DABIGATRAN ETEXILATE Pradaxa BIBR-1048-BS-RS1 BDBM50432209 BIBR-1048
CHEMBL48361 3-({2-[(4-Carbamimidoyl-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-pyridin-2-yl-amino)-propionic acid DABIGATRAN BDBM50112086
- Chen, D; Wang, S; Diao, X; Zhu, Q; Shen, H; Han, X; Wang, Y; Gong, G; Xu, Y Design, synthesis and antithrombotic evaluation of novel dabigatran etexilate analogs, a new series of non-peptides thrombin inhibitors. Bioorg Med Chem 23: 7405-16 (2015)
- Michaelis, S; Marais, A; Schrey, AK; Graebner, OY; Schaudt, C; Sefkow, M; Kroll, F; Dreger, M; Glinski, M; Koester, H; Metternich, R; Fischer, JJ Dabigatran and dabigatran ethyl ester: potent inhibitors of ribosyldihydronicotinamide dehydrogenase (NQO2). J Med Chem 55: 3934-44 (2012)
- Wang, F; Ren, YJ; Dong, MH Molecular design, synthesis and anticoagulant activity evaluation of fluorinated dabigatran analogues. Bioorg Med Chem 24: 2739-53 (2016)
- Yang, XZ; Diao, XJ; Yang, WH; Li, F; He, GW; Gong, GQ; Xu, YG Design, synthesis and antithrombotic evaluation of novel dabigatran prodrugs containing methyl ferulate. Bioorg Med Chem Lett 23: 2089-92 (2013)
- Dong, MH; Chen, HF; Ren, YJ; Shao, FM Molecular modeling studies, synthesis and biological evaluation of dabigatran analogues as thrombin inhibitors. Bioorg Med Chem 24: 73-84 (2016)
- Li, ML; Ren, YJ; Dong, MH; Ren, WX Design, synthesis and structural exploration of novel fluorinated dabigatran derivatives as direct thrombin inhibitors. Eur J Med Chem 96: 122-38 (2015)
- Yang, XZ; Yang, WH; Xu, YG; Diao, XJ; He, GW; Gong, GQ Synthesis and antithrombotic evaluation of novel dabigatran prodrugs containing a cleavable moiety with anti-platelet activity. Eur J Med Chem 57: 21-8 (2012)
- Ren, W; Ren, Y; Wang, S Design, synthesis, anticoagulant activity evaluation and molecular docking studies of a class of N-ethyl dabigatran derivatives. Eur J Med Chem 120: 148-59 (2016)
- Yang, H; Liu, Q; Gao, X; Ren, Y; Gao, Y Novel dabigatran derivatives with a fluorine atom at the C-2 position of the terminal benzene ring: Design, synthesis and anticoagulant activity evaluation. Eur J Med Chem 126: 799-809 (2017)