- acetylcholine binding protein
- muscarinic acetylcholine receptor
- neuronal acetylcholine receptor
- nicotinic acetylcholine receptor
- soluble acetylcholine receptor
- acetylcholine receptor subunit alpha/neuronal acetylcholine receptor subunit beta-2
- acetylcholine receptor subunit alpha/neuronal acetylcholine receptor subunit beta-4
- acetylcholine receptor subunit alpha
- acetylcholine receptor subunit delta
- acetylcholine receptor subunit epsilon
- muscarinic acetylcholine receptor m1
- muscarinic acetylcholine receptor m2
- muscarinic acetylcholine receptor m3
- muscarinic acetylcholine receptor m4
- muscarinic acetylcholine receptor m5
- neuronal nicotinic acetylcholine receptor
- acetylcholine receptor protein alpha chain
- acetylcholine receptor protein delta chain
- acetylcholine receptor protein epsilon chain
- acetylcholine-binding protein (ls-achbp)
- muscarinic acetylcholine receptor m2 and m4
- muscarinic acetylcholine receptor m2 and m5
- neuronal acetylcholine receptor (alpha4beta2 nachr)
- neuronal acetylcholine receptor alpha4/beta2
- neuronal acetylcholine receptor; alpha2/beta4
- neuronal acetylcholine receptor; alpha4/beta4
- nicotinic acetylcholine receptor alpha1 subunit
- nicotinic acetylcholine receptor alpha9/alpha10
- acetylcholine receptor subunit beta-like 2
- acetylcholine receptor; alpha1/beta1/delta/gamma
- neuronal acetylcholine receptor subunit alpha-2
- neuronal acetylcholine receptor subunit alpha-3
- neuronal acetylcholine receptor subunit alpha-4
- neuronal acetylcholine receptor subunit alpha-5
- neuronal acetylcholine receptor subunit alpha-6
- neuronal acetylcholine receptor subunit alpha-7
- neuronal acetylcholine receptor subunit alpha-9
- neuronal acetylcholine receptor subunit beta-2
- neuronal acetylcholine receptor subunit beta-4
- nicotinic acetylcholine receptor alpha3/beta4/alpha5
- nicotinic acetylcholine receptor alpha4/beta2/alpha5
- nicotinic acetylcholine receptor alpha6/alpha3/beta4
- acetylcholine receptor subunit alpha/beta/delta/epsilon
- acetylcholine receptor subunit alpha/beta/delta/gamma
- neuronal acetylcholine receptor alpha-2/beta-2
- neuronal acetylcholine receptor alpha-2/beta-4
- neuronal acetylcholine receptor protein alpha-6 subunit
- neuronal acetylcholine receptor protein alpha-7 subunit
- neuronal acetylcholine receptor subunit alpha-7 (nachr)
- neuronal acetylcholine receptor; alpha3/alpha6/beta2/beta3
- nicotinic acetylcholine receptor alpha-1/beta-1
- nicotinic acetylcholine receptor alpha1/beta1/epsilon/delta
- nicotinic acetylcholine receptor alpha1/beta1/gamma/delta
- nicotinic acetylcholine receptor alpha6/alpha3/beta2/beta3
- isoform alpha-4-2 of neuronal acetylcholine receptor subunit alpha-4 (alpha-4-2)/neuronal acetylcholine receptor subunit beta-2
- acetylcholine receptor protein alpha/beta/delta/gamma chain
- neuronal acetylcholine receptor subunit alpha 4 beta 2
- neuronal acetylcholine receptor subunit alpha-10/alpha-9
- neuronal acetylcholine receptor subunit alpha-3/beta-4
- neuronal acetylcholine receptor subunit alpha-4/beta-2
- neuronal acetylcholine receptor subunit alpha-6/beta-2
- neuronal acetylcholine receptor subunit alpha-6/beta-4
- neuronal acetylcholine receptor subunit beta-2/beta-4
- neuronal acetylcholine receptor protein alpha-10/alpha-9 subunit
- neuronal acetylcholine receptor protein alpha-2/beta-2 subunit
- neuronal acetylcholine receptor protein alpha-3/beta-2 subunit
- neuronal acetylcholine receptor protein alpha-4/beta-2 subunit
- nicotinic acetylcholine receptor alpha-1/beta-1/delta/epsilon
- nicotinic acetylcholine receptor alpha-3/beta-4/alpha-5
- neuronal acetylcholine receptor protein alpha-2 subunit/subunit beta-4
- neuronal acetylcholine receptor protein beta-2 subunit/subunit alpha-3
- neuronal acetylcholine receptor subunit alpha-3/alpha-5/beta-4
- neuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-3
- neuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-4
- neuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-2/beta-3
- isoform alpha-4-2 of neuronal acetylcholine receptor subunit alpha-4 (alpha-4-2)
- muscarinic acetylcholine receptor m3 [1-273,470-589,n6q,n15q,n41q,n48q,n52q,f550c]
- muscarinic acetylcholine receptor m3 [1-273,470-589,n6q,n15q,n41q,n48q,n52q,f554c]
- muscarinic acetylcholine receptor m3 [1-273,470-589,n6q,n15q,n41q,n48q,n52q,r551c]
- muscarinic acetylcholine receptor m3 [1-273,470-589,n6q,n15q,n41q,n48q,n52q,t556c]
BDBM29405 acetylcholine chloride
BDBM10759 2-acetoxyethyl(trimethyl)ammonium;bromide 2-acetoxyethyl(trimethyl)ammonium;perchlorate CHEMBL667 US10667515, Compound ACh [2-(acetyloxy)ethyl]trimethylazanium acetylcholine acetylcholine chloride cid_6060
- Nemecz, Akos; Taylor, Palmer Creating an a7 Nicotinic Acetylcholine Recognition Domain from the Acetylcholine-binding Protein Taylor Research Group (2014)
- Hansen, CP; Jensen, AA; Christensen, JK; Balle, T; Liljefors, T; Frølund, B Novel acetylcholine and carbamoylcholine analogues: development of a functionally selective alpha4beta2 nicotinic acetylcholine receptor agonist. J Med Chem 51: 7380-95 (2009)
- Lindsley, CW; Conn, PJ; Engers, DW; Bender, AM; Engers, JL Antagonists of the muscarinic acetylcholine receptor M4 US Patent US11149022 (2021)
- Xiong, Y; Roppe, J; Chen, AC; Bravo, Y; Schrader, T; Baccei, JM Muscarinic acetylcholine M1 receptor antagonists US Patent US11752149 (2023)
- Slavov, SH; Radzvilovits, M; LeFrancois, S; Stoyanova-Slavova, IB; Soti, F; Kem, WR; Katritzky, AR A computational study of the binding of 3-(arylidene) anabaseines to two major brain nicotinic acetylcholine receptors and to the acetylcholine binding protein. Eur J Med Chem 45: 2433-46 (2010)
- Kargbo, RB Allosteric Modulators of the M4 Muscarinic Acetylcholine Receptor. ACS Med Chem Lett 9: 783-784 (2018)
- Faghih, R; Gopalakrishnan, M; Briggs, CA Allosteric modulators of the alpha7 nicotinic acetylcholine receptor. J Med Chem 51: 701-12 (2008)
- Rosse, G Anabaseine analogues as modulators of nicotinic acetylcholine receptor. ACS Med Chem Lett 4: 902-3 (2013)
- Ragab, HM; Kim, JS; Dukat, M; Navarro, H; Glennon, RA Aryloxyethylamines: binding at alpha7 nicotinic acetylcholine receptors. Bioorg Med Chem Lett 16: 4283-6 (2006)
- Efange, SM; Khare, A; Parsons, SM; Bau, R; Metzenthin, T Nonsymmetrical bipiperidyls as inhibitors of vesicular acetylcholine storage. J Med Chem 36: 985-9 (1993)
- Rosse, G Positive allosteric modulators of nicotinic acetylcholine receptor. ACS Med Chem Lett 4: 319-20 (2013)
- Acharya, R; Burnett, DA; Bursavich, MG; Cook, AS; Harrison, BA; McRiner, AJ Aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors US Patent US10370370 (2019)
- Bolchi, C; Valoti, E; Binda, M; Fasoli, F; Ferrara, R; Fumagalli, L; Gotti, C; Matucci, R; Vistoli, G; Pallavicini, M Design, synthesis and binding affinity of acetylcholine carbamoyl analogues. Bioorg Med Chem Lett 23: 6481-5 (2013)
- Mazurov, AA; Speake, JD; Yohannes, D Discovery and development ofa7 nicotinic acetylcholine receptor modulators. J Med Chem 54: 7943-61 (2011)
- Abin-Carriquiry, JA; Zunini, MP; Cassels, BK; Wonnacott, S; Dajas, F In silico characterization of cytisinoids docked into an acetylcholine binding protein. Bioorg Med Chem Lett 20: 3683-7 (2010)
- Lee, NR; Zhang, X; Darna, M; Dwoskin, LP; Zheng, G Muscarinic acetylcholine receptor binding affinities of pethidine analogs. Bioorg Med Chem Lett 25: 5032-5 (2015)
- Holladay, MW; Dart, MJ; Lynch, JK Neuronal nicotinic acetylcholine receptors as targets for drug discovery. J Med Chem 40: 4169-94 (1998)
- Lindsley, CW; Conn, PJ; Engers, DW; Bollinger, S; Tarr, JC; Spearing, P; Engers, JL; Long, M; Bridges, TM Positive allosteric modulators of the muscarinic acetylcholine receptor M4 US Patent US10239887 (2019)
- Tu, Z; Luo, Z; Liu, H; Jin, H; Parsons, SM Sulfur-containing compounds targeting vesicular acetylcholine transporter US Patent US10421722 (2019)
- Kombo, DC; Mazurov, A; Tallapragada, K; Hammond, PS; Chewning, J; Hauser, TA; Vasquez-Valdivieso, M; Yohannes, D; Talley, TT; Taylor, P; Caldwell, WS Docking studies of benzylidene anabaseine interactions witha7 nicotinic acetylcholine receptor (nAChR) and acetylcholine binding proteins (AChBPs): application to the design of relateda7 selective ligands. Eur J Med Chem 46: 5625-35 (2011)
- Ding, YS; Kil, KE; Lin, KS; Ma, W; Yokota, Y; Carroll, IF A novel nicotinic acetylcholine receptor antagonist radioligand for PET studies. Bioorg Med Chem Lett 16: 1049-53 (2006)
- Iturriaga-Vásquez, P; Pérez, EG; Slater, EY; Bermúdez, I; Cassels, BK Aporphine metho salts as neuronal nicotinic acetylcholine receptor blockers. Bioorg Med Chem 15: 3368-72 (2007)
- McDonald, IM; Mate, RA; Zusi, FC; Huang, H; Post-Munson, DJ; Ferrante, MA; Gallagher, L; Bertekap, RL; Knox, RJ; Robertson, BJ; Harden, DG; Morgan, DG; Lodge, NJ; Dworetzky, SI; Olson, RE; Macor, JE Discovery of a novel series of quinolonea7 nicotinic acetylcholine receptor agonists. Bioorg Med Chem Lett 23: 1684-8 (2013)
- Jin, J; Wang, Y; Shi, D; Wang, F; Davis, RS; Jin, Q; Fu, W; Foley, JJ; Webb, EF; Dehaas, CJ; Berlanga, M; Burman, M; Sarau, HM; Morrow, DM; Rao, P; Kallal, LA; Moore, ML; Rivero, RA; Palovich, M; Salmon, M; Belmonte, KE; Busch-Petersen, J Discovery of novel and long acting muscarinic acetylcholine receptor antagonists. J Med Chem 51: 4866-9 (2008)
- Cheng, K; Khurana, S; Chen, Y; Kennedy, RH; Zimniak, P; Raufman, JP Lithocholylcholine, a bile acid/acetylcholine hybrid, is a muscarinic receptor antagonist. J Pharmacol Exp Ther 303: 29-35 (2002)
- Jin, J; Wang, Y; Shi, D; Wang, F; Fu, W; Davis, RS; Jin, Q; Foley, JJ; Sarau, HM; Morrow, DM; Moore, ML; Rivero, RA; Palovich, M; Salmon, M; Belmonte, KE; Busch-Petersen, J Muscarinic acetylcholine receptor antagonists: SAR and optimization of tyrosine ureas. Bioorg Med Chem Lett 18: 5481-6 (2008)
- Faundez-Parraguez, M; Farias-Rabelo, N; Gonzalez-Gutierrez, JP; Etcheverry-Berrios, A; Alzate-Morales, J; Adasme-Carreño, F; Varas, R; Bermudez, I; Iturriaga-Vasquez, P Neonicotinic analogues: selective antagonists fora4ß2 nicotinic acetylcholine receptors. Bioorg Med Chem 21: 2687-94 (2013)
- Mazurov, A; Miao, L; Xiao, Y Nicotinic acetylcholine receptor sub-type selective amides of diazabicycloalkanes US Patent US8921410 (2014)
- Lynagh, T; Kiontke, S; Meyhoff-Madsen, M; Gless, BH; Johannesen, J; Kattelmann, S; Christiansen, A; Dufva, M; Laustsen, AH; Devkota, K; Olsen, CA; Kümmel, D; Pless, SA; Lohse, B Peptide Inhibitors of the ?-Cobratoxin-Nicotinic Acetylcholine Receptor Interaction. J Med Chem 63: 13709-13718 (2020)
- Leonik, FM; Papke, RL; Horenstein, NA Quinuclidines as selective agonists for alpha-7 nicotinic acetylcholine receptors. Bioorg Med Chem Lett 17: 1520-2 (2007)
- Chen, X; Klöckner, J; Holze, J; Zimmermann, C; Seemann, WK; Schrage, R; Bock, A; Mohr, K; Tränkle, C; Holzgrabe, U; Decker, M Rational design of partial agonists for the muscarinic m1 acetylcholine receptor. J Med Chem 58: 560-76 (2015)
- Miller, DK; Wong, EH; Chesnut, MD; Dwoskin, LP Reboxetine: functional inhibition of monoamine transporters and nicotinic acetylcholine receptors. J Pharmacol Exp Ther 302: 687-95 (2002)
- Yu, LF; Zhang, HK; Caldarone, BJ; Eaton, JB; Lukas, RJ; Kozikowski, AP Recent developments in novel antidepressants targetinga4ß2-nicotinic acetylcholine receptors. J Med Chem 57: 8204-23 (2014)
- Christopoulos, A; Grant, MK; Ayoubzadeh, N; Kim, ON; Sauerberg, P; Jeppesen, L; El-Fakahany, EE Synthesis and pharmacological evaluation of dimeric muscarinic acetylcholine receptor agonists. J Pharmacol Exp Ther 298: 1260-8 (2001)
- Tomassoli, I; Gündisch, D The twin drug approach for novel nicotinic acetylcholine receptor ligands. Bioorg Med Chem 23: 4375-89 (2015)
- Blass, BE Allosteric Modulators of Nicotinic Acetylcholine Receptors Useful for the Treatment of Cognitive Impairment. ACS Med Chem Lett 9: 163-164 (2018)
- Fleβner, T; Böβ, F; Erb, C; Hafner, F; Schnizler, K; Lang, D; Luithle, J; Van Kampen, M; Van Der Staay, F Azabicyclic carbamates and their use as alpha-7 nicotinic acetylcholine receptor agonists US Patent US9714242 (2017)
- Jensen, AA; Mikkelsen, I; Frølund, B; Bräuner-Osborne, H; Falch, E; Krogsgaard-Larsen, P Carbamoylcholine homologs: novel and potent agonists at neuronal nicotinic acetylcholine receptors. Mol Pharmacol 64: 865-75 (2003)
- Bonner, TI; Young, AC; Brann, MR; Buckley, NJ Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes. Neuron 1: 403-10 (1988)
- Brissonnet, Y; Araoz, R; Sousa, R; Percevault, L; Brument, S; Deniaud, D; Servent, D; Le Questel, JY; Lebreton, J; Gouin, SG Di- and heptavalent nicotinic analogues to interfere with ?7 nicotinic acetylcholine receptors. Bioorg Med Chem 27: 700-707 (2019)
- Strachan, JP; Farias, JJ; Zhang, J; Caldwell, WS; Bhatti, BS Diazaspirocyclic compounds as selective ligands for thea4ß2 nicotinic acetylcholine receptor. Bioorg Med Chem Lett 22: 5089-92 (2012)
- Ziegler, N; Bätz, J; Zabel, U; Lohse, MJ; Hoffmann, C FRET-based sensors for the human M1-, M3-, and M5-acetylcholine receptors. Bioorg Med Chem 19: 1048-54 (2011)
- Li, J; Zhang, X; Zhang, Z; Padakanti, PK; Jin, H; Cui, J; Li, A; Zeng, D; Rath, NP; Flores, H; Perlmutter, JS; Parsons, SM; Tu, Z Heteroaromatic and aniline derivatives of piperidines as potent ligands for vesicular acetylcholine transporter. J Med Chem 56: 6216-33 (2013)
- Ferretti, G; Dukat, M; Giannella, M; Piergentili, A; Pigini, M; Quaglia, W; Damaj, MI; Martin, BR; Glennon, RA Homoazanicotine: a structure-affinity study for nicotinic acetylcholine (nACh) receptor binding. J Med Chem 45: 4724-31 (2002)
- Efange, SM; Khare, AB; Mach, RH; Parsons, SM Hydroxylated decahydroquinolines as ligands for the vesicular acetylcholine transporter: synthesis and biological evaluation. J Med Chem 42: 2862-9 (1999)
- Honda, H; Tomizawa, M; Casida, JE Insect muscarinic acetylcholine receptor: pharmacological and toxicological profiles of antagonists and agonists. J Agric Food Chem 55: 2276-81 (2007)
- Jacyno, JM; Harwood, JS; Lin, NH; Campbell, JE; Sullivan, JP; Holladay, MW Lycaconitine revisited: partial synthesis and neuronal nicotinic acetylcholine receptor affinities. J Nat Prod 59: 707-9 (1996)
- Schmitt, JD; Sharples, CG; Caldwell, WS Molecular recognition in nicotinic acetylcholine receptors: the importance of pi-cation interactions. J Med Chem 42: 3066-74 (1999)
- Mazurov, A; Ho, J; Low, T; Hoeng, J Novel ?7 nicotinic acetylcholine receptor modulators as potential antitussive agents. Bioorg Med Chem Lett 80: (2023)
- Chojnacka, K; Papke, RL; Horenstein, NA Synthesis and evaluation of a conditionally-silent agonist for thea7 nicotinic acetylcholine receptor. Bioorg Med Chem Lett 23: 4145-9 (2013)
- Mullen, G; Napier, J; Balestra, M; DeCory, T; Hale, G; Macor, J; Mack, R; Loch, J; Wu, E; Kover, A; Verhoest, P; Sampognaro, A; Phillips, E; Zhu, Y; Murray, R; Griffith, R; Blosser, J; Gurley, D; Machulskis, A; Zongrone, J; Rosen, A; Gordon, J (-)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the alpha 7 nicotinic acetylcholine receptor. J Med Chem 43: 4045-50 (2000)
- Elliott, RL; Kopecka, H; Gunn, DE; Lin, NH; Garvey, DS; Ryther, KB; Holladay, MW; Anderson, DJ; Campbell, JE; Sullivan, JP; Buckley, MJ; Gunther, KL; O'Neill, AB; Decker, MW; Arnerić, SP 2-(Aryloxymethyl) azacyclic analogues as novel nicotinic acetylcholine receptor (nAChR) ligands Bioorg Med Chem Lett 6: 2283-2288 (1996)
- Mukhin, AG; Gündisch, D; Horti, AG; Koren, AO; Tamagnan, G; Kimes, AS; Chambers, J; Vaupel, DB; King, SL; Picciotto, MR; Innis, RB; London, ED 5-Iodo-A-85380, an alpha4beta2 subtype-selective ligand for nicotinic acetylcholine receptors. Mol Pharmacol 57: 642-9 (2000)
- Hobbs, SH; Johnson, SJ; Kesten, SR; Pavia, MR; Davis, RE; Schwarz, RD; Coughenour, LL; Myers, SL; Dudley, DT; Moss, WH Cholinergic agents: 2-oxazolidinone analogues of the acetylcholine-receptor muscarinic agonist pilocarpine Bioorg Med Chem Lett 1: 147-150 (1991)
- German, N; Kim, JS; Jain, A; Dukat, M; Pandya, A; Ma, Y; Weltzin, M; Schulte, MK; Glennon, RA Deconstruction of thea4ß2 nicotinic acetylcholine receptor positive allosteric modulator desformylflustrabromine. J Med Chem 54: 7259-67 (2011)
- Gao, Y; Kellar, KJ; Yasuda, RP; Tran, T; Xiao, Y; Dannals, RF; Horti, AG Derivatives of dibenzothiophene for positron emission tomography imaging ofa7-nicotinic acetylcholine receptors. J Med Chem 56: 7574-89 (2013)
- Lainé, DI; Wan, Z; Yan, H; Zhu, C; Xie, H; Fu, W; Busch-Petersen, J; Neipp, C; Davis, R; Widdowson, KL; Blaney, FE; Foley, J; Bacon, AM; Webb, EF; Luttmann, MA; Burman, M; Sarau, HM; Salmon, M; Palovich, MR; Belmonte, K Design, synthesis, and structure-activity relationship of tropane muscarinic acetylcholine receptor antagonists. J Med Chem 52: 5241-52 (2010)
- Yu, R; Kompella, SN; Adams, DJ; Craik, DJ; Kaas, Q Determination of the ?-conotoxin Vc1.1 binding site on the ?9?10 nicotinic acetylcholine receptor. J Med Chem 56: 3557-67 (2013)
- Yang, Q; Lachapelle, EA; Kablaoui, NM; Webb, D; Popiolek, M; Grimwood, S; Kozak, R; O'Connor, RE; Lazzaro, JT; Butler, CR; Zhang, L Discovery of Selective M4 Muscarinic Acetylcholine Receptor Agonists with Novel Carbamate Isosteres. ACS Med Chem Lett 10: 941-948 (2019)
- Jin, J; Budzik, B; Wang, Y; Shi, D; Wang, F; Xie, H; Wan, Z; Zhu, C; Foley, JJ; Webb, EF; Berlanga, M; Burman, M; Sarau, HM; Morrow, DM; Moore, ML; Rivero, RA; Palovich, M; Salmon, M; Belmonte, KE; Lainé, DI Discovery of biphenyl piperazines as novel and long acting muscarinic acetylcholine receptor antagonists. J Med Chem 51: 5915-8 (2008)
- Lainé, DI; McCleland, B; Thomas, S; Neipp, C; Underwood, B; Dufour, J; Widdowson, KL; Palovich, MR; Blaney, FE; Foley, JJ; Webb, EF; Luttmann, MA; Burman, M; Belmonte, K; Salmon, M Discovery of novel 1-azoniabicyclo[2.2.2]octane muscarinic acetylcholine receptor antagonists. J Med Chem 52: 2493-505 (2009)
