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Found 464 Enz. Inhib. hit(s) with Target = 'Myosin light chain kinase, smooth muscle'
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM2580(K252a | methyl (15R,16S,18S)-16-hydroxy-15-methyl-...)
Affinity DataKi:  17nMAssay Description:Inhibition of human myosin light chain kinaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM6760((+)-K-252a | CHEMBL281948 | K-252a | methyl (15S,1...)
Affinity DataKi:  20nMAssay Description:Inhibition of MLCK by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM307686(2-(6-(5-methyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4...)
Affinity DataKi: <200nMAssay Description:MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM307654(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Affinity DataKi: <200nMAssay Description:MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM307609(2-(6-(4-Cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-...)
Affinity DataKi: <200nMAssay Description:MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM307649(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Affinity DataKi: <200nMAssay Description:MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM307648(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Affinity DataKi: <200nMAssay Description:MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM307674(2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-...)
Affinity DataKi: <200nMAssay Description:MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM307672(2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-...)
Affinity DataKi: <200nMAssay Description:MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM307668(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Affinity DataKi: <200nMAssay Description:MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50216683(1-(5-iodonaphthalen-1-ylsulfonyl)-1,4-diazepane | ...)
Affinity DataKi:  300nMAssay Description:Inhibition of MLCK by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM307676(2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-...)
Affinity DataKi:  600nMAssay Description:MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM307677(US10150755, Compound 69)
Affinity DataKi:  600nMAssay Description:MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM307640(N-(2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyrid...)
Affinity DataKi:  600nMAssay Description:MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM307679(2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-...)
Affinity DataKi:  600nMAssay Description:MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM307638(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Affinity DataKi:  600nMAssay Description:MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM307636(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Affinity DataKi:  600nMAssay Description:MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM15236(3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chr...)
Affinity DataKi:  1.70E+3nMAssay Description:Inhibition of MLCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50216681(1-(5-chloronaphthalen-1-ylsulfonyl)-1,4-diazepane ...)
Affinity DataKi:  3.80E+3nMAssay Description:Inhibition of MLCK by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50216681(1-(5-chloronaphthalen-1-ylsulfonyl)-1,4-diazepane ...)
Affinity DataKi:  3.80E+3nMAssay Description:Inhibition of myosin light chain kinaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM307615(2-(6-(4-cyclopropyl- 4H-1,2,4-triazol-3- yl)pyridi...)
Affinity DataKi:  5.50E+3nMAssay Description:MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM307682(2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-...)
Affinity DataKi:  5.50E+3nMAssay Description:MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM307673(5-chloro-2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl...)
Affinity DataKi:  5.50E+3nMAssay Description:MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM307671(2-(6-(4-cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-...)
Affinity DataKi:  5.50E+3nMAssay Description:MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50375645(CHEMBL219301 | US11542290, Compound A-3)
Affinity DataKi:  7.40E+3nMAssay Description:Inhibition of myosin light chain kinaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM14028((S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]...)
Affinity DataKi:  1.01E+4nMAssay Description:Binding affinity at MLCKChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Institute For Biochemistry

Curated by ChEMBL
LigandPNGBDBM15211(CHEMBL104264 | H-89 | H89 | HT-89 (H-89) | N-(2-{[...)
Affinity DataKi:  2.83E+4nMAssay Description:Inhibitory constant against MLCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM15211(CHEMBL104264 | H-89 | H89 | HT-89 (H-89) | N-(2-{[...)
Affinity DataKi:  2.83E+4nMAssay Description:Binding affinity at MLCKChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Institute For Biochemistry

Curated by ChEMBL
LigandPNGBDBM15210(CHEMBL148333 | H-8 | Lopac-M-9656 | N-(2-methylami...)
Affinity DataKi:  6.80E+4nMAssay Description:Inhibitory constant against MLCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Institute For Biochemistry

Curated by ChEMBL
LigandPNGBDBM50366348(CHEMBL1233654)
Affinity DataKi:  9.70E+4nMAssay Description:Inhibitory constant against MLCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50111446(5-Chloro-naphthalene-1-sulfonic acid (6-amino-hexy...)
Affinity DataKi:  1.10E+5nMAssay Description:Inhibition of MLCK by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50216680(1-(2-(isoquinoline-5-sulfonamido)ethyl)guanidine |...)
Affinity DataKi:  1.50E+5nMAssay Description:Binding affinity at MLCKChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Institute For Biochemistry

Curated by ChEMBL
LigandPNGBDBM6760((+)-K-252a | CHEMBL281948 | K-252a | methyl (15S,1...)
Affinity DataIC50:  0.0200nMAssay Description:Inhibition of Smooth muscle myosin light chain kinase of chicken gizzardMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Institute For Biochemistry

