot ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50556732(CHEMBL4750435)
Affinity DataIC50:  130nMAssay Description:Inhibition of PTPN12 (unknown origin) pre-incubated for 20 mins followed by fluorescence substrate addition and measured after 120 mins by DiFMUP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50436358(CHEMBL2396718)
Affinity DataIC50:  800nMAssay Description:Inhibition of recombinant PTP-PEST (unknown origin) using pNPP as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50079855((R)-2-[2,6-Dibromo-4-(6-bromo-benzo[b]naphtho[2,3-...)
Affinity DataIC50:  2.20E+3nMAssay Description:The compound was tested in vitro for the inhibitory activity against Protein tyrosine phosphatase PEST (SH-PTP1) (human PTPases.)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50079856(CHEMBL108721 | [2,6-Dibromo-4-(6-bromo-benzo[b]nap...)
Affinity DataIC50:  2.30E+3nMAssay Description:The compound was tested in vitro for the inhibitory activity against Protein tyrosine phosphatase PEST (SH-PTP1) (human PTPases.)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50436357(CHEMBL2396719)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of recombinant PTP-PEST (unknown origin) using pNPP as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50464769(CHEMBL4290098)
Affinity DataIC50:  5.22E+3nMAssay Description:Inhibition of PTP-PEST (unknown origin) using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition measured e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50464767(Chalcomoracin)
Affinity DataIC50:  8.52E+3nMAssay Description:Inhibition of PTP-PEST (unknown origin) using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition measured e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50607111(CHEMBL5218807)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PEST(unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM231167(US9340574, 7)
Affinity DataIC50: >1.00E+4nMpH: 7.0Assay Description:PTP activity was assayed using p-nitrophenyl phosphate (pNPP) as a substrate in 3,3-dimethylglutarate buffer (50 mM 3,3-dimethylglutarate, pH 7.0, 1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50544111(CHEMBL4638054)
Affinity DataIC50:  1.09E+4nMAssay Description:Inhibition of PTP-PEST (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50464771(CHEMBL4279417)
Affinity DataIC50:  1.24E+4nMAssay Description:Inhibition of PTP-PEST (unknown origin) using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition measured e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50393492(CHEMBL2159933)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of PTP-PEST expressed in Escherichia coli BL21 using pNPP substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50466478(CHEMBL4288744)
Affinity DataIC50:  1.57E+4nMAssay Description:Inhibition of recombinant human PTP-PEST using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition and measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50393491(CHEMBL2159932)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of PTP-PEST expressed in Escherichia coli BL21 using pNPP substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50393493(CHEMBL2159934)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of PTP-PEST expressed in Escherichia coli BL21 using pNPP substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50464768(CHEMBL4291588)
Affinity DataIC50:  1.86E+4nMAssay Description:Inhibition of PTP-PEST (unknown origin) using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition measured e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50193719((S)-5,7,7'-trihydroxy-2',2'-dimethyl-6-(3-methylbu...)
Affinity DataIC50:  1.86E+4nMAssay Description:Inhibition of PTP-PEST (unknown origin) using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition measured e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50393495(CHEMBL2159725)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of PTP-PEST expressed in Escherichia coli BL21 using pNPP substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50269559(2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataIC50:  2.09E+4nMAssay Description:Inhibition of PTP-PEST (unknown origin) using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition measured e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50393500(CHEMBL2159726)
Affinity DataIC50:  2.10E+4nMAssay Description:Inhibition of PTP-PEST expressed in Escherichia coli BL21 using pNPP substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50393498(CHEMBL2159930)
Affinity DataIC50:  2.75E+4nMAssay Description:Inhibition of PTP-PEST expressed in Escherichia coli BL21 using pNPP substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50393499(CHEMBL2159931)
Affinity DataIC50:  2.80E+4nMAssay Description:Inhibition of PTP-PEST expressed in Escherichia coli BL21 using pNPP substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50544431(CHEMBL4637459 | US11192850, Entry 4k)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of PTP-PEST (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50544440(CHEMBL4647367 | US11192850, Entry 4t)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of PTP-PEST (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM54792(2-(3-cyano-5,8-dimethyl-quinolin-2-yl)sulfanyl-N-(...)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of PTP-PEST expressed in Escherichia coli BL21 using pNPP substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50393502(CHEMBL2159929)
Affinity DataIC50:  3.60E+4nMAssay Description:Inhibition of PTP-PEST expressed in Escherichia coli BL21 using pNPP substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM46265(2-[(2-cyclopropyl-5,6,7,8-tetrahydrobenzothiopheno...)