- Geitmann, M; Retra, K; de Kloe, GE; Homan, E; Smit, AB; de Esch, IJ; Danielson, UH Interaction kinetic and structural dynamic analysis of ligand binding to acetylcholine-binding protein. Biochemistry 49: 8143-54 (2010)
- Alptüzün, V; Prinz, M; Hörr, V; Scheiber, J; Radacki, K; Fallarero, A; Vuorela, P; Engels, B; Braunschweig, H; Erciyas, E; Holzgrabe, U Interaction of (benzylidene-hydrazono)-1,4-dihydropyridines with beta-amyloid, acetylcholine, and butyrylcholine esterases. Bioorg Med Chem 18: 2049-59 (2010)
- Hojahmat, M; Horton, DB; Norrholm, SD; Miller, DK; Grinevich, VP; Deaciuc, AG; Dwoskin, LP; Crooks, PA Lobeline esters as novel ligands for neuronal nicotinic acetylcholine receptors and neurotransmitter transporters. Bioorg Med Chem 18: 640-9 (2010)
- Budzik, B; Wang, Y; Shi, D; Wang, F; Xie, H; Wan, Z; Zhu, C; Foley, JJ; Nuthulaganti, P; Kallal, LA; Sarau, HM; Morrow, DM; Moore, ML; Rivero, RA; Palovich, M; Salmon, M; Belmonte, KE; Laine, DI; Jin, J M3 muscarinic acetylcholine receptor antagonists: SAR and optimization of bi-aryl amines. Bioorg Med Chem Lett 19: 1686-90 (2009)
- Xu, R; Dwoskin, LP; Grinevich, VP; Deaciuc, G; Crooks, PA Neuronal nicotinic acetylcholine receptor binding affinities of boron-containing nicotine analogues. Bioorg Med Chem Lett 11: 1245-8 (2001)
- Jensen, AA; Frølund, B; Liljefors, T; Krogsgaard-Larsen, P Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations. J Med Chem 48: 4705-45 (2005)
- Gallagher, R; Qudah, T; Balle, T; Chebib, M; McLeod, MD Novel methyllycaconitine analogues selective for the ?4?2 over ?7 nicotinic acetylcholine receptors. Bioorg Med Chem 51: (2021)
- Kachel, HS; Franzyk, H; Mellor, IR Philanthotoxin Analogues That Selectively Inhibit Ganglionic Nicotinic Acetylcholine Receptors with Exceptional Potency. J Med Chem 62: 6214-6222 (2019)
- She, X; Pegoli, A; Gruber, CG; Wifling, D; Carpenter, J; Hübner, H; Chen, M; Wan, J; Bernhardt, G; Gmeiner, P; Holliday, ND; Keller, M Red-Emitting Dibenzodiazepinone Derivatives as Fluorescent Dualsteric Probes for the Muscarinic Acetylcholine M J Med Chem 63: 4133-4154 (2020)
- Mortell, KH; Schrimpf, MR; Bunnelle, WH; Anderson, DJ; Gronlien, JH; Hagene, KT; Gopalakrishnan, M Structure-activity relationships of N-substituted ligands for the alpha7 nicotinic acetylcholine receptor. Bioorg Med Chem Lett 20: 104-7 (2010)
- Crowley, BM; Bell, IM; Harvey, AJ; Campbell, BT; Greshock, TJ; Rada, VL Substituted 6-membered aryl or heteroaryl allosteric modulators of nicotinic acetylcholine receptors US Patent US11026958 (2021)
- Jepsen, TH; Jensen, AA; Lund, MH; Glibstrup, E; Kristensen, JL Synthesis and Pharmacological Evaluation of DH?E Analogues as Neuronal Nicotinic Acetylcholine Receptor Antagonists. ACS Med Chem Lett 5: 766-70 (2014)
- Wei, ZL; Xiao, Y; Kellar, KJ; Kozikowski, AP Synthesis and pharmacological characterization of bivalent ligands of epibatidine at neuronal nicotinic acetylcholine receptors. Bioorg Med Chem Lett 14: 1855-8 (2004)
- Lee, J; Davis, CB; Rivero, RA; Reitz, AB; Shank, RP Synthesis and structure-activity relationship of novel pyridyl ethers for the nicotinic acetylcholine receptor. Bioorg Med Chem Lett 10: 1063-6 (2000)
- Ivy Carroll, F; Ma, W; Navarro, HA; Abraham, P; Wolckenhauer, SA; Damaj, MI; Martin, BR Synthesis, nicotinic acetylcholine receptor binding, antinociceptive and seizure properties of methyllycaconitine analogs. Bioorg Med Chem 15: 678-85 (2006)
- Ussing, CA; Hansen, CP; Petersen, JG; Jensen, AA; Rohde, LA; Ahring, PK; Nielsen, EØ; Kastrup, JS; Gajhede, M; Frølund, B; Balle, T Synthesis, pharmacology, and biostructural characterization of novela4ß2 nicotinic acetylcholine receptor agonists. J Med Chem 56: 940-51 (2013)
- Jin, Q; Davis, RS; Bullion, AM; Jin, J; Wang, Y; Widdowson, KL; Palovich, MR; Foley, JJ; Schmidt, DB; Buckley, PT; Webb, EF; Salmon, M; Belmonte, KE; Sarau, HM; Busch-Petersen, J Tyrosine urea muscarinic acetylcholine receptor antagonists: achiral quaternary ammonium groups. Bioorg Med Chem Lett 22: 7087-91 (2012)
- de Kloe, GE; Retra, K; Geitmann, M; Källblad, P; Nahar, T; van Elk, R; Smit, AB; van Muijlwijk-Koezen, JE; Leurs, R; Irth, H; Danielson, UH; de Esch, IJ Surface plasmon resonance biosensor based fragment screening using acetylcholine binding protein identifies ligand efficiency hot spots (LE hot spots) by deconstruction of nicotinic acetylcholine receptora7 ligands. J Med Chem 53: 7192-201 (2010)
- Zlotos, DP; Buller, S; Tränkle, C; Mohr, K Bisquaternary caracurine V derivatives as allosteric modulators of ligand binding to M2 acetylcholine receptors. Bioorg Med Chem Lett 10: 2529-32 (2001)
- Pegoli, A; Wifling, D; Gruber, CG; She, X; Hübner, H; Bernhardt, G; Gmeiner, P; Keller, M Conjugation of Short Peptides to Dibenzodiazepinone-Type Muscarinic Acetylcholine Receptor Ligands Determines M J Med Chem 62: 5358-5369 (2019)
- Beinat, C; Banister, SD; van Prehn, S; Doddareddy, MR; Hibbs, D; Sako, M; Chebib, M; Tran, T; Al-Muhtasib, N; Xiao, Y; Kassiou, M Consequences of linker length alteration of thea7 nicotinic acetylcholine receptor (nAChR) agonist, SEN12333. Bioorg Med Chem Lett 22: 2380-4 (2012)
- Gruber, CG; Pegoli, A; Müller, C; Grätz, L; She, X; Keller, M Differently fluorescence-labelled dibenzodiazepinone-type muscarinic acetylcholine receptor ligands with high M RSC Med Chem 11: 823-832 (2020)
- Bodnar, AL; Cortes-Burgos, LA; Cook, KK; Dinh, DM; Groppi, VE; Hajos, M; Higdon, NR; Hoffmann, WE; Hurst, RS; Myers, JK; Rogers, BN; Wall, TM; Wolfe, ML; Wong, E Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors. J Med Chem 48: 905-8 (2005)
- Lainé, DI; Xie, H; Buffet, N; Foley, JJ; Buckley, P; Webb, EF; Widdowson, KL; Palovich, MR; Belmonte, KE Discovery of novel 8-azoniabicyclo[3.2.1]octane carbamates as muscarinic acetylcholine receptor antagonists. Bioorg Med Chem Lett 17: 6066-9 (2007)
- Wang, S; Zhu, X; Zhangsun, M; Wu, Y; Yu, J; Harvey, PJ; Kaas, Q; Zhangsun, D; Craik, DJ; Luo, S Engineered Conotoxin Differentially Blocks and Discriminates Rat and Human ?7 Nicotinic Acetylcholine Receptors. J Med Chem 64: 5620-5631 (2021)
- Acharya, R; Burnett, DA; Bursavich, MG; Cook, AS; Harrison, BA; Koenig, G; Mcriner, AJ Geminal substituted quinuclidine amide compounds as agonists of α-7 nicotonic acetylcholine receptors US Patent US10183938 (2019)
- Fitch, RW; Kaneko, Y; Klaperski, P; Daly, JW; Seitz, G; Gündisch, D Halogenated and isosteric cytisine derivatives with increased affinity and functional activity at nicotinic acetylcholine receptors. Bioorg Med Chem Lett 15: 1221-4 (2005)
- Mowrey, DD; Liu, Q; Bondarenko, V; Chen, Q; Seyoum, E; Xu, Y; Wu, J; Tang, P Insights into distinct modulation of a7 and a7ß2 nicotinic acetylcholine receptors by the volatile anesthetic isoflurane. J Biol Chem 288: 35793-800 (2013)
- Khan, IM; Yaksh, TL; Taylor, P Ligand specificity of nicotinic acetylcholine receptors in rat spinal cord: studies with nicotine and cytisine. J Pharmacol Exp Ther 270: 159-66 (1994)
- Gazzard, L; Williams, K; Chen, H; Axford, L; Blackwood, E; Burton, B; Chapman, K; Crackett, P; Drobnick, J; Ellwood, C; Epler, J; Flagella, M; Gancia, E; Gill, M; Goodacre, S; Halladay, J; Hewitt, J; Hunt, H; Kintz, S; Lyssikatos, J; Macleod, C; Major, S; Médard, G; Narukulla, R; Ramiscal, J; Schmidt, S; Seward, E; Wiesmann, C; Wu, P; Yee, S; Yen, I; Malek, S Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1. J Med Chem 58: 5053-74 (2015)
- Del Bello, F; Bonifazi, A; Giorgioni, G; Petrelli, R; Quaglia, W; Altomare, A; Falcicchio, A; Matucci, R; Vistoli, G; Piergentili, A Novel muscarinic acetylcholine receptor hybrid ligands embedding quinuclidine and 1,4-dioxane fragments. Eur J Med Chem 137: 327-337 (2017)
- Mazurov, AA; Kombo, DC; Akireddy, S; Murthy, S; Hauser, TA; Jordan, KG; Gatto, GJ; Yohannes, D Novel nicotinic acetylcholine receptor agonists containing carbonyl moiety as a hydrogen bond acceptor. Bioorg Med Chem Lett 23: 3927-34 (2013)
- Bourdin, CM; Lebreton, J; Mathé-Allainmat, M; Thany, SH Pharmacological profile of zacopride and new quaternarized fluorobenzamide analogues on mammaliana7 nicotinic acetylcholine receptor. Bioorg Med Chem Lett 25: 3184-8 (2015)
- Sippy, KB; Anderson, DJ; Bunnelle, WH; Hutchins, CW; Schrimpf, MR Preparation and characterization of N-(3-pyridinyl) spirocyclic diamines as ligands for nicotinic acetylcholine receptors. Bioorg Med Chem Lett 19: 1682-5 (2009)
- Quadri, M; Stokes, C; Gulsevin, A; Felts, ACJ; Abboud, KA; Papke, RL; Horenstein, NA Sulfonium as a Surrogate for Ammonium: A New?7 Nicotinic Acetylcholine Receptor Partial Agonist with Desensitizing Activity. J Med Chem 60: 7928-7934 (2017)
- Lewis, LM; Sheffler, D; Williams, R; Bridges, TM; Kennedy, JP; Brogan, JT; Mulder, MJ; Williams, L; Nalywajko, NT; Niswender, CM; Weaver, CD; Conn, PJ; Lindsley, CW Synthesis and SAR of selective muscarinic acetylcholine receptor subtype 1 (M1 mAChR) antagonists. Bioorg Med Chem Lett 18: 885-90 (2008)
- Jin, Z; Khan, P; Shin, Y; Wang, J; Lin, L; Cameron, MD; Lindstrom, JM; Kenny, PJ; Kamenecka, TM Synthesis and activity of substituted heteroaromatics as positive allosteric modulators fora4ß2a5 nicotinic acetylcholine receptors. Bioorg Med Chem Lett 24: 674-8 (2014)
- Tu, Z; Zhang, X; Jin, H; Yue, X; Padakanti, PK; Yu, L; Liu, H; Flores, HP; Kaneshige, K; Parsons, SM; Perlmutter, JS Synthesis and biological characterization of a promising F-18 PET tracer for vesicular acetylcholine transporter. Bioorg Med Chem 23: 4699-709 (2015)
- Huang, M; Suk, DH; Cho, NC; Bhattarai, D; Kang, SB; Kim, Y; Pae, AN; Rhim, H; Keum, G Synthesis and biological evaluation of isoxazoline derivatives as potent M1 muscarinic acetylcholine receptor agonists. Bioorg Med Chem Lett 25: 1546-51 (2015)
- Efange, SM; Khare, AB; von Hohenberg, K; Mach, RH; Parsons, SM; Tu, Z Synthesis and in vitro biological evaluation of carbonyl group-containing inhibitors of vesicular acetylcholine transporter. J Med Chem 53: 2825-35 (2010)
- Carroll, FI; Robinson, TP; Brieaddy, LE; Atkinson, RN; Mascarella, SW; Damaj, MI; Martin, BR; Navarro, HA Synthesis and nicotinic acetylcholine receptor binding properties of bridged and fused ring analogues of epibatidine. J Med Chem 50: 6383-91 (2007)
- Carroll, FI; Hu, X; Navarro, HA; Deschamps, J; Abdrakhmanova, GR; Damaj, MI; Martin, BR Synthesis and pharmacological characterization of nicotinic acetylcholine receptor properties of (+)- and (-)-pyrido-[3,4-b]homotropanes. J Med Chem 49: 3244-50 (2006)
- Sharples, CG; Karig, G; Simpson, GL; Spencer, JA; Wright, E; Millar, NS; Wonnacott, S; Gallagher, T Synthesis and pharmacological characterization of novel analogues of the nicotinic acetylcholine receptor agonist (+/-)-UB-165. J Med Chem 45: 3235-45 (2002)
- Murineddu, G; Murruzzu, C; Curzu, MM; Chelucci, G; Gotti, C; Gaimarri, A; Legnani, L; Toma, L; Pinna, GA Synthesis of 3,6-diazabicyclo[3.1.1]heptanes as novel ligands for neuronal nicotinic acetylcholine receptors. Bioorg Med Chem Lett 18: 6147-50 (2008)
- Wei, ZL; Petukhov, PA; Xiao, Y; Tückmantel, W; George, C; Kellar, KJ; Kozikowski, AP Synthesis, nicotinic acetylcholine receptor binding affinities, and molecular modeling of constrained epibatidine analogues. J Med Chem 46: 921-4 (2003)
- Petersen, IN; Crestey, F; Jensen, AA; Indurthi, DC; Pedersen, H; Andreasen, JT; Balle, T; Kristensen, JL Tying up Nicotine: New Selective Competitive Antagonist of the Neuronal Nicotinic Acetylcholine Receptors. ACS Med Chem Lett 6: 472-5 (2015)
- Wu, Y; Zhangsun, D; Zhu, X; Kaas, Q; Zhangsun, M; Harvey, PJ; Craik, DJ; McIntosh, JM; Luo, S a-Conotoxin [S9A]TxID Potently Discriminates betweena3ß4 anda6/a3ß4 Nicotinic Acetylcholine Receptors. J Med Chem 60: 5826-5833 (2017)
- Kagabu, S; Maienfisch, P; Zhang, A; Granda-Minones, J; Haettenschwiler, J; Kayser, H; Maetzke, T; Casida, JE 5-Azidoimidacloprid and an acyclic analogue as candidate photoaffinity probes for mammalian and insect nicotinic acetylcholine receptors. J Med Chem 43: 5003-9 (2001)
- Choi, KI; Cha, JH; Cho, YS; Pae, AN; Jin, C; Yook, J; Cheon, HG; Jeong, D; Kong, JY; Koh, HY Binding affinities of 3-(3-phenylisoxazol-5-yl)methylidene-1-azabicycles to acetylcholine receptors. Bioorg Med Chem Lett 9: 2795-800 (1999)
- Bannon, AW; Decker, MW; Holladay, MW; Curzon, P; Donnelly-Roberts, D; Puttfarcken, PS; Bitner, RS; Diaz, A; Dickenson, AH; Porsolt, RD; Williams, M; Arneric, SP Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors. Science 279: 77-81 (1998)
- Balsera, B; Mulet, J; Fernández-Carvajal, A; de la Torre-Martínez, R; Ferrer-Montiel, A; Hernández-Jiménez, JG; Estévez-Herrera, J; Borges, R; Freitas, AE; López, MG; García-López, MT; González-Muñiz, R; Pérez de Vega, MJ; Valor, LM; Svobodová, L; Sala, S; Sala, F; Criado, M Chalcones as positive allosteric modulators ofa7 nicotinic acetylcholine receptors: a new target for a privileged structure. Eur J Med Chem 86: 724-39 (2014)
- de la Fuente Revenga, M; Balle, T; Jensen, AA; Frølund, B Conformationally restrained carbamoylcholine homologues. Synthesis, pharmacology at neuronal nicotinic acetylcholine receptors and biostructural considerations. Eur J Med Chem 102: 352-62 (2015)
- Melancon, BJ; Gogliotti, RD; Tarr, JC; Saleh, SA; Chauder, BA; Lebois, EP; Cho, HP; Utley, TJ; Sheffler, DJ; Bridges, TM; Morrison, RD; Daniels, JS; Niswender, CM; Conn, PJ; Lindsley, CW; Wood, MR Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor. Bioorg Med Chem Lett 22: 3467-72 (2012)
- Lainé, DI; Yan, H; Xie, H; Davis, RS; Dufour, J; Widdowson, KL; Palovich, MR; Wan, Z; Foley, JJ; Schmidt, DB; Hunsberger, GE; Burman, M; Bacon, AM; Webb, EF; Luttmann, MA; Salmon, M; Sarau, HM; Umbrecht, ST; Landis, PS; Peck, BJ; Busch-Petersen, J Design, synthesis and structure-activity relationship of N-substituted tropane muscarinic acetylcholine receptor antagonists. Bioorg Med Chem Lett 22: 3366-9 (2012)
- Disingrini, T; Muth, M; Dallanoce, C; Barocelli, E; Bertoni, S; Kellershohn, K; Mohr, K; De Amici, M; Holzgrabe, U Design, synthesis, and action of oxotremorine-related hybrid-type allosteric modulators of muscarinic acetylcholine receptors. J Med Chem 49: 366-72 (2006)
- Crestey, F; Jensen, AA; Borch, M; Andreasen, JT; Andersen, J; Balle, T; Kristensen, JL Design, synthesis, and biological evaluation of Erythrina alkaloid analogues as neuronal nicotinic acetylcholine receptor antagonists. J Med Chem 56: 9673-82 (2014)
- Liang, J; Tae, HS; Xu, X; Jiang, T; Adams, DJ; Yu, R Dimerization of ?-Conotoxins as a Strategy to Enhance the Inhibition of the Human ?7 and ?9?10 Nicotinic Acetylcholine Receptors. J Med Chem 63: 2974-2985 (2020)
- PubChem, PC Discovery of Novel Allosteric Modulators of the Muscarinic Receptor M5: [3H]N-methylscopolamine Competition with Acetylcholine PubChem Bioassay (2009)
- Spearing, PK; Cho, HP; Luscombe, VB; Blobaum, AL; Boutaud, O; Engers, DW; Rodriguez, AL; Niswender, CM; Jeffrey Conn, P; Lindsley, CW; Bender, AM Discovery of a novel class of heteroaryl-pyrrolidinones as positive allosteric modulators of the muscarinic acetylcholine receptor M Bioorg Med Chem Lett 47: (2021)
- Ledneczki, I; Tapolcsányi, P; Gábor, E; Visegrády, A; Vass, M; Éles, J; Holm, P; Horváth, A; Pocsai, A; Mahó, S; Greiner, I; Krámos, B; Béni, Z; Kóti, J; Káncz, AE; Thán, M; Kolok, S; Laszy, J; Balázs, O; Bugovits, G; Nagy, J; Vastag, M; Szájli, Á; Bozó, É; Lévay, G; Lendvai, B; Némethy, Z Discovery of novel positive allosteric modulators of the ?7 nicotinic acetylcholine receptor: Scaffold hopping approach. Eur J Med Chem 214: (2021)
- Huang, Y; Zhu, Z; Xiao, Y; Laruelle, M Epibatidine analogues as selective ligands for the alpha(x)beta2-containing subtypes of nicotinic acetylcholine receptors. Bioorg Med Chem Lett 15: 4385-8 (2005)
- Ledneczki, I; Horváth, A; Tapolcsányi, P; Éles, J; Molnár, KD; Vágó, I; Visegrády, A; Kiss, L; Szigetvári, Á; Kóti, J; Krámos, B; Mahó, S; Holm, P; Kolok, S; Fodor, L; Thán, M; Kostyalik, D; Balázs, O; Vastag, M; Greiner, I; Lévay, G; Lendvai, B; Némethy, Z HTS-based discovery and optimization of novel positive allosteric modulators of the ?7 nicotinic acetylcholine receptor. Eur J Med Chem 222: (2021)
- Zhang, A; Kayser, H; Maienfisch, P; Casida, JE Insect nicotinic acetylcholine receptor: conserved neonicotinoid specificity of [(3)H]imidacloprid binding site. J Neurochem 75: 1294-303 (2000)
- Chen, J; Norrholm, S; Dwoskin, LP; Crooks, PA; Bai, D N,N-disubstituted piperazines: synthesis and affinities at alpha4beta2(*) and alpha7(*) neuronal nicotinic acetylcholine receptors. Bioorg Med Chem Lett 13: 97-100 (2002)
- Sabnis, RW Novel Spiropiperidine Allosteric Modulators of Nicotinic Acetylcholine Receptors for Treating Central Nervous System Disorders. ACS Med Chem Lett 12: 1866-1867 (2021)
- Latli, B; D'Amour, K; Casida, JE Novel and potent 6-chloro-3-pyridinyl ligands for the alpha4beta2 neuronal nicotinic acetylcholine receptor. J Med Chem 42: 2227-34 (1999)
- Rotella, DP Substituted Benzylspiroindolin-2-one Analogues as Positive Allosteric Modulators of the Muscarinic Acetylcholine Receptor M1. ACS Med Chem Lett 4: (2013)
- Kozaka, T; Uno, I; Kitamura, Y; Miwa, D; Ogawa, K; Shiba, K Syntheses and in vitro evaluation of decalinvesamicol analogues as potential imaging probes for vesicular acetylcholine transporter (VAChT). Bioorg Med Chem 20: 4936-41 (2012)
- Tu, Z; Wang, W; Cui, J; Zhang, X; Lu, X; Xu, J; Parsons, SM Synthesis and evaluation of in vitro bioactivity for vesicular acetylcholine transporter inhibitors containing two carbonyl groups. Bioorg Med Chem 20: 4422-9 (2012)
