Found 100 Enz. Inhib. hit(s) with Target = 'Potassium voltage-gated channel subfamily E/KQT member 1'
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of human IKs-channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of IKs currents in Xenopus oocytesMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of human IKs-channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of human IKs-channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 240nMAssay Description:Inhibition of human IKs-channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 250nMAssay Description:Inhibition of human IKs-channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:Inhibition of human IKs-channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 440nMAssay Description:Inhibition of human IKs-channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 700nMAssay Description:Inhibition of human IKs-channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 790nMAssay Description:Inhibition of human KCNQ1/KCNE1 expressed in HEK293 cells assessed as reduction in slowly activating delayed rectifier cardiac potassium current by p...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 900nMAssay Description:Inhibition of human IKs-channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human IKs-channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human IKs-channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 1.30E+3nMAssay Description:Antagonist activity at KCNQ1/MINK expressed in CHO cells assessed as inhibition of KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induct...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 1.90E+3nMAssay Description:Antagonist activity at KCNQ1/MINK expressed in CHO cells assessed as inhibition of KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induct...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of Iks current KvLQT1 potassium channelMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of human IKs-channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 2.90E+3nMAssay Description:Antagonist activity at KCNQ1/MINK expressed in CHO cells assessed as inhibition of KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induct...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of human IKs-channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 3.40E+3nMAssay Description:Antagonist activity at KCNQ1/MINK expressed in CHO cells assessed as inhibition of KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induct...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 3.40E+3nMAssay Description:Antagonist activity at KCNQ1/MINK expressed in CHO cells assessed as inhibition of KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induct...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human IKs-channel expressed in Xenopus oocytes,(Experiment 1)More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human IKs-channel expressed in Xenopus oocytes,(Experiment 2)More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 5.80E+3nMAssay Description:Antagonist activity at KCNQ1/MINK expressed in CHO cells assessed as inhibition of KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induct...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 5.80E+3nMAssay Description:Antagonist activity at KCNQ1/MINK expressed in CHO cells assessed as inhibition of KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induct...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of human IKs-channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 8.12E+3nMAssay Description:Antagonist activity at KCNQ1/E1 expressed in CHO cells incubated for 3 mins by automated patch clamp assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using I...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 1.50E+4nMAssay Description:Antagonist activity at KCNQ1/MINK expressed in CHO cells assessed as inhibition of KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induct...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 1.50E+4nMAssay Description:Antagonist activity at KCNQ1/MINK expressed in CHO cells assessed as inhibition of KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induct...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 1.58E+4nMAssay Description:Inhibition of slow delayed inward rectifying potassium current (Iks) in Chinese Hamster Ovary (CHO) cells transfected with KCNQ1 / Kv1.7 / KvLQT1 and...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 1.70E+4nMAssay Description:Antagonist activity at KCNQ1/MINK expressed in CHO cells assessed as inhibition of KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induct...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using I...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 2.20E+4nMAssay Description:Antagonist activity at KCNQ1/MINK expressed in CHO cells assessed as inhibition of KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induct...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human KCNQ1/KCNE1More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of human KCNQ1/KCNE1More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 2.51E+4nMAssay Description:Inhibition of slow delayed inward rectifying potassium current (Iks) in Chinese Hamster Ovary (CHO) cells expressing hKvLQT1/hminK measured using Ion...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Positive allosteric modulation of GABAA receptor alpha1beta2gamma2 (unknown origin) expressed in mouse LTK cells assessed as potentiation of GABA-med...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Antagonist activity at KCNQ1/MINK expressed in CHO cells assessed as inhibition of KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induct...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 3.16E+4nMAssay Description:Inhibition of slow delayed inward rectifying potassium current (Iks) in Chinese Hamster Ovary (CHO) cells expressing hKvLQT1/hminK measured using Ion...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 3.30E+4nMAssay Description:Antagonist activity at KCNQ1/MINK expressed in CHO cells assessed as inhibition of KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induct...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 3.50E+4nMAssay Description:Antagonist activity at KCNQ1/MINK expressed in CHO cells assessed as inhibition of KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induct...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 3.98E+4nMAssay Description:Inhibition of fast sodium current (INa) in Chinese Hamster Ovary (CHO) K1 cells transfected with human Nav1.5 measured using IonWorks Quattro automat...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 4.10E+4nMAssay Description:Antagonist activity at KCNQ1/MINK expressed in CHO cells assessed as inhibition of KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induct...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 4.10E+4nMAssay Description:Antagonist activity at KCNQ1/MINK expressed in CHO cells assessed as inhibition of KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induct...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 4.45E+4nMAssay Description:Inhibition of human IKs-channel expressed in Xenopus oocytes,(Experiment 1)More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 4.90E+4nMAssay Description:Antagonist activity at KCNQ1/MINK expressed in CHO cells assessed as inhibition of KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induct...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 5.01E+4nMAssay Description:Inhibition of fast sodium current (INa) in HEK293 cells transfected with human Nav1.5 measured using IonWorks Quattro automated patch clamp platformMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 5.01E+4nMAssay Description:Inhibition of transient outward potassium current (Ito) current in Chinese Hamster Ovary (CHO) K1 cells expressing human Kv4.3 measured using IonWork...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Homo sapiens (Human))
Aventis Pharma Deutschland
Curated by ChEMBL
Aventis Pharma Deutschland
Curated by ChEMBL
Affinity DataIC50: 5.01E+4nMAssay Description:Inhibition of slow delayed inward rectifying potassium current (Iks) in Chinese Hamster Ovary (CHO) cells expressing hKvLQT1/hminK measured using Ion...More data for this Ligand-Target Pair