Curated by ChEMBL
LigandPNGBDBM50058332(CHEMBL299496 | methyl 10,23-di(ethylsulfanylmethyl...)
Affinity DataIC50: >10nMAssay Description:Inhibition of Smooth muscle myosin light chain kinase of chicken gizzardMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Institute For Biochemistry

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  10nMAssay Description:In vitro for inhibitory activity against myosin light-chain kinase from chicken gizzard (M-kinase)More data for this Ligand-Target Pair
In DepthDetails Article
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Institute For Biochemistry

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  10nMpH: 7.2 T: 2°CAssay Description:The activity of MLCK is measured by its ability to transfer 32P from [gamma-32P]ATP to myosin light-chain.More data for this Ligand-Target Pair
In DepthDetails Article
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  10nMAssay Description:Tested for inhibition of Myosin light chain kinase from chicken gizzardMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM199250(US9221808, 1bo | US9221808, 1bo-HCl | US9221808, 1...)
Affinity DataIC50:  16nMAssay Description:Inhibition of MLCK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM3040(23-(3-aminopropyl)-3-methyl-3,13,23-triazahexacycl...)
Affinity DataIC50:  18nMAssay Description:Tested for inhibition of Myosin light chain kinase from chicken gizzardMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Institute For Biochemistry

Curated by ChEMBL
LigandPNGBDBM3040(23-(3-aminopropyl)-3-methyl-3,13,23-triazahexacycl...)
Affinity DataIC50:  18nMpH: 7.2 T: 2°CAssay Description:The activity of MLCK is measured by its ability to transfer 32P from [gamma-32P]ATP to myosin light-chain.More data for this Ligand-Target Pair
In DepthDetails Article
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM6760((+)-K-252a | CHEMBL281948 | K-252a | methyl (15S,1...)
Affinity DataIC50:  22nMAssay Description:Inhibition of Myosin light chain kinase 1 (MLCK1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50118955(CHEMBL94678 | Compound K-252a(epi))
Affinity DataIC50:  25nMAssay Description:Inhibition of Myosin light chain kinase 1 (MLCK1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM3035(3-{7,19-dihydroxy-23-methyl-14-oxo-3,13,23-triazah...)
Affinity DataIC50:  30nMAssay Description:Tested for inhibition of Myosin light chain kinase from chicken gizzardMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Institute For Biochemistry

Curated by ChEMBL
LigandPNGBDBM3035(3-{7,19-dihydroxy-23-methyl-14-oxo-3,13,23-triazah...)
Affinity DataIC50:  30nMpH: 7.2 T: 2°CAssay Description:The activity of MLCK is measured by its ability to transfer 32P from [gamma-32P]ATP to myosin light-chain.More data for this Ligand-Target Pair
In DepthDetails Article
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Institute For Biochemistry

Curated by ChEMBL
LigandPNGBDBM3038(23-[3-(dimethylamino)propyl]-7,19-dihydroxy-3,13,2...)
Affinity DataIC50:  31nMpH: 7.2 T: 2°CAssay Description:The activity of MLCK is measured by its ability to transfer 32P from [gamma-32P]ATP to myosin light-chain.More data for this Ligand-Target Pair
In DepthDetails Article
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50284317(3-(9-methoxy-13-methyl-5,7-dioxo-6,7,12,13-tetrahy...)
Affinity DataIC50:  32nMAssay Description:Tested for inhibition of Myosin light chain kinase from chicken gizzardMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Institute For Biochemistry

Curated by ChEMBL
LigandPNGBDBM3047(4-{19-methoxy-23-methyl-12,14-dioxo-3,13,23-triaza...)
Affinity DataIC50:  32nMpH: 7.2 T: 2°CAssay Description:The activity of MLCK is measured by its ability to transfer 32P from [gamma-32P]ATP to myosin light-chain.More data for this Ligand-Target Pair
In DepthDetails Article
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Institute For Biochemistry

Curated by ChEMBL
LigandPNGBDBM50074653(CHEMBL385812 | R-K-K-Y-(Ach)-Y-R-R-K-NH2)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity against MLCK (smooth muscle myosin light chain kinase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  43.2nMAssay Description:Inhibition of human MLCK using KKLNRTLSFAEPG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
Institute For Biochemistry

Curated by ChEMBL
LigandPNGBDBM3044(3-{7-methoxy-23-methyl-12,14-dioxo-3,13,23-triazah...)
Affinity DataIC50:  49nMpH: 7.2 T: 2°CAssay Description:The activity of MLCK is measured by its ability to transfer 32P from [gamma-32P]ATP to myosin light-chain.More data for this Ligand-Target Pair
In DepthDetails Article
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