- Kane, BE; Grant, MK; El-Fakahany, EE; Ferguson, DM Synthesis and evaluation of xanomeline analogs--probing the wash-resistant phenomenon at the M1 muscarinic acetylcholine receptor. Bioorg Med Chem 16: 1376-92 (2008)
- Assaad, T; Mavel, S; Parsons, SM; Kruse, S; Galineau, L; Allouchi, H; Kassiou, M; Chalon, S; Guilloteau, D; Emond, P Synthesis and in vitro evaluation of N-substituted aza-trozamicol analogs as vesicular acetylcholine transporter ligands. Bioorg Med Chem Lett 16: 2654-7 (2006)
- Liu, Y; Paige, M; Olson, TT; Al-Muhtasib, N; Xie, T; Hou, S; White, MP; Cordova, A; Guo, JL; Kellar, KJ; Xiao, Y; Brown, ML Synthesis and pharmacological characterization of new neuronal nicotinic acetylcholine receptor ligands derived from Sazetidine-A. Bioorg Med Chem Lett 24: 2954-6 (2014)
- Ho, TNT; Abraham, N; Lewis, RJ Synthesis of full-length homodimer ?D-VxXXB that targets human ?7 nicotinic acetylcholine receptors. RSC Med Chem 13: 1410-1419 (2022)
- Sarasamkan, J; Scheunemann, M; Apaijai, N; Palee, S; Parichatikanond, W; Arunrungvichian, K; Fischer, S; Chattipakorn, S; Deuther-Conrad, W; Schüürmann, G; Brust, P; Vajragupta, O Varying Chirality Across Nicotinic Acetylcholine Receptor Subtypes: Selective Binding of Quinuclidine Triazole Compounds. ACS Med Chem Lett 7: 890-895 (2016)
- Efange, SM; Michelson, RH; Dutta, AK; Parsons, SM Acyclic analogues of 2-(4-phenylpiperidino)cyclohexanol (vesamicol): conformationally mobile inhibitors of vesicular acetylcholine transport. J Med Chem 34: 2638-43 (1991)
- Whiteaker, P; Sharples, CG; Wonnacott, S Agonist-induced up-regulation of alpha4beta2 nicotinic acetylcholine receptors in M10 cells: pharmacological and spatial definition. Mol Pharmacol 53: 950-62 (1998)
- Bräuner-Osborne, H; Ebert, B; Brann, MR; Falch, E; Krogsgaard-Larsen, P Annulated heterocyclic bioisosteres of norarecoline. Synthesis and molecular pharmacology at five recombinant human muscarinic acetylcholine receptors. J Med Chem 38: 2188-95 (1995)
- Hansen, CP; Jensen, AA; Balle, T; Bitsch-Jensen, K; Hassan, MM; Liljefors, T; Frølund, B Carbamoylcholine analogs as nicotinic acetylcholine receptor agonists--structural modifications of 3-(dimethylamino)butyl dimethylcarbamate (DMABC). Bioorg Med Chem Lett 19: 87-91 (2008)
- Luo, S; Zhangsun, D; Zhu, X; Wu, Y; Hu, Y; Christensen, S; Harvey, PJ; Akcan, M; Craik, DJ; McIntosh, JM Characterization of a novela-conotoxin TxID from Conus textile that potently blocks rata3ß4 nicotinic acetylcholine receptors. J Med Chem 56: 9655-63 (2014)
- Ullrich, T; Krich, S; Binder, D; Mereiter, K; Anderson, DJ; Meyer, MD; Pyerin, M Conformationally constrained nicotines: polycyclic, bridged, and spiro-annulated analogues as novel ligands for the nicotinic acetylcholine receptor. J Med Chem 45: 4047-54 (2002)
- Yenugonda, VM; Xiao, Y; Levin, ED; Rezvani, AH; Tran, T; Al-Muhtasib, N; Sahibzada, N; Xie, T; Wells, C; Slade, S; Johnson, JE; Dakshanamurthy, S; Kong, HS; Tomita, Y; Liu, Y; Paige, M; Kellar, KJ; Brown, ML Design, synthesis and discovery of picomolar selective α4β2 nicotinic acetylcholine receptor ligands. J Med Chem 56: 8404-21 (2013)
- Albrecht, BK; Berry, V; Boezio, AA; Cao, L; Clarkin, K; Guo, W; Harmange, JC; Hierl, M; Huang, L; Janosky, B; Knop, J; Malmberg, A; McDermott, JS; Nguyen, HQ; Springer, SK; Waldon, D; Woodin, K; McDonough, SI Discovery and optimization of substituted piperidines as potent, selective, CNS-penetrant alpha4beta2 nicotinic acetylcholine receptor potentiators. Bioorg Med Chem Lett 18: 5209-12 (2008)
- Chang, YP; Banerjee, J; Dowell, C; Wu, J; Gyanda, R; Houghten, RA; Toll, L; McIntosh, JM; Armishaw, CJ Discovery of a potent and selectivea3ß4 nicotinic acetylcholine receptor antagonist from ana-conotoxin synthetic combinatorial library. J Med Chem 57: 3511-21 (2014)
- Liu, J; Yu, LF; Eaton, JB; Caldarone, B; Cavino, K; Ruiz, C; Terry, M; Fedolak, A; Wang, D; Ghavami, A; Lowe, DA; Brunner, D; Lukas, RJ; Kozikowski, AP Discovery of isoxazole analogues of sazetidine-A as selectivea4ß2-nicotinic acetylcholine receptor partial agonists for the treatment of depression. J Med Chem 54: 7280-8 (2011)
- Hughes, AD; Chin, KH; Dunham, SL; Jasper, JR; King, KE; Lee, TW; Mammen, M; Martin, J; Steinfeld, T Discovery of muscarinic acetylcholine receptor antagonist and beta 2 adrenoceptor agonist (MABA) dual pharmacology molecules. Bioorg Med Chem Lett 21: 1354-8 (2011)
- Sumiyoshi, T; Enomoto, T; Takai, K; Takahashi, Y; Konishi, Y; Uruno, Y; Tojo, K; Suwa, A; Matsuda, H; Nakako, T; Sakai, M; Kitamura, A; Uematsu, Y; Kiyoshi, A Discovery of novel N-substituted oxindoles as selective m1 and m4 muscarinic acetylcholine receptors partial agonists. ACS Med Chem Lett 4: 244-8 (2013)
- Kombo, DC; Mazurov, AA; Chewning, J; Hammond, PS; Tallapragada, K; Hauser, TA; Speake, J; Yohannes, D; Caldwell, WS Discovery of novela7 nicotinic acetylcholine receptor ligands via pharmacophoric and docking studies of benzylidene anabaseine analogs. Bioorg Med Chem Lett 22: 1179-86 (2012)
- Akincioglu, A; Akincioglu, H; Gülçin, I; Durdagi, S; Supuran, CT; Göksu, S Discovery of potent carbonic anhydrase and acetylcholine esterase inhibitors: novel sulfamoylcarbamates and sulfamides derived from acetophenones. Bioorg Med Chem 23: 3592-602 (2015)
- Enz, A; Feuerbach, D; Frederiksen, MU; Gentsch, C; Hurth, K; Müller, W; Nozulak, J; Roy, BL Gamma-lactams--a novel scaffold for highly potent and selective alpha 7 nicotinic acetylcholine receptor agonists. Bioorg Med Chem Lett 19: 1287-91 (2009)
- Bisson, WH; Scapozza, L; Westera, G; Mu, L; Schubiger, PA Ligand selectivity for the acetylcholine binding site of the rat alpha4beta2 and alpha3beta4 nicotinic subtypes investigated by molecular docking. J Med Chem 48: 5123-30 (2005)
- Liang, J; Tae, HS; Zhao, Z; Li, X; Zhang, J; Chen, S; Jiang, T; Adams, DJ; Yu, R Mechanism of Action and Structure-Activity Relationship of ?-Conotoxin Mr1.1 at the Human ?9?10 Nicotinic Acetylcholine Receptor. J Med Chem 65: 16204-16217 (2022)
- Carroll, FI; Blough, BE; Mascarella, SW; Navarro, HA; Eaton, JB; Lukas, RJ; Damaj, MI Nicotinic Acetylcholine Receptor Efficacy and Pharmacological Properties of 3-(Substituted phenyl)-2ß-substituted Tropanes. J Med Chem 53: 8345-53 (2010)
- Nielsen, SF; Nielsen, EO; Olsen, GM; Liljefors, T; Peters, D Novel potent ligands for the central nicotinic acetylcholine receptor: synthesis, receptor binding, and 3D-QSAR analysis. J Med Chem 43: 2217-26 (2000)
- Zaveri, N; Jiang, F; Olsen, C; Polgar, W; Toll, L Novela3ß4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation. J Med Chem 53: 8187-91 (2010)
- Abdel-Magid, AF Positive Allosteric Modulators of alpha7 Nicotinic Acetylcholine Receptor for the Treatment of Several Central Nervous System Diseases. ACS Med Chem Lett 15: 6-8 (2024)
- Rötering, S; Scheunemann, M; Fischer, S; Hiller, A; Peters, D; Deuther-Conrad, W; Brust, P Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging ofa7 nicotinic acetylcholine receptors. Bioorg Med Chem 21: 2635-42 (2013)
- Haydar, SN; Ghiron, C; Bettinetti, L; Bothmann, H; Comery, TA; Dunlop, J; La Rosa, S; Micco, I; Pollastrini, M; Quinn, J; Roncarati, R; Scali, C; Valacchi, M; Varrone, M; Zanaletti, R SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist. Bioorg Med Chem 17: 5247-58 (2009)
- Almeida, LE; Pereira, EF; Camara, AL; Maelicke, A; Albuquerque, EX Sensitivity of neuronal nicotinic acetylcholine receptors to the opiate antagonists naltrexone and naloxone: receptor blockade and up-regulation. Bioorg Med Chem Lett 14: 1879-87 (2004)
- Wang, X; Xiao, H; Wang, J; Huang, Z; Peng, G; Xie, W; Bian, X; Liu, H; Shi, C; Yang, T; Li, X; Gao, J; Meng, Y; Jiang, Q; Chen, W; Hu, F; Wei, N; Wang, X; Zhang, L; Wang, K; Sun, Q Synthesis and Biological Evaluation of Novel Triazine Derivatives as Positive Allosteric Modulators of ?7 Nicotinic Acetylcholine Receptors. J Med Chem 64: 12379-12396 (2021)
- Simoni, D; Rondanin, R; Marchetti, P; Rullo, C; Baruchello, R; Grisolia, G; Barbato, G; Giovannini, R; Marchioro, C; Capelli, AM; Virginio, C; Bozzoli, A; Borea, PA; Merighi, S; Donati, D Synthesis and biological activity of a novel class nicotinic acetylcholine receptors (nAChRs) ligands structurally related to anatoxin-a. Bioorg Med Chem Lett 21: 5423-7 (2011)
- Toyooka, N; Kobayashi, S; Zhou, D; Tsuneki, H; Wada, T; Sakai, H; Nemoto, H; Sasaoka, T; Garraffo, HM; Spande, TF; Daly, JW Synthesis of poison-frog alkaloids 233A, 235U, and 251AA and their inhibitory effects on neuronal nicotinic acetylcholine receptors. Bioorg Med Chem Lett 17: 5872-5 (2007)
- Tasso, B; Canu Boido, C; Terranova, E; Gotti, C; Riganti, L; Clementi, F; Artali, R; Bombieri, G; Meneghetti, F; Sparatore, F Synthesis, binding, and modeling studies of new cytisine derivatives, as ligands for neuronal nicotinic acetylcholine receptor subtypes. J Med Chem 52: 4345-57 (2009)
- Ivy Carroll, F; Yokota, Y; Ma, W; Lee, JR; Brieaddy, LE; Burgess, JP; Navarro, HA; Damaj, MI; Martin, BR Synthesis, nicotinic acetylcholine receptor binding, and pharmacological properties of 3'-(substituted phenyl)deschloroepibatidine analogs. Bioorg Med Chem 16: 746-54 (2008)
- Yamauchi, JG; Gomez, K; Grimster, N; Dufouil, M; Nemecz, A; Fotsing, JR; Ho, K; Talley, TT; Sharpless, K; Fokin, VV; Taylor, P Synthesizing Selective Agonists for the ?7 Nicotinic Receptor with in situ Click-Chemistry on Acetylcholine Binding Protein Templates. Mol Pharmacol 82: 687-699 (2014)
- Zheng, N; Christensen, SB; Blakely, A; Dowell, C; Purushottam, L; McIntosh, JM; Chou, DH Development of Conformationally Constrained ?-RgIA Analogues as Stable Peptide Antagonists of Human ?9?10 Nicotinic Acetylcholine Receptors. J Med Chem 63: 8380-8387 (2020)
- Lindemann, M; Deuther-Conrad, W; Moldovan, R; Sekhar, KVGC; Brust, P; Wenzel, B Do spiroindolines have the potential to replace vesamicol as lead compound for the development of radioligands targeting the vesicular acetylcholine transporter? Bioorg Med Chem 25: 5107-5113 (2017)
- Raasch, A; Scharfenstein, O; Tränkle, C; Holzgrabe, U; Mohr, K Elevation of ligand binding to muscarinic M(2) acetylcholine receptors by bis(ammonio)alkane-type allosteric modulators. J Med Chem 45: 3809-12 (2002)
- Rizzi, L; Dallanoce, C; Matera, C; Magrone, P; Pucci, L; Gotti, C; Clementi, F; De Amici, M Epiboxidine and novel-related analogues: a convenient synthetic approach and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes. Bioorg Med Chem Lett 18: 4651-4 (2008)
- Matera, C; Quadri, M; Sciaccaluga, M; Pomè, DY; Fasoli, F; De Amici, M; Fucile, S; Gotti, C; Dallanoce, C; Grazioso, G Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for thea3ß4 nicotinic acetylcholine receptor subtype. Eur J Med Chem 108: 392-405 (2016)
- Yu, R; Tae, HS; Tabassum, N; Shi, J; Jiang, T; Adams, DJ Molecular Determinants Conferring the Stoichiometric-Dependent Activity of ?-Conotoxins at the Human ?9?10 Nicotinic Acetylcholine Receptor Subtype. J Med Chem 61: 4628-4634 (2018)
- Audouze, K; Nielsen, EØ; Olsen, GM; Ahring, P; Jørgensen, TD; Peters, D; Liljefors, T; Balle, T New ligands with affinity for the alpha4beta2 subtype of nicotinic acetylcholine receptors. Synthesis, receptor binding, and 3D-QSAR modeling. J Med Chem 49: 3159-71 (2006)
- Dallanoce, C; Frigerio, F; Grazioso, G; Matera, C; Visconti, GL; De Amici, M; Pucci, L; Pistillo, F; Fucile, S; Gotti, C; Clementi, F; De Micheli, C New spirocyclic¿²-isoxazoline derivatives related to selective agonists ofa7 neuronal nicotinic acetylcholine receptors. Eur J Med Chem 46: 5790-9 (2011)
- Barthel, C; Sorger, D; Deuther-Conrad, W; Scheunemann, M; Schweiger, S; Jäckel, P; Roghani, A; Steinbach, J; Schüürmann, G; Sabri, O; Brust, P; Wenzel, B New systematically modified vesamicol analogs and their affinity and selectivity for the vesicular acetylcholine transporter - A critical examination of the lead structure. Eur J Med Chem 100: 50-67 (2015)
- Jensen, AA; Zlotos, DP; Liljefors, T Pharmacological characteristics and binding modes of caracurine V analogues and related compounds at the neuronal alpha7 nicotinic acetylcholine receptor. J Med Chem 50: 4616-29 (2007)
- Kombo, DC; Hauser, TA; Grinevich, VP; Melvin, MS; Strachan, JP; Sidach, SS; Chewning, J; Fedorov, N; Tallapragada, K; Breining, SR; Miller, CH Pharmacological properties and predicted binding mode of arylmethylene quinuclidine-like derivatives at the ?3?4 nicotinic acetylcholine receptor (nAChR). Bioorg Med Chem Lett 23: 1450-5 (2013)
- Ho, TNT; Lee, HS; Swaminathan, S; Goodwin, L; Rai, N; Ushay, B; Lewis, RJ; Rosengren, KJ; Conibear, AC Posttranslational modifications of ?-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding. RSC Med Chem 12: 1574-1584 (2021)
- Yu, J; Zhu, X; Harvey, PJ; Kaas, Q; Zhangsun, D; Craik, DJ; Luo, S Single Amino Acid Substitution in ?-Conotoxin TxID Reveals a Specific ?3?4 Nicotinic Acetylcholine Receptor Antagonist. J Med Chem 61: 9256-9265 (2018)
- Strømgaard, K; Mellor, IR; Andersen, K; Neagoe, I; Pluteanu, F; Usherwood, PN; Krogsgaard-Larsen, P; Jaroszewski, JW Solid-phase synthesis and pharmacological evaluation of analogues of PhTX-12-A potent and selective nicotinic acetylcholine receptor antagonist. Bioorg Med Chem Lett 12: 1159-62 (2002)
- Gopalakrishnan, M; Monteggia, LM; Anderson, DJ; Molinari, EJ; Piattoni-Kaplan, M; Donnelly-Roberts, D; Arneric, SP; Sullivan, JP Stable expression, pharmacologic properties and regulation of the human neuronal nicotinic acetylcholine alpha 4 beta 2 receptor. J Pharmacol Exp Ther 276: 289-97 (1996)
- Cheng, J; Zhang, C; Stevens, ED; Izenwasser, S; Wade, D; Chen, S; Paul, D; Trudell, ML Synthesis and biological evaluation at nicotinic acetylcholine receptors of N-arylalkyl- and N-aryl-7-azabicyclo[2.2.1]heptanes. J Med Chem 45: 3041-7 (2002)
- Zhang, HK; Eaton, JB; Fedolak, A; Gunosewoyo, H; Onajole, OK; Brunner, D; Lukas, RJ; Yu, LF; Kozikowski, AP Synthesis and biological evaluation of novel hybrids of highly potent and selectivea4ß2-Nicotinic acetylcholine receptor (nAChR) partial agonists. Eur J Med Chem 124: 689-697 (2016)
- Frost, JM; Bunnelle, WH; Tietje, KR; Anderson, DJ; Rueter, LE; Curzon, P; Surowy, CS; Ji, J; Daanen, JF; Kohlhaas, KL; Buckley, MJ; Henry, RF; Dyhring, T; Ahring, PK; Meyer, MD Synthesis and structure-activity relationships of 3,8-diazabicyclo[4.2.0]octane ligands, potent nicotinic acetylcholine receptor agonists. J Med Chem 49: 7843-53 (2006)
- Skaddan, MB; Kilbourn, MR; Snyder, SE; Sherman, PS; Desmond, TJ; Frey, KA Synthesis, (18)F-labeling, and biological evaluation of piperidyl and pyrrolidyl benzilates as in vivo ligands for muscarinic acetylcholine receptors. J Med Chem 43: 4552-62 (2000)
- Carroll, FI; Ma, W; Yokota, Y; Lee, JR; Brieaddy, LE; Navarro, HA; Damaj, MI; Martin, BR Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 3'-substituted deschloroepibatidine analogues. Novel nicotinic antagonists. J Med Chem 48: 1221-8 (2005)
- Ondachi, PW; Ye, Z; Castro, AH; Luetje, CW; Damaj, MI; Mascarella, SW; Navarro, HA; Carroll, FI Synthesis, nicotinic acetylcholine receptor binding, in vitro and in vivo pharmacology properties of 3'-(substituted pyridinyl)-deschloroepibatidine analogs. Bioorg Med Chem 23: 5693-701 (2015)
- Gohlke, H; Schwarz, S; Gündisch, D; Tilotta, MC; Weber, A; Wegge, T; Seitz, G 3D QSAR analyses-guided rational design of novel ligands for the (alpha4)2(beta2)3 nicotinic acetylcholine receptor. J Med Chem 46: 2031-48 (2003)
- Akdemir, A; Rucktooa, P; Jongejan, A; Elk, R; Bertrand, S; Sixma, TK; Bertrand, D; Smit, AB; Leurs, R; de Graaf, C; de Esch, IJ Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors. Bioorg Med Chem 19: 6107-19 (2011)
- Nassif-Makki, T; Tränkle, C; Zlotos, D; Bejeuhr, G; Cambareri, A; Pfletschinger, C; Kostenis, E; Mohr, K; Holzgrabe, U Bisquaternary ligands of the common allosteric site of M2 acetylcholine receptors: search for the minimum essential distances between the pharmacophoric elements. J Med Chem 42: 849-58 (1999)
- Hone, AJ; Kaas, Q; Kearns, I; Hararah, F; Gajewiak, J; Christensen, S; Craik, DJ; McIntosh, JM Computational and Functional Mapping of Human and Rat ?6?4 Nicotinic Acetylcholine Receptors Reveals Species-Specific Ligand-Binding Motifs. J Med Chem 64: 1685-1700 (2021)
- Deligia, F; Deiana, V; Gotti, C; Lazzari, P; Bottazzi, ME; Pucci, L; Fasoli, F; Ragusa, G; Pinna, GA; Murineddu, G Design of novel 3,6-diazabicyclo[3.1.1]heptane derivatives with potent and selective affinities fora4ß2 neuronal nicotinic acetylcholine receptors. Eur J Med Chem 103: 429-37 (2015)
- Uruno, Y; Konishi, Y; Suwa, A; Takai, K; Tojo, K; Nakako, T; Sakai, M; Enomoto, T; Matsuda, H; Kitamura, A; Sumiyoshi, T Discovery of dihydroquinazolinone derivatives as potent, selective, and CNS-penetrant M(1) and M(4) muscarinic acetylcholine receptors agonists. Bioorg Med Chem Lett 25: 5357-61 (2015)
- Zhu, X; Pan, S; Xu, M; Zhang, L; Yu, J; Yu, J; Wu, Y; Fan, Y; Li, H; Kasheverov, IE; Kudryavtsev, DS; Tsetlin, VI; Xue, Y; Zhangsun, D; Wang, X; Luo, S High Selectivity of an ?-Conotoxin LvIA Analogue for ?3?2 Nicotinic Acetylcholine Receptors Is Mediated by ?2 Functionally Important Residues. J Med Chem 63: 13656-13668 (2020)
- Murineddu, G; Gotti, C; Asproni, B; Corona, P; Martinello, K; Plutino, S; Fucile, S; Temml, V; Moretti, M; Viani, P; Schuster, D; Piras, S; Deligia, F; Pinna, GA Novel N-aryl nicotinamide derivatives: Taking stock on 3,6-diazabicyclo[3.1.1]heptanes as ligands for neuronal acetylcholine receptors. Eur J Med Chem 180: 51-61 (2019)
- Edink, E; Akdemir, A; Jansen, C; van Elk, R; Zuiderveld, O; de Kanter, FJ; van Muijlwijk-Koezen, JE; Smit, AB; Leurs, R; de Esch, IJ Structure-based design, synthesis and structure-activity relationships of dibenzosuberyl- and benzoate-substituted tropines as ligands for acetylcholine-binding protein. Bioorg Med Chem Lett 22: 1448-54 (2012)
