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Query String: AMINOGLUTETHIMIDE

AMINOGLUTETHIMIDE CHEMBL2051951 BDBM50406639
BDBM50406640 AMINOGLUTETHIMIDE CHEMBL1394757
Aminoglutethimide AG, 4 Cytadren EN300-53368 3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione Elipten CHEMBL488 BDBM9460 aminoglutethimide (AG) 3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione

Foster, AB; Jarman, M; Leung, CS; Rowlands, MG; Taylor, GN; Plevey, RG; Sampson, P Analogues of aminoglutethimide: selective inhibition of aromatase. J Med Chem 28: 200-4 (1985)
Foster, AB; Jarman, M; Leung, CS; Rowlands, MG; Taylor, GN Analogues of aminoglutethimide: selective inhibition of cholesterol side-chain cleavage. J Med Chem 26: 50-4 (1983)
Daly, MJ; Jones, GW; Nicholls, PJ; Smith, HJ; Rowlands, MG; Bunnett, MA Synthesis and biochemical evaluation of analogues of aminoglutethimide based on phenylpyrrolidine-2,5-dione. J Med Chem 29: 520-3 (1986)
Rowlands, MG; Bunnett, MA; Foster, AB; Jarman, M; Stanek, J; Schweizer, E Analogues of aminoglutethimide based on 1-phenyl-3-azabicyclo[3.1.0]hexane-2,4-dione: selective inhibition of aromatase activity. J Med Chem 31: 971-6 (1988)

CYP19 Assay Inhibition of human placental aromatase was determined by monitoring the amount of 3H2O released as the enzyme converts [1beta-3H]androst-4-ene-3,17-dione to estrone. The aqueous layer was extracted with chloroform, and the amount of radioactivity was determined by scintillation counting. Each sample was run in triplicate, and background values were determined with microsomal protein inactivated by boiling. Sample containing aminoglutethimide was used as a positive control.