CHEMBL231779 BMS-562247 Apixaban 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide US9938272, Example Apixaban BDBM19023
- Luettgen, JM; Knabb, RM; He, K; Pinto, DJ; Rendina, AR Apixaban inhibition of factor Xa: Microscopic rate constants and inhibition mechanism in purified protein systems and in human plasma. J Enzyme Inhib Med Chem 26: 514-26 (2011)
- Wang, Y; Sun, X; Yang, D; Guo, Z; Fan, X; Nie, M; Zhang, F; Liu, Y; Li, Y; Wang, Y; Gong, P; Liu, Y Design, synthesis, and structure-activity relationship of novel and effective apixaban derivatives as FXa inhibitors containing 1,2,4-triazole/pyrrole derivatives as P2 binding element. Bioorg Med Chem 24: 5646-5661 (2016)
- Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro- 1H-pyrazolo[3,4-c]pyridine-3-carboxamide (Apixaban, BMS-562247), a Highly Potent, Selective, Efficacious, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa. J Med Chem 50: 5339-56 (2007)