- Ondachi, PW; Castro, AH; Bartkowiak, JM; Luetje, CW; Damaj, MI; Mascarella, SW; Navarro, HA; Carroll, FI Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2'-fluoro-3'-(substituted pyridinyl)-7-deschloroepibatidine analogues. J Med Chem 57: 836-48 (2014)
- ChEMBL_532109 (CHEMBL969428) Inhibition of rat brain acetylcholine esterase in presence of acetylcholine substrate by chemiluminescent assay
- ChEBML_138564 muscarinic acetylcholine receptor M1
- ChEMBL_450457 (CHEMBL900744) Inhibition of acetylcholine esterase
- ChEMBL_1549986 (CHEMBL3755284) Mixed inhibition of electric eel acetylcholine esterase using acetylcholine iodide as substrate by Ellman's method
- ChEMBL_1549993 (CHEMBL3755444) Non-competitive inhibition of electric eel acetylcholine esterase using acetylcholine iodide as substrate by Ellman's method
- ChEMBL_532107 (CHEMBL969426) Inhibition of electric eel acetylcholine esterase type V-S in presence of acetylcholine substrate by chemiluminescent assay
- ChEBML_138180 Affinity for Muscarinic acetylcholine receptor M2
- ChEBML_144330 Affinity for nicotinic acetylcholine receptor alpha7
- ChEMBL_1281569 (CHEMBL3102254) Inhibition of human acetylcholine esterase
- ChEMBL_138564 (CHEMBL745519) muscarinic acetylcholine receptor M1
- ChEMBL_714885 (CHEMBL1663831) Inhibition of human acetylcholine esterase
- ChEMBL_144171 (CHEMBL749552) Affinity for Nicotinic acetylcholine receptor alpha7
- ChEMBL_1454323 (CHEMBL3364163) Inhibition of acetylcholine esterase (unknown origin)
- ChEMBL_138372 (CHEMBL749058) In vitro antagonistic activity against peripheral Muscarinic acetylcholine receptor in guinea pig ileum as inhibition of acetylcholine induced muscle contraction
- ChEMBL_2129874 (CHEMBL4839303) Antagonist activity at human muscarinic acetylcholine M4 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization
- ChEMBL_1444281 (CHEMBL3380864) Negative allosteric modulation of human muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
- ChEMBL_1444284 (CHEMBL3380867) Negative allosteric modulation of rat muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo4AM staining-based fluorescence assay
- ChEMBL_1588015 (CHEMBL3824950) Positive allosteric modulation at rat muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization
- ChEMBL_1588017 (CHEMBL3824952) Positive allosteric modulation at human muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization
- ChEMBL_1712855 (CHEMBL4122904) Positive allosteric modulation of human muscarinic acetylcholine M1 receptor expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization
- ChEBML_138181 Binding affinity to cloned Muscarinic acetylcholine receptor M2
- ChEBML_138401 Affinity towards human muscarinic acetylcholine receptor M1
- ChEBML_138418 Binding affinity against Muscarinic acetylcholine receptor M1
- ChEBML_138698 Affinity towards human muscarinic acetylcholine receptor M3
- ChEBML_138712 Binding affinity against Muscarinic acetylcholine receptor M3
- ChEBML_138981 Binding affinity to cloned Muscarinic acetylcholine receptor M3
- ChEBML_139120 Affinity towards human Muscarinic acetylcholine receptor M4
- ChEBML_139127 Binding affinity against Muscarinic acetylcholine receptor M4
- ChEBML_139215 Binding affinity to cloned Muscarinic acetylcholine receptor M1
- ChEBML_139258 Binding affinity to cloned Muscarinic acetylcholine receptor M4
- ChEBML_139391 Affinity towards human Muscarinic acetylcholine receptor M5
- ChEBML_139519 Binding affinity to cloned Muscarinic acetylcholine receptor M5
- ChEBML_139642 Affinity towards human muscarinic acetylcholine receptor M2
- ChEBML_139750 Antagonistic activity against Muscarinic acetylcholine receptor M2
- ChEBML_139773 Binding affinity against Muscarinic acetylcholine receptor M2
- ChEBML_140179 Binding affinity towards Muscarinic acetylcholine receptor M2
- ChEBML_1688610 Inhibition of muscarinic acetylcholine M5 receptor (unknown origin)
- ChEMBL_139465 (CHEMBL752173) Binding affinity was measured for Muscarinic acetylcholine receptor
- ChEMBL_140138 (CHEMBL749187) Binding affinity towards Muscarinic acetylcholine receptor
- ChEMBL_140140 (CHEMBL749189) Binding affinity towards Muscarinic acetylcholine receptor
- ChEMBL_143876 (CHEMBL751860) Affinity for nicotinic acetylcholine receptor alpha4-beta2
- ChEMBL_143877 (CHEMBL883546) Affinity for nicotinic acetylcholine receptor alpha4-beta2
- ChEMBL_1454326 (CHEMBL3364166) Binding affinity to acetylcholine esterase (unknown origin)
- ChEMBL_29095 (CHEMBL636833) Inhibitory activity against acetylcholine esterase (AChE)
- ChEMBL_302412 (CHEMBL875203) Affinity for rat Muscarinic acetylcholine receptor M2
- ChEMBL_302413 (CHEMBL828817) Affinity for rat Muscarinic acetylcholine receptor M3
- ChEMBL_697209 (CHEMBL1640629) Binding affinity to muscarinic acetylcholine receptor M1
- ChEMBL_697210 (CHEMBL1640630) Binding affinity to muscarinic acetylcholine receptor M2
- ChEMBL_697211 (CHEMBL1640631) Binding affinity to muscarinic acetylcholine receptor M3
- ChEMBL_697212 (CHEMBL1640632) Binding affinity to muscarinic acetylcholine receptor M4
- ChEMBL_697213 (CHEMBL1640633) Binding affinity to muscarinic acetylcholine receptor M5
- ChEMBL_1613481 (CHEMBL3855281) Activity at human muscarinic acetylcholine receptor M1 transfected in CHO-K1 cells assessed as intracellular calcium levels in presence of acetylcholine by FLIPR assay
- ChEMBL_1613482 (CHEMBL3855282) Activity at human muscarinic acetylcholine receptor M3 transfected in CHO-K1 cells assessed as intracellular calcium levels in presence of acetylcholine by FLIPR assay
- ChEMBL_2104990 (CHEMBL4813493) Positive allosteric modulation of human muscarinic acetylcholine M1 receptor expressed in CHO cells in presence of acetylcholine at EC20 concentration by calcium mobilization assay
- ChEMBL_2104993 (CHEMBL4813496) Positive allosteric modulation of human muscarinic acetylcholine M3 receptor expressed in CHO cells in presence of acetylcholine at EC20 concentration by calcium mobilization assay
- ChEMBL_2104995 (CHEMBL4813498) Positive allosteric modulation of human muscarinic acetylcholine M5 receptor expressed in CHO cells in presence of acetylcholine at EC20 concentration by calcium mobilization assay
- ChEMBL_2129875 (CHEMBL4839304) Antagonist activity at human muscarinic acetylcholine M4 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization relative to control
- ChEMBL_510504 (CHEMBL995212) Antagonist activity at human muscarinic acetylcholine M1 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
- ChEMBL_510508 (CHEMBL995216) Antagonist activity at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
- ChEMBL_1284790 (CHEMBL3107813) Negative allosteric modulation of rat muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assay
- ChEMBL_1284798 (CHEMBL3107821) Negative allosteric modulation of rat muscarinic acetylcholine receptor M4 expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization incubated for 150 secs prior to acetylcholine induction by Fluo-4 AM staining-based fluorescence assay
- ChEMBL_1668507 (CHEMBL4018395) Positive allosteric modulation of human muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as increase in acetylcholine-induced calcium mobilization preincubated for 10 mins followed by acetylcholine addition by Fluo-8-AM dye based FLIPR assay
- ChEMBL_1549983 (CHEMBL3755281) Inhibition of electric eel acetylcholine esterase preincubated for 10 mins followed by the addition of acetylcholine iodide as substrate measured after 5 mins by Ellman's method
- ChEMBL_2104992 (CHEMBL4813495) Positive allosteric modulation of human muscarinic acetylcholine M2/Gqi5 receptor expressed in CHO cells in presence of acetylcholine at EC20 concentration by calcium mobilization assay
- ChEMBL_2104994 (CHEMBL4813497) Positive allosteric modulation of human muscarinic acetylcholine M4/Gqi5 receptor expressed in CHO cells in presence of acetylcholine at EC20 concentration by calcium mobilization assay
- ChEMBL_2145726 (CHEMBL5030006) Positive allosteric modulation of human muscarinic acetylcholine M4/Gqi5 receptor expressed in CHO cells in presence of acetylcholine at EC20 concentration by calcium mobilization assay
- ChEMBL_2219875 (CHEMBL5133209) Inhibition of human muscarinic acetylcholine M4 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay
- ChEMBL_2219877 (CHEMBL5133211) Inhibition of rat muscarinic acetylcholine M4 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay
- ChEMBL_2219879 (CHEMBL5133213) Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 in the presence of acetylcholine at EC80 concentration by calcium mobilization assay
- ChEMBL_2309324 Inhibition of rat alpha7 nAChR expressed in Stage V-VI Xenopus laevis Oocytes assessed as inhibition of acetylcholine-induced current in presence of acetylcholine by electrophysiological recording
- ChEMBL_790181 (CHEMBL1925521) Antagonist activity at human muscarinic acetylcholine receptor 4 expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization
- ChEMBL_790182 (CHEMBL1925522) Antagonist activity at human muscarinic acetylcholine receptor 1 expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization
- ChEMBL_1770306 (CHEMBL4222418) Positive allosteric modulation of human muscarinic acetylcholine receptor M1 expressed in CHO cells assessed as potentiation of acetylcholine-induced calcium mobilization preincubated for 2.5 mins followed by acetylcholine addition measured after 1 min by Fluo-4AM-based FLIPR assay
- ChEBML_138398 Dissociation constant for human Muscarinic acetylcholine receptor M1 was determined.
- ChEBML_139639 Dissociation constant for human Muscarinic acetylcholine receptor M2 was determined.
- ChEBML_140145 Compound was tested for inhibitory activity against Muscarinic acetylcholine receptor
- ChEMBL_138129 (CHEMBL747251) Pseudo hill coefficient at Muscarinic acetylcholine receptor M1
- ChEMBL_138181 (CHEMBL749202) Binding affinity to cloned Muscarinic acetylcholine receptor M2
- ChEMBL_138186 (CHEMBL749207) Inhibitory activity against Muscarinic acetylcholine receptor M2
- ChEMBL_138280 (CHEMBL744237) Binding affinity against muscarinic acetylcholine receptor M1
- ChEMBL_138383 (CHEMBL749218) Dissociation constant of the drug-Muscarinic acetylcholine receptor complex.
- ChEMBL_139209 (CHEMBL745684) Binding affinity to cloned Muscarinic acetylcholine receptor M1
- ChEMBL_139263 (CHEMBL745071) Binding affinity against Muscarinic acetylcholine receptor M4
- ChEMBL_139387 (CHEMBL747700) Binding affinity against muscarinic acetylcholine receptor M5
- ChEMBL_139623 (CHEMBL749005) Binding affinity against muscarinic acetylcholine receptor M2
- ChEMBL_139751 (CHEMBL745192) Antagonistic activity against Muscarinic acetylcholine receptor M2
- ChEMBL_139752 (CHEMBL745193) Antagonistic activity against muscarinic acetylcholine receptor M2
- ChEMBL_139756 (CHEMBL745197) Binding affinity against muscarinic acetylcholine receptor M2
- ChEMBL_139757 (CHEMBL745198) Binding affinity against muscarinic acetylcholine receptor M2
- ChEMBL_139759 (CHEMBL748895) Binding affinity for human Muscarinic acetylcholine receptor M2
- ChEMBL_143089 (CHEMBL748739) Agonist activity against Nicotinic acetylcholine receptor (nAchR)
- ChEMBL_1496344 (CHEMBL3579948) Inhibition of muscarinic acetylcholine receptor M1 (unknown origin)
- ChEMBL_1496345 (CHEMBL3579949) Inhibition of muscarinic acetylcholine receptor M2 (unknown origin)
- ChEMBL_1496346 (CHEMBL3579950) Inhibition of muscarinic acetylcholine receptor M4 (unknown origin)
- ChEMBL_213558 (CHEMBL817828) Binding to vesicular acetylcholine transporter of torpedo synaptic vesicles
- ChEMBL_2163946 (CHEMBL5048807) Inhibition of alpha7 nicotinic acetylcholine receptor (unknown origin)
- ChEMBL_223060 (CHEMBL841531) Binding affinity against nicotinic acetylcholine receptor (nAChR)
- ChEMBL_302296 (CHEMBL827057) Ki value for rat Muscarinic acetylcholine receptor M3
- ChEMBL_320786 (CHEMBL884741) Inhibition constant against nicotinic acetylcholine receptor alpha7
- ChEMBL_320815 (CHEMBL872350) Affinity towards cloned Muscarinic acetylcholine receptor M1
- ChEMBL_320816 (CHEMBL872351) Affinity towards cloned Muscarinic acetylcholine receptor M2
- ChEMBL_320817 (CHEMBL872352) Affinity towards cloned Muscarinic acetylcholine receptor M3
- ChEMBL_320818 (CHEMBL872353) Affinity towards cloned Muscarinic acetylcholine receptor M4
- ChEMBL_320819 (CHEMBL872354) Affinity towards cloned Muscarinic acetylcholine receptor M5
- ChEMBL_321367 (CHEMBL881511) Inhibitory concentration against muscarinic acetylcholine receptor M1
- ChEMBL_321368 (CHEMBL881512) Inhibitory concentration against muscarinic acetylcholine receptor M2
- ChEMBL_909611 (CHEMBL3057497) Inhibition of alpha4beta2 nicotinic acetylcholine receptor (unknown origin)
- ChEMBL_1436836 (CHEMBL3387209) Antagonist activity at muscarinic acetylcholine receptor M2 (unknown origin) expressed in CHOK1 cells after 15 mins by calcium flux/FLIPR assay in presence of acetylcholine
- ChEMBL_1549987 (CHEMBL3755285) Inhibition of human acetylcholine esterase preincubated for 10 mins followed by the addition of 550 uM of acetylcholine iodide as substrate measured after 20 mins by Ellman's method
- ChEMBL_2023308 (CHEMBL4677121) Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Galpha15 assessed as inhibition of acetylcholine-induced calcium mobilization relative to acetylcholine
- ChEMBL_2309318 Inhibition of rat alpha2/beta2 nAChR expressed in Stage V-VI Xenopus laevis Oocytes assessed as inhibition of acetylcholine-induced current in presence of acetylcholine by electrophysiological recording
- ChEMBL_2309319 Inhibition of rat alpha2/beta4 nAChR expressed in Stage V-VI Xenopus laevis Oocytes assessed as inhibition of acetylcholine-induced current in presence of acetylcholine by electrophysiological recording
- ChEMBL_2309320 Inhibition of rat alpha3/beta2 nAChR expressed in Stage V-VI Xenopus laevis Oocytes assessed as inhibition of acetylcholine-induced current in presence of acetylcholine by electrophysiological recording
- ChEMBL_2309321 Inhibition of rat alpha3/beta4 nAChR expressed in Stage V-VI Xenopus laevis Oocytes assessed as inhibition of acetylcholine-induced current in presence of acetylcholine by electrophysiological recording
- ChEMBL_2309322 Inhibition of rat alpha4/beta2 nAChR expressed in Stage V-VI Xenopus laevis Oocytes assessed as inhibition of acetylcholine-induced current in presence of acetylcholine by electrophysiological recording
- ChEMBL_2309323 Inhibition of rat alpha4/beta4 nAChR expressed in Stage V-VI Xenopus laevis Oocytes assessed as inhibition of acetylcholine-induced current in presence of acetylcholine by electrophysiological recording
- ChEMBL_2309325 Inhibition of rat alpha9/alpha10 nAChR expressed in Stage V-VI Xenopus laevis Oocytes assessed as inhibition of acetylcholine-induced current in presence of acetylcholine by electrophysiological recording
- ChEMBL_2309326 Inhibition of rat alpha6/alpha3beta2beta3 nAChR expressed in Stage V-VI Xenopus laevis Oocytes assessed as inhibition of acetylcholine-induced current in presence of acetylcholine by electrophysiological recording
- ChEMBL_2309327 Inhibition of rat alpha6/alpha3beta4 nAChR expressed in Stage V-VI Xenopus laevis Oocytes assessed as inhibition of acetylcholine-induced current in presence of acetylcholine by electrophysiological recording
- ChEMBL_2309328 Inhibition of mouse alpha1/beta1deltaepsilon nAChR expressed in Stage V-VI Xenopus laevis Oocytes assessed as inhibition of acetylcholine-induced current in presence of acetylcholine by electrophysiological recording
- ChEMBL_510506 (CHEMBL995214) Antagonist activity at human muscarinic acetylcholine M2 receptor expressed in CHO cells coexpressed with Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization by FLIPR assay
- ChEMBL_915450 (CHEMBL3076134) Inhibition of [3H]nicotine binding to alpha4 nicotinic acetylcholine receptor in Mus musculus (mouse) M10 cells co-expressing beta2 nicotinic acetylcholine receptor subunits
- ChEMBL_1770303 (CHEMBL4222415) Positive allosteric modulation of human muscarinic acetylcholine receptor M1 expressed in CHO-NFAT cells assessed as potentiation of acetylcholine-induced calcium mobilization preincubated for 4 mins followed by acetylcholine addition measured after 4 mins by Fluo-4AM-based FLIPR assay
- ChEMBL_820325 (CHEMBL2037747) Inhibition of electric eel acetylcholine esterase using acetylcholine chloride as substrate incubated for 5 mins prior to substrate addition measured every 3 mins by Ellman's assay
- ChEMBL_823696 (CHEMBL2045011) Inhibition of electric eel acetylcholine esterase using acetylcholine chloride as substrate incubated for 15 mins prior to substrate addition measured every 1 min by Ellman's assay
- ChEMBL_915451 (CHEMBL3076135) Inhibition of [3H]nicotine binding to alpha3 nicotinic acetylcholine receptor in Homo sapiens (human) SH-SY5Y cells co-expressing beta2beta4alpha5 Nicotinic acetylcholine receptor subunits
- ChEMBL_915454 (CHEMBL3076138) Inhibition of [3H]alpha-BGT binding to alpha1 nicotinic acetylcholine receptor in Homo sapiens (human) TE671 cells co-expressing gammaalpha1deltabeta1 nicotinic acetylcholine receptor subunits
- ChEBML_138412 Binding affinity towards the cloned human Muscarinic acetylcholine receptor M1
- ChEBML_138806 Displacement of [3H]pirenzepine from cerebral Muscarinic acetylcholine receptor M1
- ChEBML_139395 The compound was tested for the binding affinity against Muscarinic acetylcholine receptor M5
- ChEBML_139762 Binding affinity against cloned human muscarinic acetylcholine receptor M2.