Affinity DataIC50:  3.90E+4nMAssay Description:Inhibition of PTP-PEST expressed in Escherichia coli BL21 using pNPP substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50393501(CHEMBL2159928)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of PTP-PEST expressed in Escherichia coli BL21 using pNPP substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM46264(3-[2-azaspiro[5.5]undecan-2-yl-(1-cyclopentyl-1,2,...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of PTP-PEST expressed in Escherichia coli BL21 using pNPP substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50558482(CHEMBL4742123)
Affinity DataIC50:  4.35E+4nMAssay Description:Inhibition of His-tagged PTP-PEST (unknown origin) expressed in Escherichia coli BL21 cells using para-nitrophenyl phosphate as substrate incubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50466482(CHEMBL4282817)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant human PTP-PEST using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition and measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50466475(CHEMBL4292242)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant human PTP-PEST using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition and measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50544427(CHEMBL4632818 | US11192850, Entry 4g)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of PTP-PEST (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50466479(CHEMBL4280516)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant human PTP-PEST using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition and measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50558481(CHEMBL4783639)
Affinity DataIC50:  6.69E+4nMAssay Description:Inhibition of His-tagged PTP-PEST (unknown origin) expressed in Escherichia coli BL21 cells using para-nitrophenyl phosphate as substrate incubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50558487(CHEMBL4786243)
Affinity DataIC50:  6.99E+4nMAssay Description:Inhibition of His-tagged PTP-PEST (unknown origin) expressed in Escherichia coli BL21 cells using para-nitrophenyl phosphate as substrate incubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50558488(CHEMBL4794972)
Affinity DataIC50:  7.20E+4nMAssay Description:Inhibition of PEST(unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50558488(CHEMBL4794972)
Affinity DataIC50:  7.23E+4nMAssay Description:Inhibition of His-tagged PTP-PEST (unknown origin) expressed in Escherichia coli BL21 cells using para-nitrophenyl phosphate as substrate incubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50108046((oxyresveratrol)4-[(E)-2-(3,5-dihydroxyphenyl)viny...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of PTP-PEST (unknown origin) using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition measured e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50242014(CHEMBL464006 | Morusin | Morusin, 3 | TCMDC-124149...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of PTP-PEST (unknown origin) using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition measured e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50607110(CHEMBL5219519)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of PEST(unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50558461(CHEMBL4760367)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of His-tagged PTP-PEST (unknown origin) expressed in Escherichia coli BL21 cells using para-nitrophenyl phosphate as substrate incubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50558485(CHEMBL4800195)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of His-tagged PTP-PEST (unknown origin) expressed in Escherichia coli BL21 cells using para-nitrophenyl phosphate as substrate incubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50558484(CHEMBL4748824)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of His-tagged PTP-PEST (unknown origin) expressed in Escherichia coli BL21 cells using para-nitrophenyl phosphate as substrate incubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50558483(CHEMBL4778085)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of His-tagged PTP-PEST (unknown origin) expressed in Escherichia coli BL21 cells using para-nitrophenyl phosphate as substrate incubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 12(Homo sapiens (Human))
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandPNGBDBM50558486(CHEMBL4797766)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of His-tagged PTP-PEST (unknown origin) expressed in Escherichia coli BL21 cells using para-nitrophenyl phosphate as substrate incubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed