TEKTURNA ALISKIREN FUMARATE Aliskiren hemifumarate BDBM50392952
Aliskiren Hemifumarate BDBM17950 Rasilez Aliskiren TEKTURNA (2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethylethyl)-4-hydroxy-7-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-8-methyl-2-(propan-2-yl)nonanamide ALISKIREN FUMARATE CHEMBL1639
- Yamaguchi, Y; Menear, K; Cohen, NC; Mah, R; Cumin, F; Schnell, C; Wood, JM; Maibaum, J The P1N-isopropyl motif bearing hydroxyethylene dipeptide isostere analogues of aliskiren are in vitro potent inhibitors of the human aspartyl protease renin. Bioorg Med Chem Lett 19: 4863-7 (2009)
- Maibaum, J; Stutz, S; Göschke, R; Rigollier, P; Yamaguchi, Y; Cumin, F; Rahuel, J; Baum, HP; Cohen, NC; Schnell, CR; Fuhrer, W; Gruetter, MG; Schilling, W; Wood, JM Structural Modification of the P2' Position of 2,7-Dialkyl-Substituted 5(S)-Amino-4(S)-hydroxy-8-phenyl-octanecarboxamides: The Discovery of Aliskiren, a Potent Nonpeptide Human Renin Inhibitor Active after Once Daily Dosing in Marmosets. J Med Chem 50: 4832-44 (2007)