- ChEBML_139763 Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2
- ChEBML_139772 Binding affinity against human cloned Muscarinic acetylcholine receptor M2.
- ChEBML_140175 Binding affinity at human cloned acetylcholine receptor M2 in CHO cells.
- ChEBML_143096 Alpha 7 nicotinic acetylcholine receptor binding activity in PC12 cells
- ChEBML_143223 Binding affinity towards alpha3-beta4 neuronal nicotinic acetylcholine receptor
- ChEMBL_138763 (CHEMBL747849) Binding affinity to Muscarinic acetylcholine receptor in rat cerebral cortex
- ChEMBL_139096 (CHEMBL744272) Binding affinity for rat cortex Muscarinic acetylcholine receptor M1
- ChEMBL_139464 (CHEMBL752172) Binding affinity towards Muscarinic acetylcholine receptor in rat was determined
- ChEMBL_143404 (CHEMBL752659) Binding affinity towards Nicotinic acetylcholine receptor alpha3-beta4
- ChEMBL_143409 (CHEMBL750052) Agonistic potency against nicotinic acetylcholine receptor alpha3-beta4
- ChEMBL_143410 (CHEMBL750053) Inhibitory activity against nicotinic acetylcholine receptor alpha3-beta4
- ChEMBL_143698 (CHEMBL754233) Affinity for Nicotinic acetylcholine receptor alpha4-beta2 in rat brain
- ChEMBL_1437330 (CHEMBL3385425) Allosteric agonist activity at human muscarinic acetylcholine receptor M5
- ChEMBL_143882 (CHEMBL751865) Binding affinity towards nicotinic acetylcholine receptor alpha4-beta2
- ChEMBL_143883 (CHEMBL751866) Binding affinity towards nicotinic acetylcholine receptor alpha4-beta2
- ChEMBL_144175 (CHEMBL749556) Binding affinity at rat brain Nicotinic acetylcholine receptor alpha7
- ChEMBL_1473617 (CHEMBL3420956) Binding affinity to muscarinic M1 acetylcholine receptor (unknown origin)
- ChEMBL_1712854 (CHEMBL4122903) Positive allosteric modulation of human muscarinic acetylcholine M1 receptor
- ChEMBL_1712856 (CHEMBL4122905) Positive allosteric modulation of rat muscarinic acetylcholine M1 receptor
- ChEMBL_1789227 (CHEMBL4260961) Antagonist activity at muscarinic acetylcholine receptor M1 (unknown origin)
- ChEMBL_1979085 (CHEMBL4612220) Binding affinity to muscarinic acetylcholine receptor M1 (unknown origin)
- ChEMBL_1979086 (CHEMBL4612221) Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin)
- ChEMBL_1979087 (CHEMBL4612222) Binding affinity to muscarinic acetylcholine receptor M3 (unknown origin)
- ChEMBL_1979088 (CHEMBL4612223) Binding affinity to muscarinic acetylcholine receptor M4 (unknown origin)
- ChEMBL_1979089 (CHEMBL4612224) Binding affinity to muscarinic acetylcholine receptor M5 (unknown origin)
- ChEMBL_2068302 (CHEMBL4723555) Binding affinity to muscarinic acetylcholine receptor M1 (unknown origin)
- ChEMBL_2068303 (CHEMBL4723556) Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin)
- ChEMBL_2068304 (CHEMBL4723557) Binding affinity to muscarinic acetylcholine receptor M3 (unknown origin)
- ChEMBL_2068305 (CHEMBL4723558) Binding affinity to muscarinic acetylcholine receptor M4 (unknown origin)
- ChEMBL_213559 (CHEMBL817829) Displacement of [3H]vesamicol from Vesicular Acetylcholine Transporter (VAChT)
- ChEMBL_2247008 (CHEMBL5161218) Inhibition of nicotinic acetylcholine receptor alpha 1 (unknown origin)
- ChEMBL_2247009 (CHEMBL5161219) Inhibition of nicotinic acetylcholine receptor alpha 7 (unknown origin)
- ChEMBL_302242 (CHEMBL830258) Dissociation constant against Nicotinic acetylcholine receptor alpha3-beta2
- ChEMBL_302243 (CHEMBL830259) Dissociation constant against Nicotinic acetylcholine receptor alpha3-beta4
- ChEMBL_302244 (CHEMBL830260) Dissociation constant against Nicotinic acetylcholine receptor alpha4-beta2
- ChEMBL_302786 (CHEMBL839471) Binding affinity for rat Nicotinic acetylcholine receptor alpha2-beta2
- ChEMBL_302787 (CHEMBL839472) Binding affinity for rat Nicotinic acetylcholine receptor alpha2-beta4
- ChEMBL_302788 (CHEMBL839473) Binding affinity for rat Nicotinic acetylcholine receptor alpha3-beta2
- ChEMBL_302789 (CHEMBL839474) Binding affinity for rat Nicotinic acetylcholine receptor alpha3-beta4
- ChEMBL_302790 (CHEMBL876358) Binding affinity for rat Nicotinic acetylcholine receptor alpha4-beta4
- ChEMBL_304161 (CHEMBL877116) Effective concentration against rat alpha7 nicotinic acetylcholine receptor
- ChEMBL_304167 (CHEMBL830005) Effective concentration against Nicotinic acetylcholine receptor alpha 7
- ChEMBL_304195 (CHEMBL830024) Effective concentration against Nicotinic acetylcholine receptor alpha2-beta4
- ChEMBL_304196 (CHEMBL830025) Effective concentration against Nicotinic acetylcholine receptor alpha3-beta2
- ChEMBL_304198 (CHEMBL830027) Effective concentration against Nicotinic acetylcholine receptor alpha4-beta2
- ChEMBL_305504 (CHEMBL831106) Inhibitory concentration against Nicotinic acetylcholine receptor alpha 7
- ChEMBL_305538 (CHEMBL828558) Inhibitory concentration against Nicotinic acetylcholine receptor alpha 7
- ChEMBL_305724 (CHEMBL829396) Inhibitory concentration against Nicotinic acetylcholine receptor alpha2-beta2
- ChEMBL_305725 (CHEMBL829397) Inhibitory concentration against Nicotinic acetylcholine receptor alpha2-beta4
- ChEMBL_305726 (CHEMBL829398) Inhibitory concentration against Nicotinic acetylcholine receptor alpha3-beta2
- ChEMBL_305728 (CHEMBL829400) Inhibitory concentration against Nicotinic acetylcholine receptor alpha4-beta2
- ChEMBL_305760 (CHEMBL827098) Inhibitory concentration against Nicotinic acetylcholine receptor alpha4-beta2
- ChEMBL_306021 (CHEMBL833536) Inhibitory concentration against human Muscarinic acetylcholine receptor M1
- ChEMBL_659488 (CHEMBL1248541) Binding affinity to human acetylcholine esterase by radioligand displacement assay
- ChEMBL_982013 (CHEMBL2428368) Binding affinity to muscarinic acetylcholine receptor M2 (unknown origin)
- ChEMBL_2219910 (CHEMBL5133244) Inhibition of rat muscarinic acetylcholine M1 receptor expressed in CHO cells co-expressing Gqi5 preincubated with compound followed by acetylcholine addition at EC80 concentration by calcium mobilization assay
- ChEMBL_2219911 (CHEMBL5133245) Inhibition of rat muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 preincubated with compound followed by acetylcholine addition at EC80 concentration by calcium mobilization assay
- ChEMBL_2219912 (CHEMBL5133246) Inhibition of rat muscarinic acetylcholine M3 receptor expressed in CHO cells co-expressing Gqi5 preincubated with compound followed by acetylcholine addition at EC80 concentration by calcium mobilization assay
- ChEMBL_2219913 (CHEMBL5133247) Inhibition of rat muscarinic acetylcholine M5 receptor expressed in CHO cells co-expressing Gqi5 preincubated with compound followed by acetylcholine addition at EC80 concentration by calcium mobilization assay
- ChEMBL_2219914 (CHEMBL5133248) Inhibition of human muscarinic acetylcholine M1 receptor expressed in CHO cells co-expressing Gqi5 preincubated with compound followed by acetylcholine addition at EC80 concentration by calcium mobilization assay
- ChEMBL_2219915 (CHEMBL5133249) Inhibition of human muscarinic acetylcholine M2 receptor expressed in CHO cells co-expressing Gqi5 preincubated with compound followed by acetylcholine addition at EC80 concentration by calcium mobilization assay
- ChEMBL_1729568 (CHEMBL4144846) Antagonist activity at mAChR M3 in human CCRF-CEM cells assessed as inhibition of acetylcholine-mediated calcium flux incubated for 25 mins followed by acetylcholine stimulation measured for 90 secs
- ChEBML_138302 Muscarinic acetylcholine receptor M3 agonistic/antagonistic activity in guinea pig ileum
- ChEBML_138940 Binding affinity against muscarinic acetylcholine receptor M1 of rat cerebral cortex.
- ChEBML_139201 Binding affinity against muscarinic acetylcholine receptor M3 of rat sabmandibular glands
- ChEBML_140152 Binding affinity for Muscarinic acetylcholine receptor was determined by using [3H]QNB as radioligand
- ChEBML_143888 Blockage of Nicotinic acetylcholine receptor alpha4-beta2 noncompetitively in cultured hippocampal neurons
- ChEBML_144198 Inhibition of [3H]-MLA binding to Nicotinic acetylcholine receptor alpha7 in rat brain
- ChEBML_1685391 Activity at human M2 receptor assessed as increase in acetylcholine-induced calcium mobilization
- ChEBML_184442 Evaluated for the phosphatidyl inositol turnover at Muscarinic acetylcholine receptor M1 in rat cortex
- ChEBML_27376 Compound was evaluated for reversible inhibition of hydrolysis acetylcholine by acetylcholinesterase and represented as KI(competitive)
- ChEMBL_138191 (CHEMBL747835) Dissociation constant at muscarinic acetylcholine receptor M3 guinea pig bladder.
- ChEMBL_138192 (CHEMBL747836) Dissociation constant at muscarinic acetylcholine receptor M3 of guinea pig ileum.
- ChEMBL_138211 (CHEMBL748440) In vitro binding affinity against Muscarinic acetylcholine receptors in rat brain.
- ChEMBL_138261 (CHEMBL743978) Displacement of [3H]QNB from rat ileum Muscarinic acetylcholine receptor
- ChEMBL_138381 (CHEMBL749216) Dissociation constant towards Muscarinic acetylcholine receptor in guinea pig ileum
- ChEMBL_138412 (CHEMBL744774) Binding affinity towards the cloned human Muscarinic acetylcholine receptor M1
- ChEMBL_138635 (CHEMBL749266) Dissociation constant towards Muscarinic acetylcholine receptor in guinea pig ileum
- ChEMBL_138690 (CHEMBL747657) Binding affinity towards Muscarinic acetylcholine receptor M1 of cerebral cortex
- ChEMBL_138762 (CHEMBL747848) Binding affinity against the Muscarinic acetylcholine receptor using [3H]- QNB
- ChEMBL_138806 (CHEMBL751541) Displacement of [3H]pirenzepine from cerebral Muscarinic acetylcholine receptor M1
- ChEMBL_138855 (CHEMBL748616) Binding affinity against muscarinic acetylcholine receptor M2 of rat heart.
- ChEMBL_138919 (CHEMBL746569) The compound was tested for inhibition of [3H]QNB binding to Muscarinic acetylcholine receptor
- ChEMBL_138944 (CHEMBL745924) Binding affinity towards rat Muscarinic acetylcholine receptor M1 was determined
- ChEMBL_138945 (CHEMBL745925) Affinity for rat M1 acetylcholine receptor using [3H]pirenzepine displacement.
- ChEMBL_138953 (CHEMBL742765) Binding affinity against Muscarinic acetylcholine receptor M1 sites of rat
- ChEMBL_139256 (CHEMBL745529) Inhibition of NG 108-15 binding to Muscarinic acetylcholine receptor M4
- ChEMBL_139763 (CHEMBL748899) Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2
- ChEMBL_140180 (CHEMBL744097) Binding affinity towards rat Muscarinic acetylcholine receptor M2 was determined
- ChEMBL_143096 (CHEMBL749346) Alpha 7 nicotinic acetylcholine receptor binding activity in PC12 cells
- ChEMBL_143102 (CHEMBL749352) Tested for binding affinity against Nicotinic acetylcholine receptor alpha2-beta2
- ChEMBL_143103 (CHEMBL749353) Tested for binding affinity against Nicotinic acetylcholine receptor alpha2-beta2
- ChEMBL_143230 (CHEMBL750091) Tested for binding affinity against Nicotinic acetylcholine receptor alpha2-beta4
- ChEMBL_143231 (CHEMBL750092) Tested for binding affinity against Nicotinic acetylcholine receptor alpha2-beta4
- ChEMBL_143244 (CHEMBL752532) Tested for binding affinity against Nicotinic acetylcholine receptor alpha3-beta2
- ChEMBL_143245 (CHEMBL752533) Tested for binding affinity against Nicotinic acetylcholine receptor alpha3-beta2
- ChEMBL_143394 (CHEMBL857598) Tested for binding affinity against Nicotinic acetylcholine receptor alpha3-beta4
- ChEMBL_143395 (CHEMBL750861) Tested for binding affinity against Nicotinic acetylcholine receptor alpha3-beta4
- ChEMBL_143544 (CHEMBL754722) Binding affinity against human Nicotinic acetylcholine receptor alpha4-beta2
- ChEMBL_143565 (CHEMBL755476) Functional potency for Nicotinic acetylcholine receptor alpha4-beta2 (rat brain)
- ChEMBL_143696 (CHEMBL883403) Tested for binding affinity against Nicotinic acetylcholine receptor alpha4-beta2
- ChEMBL_143702 (CHEMBL756002) Binding potency for Nicotinic acetylcholine receptor alpha4-beta2 (rat brain)
- ChEMBL_143706 (CHEMBL756006) Tested for binding affinity against Nicotinic acetylcholine receptor alpha4-beta2
- ChEMBL_143710 (CHEMBL857696) Evaluated for binding affinity towards nicotinic acetylcholine receptor alpha4-beta2
- ChEMBL_143718 (CHEMBL753469) Inhibition of [3H]-nicotine binding at the nicotinic acetylcholine receptor alpha4-beta2
- ChEMBL_144012 (CHEMBL750427) Tested for binding affinity against Nicotinic acetylcholine receptor alpha4-beta4
- ChEMBL_144013 (CHEMBL750428) Tested for binding affinity against Nicotinic acetylcholine receptor alpha4-beta4
- ChEMBL_144041 (CHEMBL751077) Functional potency for Nicotinic acetylcholine receptor alpha-7 (rat brain)
- ChEMBL_144042 (CHEMBL883540) Functional potency for Nicotinic acetylcholine receptor alpha-7 (rat brain)
- ChEMBL_144176 (CHEMBL749557) Binding affinity in rat hippocampi against Nicotinic acetylcholine receptor alpha7
- ChEMBL_144182 (CHEMBL749563) Binding potency for Nicotinic acetylcholine receptor alpha-7 (rat brain)
- ChEMBL_144183 (CHEMBL749304) Binding potency for Nicotinic acetylcholine receptor alpha-7 (rat brain)
- ChEMBL_1500179 (CHEMBL3584728) Inhibition of human acetylcholine esterase by horseradish peroxidase-coupled fluorescence assay
- ChEMBL_1700418 (CHEMBL4051400) Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2
- ChEMBL_223059 (CHEMBL841530) Compound was evaluated for the binding constant for association with nicotinic acetylcholine receptor (nAChR)
- ChEMBL_303090 (CHEMBL828762) Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta2; Not significant
- ChEMBL_303167 (CHEMBL876380) Binding affinity against nicotinic acetylcholine receptor subtype alpha2-beta2
- ChEMBL_303210 (CHEMBL829835) Inhibition of [3H]MLA binding to rat alpha7 nicotinic acetylcholine receptor
- ChEMBL_303420 (CHEMBL840083) Inhibition of [3H]epibatidine binding to Nicotinic acetylcholine receptor alpha3-beta2
- ChEMBL_304157 (CHEMBL829996) Effective concentration against alpha3-beta4 Nicotinic acetylcholine receptor (nAChR)
- ChEMBL_304158 (CHEMBL829997) Effective concentration against rat alpha-7 nicotinic acetylcholine receptor
- ChEMBL_304171 (CHEMBL829168) Effective concentration against rat alpha3-beta4 nicotinic acetylcholine receptor
- ChEMBL_304172 (CHEMBL877117) Effective concentration against rat alpha4-beta2 nicotinic acetylcholine receptor
- ChEMBL_469306 (CHEMBL931592) Activity at alpha7 nACh receptor assessed as modulation of acetylcholine-induced response
- ChEMBL_73104 (CHEMBL684492) Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.
- ChEMBL_73105 (CHEMBL684493) Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.
- ChEMBL_816768 (CHEMBL2025880) Inhibition of electric eel AChE using acetylcholine as substrate by Ellman's method
- ChEMBL_851198 (CHEMBL2155626) Antagonist activity at alpha7 nAChR assessed as amplitude of acetylcholine evoked currents
- ChEMBL_851200 (CHEMBL2155628) Antagonist activity at alpha4beta2 nAChR assessed as amplitude of acetylcholine evoked currents
- ChEMBL_915457 (CHEMBL3076141) Inhibition of [3H]IMI binding to Drosophila melanogaster neuronal acetylcholine receptor
- ChEMBL_983858 (CHEMBL2433296) Positive allosteric modulation at muscarinic acetylcholine receptor M1(unknown origin)
- ChEBML_1712853 Positive allosteric modulation of human muscarinic acetylcholine M1 receptor expressed in CHO-NFAT cells assessed as potentiation of acetylcholine-induced calcium mobilization after 4 hrs by CCF4-AM dye-based assay
- ChEBML_1734264 Antagonist activity at mAChR in human CCRF-CEM cells assessed as inhibition of acetylcholine-induced calcium flux pretreated for 25 mins followed by acetylcholine addition measured for 90 secs by calcium-dye based assay
- ChEMBL_1741062 (CHEMBL4156812) Antagonist activity at mAChR in human CCRF-CEM cells assessed as inhibition of acetylcholine-induced calcium release preincubated for 25 mins followed by acetylcholine stimulation and measured for 90 secs by calcium flux assay
- ChEBML_138407 Binding affinity against human Muscarinic acetylcholine receptor M1 in transfected CHO cells
- ChEBML_138413 Binding affinity against Muscarinic acetylcholine receptor M1 expressed in CHO-K1 cells
- ChEBML_138643 Compound was tested for the binding affinity towards muscarinic acetylcholine receptor in mouse brain membrane
- ChEBML_138705 Binding affinity against human muscarinic acetylcholine receptor M3 in transfected CHO cells
- ChEBML_138706 Binding affinity against Muscarinic acetylcholine receptor M3 expressed in CHO-K1 cells
- ChEBML_138792 Inhibition of [3H]pirenzepine binding to rat brain membrane Muscarinic acetylcholine receptor M1
- ChEBML_138852 Inhibition of [3H]QNB binding to Muscarinic acetylcholine receptor M3 transfected with CHO cell
- ChEBML_138935 Inhibition of [3H]QNB binding to Muscarinic acetylcholine receptor M1 transfected with CHO cell
- ChEBML_138954 Displacement of [3H]pirenzepine from muscarinic acetylcholine receptor M1 of rat brain membrane
- ChEBML_139068 Displacement of [3H]pirenzepine from muscarinic acetylcholine receptor M1 in rat cortex homogenates
- ChEBML_139069 Ability to displace [3H]pirenzepine radioligand for the Muscarinic acetylcholine receptor M1 in rat brain
- ChEBML_139463 Binding affinity to muscarinic acetylcholine receptor was determined in presence of [3H]QNB radioligand (in vitro)
- ChEBML_139466 Inhibition of [3H]N-methylscopolamine binding to muscarinic acetylcholine receptor of rat cerebral cortex.
- ChEBML_139760 Binding affinity against human muscarinic acetylcholine receptor M2 in transfected CHO cells
- ChEBML_1696021 Positive allosteric modulation of rat M4 receptor assessed as increase in acetylcholine-induced response
- ChEBML_27660 Inhibition of active transport of [3H]acetylcholine using purified Torpedo californica synaptic vesicles
- ChEMBL_138172 (CHEMBL858421) Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2
- ChEMBL_138302 (CHEMBL744332) Muscarinic acetylcholine receptor M3 agonistic/antagonistic activity in guinea pig ileum
- ChEMBL_138312 (CHEMBL743823) Dissociation constant for complex with muscarinic acetylcholine receptor M3 of guinea pig ileum
- ChEMBL_138918 (CHEMBL746568) Displacement of [3H]QNB from Muscarinic acetylcholine receptor of rat brain membrane
- ChEMBL_138940 (CHEMBL745920) Binding affinity against muscarinic acetylcholine receptor M1 of rat cerebral cortex.
- ChEMBL_139318 (CHEMBL752311) Inhibition of [3H]QNB binding against muscarinic acetylcholine receptor in rat brain.
- ChEMBL_139319 (CHEMBL752312) Inhibition of [3H]QNB binding against muscarinic acetylcholine receptor in rat heart.
- ChEMBL_139322 (CHEMBL749927) Inhibition of [3H]pirenzepine binding against muscarinic acetylcholine receptor in rat brain.
