APREMILAST BDBM50248919 CHEMBL514800 (S)-N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide US10662189, Compound Apremilast
- Man, HW; Schafer, P; Wong, LM; Patterson, RT; Corral, LG; Raymon, H; Blease, K; Leisten, J; Shirley, MA; Tang, Y; Babusis, DM; Chen, R; Stirling, D; Muller, GW Discovery of (S)-N-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl] acetamide (apremilast), a potent and orally active phosphodiesterase 4 and tumor necrosis factor-alpha inhibitor. J Med Chem 52: 1522-4 (2009)