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Query String: ALBENDAZOLE

Albenza BDBM50241293 (5-Propylsulfanyl-1H-benzoimidazol-2-yl)-carbamic acid methyl ester ALBENDAZOLE methyl 6-(propylthio)-1H-benzo[d]imidazol-2-ylcarbamate CHEMBL1483 SK&F-62979 methyl 5-(propylthio)-1H-benzo[d]imidazol-2-ylcarbamate

CYP Inhibition Assay Incubation of phenacetin, diclofenac, dextromethorphan, mephenotoin, albendazole and testosterone with human liver microsomes in the presence of in each case eight different concentrations of a compound formula (B) (as potential inhibitor) is carried out on a incubator shaker at 37 C. Standard incubation mixtures comprise NADPH and substrates in 100 mM phosphate buffer (pH 7.4) in a total volume of 200 μl. Test compound are dissolved in acetonitrile. Incubated with pooled human liver microsomes at 37° C. for a defined time. The reactions are stopped by adding 100 μl of acetonitrile in which a suitable internal standard is always present. Precipitated proteins are removed by centrifugation, and the supernatants analyzed by LC-MS/MS.