- ChEMBL_139641 (CHEMBL748254) Affinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cells
- ChEMBL_140144 (CHEMBL749193) Binding affinity against Muscarinic acetylcholine receptor using [3H]quinuclidinyl benzilate
- ChEMBL_140153 (CHEMBL745459) Binding affinity against Muscarinic acetylcholine receptor using [3H]QNB as the radioligand.
- ChEMBL_140177 (CHEMBL745629) Binding affinity against muscarinic acetylcholine receptor M3 of rat sabmandibular glands
- ChEMBL_142767 (CHEMBL750488) The compound was tested for inhibitory potency against Nicotinic acetylcholine receptor in Rat muscle.
- ChEMBL_143095 (CHEMBL749345) Binding affinities for the alpha 7 nicotinic acetylcholine receptor was determined in PC12 cells
- ChEMBL_143243 (CHEMBL752531) Inhibition of rat Nicotinic acetylcholine receptor alpha3-beta2 expressed in Xenopus Oocytes
- ChEMBL_143563 (CHEMBL755335) Compound was evaluated for functional potencies and efficacies at ratNicotinic acetylcholine receptor alpha4-beta2
- ChEMBL_143700 (CHEMBL756000) Binding affinity in rat forebrain against Nicotinic acetylcholine receptor alpha4-beta2
- ChEMBL_143884 (CHEMBL751867) In vitro Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta2 was determined
- ChEMBL_143887 (CHEMBL751870) Blockage of Nicotinic acetylcholine receptor alpha4-beta2 noncompetitively in acute hippocampal slices
- ChEMBL_143888 (CHEMBL751871) Blockage of Nicotinic acetylcholine receptor alpha4-beta2 noncompetitively in cultured hippocampal neurons
- ChEMBL_144023 (CHEMBL750438) Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor alpha7
- ChEMBL_144030 (CHEMBL750445) Binding affinity against human Nicotinic acetylcholine receptor alpha-7 was determined
- ChEMBL_144331 (CHEMBL751842) Blockage of Nicotinic acetylcholine receptor alpha-7 noncompetitively in cultured hippocampal neurons
- ChEMBL_144332 (CHEMBL751843) Blockage of Nicotinic acetylcholine receptor alpha-7 noncompetitively in hippocampal primary cultures
- ChEMBL_144957 (CHEMBL755075) Inhibition of recombinant embryonic mouse muscle Nicotinic Acetylcholine Receptor (3 oocytes)
- ChEMBL_1504716 (CHEMBL3594852) Displacement of [3H]-nicotine from alpha4beta2 nicotine acetylcholine receptor (unknown origin)
- ChEMBL_1557341 (CHEMBL3774025) Binding affinity to human muscarinic acetylcholine M5 receptor by radioligand binding assay
- ChEMBL_184442 (CHEMBL790102) Evaluated for the phosphatidyl inositol turnover at Muscarinic acetylcholine receptor M1 in rat cortex
- ChEMBL_1888969 (CHEMBL4390723) Inhibition of AChE (unknown origin) using acetylcholine iodide as substrate by Ellman method
- ChEMBL_222719 (CHEMBL844387) Binding affinity against muscarinic acetylcholine receptor M1 of rat cerebral cortex.
- ChEMBL_27375 (CHEMBL642521) Compound was evaluated for reversible inhibition of hydrolysis acetylcholine by acetylcholinesterase and represented as KI(com)
- ChEMBL_27376 (CHEMBL642409) Compound was evaluated for reversible inhibition of hydrolysis acetylcholine by acetylcholinesterase and represented as KI(competitive)
- ChEMBL_27377 (CHEMBL642410) Compound was evaluated for reversible inhibition of hydrolysis acetylcholine by acetylcholinesterase and represented as KI(noncompetitive)
- ChEMBL_27378 (CHEMBL642411) Compound was evaluated for reversible inhibition of hydrolysis of acetylcholine by acetylcholinesterase and represented as KI(competitive)
- ChEMBL_302237 (CHEMBL828857) Dissociation constant for rat Nicotinic acetylcholine receptor alpha-7 at 45 pM
- ChEMBL_303011 (CHEMBL830250) Inhibition of [3H]-MLA binding to rat alpha-7 nicotinic acetylcholine receptor
- ChEMBL_303189 (CHEMBL829683) Inhibition of [3H]epibatidine binding to rat Nicotinic acetylcholine receptor alpha4-beta2
- ChEMBL_303228 (CHEMBL827193) Inhibition of [3H]nicotine binding to rat alpha4-beta2 nicotinic acetylcholine receptor
- ChEMBL_303347 (CHEMBL839662) Inhibition of [125I]alpha-bungarotoxin binding to rat nicotinic acetylcholine receptor alpha7
- ChEMBL_303477 (CHEMBL838851) Inhibition of [3H]epibatidine binding to rat Nicotinic acetylcholine receptor alpha3-beta4
- ChEMBL_303478 (CHEMBL838852) Inhibition of [3H]epibatidine binding to rat Nicotinic acetylcholine receptor alpha4-beta2
- ChEMBL_306411 (CHEMBL828752) Inhibition of [125I]alpha-bungarotoxin binding to rat nicotinic acetylcholine receptor alpha7
- ChEMBL_310491 (CHEMBL834065) Change in membrane potential in TE-671 cells expressing acetylcholine neuromuscular receptors
- ChEMBL_532108 (CHEMBL969427) Inhibition of horse serum butyrylcholine esterase in presence of acetylcholine substrate by chemiluminescent assay
- ChEMBL_741147 (CHEMBL1764418) Mixed inhibition of Electrophorus electricus acetylcholinesterase using acetylcholine as substrate by Ellman's method
- ChEMBL_935571 (CHEMBL2320107) Positive allosteric modulation of rat muscarinic M5 receptor assessed as acetylcholine response
- ChEMBL_935573 (CHEMBL2320109) Positive allosteric modulation of rat muscarinic M3 receptor assessed as acetylcholine response
- ChEMBL_935576 (CHEMBL2320112) Positive allosteric modulation of rat muscarinic M2 receptor assessed as acetylcholine response
- ChEMBL_935580 (CHEMBL2320116) Positive allosteric modulation of rat muscarinic M1 receptor assessed as acetylcholine response
- ChEMBL_935589 (CHEMBL2320371) Positive allosteric modulation of rat muscarinic M4 receptor assessed as acetylcholine response
- ChEMBL_980915 (CHEMBL2421450) Inhibition of purified human erythrocyte AChE using acetylcholine as substrate by Ellman's method
- ChEMBL_1712853 (CHEMBL4122902) Positive allosteric modulation of human muscarinic acetylcholine M1 receptor expressed in CHO-NFAT cells assessed as potentiation of acetylcholine-induced calcium mobilization after 4 hrs by CCF4-AM dye-based assay
- ChEMBL_1734264 (CHEMBL4149800) Antagonist activity at mAChR in human CCRF-CEM cells assessed as inhibition of acetylcholine-induced calcium flux pretreated for 25 mins followed by acetylcholine addition measured for 90 secs by calcium-dye based assay
- ChEMBL_2172717 (CHEMBL5057851) Inhibition of human (alpha4)3(beta2)2 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response in presence of 100 uM acetylcholine by two-electrode voltage-clamp method
- ChEMBL_2172719 (CHEMBL5057853) Inhibition of human (alpha4)2(beta2)3 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response in presence of 3 uM acetylcholine by two-electrode voltage-clamp method
- ChEMBL_1809635 (CHEMBL4309095) Positive allosteric modulation of human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as increase in acetylcholine-induced channel current by measuring acetylcholine EC50 at 10 uM at -90 mV holding potential preincubated for 2 mins followed by co-application with acetylcholine for 10 secs by two-electrode voltage clamp method (Rvb = 256.4 +/- 20.1 uM)
- ChEMBL_2348168 Positive allosteric modulation of human alpha7 nAChR expressed in HEK cells assessed as potentiation of acetylcholine induced peak current amplitude preincubated for 58 secs followed by acetylcholine stimulation for 1 secs by automated patch-clamp electrophysiology
- ChEMBL_1888405 (CHEMBL4390082) Positive allosteric modulation activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as increase in acetylcholine-induced channel current by measuring acetylcholine EC50 at 10 uM at -90 mV holding potential preincubated for 2 mins followed by co-application with acetylcholine for 10 secs by two-electrode voltage clamp method (Rvb = 231.8 +/- 2 uM)
- ChEBML_138139 Inhibition of [3H]QNB binding to CHO cells bearing transfected muscarinic acetylcholine receptor M1
- ChEBML_138278 Ability to displace [3H]oxotremorine from Muscarinic acetylcholine receptor M1 expressed in CHO cells.
- ChEBML_138301 In vitro contraction of guinea pig myenteric plexus preparation (mediated by muscarinic acetylcholine receptor M3)
- ChEBML_138550 Inhibition of [3H]pirenzepine binding to mouse muscarinic acetylcholine receptor M1 from cerebral cortex
- ChEBML_138691 Binding affinity towards muscarinic receptor of cerebral cortex containing Muscarinic acetylcholine receptor M1
- ChEBML_138961 Binding affinity to m-AcChR subtype Muscarinic acetylcholine receptor M3 of rat sabmandibular glands
- ChEBML_139462 Binding affinity to muscarinic acetylcholine receptor was determined in presence of [3H]OXO-M radioligand (in vitro)
- ChEBML_139765 Binding affinity against Muscarinic acetylcholine receptor M2 stably expressed in CHO-K1 cells.
- ChEBML_140042 Binding affinity towards muscarinic receptor of gastric fundus containing Muscarinic acetylcholine receptor M2
- ChEBML_140043 Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates
- ChEBML_140160 Binding affinity against Muscarinic acetylcholine receptor M1 by displacement of [3H]pirenzepine in bovine striatum
- ChEBML_140188 Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem
- ChEBML_144181 Binding affinity towards Nicotinic acetylcholine receptor alpha-7 using [3H]-MLA as radioligand
- ChEBML_144185 Inhibition of [125I]MLA binding to Nicotinic acetylcholine receptor alpha7 from rat brain membranes
- ChEBML_1679911 Positive allosteric modulation of rat M4 receptor assessed as increase in acetylcholine-induced calcium mobilization
- ChEMBL_138132 (CHEMBL747253) Compound is evaluated for in vitro receptor binding affinity against Muscarinic acetylcholine receptor M1
- ChEMBL_138264 (CHEMBL743981) Compound was tested for its potency against Muscarinic acetylcholine receptor in guinea pig ileum
- ChEMBL_138316 (CHEMBL743827) Binding affinity towards Muscarinic acetylcholine receptor M3 was determined in guinea pig ileum
- ChEMBL_138351 (CHEMBL858331) Compound was evaluated for binding activity against [3H]dexetimide as radioligand for muscarinic-acetylcholine receptor
- ChEMBL_138385 (CHEMBL749219) Inhibition of [3H]QNB binding against muscarinic acetylcholine receptor in guinea pig ileum
- ChEMBL_138539 (CHEMBL746257) Affinity for Muscarinic acetylcholine receptor M1 expressed in CHO cells by [3H]NMS displacement.
- ChEMBL_138542 (CHEMBL746260) Compound was tested for binding affinity against human cloned Muscarinic acetylcholine receptor M1
- ChEMBL_138556 (CHEMBL746423) Tested against Muscarinic acetylcholine receptor M1 expressed in A9 L cell line
- ChEMBL_138643 (CHEMBL749273) Compound was tested for the binding affinity towards muscarinic acetylcholine receptor in mouse brain membrane
- ChEMBL_138645 (CHEMBL749274) Dissociation constant towards Muscarinic acetylcholine receptor was determined by using [3H]4NMPB as radioligand
- ChEMBL_138646 (CHEMBL749275) Compound was tested for the binding affinity towards muscarinic acetylcholine receptor in mouse brain membrane
- ChEMBL_138647 (CHEMBL749276) Dissociation constant towards Muscarinic acetylcholine receptor was determined by using [3H]4NMPB as radioligand
- ChEMBL_138656 (CHEMBL748800) Displacement of [3H]quinuclidinyl benzilate (QNB) from Muscarinic acetylcholine receptor in rat brain
- ChEMBL_138657 (CHEMBL872439) Displacement of [3H]quinuclidinyl benzilate(QNB) from Muscarinic acetylcholine receptor in rat brain
- ChEMBL_138660 (CHEMBL748803) Binding affinity against Muscarinic acetylcholine receptor in rat brain using [3H]- QNB
- ChEMBL_138775 (CHEMBL747403) Binding affinity against Muscarinic acetylcholine receptor in rat brain using [3H]- QNB
- ChEMBL_138778 (CHEMBL747406) Inhibition of [3H]oxotremorine-M binding to rat brain membrane Muscarinic acetylcholine receptor
- ChEMBL_138803 (CHEMBL751538) Displacement of [3H]pirenzepine (Pz) from rat hippocampus muscarinic acetylcholine receptor M1
- ChEMBL_138827 (CHEMBL752409) Affinity for Muscarinic acetylcholine receptor M3 expressed in CHO cells by [3H]-NMS displacement.
- ChEMBL_138834 (CHEMBL753022) Tested against Muscarinic acetylcholine receptor M3 expressed in A9 L cell line
- ChEMBL_138952 (CHEMBL742764) Binding affinity against Muscarinic acetylcholine receptor M1 by using [3H]pirenzepine as a radioligand
- ChEMBL_138954 (CHEMBL742766) Displacement of [3H]pirenzepine from muscarinic acetylcholine receptor M1 of rat brain membrane
- ChEMBL_138959 (CHEMBL742771) Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor in rat cortex
- ChEMBL_138975 (CHEMBL857564) Inhibition of [3H]NMS binding to rat submaxillary gland Muscarinic acetylcholine receptor M3
- ChEMBL_139069 (CHEMBL745664) Ability to displace [3H]pirenzepine radioligand for the Muscarinic acetylcholine receptor M1 in rat brain
- ChEMBL_139224 (CHEMBL745699) Dissociation constant at muscarinic acetylcholine receptor M2 guinea pig heart(atria force).
- ChEMBL_139225 (CHEMBL745700) Dissociation constant at muscarinic acetylcholine receptor M2 of guinea pig heart(atria rate).
- ChEMBL_139240 (CHEMBL746455) Affinity for Muscarinic acetylcholine receptor M4 expressed in CHO cells by [3H]NMS displacement.
- ChEMBL_139314 (CHEMBL752307) Inhibition of [3H]QNB binding to muscarinic acetylcholine receptor of rat heart membrane preparation.
- ChEMBL_139341 (CHEMBL749945) Compound is evaluated for in vitro receptor binding affinity against Muscarinic acetylcholine receptor M2
- ChEMBL_139382 (CHEMBL747135) Agonistic activity against muscarinic acetylcholine receptor M5 expressed in NIH 3T3 cells
- ChEMBL_139383 (CHEMBL747136) Agonistic activity against muscarinic acetylcholine receptor M5 expressed in NIH 3T3 cells.
- ChEMBL_139389 (CHEMBL747002) Inhibition of [3H]- NMS binding against human recombinant Muscarinic acetylcholine receptor M5
- ChEMBL_139390 (CHEMBL747003) Affinity for human muscarinic acetylcholine receptor M5 subtype expressed in CHO-K1 cells
- ChEMBL_139394 (CHEMBL747160) Inhibition of [3H]- NMS binding against human recombinant Muscarinic acetylcholine receptor M5
- ChEMBL_139457 (CHEMBL752165) Binding affinity against Muscarinic acetylcholine receptor using [3H]-OXO-M as the radioligand.
- ChEMBL_139463 (CHEMBL752171) Binding affinity to muscarinic acetylcholine receptor was determined in presence of [3H]QNB radioligand (in vitro)
- ChEMBL_139466 (CHEMBL748174) Inhibition of [3H]N-methylscopolamine binding to muscarinic acetylcholine receptor of rat cerebral cortex.
- ChEMBL_139512 (CHEMBL748269) Affinity for Muscarinic acetylcholine receptor M5 expressed in CHO cells by [3H]NMS displacement.
- ChEMBL_139885 (CHEMBL857563) Affinity for Muscarinic acetylcholine receptor M2 expressed in CHO cells by [3H]NMS displacement.
- ChEMBL_139889 (CHEMBL744476) Compound was tested for binding affinity against human cloned Muscarinic acetylcholine receptor M2
- ChEMBL_140045 (CHEMBL745720) Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart
- ChEMBL_140141 (CHEMBL749190) The compound was tested for binding affinity against Muscarinic acetylcholine receptor using QNB as radioligand
- ChEMBL_140142 (CHEMBL749191) The compound was tested for binding affinity against muscarinic acetylcholine receptor using QNB as radioligand
- ChEMBL_140161 (CHEMBL745466) Binding affinity towards Muscarinic acetylcholine receptor M1 was determined in calf brain membrane
- ChEMBL_140178 (CHEMBL745630) Binding affinity to m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart
- ChEMBL_140181 (CHEMBL744098) Affinity for rat M1 acetylcholine receptor using [3H]-AF DX 384 displacement.
- ChEMBL_143225 (CHEMBL750086) Binding affinity towards nicotinic acetylcholine receptor alpha2-beta2 using [3H]epibatidine
- ChEMBL_143232 (CHEMBL750093) Binding affinity towards Nicotinic acetylcholine receptor alpha2-beta4 using [3H]epibatidine
- ChEMBL_143249 (CHEMBL752537) Binding affinity towards Nicotinic acetylcholine receptor alpha3-beta2 using [3H]epibatidine
- ChEMBL_143405 (CHEMBL872961) Binding affinity towards Nicotinic acetylcholine receptor alpha3-beta4 using [3H]epibatidine
- ChEMBL_143541 (CHEMBL754719) Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor alpha4-beta2
- ChEMBL_143543 (CHEMBL754721) Compound was evaluated for functional potency and efficacy at human Nicotinic acetylcholine receptor alpha4-beta2
- ChEMBL_143552 (CHEMBL755325) Antagonism of ACh response at Nicotinic acetylcholine receptor alpha4-beta2 expressed in xenopus oocytes
- ChEMBL_143560 (CHEMBL755332) Compound was evaluated for functional potencies and efficacies at rat Nicotinic acetylcholine receptor alpha4-beta2
- ChEMBL_143564 (CHEMBL755336) Compound was evaluated for functional potency and efficacy at human Nicotinic acetylcholine receptor alpha4-beta2
- ChEMBL_143697 (CHEMBL754303) Displacement of [3H]cytisine from Nicotinic acetylcholine receptor alpha4-beta2 in rat forebrain
- ChEMBL_143728 (CHEMBL756124) Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta2 using [3H]epibatidine
- ChEMBL_143866 (CHEMBL751222) Inhibition of [3H]nicotine binding to Nicotinic acetylcholine receptor alpha4-beta2 in rat brain
- ChEMBL_143873 (CHEMBL751229) [3H](+/-)-epibatidine binding to Nicotinic acetylcholine receptor alpha4-beta2 from rat membranes
- ChEMBL_143886 (CHEMBL751869) Blockage of Nicotinic acetylcholine receptor alpha4-beta2 noncompetitively in CA1 stratum radiatum interneurons
- ChEMBL_144015 (CHEMBL750430) Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta4 using [3H]epibatidine
- ChEMBL_144034 (CHEMBL872836) Compound was evaluated for inhibition of rat Nicotinic acetylcholine receptor alpha7 (nAChR) in Xenopus Oocytes
- ChEMBL_144168 (CHEMBL748943) Binding affinity of Norditerpenoid Alkaloids at rat neuronal alpha7-type nicotinic acetylcholine receptor
- ChEMBL_144964 (CHEMBL755082) Compound was evaluated for inhibition of [3H]TCP binding to Nicotinic acetylcholine receptor of Torpedo californica
- ChEMBL_1504717 (CHEMBL3594853) Displacement of [3H]-methyllycaconitine from alpha7 nicotine acetylcholine receptor in rat brain membranes
- ChEMBL_1746221 (CHEMBL4180731) Positive allosteric modulation of human M1 receptor assessed as increase in acetylcholine-induced response
- ChEMBL_1746222 (CHEMBL4180732) Positive allosteric modulation of human M2 receptor assessed as increase in acetylcholine-induced response
- ChEMBL_1746223 (CHEMBL4180733) Positive allosteric modulation of human M3 receptor assessed as increase in acetylcholine-induced response
- ChEMBL_1746224 (CHEMBL4180734) Positive allosteric modulation of human M5 receptor assessed as increase in acetylcholine-induced response
- ChEMBL_1804487 (CHEMBL4303090) Activity of compound against Muscarinic acetylcholine receptor M1 (CHRM1) by displacement of 3H-QNB
- ChEMBL_1804550 (CHEMBL4303774) Activity of compound against Muscarinic acetylcholine receptor M2 (CHRM2) by displacement of 3H-QNB
- ChEMBL_1804551 (CHEMBL4303775) Activity of compound against Muscarinic acetylcholine receptor M3 (CHRM3) by displacement of 3H-QNB
- ChEMBL_1804552 (CHEMBL4303776) Activity of compound against Muscarinic acetylcholine receptor M4 (CHRM4) by displacement of 3H-QNB
- ChEMBL_1804553 (CHEMBL4303777) Activity of compound against Muscarinic acetylcholine receptor M5 (CHRM5) by displacement of 3H-QNB
- ChEMBL_222735 (CHEMBL845219) Tested for affinity against muscarinic acetylcholine using [3H]quinuclidinyl benzylate in rat brain
- ChEMBL_2261387 (CHEMBL5216398) Binding affinity to Muscarinic acetylcholine receptor M1 (unknown origin) assessed as inhibition constant
- ChEMBL_2261388 (CHEMBL5216399) Binding affinity to Muscarinic acetylcholine receptor M2 (unknown origin) assessed as inhibition constant
- ChEMBL_2261389 (CHEMBL5216400) Binding affinity to Muscarinic acetylcholine receptor M3 (unknown origin) assessed as inhibition constant
- ChEMBL_27660 (CHEMBL636849) Inhibition of active transport of [3H]acetylcholine using purified Torpedo californica synaptic vesicles
- ChEMBL_28502 (CHEMBL645931) In vitro inhibitory concentration against Muscarinic acetylcholine receptor derived from rat adrenals
- ChEMBL_303377 (CHEMBL839695) Inhibition of [3H]alpha-bungarotoxin binding to nicotinic acetylcholine receptor alpha7 of IMR32 cells
- ChEMBL_304220 (CHEMBL828936) Effective concentration against alpha3-beta4 nicotinic acetylcholine receptor expressed in IMR32 cell
- ChEMBL_304305 (CHEMBL830100) Effective concentration against Nicotinic acetylcholine receptor alpha 7 expressed in xenopus oocytes
- ChEMBL_304329 (CHEMBL839756) Effective concentration against Nicotinic acetylcholine receptor alpha3-beta2 expressed in xenopus oocytes
- ChEMBL_306078 (CHEMBL833032) Inhibitory concentration against Nicotinic acetylcholine receptor alpha7; Range is 0.5-8 nM
- ChEMBL_306101 (CHEMBL830876) Inhibitory concentration against Nicotinic acetylcholine receptor alpha7; Range is 100-200 nM
- ChEMBL_306102 (CHEMBL830877) Inhibitory concentration against Nicotinic acetylcholine receptor alpha9; Range is 100-200 nM
- ChEMBL_306126 (CHEMBL833065) Inhibitory concentration against Nicotinic acetylcholine receptor alpha7; Range is 0.3-1.5 nM
- ChEMBL_306143 (CHEMBL831378) Inhibitory concentration against Nicotinic acetylcholine receptor alpha7; Range is 0.3-1.5 nM
- ChEMBL_306526 (CHEMBL827277) Inhibitory concentration against Nicotinic acetylcholine receptor alpha3-beta2 expressed in xenopus oocytes
- ChEMBL_320891 (CHEMBL872390) Binding affinity for rat cortex muscarinic acetylcholine receptor M1 using [3H]pirenzepine
- ChEMBL_321674 (CHEMBL872169) Agonistic activity against Muscarinic acetylcholine receptor of guinea pig ileal longitudinal muscle
- ChEMBL_39943 (CHEMBL653226) Effect on alpha3-beta4 neuronal nicotinic acetylcholine receptor-stimulated adrenal catecholamine secretion
- ChEMBL_613843 (CHEMBL1067133) Inhibition of human recombinant AChE-mediated hydrolysis of acetylcholine by Lineweaver-Burke plot analysis
- ChEMBL_653619 (CHEMBL1226991) Displacement of acetylcholine from AChE in Swiss Webster mouse brain after 5 mins
- ChEMBL_674713 (CHEMBL1273966) Inhibition of equine BChE after 15 mins by Ellman's method using acetylcholine as substrate
- ChEMBL_851173 (CHEMBL2157830) Partial agonist activity at human alpha7 nAChR expressed in Xenopus oocytes relative to acetylcholine
- ChEMBL_851174 (CHEMBL2157831) Partial agonist activity at human alpha7 nAChR expressed in GH4C1 cells relative to acetylcholine
- ChEMBL_1508833 (CHEMBL3603305) Antagonist activity at rat alpha-7 nicotinic acetylcholine receptor expressed in Xenopus oocytes assessed as inhibition of acetylcholine-induced currents preincubated for 10 mins followed by nicotine induction by two-electrode voltage-clamp electrophysiology assay
- ChEMBL_1636028 (CHEMBL3878926) Antagonist activity at human 5-HT3A expressed in HEK293 cells assessed as reduction in acetylcholine-induced activity preincubated for 30 mins followed by addition of acetylcholine measured for 2 mins by Fluo-4AM dye based FLIPR assay
- ChEMBL_830306 (CHEMBL2060895) Positive allosteric modulation of human M4 receptor expressed in CHO-K1 cells coexpressing Gqi5 assessed as potentiation of acetylcholine-mediated calcium mobilization incubated for 144 secs prior to acetylcholine addition by Fluo-4-AM staining
- ChEMBL_1700423 (CHEMBL4051405) Ratio of binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as dissociation rate constant to binding affinity to human muscarinic acetylcholine receptor M2 expressed in CHOK9 cells assessed as association rate constant
- ChEMBL_1863409 (CHEMBL4364384) Positive allosteric modulatory activity at rat alpha7 nAChR expressed in GH4C1 cells assessed as potentiation of acetylcholine response at -70 mV holding potential preincubated for 30 secs followed by co-application with acetylcholine by manual patch clamp assay
- ChEMBL_2223584 (CHEMBL5136918) Antagonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response treated for 1 sec in presence of acetylcholine at holding potential of -70 mV by two electrode voltage-clamp assay
- ChEMBL_2223585 (CHEMBL5136919) Antagonist activity at human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response treated for 1 sec in presence of acetylcholine at holding potential of -70 mV by two electrode voltage-clamp assay
- ChEBML_138791 Ability to displace [3H]pirenzepine (pir) from muscarinic acetylcholine receptor M1 in rat cortical tissue.
- ChEBML_138949 Binding affinity towards muscarinic acetylcholine receptor M1 in rat heart using [3H]pirenzepine as radioligand
- ChEBML_138964 Inhibition of binding of [3H]N-methylscopolamine to muscarinic acetylcholine receptor M3 of transfected rat A9L cells.
- ChEBML_138979 The compound was tested for binding activity against muscarinic acetylcholine receptor M3, using [3H]-QNB as the radioligand.
- ChEBML_138980 The compound was tested for binding activity against muscarinic acetylcholine receptor M3, using [3H]-QNB as the radioligand.
- ChEBML_139082 Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M1 of transfected A9L cells.
- ChEBML_139202 The compound was tested for binding activity against muscarinic acetylcholine receptor M1, using [3H]QNB as the radioligand.
- ChEBML_139254 Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M4 of NG108-15 cells.
- ChEBML_139764 Binding affinity against human muscarinic acetylcholine receptor M2 using [3H]N-methylscopolamine as radioligand
- ChEBML_140146 Compound was tested for the binding affinity against muscarinic acetylcholine receptor
by using [3H]QNB as radioligand
- ChEBML_140154 Muscarinic acetylcholine receptor binding affinity was determined using [3H]NMS for NG108-15 neuroblastoma cells
- ChEBML_144040 Activation responses to that evoked by ACh at human Nicotinic acetylcholine receptor alpha-7 expressed in xenopus oocytes
- ChEMBL_138140 (CHEMBL747398) Inhibition of [3H]QNB binding to CHO cells bearing transfected muscarinic acetylcholine receptor M3
- ChEMBL_138278 (CHEMBL744235) Ability to displace [3H]oxotremorine from Muscarinic acetylcholine receptor M1 expressed in CHO cells.
- ChEMBL_138281 (CHEMBL744238) Binding affinity of [3H]-QNB to CHO cells expressing human Muscarinic acetylcholine receptor M1
- ChEMBL_138289 (CHEMBL744321) In vitro affinity against human Muscarinic acetylcholine receptor M1 using quinuclidynyl benzylate (QNB)
- ChEMBL_138395 (CHEMBL744151) In vitro inhibition of binding of (-)-[3H]-NMS to Muscarinic acetylcholine receptor of rat cerebral cortex was determined
- ChEMBL_138399 (CHEMBL744762) Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M1 expressed in CHO cells
- ChEMBL_138544 (CHEMBL746412) Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M1 in transfected CHO cells.
- ChEMBL_138658 (CHEMBL748801) Binding activity against muscarinic acetylcholine receptor in rat brain using [3H]QNB as the radioligand
- ChEMBL_138661 (CHEMBL748804) Binding affinity against Muscarinic acetylcholine receptor in rat striatal membrane using [3H]haloperidol
- ChEMBL_138696 (CHEMBL747663) Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M3 expressed in CHO cells
- ChEMBL_138765 (CHEMBL748832) Compound was evaluated for the inhibition of binding of [3H]QNB (quinuclidinyl benzilate) to striatal Muscarinic acetylcholine receptor
- ChEMBL_138784 (CHEMBL747412) Concentration of compound for 50% displacement of [3H]QNB from Muscarinic acetylcholine receptor in rat brain
- ChEMBL_138832 (CHEMBL752414) Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M3 in transfected CHO cells.
- ChEMBL_138903 (CHEMBL744135) In vitro displacement of [3H]oxotremorine-M from muscarinic acetylcholine receptor in rat brain cortex
- ChEMBL_138934 (CHEMBL746583) Binding activity against rat muscarinic acetylcholine receptor M1 using [3H]QNB as the radioligand
- ChEMBL_138942 (CHEMBL745922) Binding affinity towards Muscarinic acetylcholine receptor M1 using [3H]pirenzepine as radioligand was determined
- ChEMBL_138951 (CHEMBL745931) Binding affinity at Muscarinic acetylcholine receptor M1 in Rat brain homogenate by [3H]pirenzepine displacement.
- ChEMBL_138958 (CHEMBL742770) Compound was evaluated for its binding affinity towards Muscarinic acetylcholine receptor M1 in rat cortex
- ChEMBL_138961 (CHEMBL742773) Binding affinity to m-AcChR subtype Muscarinic acetylcholine receptor M3 of rat sabmandibular glands
- ChEMBL_138978 (CHEMBL742788) Binding activity against rat muscarinic acetylcholine receptor M3 using [3H]QNB as the radioligand
- ChEMBL_139075 (CHEMBL745670) Displacement of [3H]pirenzepine binding at Muscarinic acetylcholine receptor M1 in rat brain P2 membranes.
- ChEMBL_139238 (CHEMBL857188) Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M4 expressed in A9 L cells
- ChEMBL_139243 (CHEMBL746610) Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M4 in transfected CHO cells.
- ChEMBL_139311 (CHEMBL752305) Inhibition of [3H]- Oxo-M binding to muscarinic acetylcholine receptor of rat brain membrane preparations
- ChEMBL_139312 (CHEMBL857625) Inhibition of [3H]- Oxo-M binding to muscarinic acetylcholine receptor of rat heart membrane preparation.
- ChEMBL_139317 (CHEMBL752310) The compound was tested for inhibition of [3H]NMS binding against muscarinic acetylcholine receptor in rat brain
- ChEMBL_139320 (CHEMBL752313) Inhibition of [3H]OXO-M binding against muscarinic acetylcholine receptor in rat brain membranes
- ChEMBL_139452 (CHEMBL751549) Binding activity to the muscarinic acetylcholine receptor in rat cortex, assayed using [3H]CD as a radioligand.
- ChEMBL_139453 (CHEMBL751550) Binding activity to the muscarinic acetylcholine receptor in rat cortex, assayed using [3H]PZ as a radioligand.
- ChEMBL_139454 (CHEMBL751551) Binding activity against Muscarinic acetylcholine receptor in rat cortex, using [3H]QNB as a radioligand.
- ChEMBL_139456 (CHEMBL751553) Binding activity to muscarinic acetylcholine receptor in rat heart, assayed using [3H]-QNB as a radioligand.
- ChEMBL_139462 (CHEMBL752170) Binding affinity to muscarinic acetylcholine receptor was determined in presence of [3H]OXO-M radioligand (in vitro)
- ChEMBL_139517 (CHEMBL748274) Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M5 in transfected CHO cells.
- ChEMBL_139579 (CHEMBL741870) In vitro inhibition of binding of (-)-[3H]-NMS to Muscarinic acetylcholine receptor of rat cerebral cortex was determined
- ChEMBL_139581 (CHEMBL741872) In vitro for binding affinity for muscarinic acetylcholine receptors in homogenized rat brain in the presence of [3H]scopolamine.
- ChEMBL_139624 (CHEMBL749006) Binding affinity of [3H]QNB to CHO cells expressing human Muscarinic acetylcholine receptor M2
- ChEMBL_139640 (CHEMBL748253) Inhibition of [3H]NMS binding to human muscarinic acetylcholine receptor M2 expressed in CHO cells
- ChEMBL_139743 (CHEMBL743996) The ability to displace [3H]QNB from Muscarinic acetylcholine receptor in rat brain membrane was determined
- ChEMBL_139744 (CHEMBL743997) Binding activity against Muscarinic acetylcholine receptor in rat cortex, using [3H]QNB as a radioligand.
- ChEMBL_139767 (CHEMBL748903) Compound was tested for its binding affinity against cloned human Muscarinic acetylcholine receptor M2
- ChEMBL_139782 (CHEMBL857186) Inhibitory activity was evaluated against Muscarinic acetylcholine receptor M2 expressed in A9 L cells
- ChEMBL_139858 (CHEMBL746355) Binding activity against Muscarinic acetylcholine receptor in rat cortex, using [3H]QNB as a radioligand.
- ChEMBL_139891 (CHEMBL744478) Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M2 in transfected CHO cells.
- ChEMBL_140026 (CHEMBL745569) Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart
- ChEMBL_140041 (CHEMBL744021) Inhibition of [3H]N-methylscopolamine to rat muscarinic acetylcholine receptor M2 from heart tissue
- ChEMBL_140044 (CHEMBL744024) Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane
- ChEMBL_140047 (CHEMBL745864) Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.
- ChEMBL_140157 (CHEMBL745463) The compound was evaluated for its ability to inhibit [3H]NMS binding to Muscarinic acetylcholine receptor in heart
- ChEMBL_140174 (CHEMBL745478) Binding affinity against Muscarinic acetylcholine receptor M2 by displacement of [3H]QNB in rat myocardium
- ChEMBL_140176 (CHEMBL745628) Binding affinity against m-AcChR subtype Muscarinic acetylcholine receptor M2 of rat heart.
- ChEMBL_140182 (CHEMBL744099) Inhibition of [3H]N-methylscopolamine binding to Muscarinic acetylcholine receptor M2 of rat heart membranes
- ChEMBL_140187 (CHEMBL744904) Compound was evaluated for its binding affinity towards Muscarinic acetylcholine receptor M2 in rat brainstem
- ChEMBL_140188 (CHEMBL744905) Compound was evaluated for its binding affinity towards muscarinic acetylcholine receptor M2 in rat brainstem
- ChEMBL_142900 (CHEMBL882328) Compound was evaluated for functional potencies and efficacies at rat Nicotinic acetylcholine receptor subtype PC12 (ganglionic)
- ChEMBL_143065 (CHEMBL750930) In vitro inhibition of 5-(125I)A-85380 binding to nicotinic acetylcholine receptor (nAChR) of rat brain
- ChEMBL_143715 (CHEMBL753466) Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta2 using [3H]nicotine as radioligand
- ChEMBL_143729 (CHEMBL756125) Binding affinity towards nicotinic acetylcholine receptor alpha4-beta2 from rat brain homogenates
- ChEMBL_143859 (CHEMBL748863) Inhibition of [125I]-analogue binding to Nicotinic acetylcholine receptor alpha4-beta2 from rat membranes
- ChEMBL_143860 (CHEMBL748864) Inhibition of [3H]epibatidine binding to Nicotinic acetylcholine receptor alpha4-beta2 from rat membranes
- ChEMBL_143861 (CHEMBL748865) Inhibition of [3H]epibatidine binding to Nicotinic acetylcholine receptor alpha4-beta2 from rat membranes
- ChEMBL_143864 (CHEMBL750613) Inhibition of [3H]nicotine binding to Nicotinic acetylcholine receptor alpha4-beta2 from rat membranes
- ChEMBL_143867 (CHEMBL751223) Inhibition of [3H]nicotine binding to Nicotinic acetylcholine receptor alpha4-beta2 in rat brain membranes
- ChEMBL_144167 (CHEMBL748942) Compound was evaluated for inhibition of rat Nicotinic acetylcholine receptor alpha-7 (nAChR) in Xenopus Oocytes
- ChEMBL_144177 (CHEMBL749558) Binding affinity in rat hippocampi against Nicotinic acetylcholine receptor alpha7; value range is 1000.
- ChEMBL_144185 (CHEMBL749306) Inhibition of [125I]MLA binding to Nicotinic acetylcholine receptor alpha7 from rat brain membranes
- ChEMBL_144958 (CHEMBL755076) Inhibition of currents when compound wascoapplied with acetylcholine to recombinant Torpedo nAcChoR (from 6 oocytes)
- ChEMBL_144959 (CHEMBL755077) Inhibition of currents when compound wascoapplied with acetylcholine to recombinant Torpedo nAcChoR (from 6 oocytes)
- ChEMBL_1588013 (CHEMBL3824948) Positive allosteric modulation at human muscarinic acetylcholine receptor M1 assessed as effect on receptor internalization
- ChEMBL_1679911 (CHEMBL4030188) Positive allosteric modulation of rat M4 receptor assessed as increase in acetylcholine-induced calcium mobilization
- ChEMBL_1700417 (CHEMBL4051399) Displacement of [3H]NMS from human muscarinic acetylcholine receptor M2 expressed in CHOK1 cells
- ChEMBL_1810469 (CHEMBL4309929) Positive allosteric modulation of M5 AchR (unknown origin) assessed as increase in acetylcholine-induced response
- ChEMBL_1929130 (CHEMBL4432306) Antagonist activity at human muscarinic M5 receptor assessed as inhibition of acetylcholine-induced calcium response
- ChEMBL_1929131 (CHEMBL4432307) Antagonist activity at human muscarinic M1 receptor assessed as inhibition of acetylcholine-induced calcium response
- ChEMBL_1929132 (CHEMBL4432308) Antagonist activity at human muscarinic M2 receptor assessed as inhibition of acetylcholine-induced calcium response
- ChEMBL_1929133 (CHEMBL4432309) Antagonist activity at human muscarinic M3 receptor assessed as inhibition of acetylcholine-induced calcium response
- ChEMBL_1929134 (CHEMBL4432310) Antagonist activity at human muscarinic M4 receptor assessed as inhibition of acetylcholine-induced calcium response
- ChEMBL_1993992 (CHEMBL4627887) Inhibition of Electric eel AChE using acetylcholine iodide as substrate by spectrophotometry based Ellman's method
- ChEMBL_2130782 (CHEMBL4840211) Inhibition of electric eel AChE using acetylcholine iodide as a substrate by Cornish-Bowden plot analysis
- ChEMBL_2224364 (CHEMBL5137877) Inhibition of AChE (unknown origin) using acetylcholine as substrate preincubated for 15 mins by Ellman's method
- ChEMBL_223069 (CHEMBL842919) Ability to block activation of acetylcholine-stimulated currents in human alpha-7 homomers expressed in oocytes
- ChEMBL_2309362 Inhibition of rat alpha6/alpha3beta4 nAChR expressed in Xenopus Oocytes in presence of acetylcholine by Voltage-clamp recording
- ChEMBL_303326 (CHEMBL840051) Inhibition of [3H]-MLA binding to alpha-7 nicotinic acetylcholine receptor of rat brain membrane
- ChEMBL_303385 (CHEMBL839702) Inhibition of [3H]MLA binding to alpha4-beta2 nicotinic acetylcholine receptor of rat brain membrane
- ChEMBL_303391 (CHEMBL839962) Inhibition of methyllycaconitine (MLA) binding to Nicotinic acetylcholine receptor alpha-7 in rat brain homogenates
- ChEMBL_303459 (CHEMBL839719) Inhibition of [3H]nicotine binding to alpha4-beta2 nicotinic acetylcholine receptor of rat brain membrane
- ChEMBL_303479 (CHEMBL838853) Inhibition of [3H]nicotine binding to alpha4-beta2 nicotinic acetylcholine receptor of rat brain membrane
- ChEMBL_303546 (CHEMBL839751) Inhibition of [3H]epibatidine binding to Nicotinic acetylcholine receptor alpha4-beta2 in rat cerebral cortex
- ChEMBL_303577 (CHEMBL828976) Inhibition of [3H]-BTX binding to Nicotinic acetylcholine receptor alpha-7 of rat hippocampal membranes
- ChEMBL_303639 (CHEMBL828849) Inhibition of [3H]nicotine binding to Nicotinic acetylcholine receptor alpha4-beta2 of rat cortical membranes
- ChEMBL_303640 (CHEMBL828850) Inhibition of [3H]- cytisine binding to Nicotinic acetylcholine receptor alpha4-beta2 of rat cortical membranes
- ChEMBL_303641 (CHEMBL828851) Inhibition of [3H]cytisine binding to Nicotinic acetylcholine receptor alpha4-beta2 of rat cortical membranes
- ChEMBL_303642 (CHEMBL828852) Inhibition of [3H]cytisine binding to Nicotinic acetylcholine receptor alpha4-beta2 of rat cortical membranes
- ChEMBL_303679 (CHEMBL830439) Inhibition of [3H]epibatidine binding to Nicotinic acetylcholine receptor alpha4-beta2 of rat cortical membranes
- ChEMBL_303683 (CHEMBL830443) Displacement of [3H]-cytisine from Alpha4-beta2 Nicotinic acetylcholine receptor of rat brain homogenates
- ChEMBL_303705 (CHEMBL829040) Displacement of [3H]epibatidine from Alpha3 Beta4 Nicotinic acetylcholine receptor of rat brain homogenates
- ChEMBL_304253 (CHEMBL829724) Effective concentration against alpha3-beta4 nicotinic acetylcholine receptor (nAChR) expressed in IMR32 cell
- ChEMBL_304254 (CHEMBL829725) Effective concentration against alpha3-beta4 nicotinic acetylcholine receptor (nAChR) expressed in IMR32 cell
- ChEMBL_304259 (CHEMBL829730) Effective concentration against Nicotinic acetylcholine receptor alpha 7 in rat mid brain slices
- ChEMBL_304286 (CHEMBL829887) Effective concentration against alpha3-beta4 nicotinic acetylcholine receptor (nAChR) expressed in Xenopus oocytes
- ChEMBL_305955 (CHEMBL874549) Inhibitory concentration against Nicotinic acetylcholine receptor alpha-7 Range is 3-5 nM
- ChEMBL_306141 (CHEMBL831376) Inhibitory concentration against Nicotinic acetylcholine receptor alpha4-beta2; Range is 3-5 nM
- ChEMBL_306172 (CHEMBL830967) Inhibitory concentration against Nicotinic acetylcholine receptor alpha3-beta2; Range is 3-5 nM
- ChEMBL_306215 (CHEMBL831124) Inhibitory concentration against Nicotinic acetylcholine receptor alpha3-beta2; Range is 0.5-8 nM
- ChEMBL_306217 (CHEMBL874559) Inhibitory concentration against Nicotinic acetylcholine receptor alpha4-beta2; Range is 0.5-8 nM
- ChEMBL_306274 (CHEMBL827551) Inhibitory concentration against Nicotinic acetylcholine receptor alpha2-beta2; Range is 0.3-1.5 nM
- ChEMBL_306275 (CHEMBL827552) Inhibitory concentration against Nicotinic acetylcholine receptor alpha2-beta4; Range is 0.3-1.5 nM
- ChEMBL_306276 (CHEMBL827553) Inhibitory concentration against Nicotinic acetylcholine receptor alpha3-beta2; Range is 0.3-1.5 nM
- ChEMBL_306279 (CHEMBL828422) Inhibitory concentration against Nicotinic acetylcholine receptor alpha4-beta2; Range is 0.3-1.5 nM
- ChEMBL_306297 (CHEMBL828589) Inhibitory concentration against Nicotinic acetylcholine receptor alpha2-beta4; Range is 0.3-1.5 nM
- ChEMBL_306298 (CHEMBL828590) Inhibitory concentration against Nicotinic acetylcholine receptor alpha4-beta2; Range is 0.3-1.5 nM
- ChEMBL_320907 (CHEMBL881234) Binding affinity for rat heart muscarinic acetylcholine receptor M2 using [3H]quinuclidinyl benzilate
- ChEMBL_563561 (CHEMBL961848) Activity at human alpha7 nAChR expressed in Xenopus oocytes assessed as inhibition of acetylcholine-evoked current
- ChEMBL_563562 (CHEMBL961849) Activity at human alpha4beta2 nAChR expressed in Xenopus oocytes assessed as inhibition of acetylcholine-evoked current
- ChEMBL_611542 (CHEMBL1066386) Displacement of [125I]BTX from rat alpha7 nicotinic acetylcholine receptor expressed in GH4C1 cells
- ChEMBL_611804 (CHEMBL1069499) Displacement of [125I]BTX from human alpha7 nicotinic acetylcholine receptor expressed in IMR32 cells
- ChEMBL_645015 (CHEMBL1211464) Displacement of [125I]alpha-bungarotoxin from alpha7 nicotinic acetylcholine receptor in rat brain membrane
- ChEMBL_674712 (CHEMBL1273965) Inhibition of electric eel AChE after 15 mins by Ellman's method using acetylcholine as substrate
- ChEMBL_792865 (CHEMBL1931050) Inhibition of equine serum BuChE using acetylcholine as substrate preincubated for 15 mins by Ellman's method
- ChEMBL_828579 (CHEMBL2060094) Antagonist activity at human muscarinic M2 receptor assessed as inhibition of acetylcholine-induced calcium mobilization
- ChEMBL_830694 (CHEMBL2061629) Antagonist activity at human muscarinic M5 receptor assessed as inhibition of acetylcholine-induced calcium mobilization
- ChEMBL_830695 (CHEMBL2061630) Antagonist activity at human muscarinic M4 receptor assessed as inhibition of acetylcholine-induced calcium mobilization
- ChEMBL_830696 (CHEMBL2061631) Antagonist activity at human muscarinic M3 receptor assessed as inhibition of acetylcholine-induced calcium mobilization
- ChEMBL_908778 (CHEMBL3066846) Displacement of [3H]IMI from Musca domestica (house fly) brain nicotinic acetylcholine receptor
- ChEMBL_939334 (CHEMBL2327469) Competitive inhibition of Electrophorus electricus AChE using acetylcholine as substrate by Lineweaver-Burk plot method
- ChEMBL_957891 (CHEMBL2377916) Competitive inhibition of equine serum BChE by Lineweaver Burk reciprocal plot analysis in presence of acetylcholine
- ChEMBL_960029 (CHEMBL2384199) Positive allosteric modulation of rat muscarinic M5 receptor assessed as effect on acetylcholine-induced response
- ChEMBL_1765196 (CHEMBL4200443) Positive allosteric modulation of human muscarinic acetylcholine receptor M4 expressed in CHO-K1 cells coexpressing Galphaqi5 assessed as increase in acetylcholine-induced IP accumulation incubated for 16 to 20 hrs measured for 3.5 to 4 mins by FLIPR assay
- ChEMBL_1906149 (CHEMBL4408507) Induction of desensitization at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine induced current treated with compound prior to 100 uM acetylcholine challenge at -90 mV holding potential by two-electrode voltage clamp method
- Cell-Based Functional Assay (M1) Muscarinic acetylcholine receptor M1 was cloned into an expression vector and transfected in CHO cells along with CRE-Luc reporter system. Isolated colonies were screened with 10,000 nM acetylcholine. Clones exhibiting highest acetylcholine dependent reporter gene induction were utilized in the evaluation of known and novel compounds. Increasing concentrations of the compound were incubated with or without 10,000 nM acetylcholine for antagonist or agonist mode, respectively, for 5 h in 96 well plate. After incubation, cells were harvested, lysed and reporter gene activity was determined.
- ChEMBL_1780191 (CHEMBL4237183) Positive allosteric modulation of rat M1 receptor expressed in CHO cells assessed as increase in acetylcholine-induced calcium mobilization pretreated for 2.5 mins followed by acetylcholine addition and measured after 1 min by Fluo-4-AM dye based assay
- ChEMBL_1780193 (CHEMBL4237185) Positive allosteric modulation of human M1 receptor expressed in CHO cells assessed as increase in acetylcholine-induced calcium mobilization pretreated for 2.5 mins followed by acetylcholine addition and measured after 1 min by Fluo-4-AM dye based assay
- ChEMBL_1780206 (CHEMBL4237198) Positive allosteric modulation of human M3 receptor expressed in CHO cells assessed as increase in acetylcholine-induced calcium mobilization pretreated for 2.5 mins followed by acetylcholine addition and measured after 1 min by Fluo-4-AM dye based assay
- ChEMBL_1780208 (CHEMBL4237200) Positive allosteric modulation of human M5 receptor expressed in CHO cells assessed as increase in acetylcholine-induced calcium mobilization pretreated for 2.5 mins followed by acetylcholine addition and measured after 1 min by Fluo-4-AM dye based assay
- ChEBML_131447 Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine
- ChEBML_138160 Inhibitory constant by the inhibition of [3H]N-methylscopolamine (NMS) binding to Muscarinic acetylcholine receptor M2 of rat heart
- ChEBML_138403 Antimuscarinic potency and subset specificity was characterised by inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M1 subtype
- ChEBML_138664 Compound was evaluated for the competitive inhibition of [3H]pirenzepine binding to muscarinic acetylcholine receptor M1 of mouse cerebral cortex
- ChEBML_138700 Antimuscarinic potency and subset specificity was characterised by inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M3 subtype
- ChEBML_139204 Displacement of [3H]QNB in genetically transformed mouse cell line (m1C2) transfected with Muscarinic acetylcholine receptor M1
- ChEBML_139257 Inhibition of binding of [3H]N-methylscopolamine to Muscarinic acetylcholine receptor M4 in NG 108-15 cell homogenates
- ChEBML_139893 Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex
- ChEBML_140039 Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine
- ChEBML_140147 Compound was tested in vitro for its ability to displace [3H]QNB from brain Muscarinic acetylcholine receptor by 50 %
- ChEBML_140172 In vitro receptor binding against Muscarinic acetylcholine receptor M2 in rat heart was determined using [3H]pirenzepine
- ChEBML_140173 Compound was tested for binding activity against rat muscarinic acetylcholine receptor M2 using [3H]QNB as the radioligand
- ChEBML_165078 Efficacy at muscarinic acetylcholine receptor M1 measured by the ability to inhibit the electrically stimulated twitch of the rabbit vas deferens
- ChEBML_222112 Compound was tested for the inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane
- ChEMBL_138477 (CHEMBL857565) Ability to displace [3H]QNB from HM1 receptor binding to acetylcholine was evaluated by ligand inhibition assay
- ChEMBL_138478 (CHEMBL747467) Ability to displace [3H]QNB from HM1 receptor binding to acetylcholine was evaluated by ligand inhibition assay
- ChEMBL_138483 (CHEMBL749096) Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay
- ChEMBL_138484 (CHEMBL749713) Ability to displace [3H]QNB from HM2 receptor binding to acetylcholine was evaluated by ligand inhibition assay
- ChEMBL_138557 (CHEMBL746424) Binding affinity against mouse Muscarinic acetylcholine receptor M1 using cerebral cortex and [3H]pirenzepine
- ChEMBL_138558 (CHEMBL746425) Binding affinity against mouse muscarinic acetylcholine receptor M1 using cerebral cortex and [3H]pirenzepine
- ChEMBL_138662 (CHEMBL748805) Binding affinity against Muscarinic acetylcholine receptor was measured using radioligand ([3H]QNB) binding assay
- ChEMBL_138764 (CHEMBL747850) Binding affinity was determined against Muscarinic acetylcholine receptor using [3H]QNB as radioligand in rat brain.
- ChEMBL_138772 (CHEMBL747400) In vitro ability to displace [3H]quinuclidinyl benzilate (QNB) from rat cerebral cortexMuscarinic acetylcholine receptor
- ChEMBL_138788 (CHEMBL872434) In Vitro binding affinity to the muscarinic acetylcholine receptor site in rat brain by using [3H]QNB as the radioligand.
- ChEMBL_138802 (CHEMBL751537) Displacement of [3H]oxotremorine-M (Oxo-M) from rat hippocampus muscarinic acetylcholine receptor M1
- ChEMBL_138812 (CHEMBL747493) Binding activity against muscarinic acetylcholine receptor M1 in rat brain, using [3H]-Pz as the radioligand.
- ChEMBL_138949 (CHEMBL745929) Binding affinity towards muscarinic acetylcholine receptor M1 in rat heart using [3H]pirenzepine as radioligand
- ChEMBL_138966 (CHEMBL742778) Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M3 in rat cerebral cortical membranes
- ChEMBL_138980 (CHEMBL747472) The compound was tested for binding activity against muscarinic acetylcholine receptor M3, using [3H]-QNB as the radioligand.
- ChEMBL_139078 (CHEMBL745814) Inhibition of binding of [3H]oxotremorine M to Muscarinic acetylcholine receptor M1 in rat cerebral cortical membranes
- ChEMBL_139079 (CHEMBL745815) Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M1 in rat cerebral cortical membranes
- ChEMBL_139082 (CHEMBL745818) Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M1 of transfected A9L cells.
- ChEMBL_139125 (CHEMBL749863) Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M4 in CHO cell membranes
- ChEMBL_139126 (CHEMBL749864) Inhibition of [3H]- quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M4 expressed in CHO cell membranes
- ChEMBL_139202 (CHEMBL743913) The compound was tested for binding activity against muscarinic acetylcholine receptor M1, using [3H]QNB as the radioligand.
- ChEMBL_139253 (CHEMBL745526) Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M4 in rat cerebral cortical membranes
- ChEMBL_139254 (CHEMBL745527) Inhibition of binding of [3H]N-Methyl-scopolamine to Muscarinic acetylcholine receptor M4 of NG108-15 cells.
- ChEMBL_139458 (CHEMBL752166) Binding affinity against Muscarinic acetylcholine receptor using [3H]oxotremorine-M as radioligand in rat cortex
- ChEMBL_139460 (CHEMBL752168) Binding affinity against Muscarinic acetylcholine receptors using [3H]oxotremorine-M as radioligand in rat cortex
- ChEMBL_139634 (CHEMBL748247) Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the absence of GTP
- ChEMBL_139635 (CHEMBL748248) Inhibitory activity against [3H]quinuclidinyl Benzilate binding to Muscarinic acetylcholine receptor M2 in the presence of GTP
- ChEMBL_140197 (CHEMBL745149) Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes
- ChEMBL_142599 (CHEMBL750565) Compound was evaluated for functional potencies and efficacies at human Nicotinic acetylcholine receptor subtype IMR-32 (ganglionic)
- ChEMBL_142603 (CHEMBL750569) Compound was evaluated for functional potency and efficacy at human muscle type Nicotinic acetylcholine receptor in TE671 cells
- ChEMBL_142765 (CHEMBL750486) Binding affinity towards Nicotinic acetylcholine receptor by the displacement of [3H]-nicotine from rat cortical membranes
- ChEMBL_142899 (CHEMBL748708) The compound was tested for the inhibition of binding of [3H]epibatidine to central nicotinic acetylcholine receptor (nAChR) in rat brain.
- ChEMBL_1432884 (CHEMBL3383297) Inhibition of AChE (unknown origin) assessed as inhibition of acetylcholine hydrolysis preincubated for 15 mins by Ellman method
- ChEMBL_143392 (CHEMBL750859) Antagonism of ACh-evoked responses at human Nicotinic acetylcholine receptor alpha3-beta4 expressed in xenopus oocytes
- ChEMBL_143402 (CHEMBL752657) Functional potency measured as stimulation at rat Nicotinic acetylcholine receptor alpha3-beta4 expressed in Xenopus oocytes
- ChEMBL_143704 (CHEMBL756004) Inhibition of binding of [3H]nicotine to Nicotinic acetylcholine receptor alpha4-beta2 in rat cerebral cortical membranes
- ChEMBL_143717 (CHEMBL753468) Inhibition of [3H]epibatidine binding at the nicotinic acetylcholine receptor alpha4-beta2 in male rat cerebral cortex
- ChEMBL_143719 (CHEMBL753470) Inhibition of [3H]pibatidine binding at the nicotinic acetylcholine receptor alpha4-beta2 in male rat cerebral cortex
- ChEMBL_143721 (CHEMBL753472) Functional potency measured as stimulation at rat Nicotinic acetylcholine receptor alpha4-beta2 expressed in Xenopus oocytes
- ChEMBL_143727 (CHEMBL756123) Binding affinity to Nicotinic acetylcholine receptor alpha4-beta2 using +/-[3H]epibatidine as radioligand in rat brain
- ChEMBL_143879 (CHEMBL751862) Binding affinity at heteropentameric Nicotinic acetylcholine receptor alpha4-beta2 subtype using [3H]bungarotoxin as radioligand
- ChEMBL_1439748 (CHEMBL3385584) Inhibition of acetylcholinesterase (unknown origin) assessed as inhibition of acetylcholine hydrolysis after 30 mins by Ellmann's method
- ChEMBL_144014 (CHEMBL750429) Functional potency measured as stimulation at rat Nicotinic acetylcholine receptor alpha4-beta4 expressed in Xenopus oocytes
- ChEMBL_144025 (CHEMBL750440) Receptor activation after 10 uM application and 300 uM of ACh for Nicotinic acetylcholine receptor alpha7
- ChEMBL_144026 (CHEMBL750441) Receptor activation after 100 uM application and 300 uM of ACh for Nicotinic acetylcholine receptor alpha7
- ChEMBL_144040 (CHEMBL751076) Activation responses to that evoked by ACh at human Nicotinic acetylcholine receptor alpha-7 expressed in xenopus oocytes
- ChEMBL_144043 (CHEMBL884515) Potency was determined by measuring current activation in Xenopus oocytes expressing rat Nicotinic acetylcholine receptor alpha7
- ChEMBL_144180 (CHEMBL749561) Binding affinity to subtype Nicotinic acetylcholine receptor alpha7 using [3H]-MLA as radioligand in rat brain
- ChEMBL_1457825 (CHEMBL3370303) Activity at human muscarinic acetylcholine receptor subtype 3 expressed in CHO cells by calcium mobilization assay
- ChEMBL_1457827 (CHEMBL3370305) Activity at human muscarinic acetylcholine receptor subtype 1 expressed in CHO cells by calcium mobilization assay
- ChEMBL_1457828 (CHEMBL3370306) Activity at rat muscarinic acetylcholine receptor subtype 5 expressed in CHO cells by calcium mobilization assay
- ChEMBL_1457830 (CHEMBL3370308) Activity at rat muscarinic acetylcholine receptor subtype 3 expressed in CHO cells by calcium mobilization assay
- ChEMBL_1457832 (CHEMBL3370310) Activity at rat muscarinic acetylcholine receptor subtype 1 expressed in CHO cells by calcium mobilization assay
- ChEMBL_1588012 (CHEMBL3824947) Positive allosteric modulation at human muscarinic acetylcholine receptor M1 assessed as effect on beta-arrestin recruitment
- ChEMBL_1984257 (CHEMBL4617663) Inhibition of Electrophorus electricus AChE using acetylcholine iodide as substrate incubated for 15 mins by Ellman's method
- ChEMBL_2032522 (CHEMBL4686680) Inhibition of human serum BuChE using acetylcholine iodide as substrate incubated for 15 mins by Ellman's method
- ChEMBL_2032523 (CHEMBL4686681) Inhibition of human erythrocytes AChE using acetylcholine iodide as substrate incubated for 15 mins by Ellman's method
- ChEMBL_2032526 (CHEMBL4686684) Inhibition of Electrophorus electricus AChE using acetylcholine iodide as substrate incubated for 15 mins by Ellman's method
- ChEMBL_2195270 (CHEMBL5107630) Displacement of [3H]-epibatidine from recombinant Lymnaea stagnalis Acetylcholine-binding protein by radioligand binding assay
- ChEMBL_2233511 (CHEMBL5147283) Inhibition of AChE (unknown origin) using acetylcholine iodide as substrate incubated for 10 mins by Ellman's method
- ChEMBL_2233512 (CHEMBL5147284) Inhibition of BChE (unknown origin) using acetylcholine iodide as substrate incubated for 10 mins by Ellman's method
- ChEMBL_2260120 (CHEMBL5215131) Inhibition of AChE (unknown origin) using acetylcholine as substrate by BioTek Synergy HT microplate reader method
- ChEMBL_2271719 Inhibition of human AChE using acetylcholine as substrate incubated for 5 mins followed by substrate addition by Ellman's method
- ChEMBL_2277745 Antagonist activity at human muscarinic M5 receptor expressed in CHO cells in the presence of acetylcholine by calcium mobilisation assay
- ChEMBL_2277750 Antagonist activity at rat muscarinic M5 receptor expressed in CHO cells in the presence of acetylcholine by calcium mobilisation assay
- ChEMBL_2277752 Antagonist activity at human muscarinic M1 receptor expressed in CHO cells in the presence of acetylcholine by calcium mobilisation assay
- ChEMBL_2277754 Antagonist activity at human muscarinic M4 receptor expressed in CHO cells in the presence of acetylcholine by calcium mobilisation assay
- ChEMBL_303295 (CHEMBL827428) Inhibition of [125I]-iodo-MLA binding to Nicotinic acetylcholine receptor alpha-7 of rat cerebral cortex
- ChEMBL_303475 (CHEMBL838850) Inhibition of [125I]-iodo-MLA binding to Nicotinic acetylcholine receptor alpha-7 in rat cerebral cortex
- ChEMBL_303631 (CHEMBL828841) Inhibition of [125I]alpha-bungarotoxin binding to nicotinic acetylcholine receptor alpha1 beta gamma delta of electroplax
- ChEMBL_303690 (CHEMBL829735) Inhibition of [3H](-)-nicotine binding to rat brain (minus cerebellum) Nicotinic acetylcholine receptor alpha4-beta2
- ChEMBL_303782 (CHEMBL830139) Inhibition of 3 nM [3H]-MLA binding to Nicotinic acetylcholine receptor alpha7 of rat brain membranes
- ChEMBL_310608 (CHEMBL837186) Potency against rat nicotinic acetylcholine alpha-7 subunit expressed in Xenopus oocytes as current activation
- ChEMBL_320917 (CHEMBL881344) Binding affinity for rat salivary gland muscarinic acetylcholine receptor M3 using [3H]N-methylscopolamine
- ChEMBL_320958 (CHEMBL885365) Binding affinity for rat brain Nicotinic acetylcholine receptor alpha4-beta2 using [3H]S-(-)-nicotine
- ChEMBL_546015 (CHEMBL1028493) Displacement of (+/-)-[3H]epibatidine from alpha4beta2 nicotinic acetylcholine receptor in rat brain cortex membrane homogenates
- ChEMBL_546017 (CHEMBL1028495) Displacement of [3H]cytisine from alpha4beta2 nicotinic acetylcholine receptor in rat brain cortex membrane homogenates
- ChEMBL_546018 (CHEMBL1028496) Displacement of [3H]cytisine from alpha4beta2 nicotinic acetylcholine receptor in rat brain minus cerebellum membrane
- ChEMBL_546019 (CHEMBL1028497) Displacement of [3H]A585539 from alpha7 nicotinic acetylcholine receptor in rat brain minus cerebellum membrane
- ChEMBL_769761 (CHEMBL1831567) Displacement of [3H]QNB from muscarinic acetylcholine M5 receptor after 1.5 hrs by scintillation counting
- ChEMBL_792862 (CHEMBL1931047) Inhibition of electric eel AChE using acetylcholine chloride as substrate preincubated for 15 mins by Ellman's method
- ChEMBL_851712 (CHEMBL2155929) Inhibition of electric eel AChE using acetylcholine iodide as substrate preincubated for 20 mins by Ellman's method
- ChEMBL_909515 (CHEMBL3064685) Inhibition of Electrophorus electricus (electric eel) acetylcholinesterase (AChE) using acetylcholine iodide as substrate by Ellman method
- ChEMBL_939332 (CHEMBL2327297) Non-competitive inhibition of Electrophorus electricus AChE using acetylcholine as substrate by Lineweaver-Burk plot method
- ChEMBL_948622 (CHEMBL2345138) Inhibition of electric eel AChE using acetylcholine iodide as substrate after 10 mins by Ellman method
- ChEMBL_957892 (CHEMBL2377917) Mixed-type inhibition of electric eel AChE by Lineweaver Burk reciprocal plot analysis in presence of acetylcholine