Query String: DAUNORUBICIN
Cerubidine BDBM50368352 DAUNORUBICIN
DAUNORUBICIN HYDROCHLORIDE SMR000058559 (7S,9S)-9-acetyl-7-[[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-2-oxanyl]oxy]-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride BDBM32017 Daunorubicin (7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-tetrahydropyran-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-quinone;hydrochloride (7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride cid_62770 (7S,9S)-7-[(2R,4S,5S,6S)-4-azanyl-6-methyl-5-oxidanyl-oxan-2-yl]oxy-9-ethanoyl-4-methoxy-6,9,11-tris(oxidanyl)-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride MLS000069508
- Wang, E; Casciano, CN; Clement, RP; Johnson, WW Cholesterol interaction with the daunorubicin binding site of P-glycoprotein. Biochem Biophys Res Commun 276: 909-16 (2000)
- Hegedüs, R; Manea, M; Orbán, E; Szabó, I; Kiss, E; Sipos, E; Halmos, G; Mezo, G Enhanced cellular uptake and in vitro antitumor activity of short-chain fatty acid acylated daunorubicin-GnRH-III bioconjugates. Eur J Med Chem 56: 155-165 (2012)
- Priebe, W; Krawczyk, M; Kuo, MT; Yamane, Y; Savaraj, N; Ishikawa, T Doxorubicin- and daunorubicin-glutathione conjugates, but not unconjugated drugs, competitively inhibit leukotriene C4 transport mediated by MRP/GS-X pump. Biochem Biophys Res Commun 247: 859-63 (1998)
- ChEMBL_836604 (CHEMBL2077345) TP_TRANSPORTER: inhibition of Daunorubicin efflux (Daunorubicin: uM) in G185 cells
- ChEMBL_837188 (CHEMBL2076732) TP_TRANSPORTER: inhibition of Daunorubicin transepithelial transport (basal to apical) (Daunorubicin: 5 uM) in Caco-2 cells
- ChEMBL_839273 (CHEMBL2077944) TP_TRANSPORTER: inhibition of Daunorubicin uptake (Daunorubicin: 0.6 uM) in membrane vesicles from GLC4/ADR cells
- ChEMBL_835975 (CHEMBL2077113) TP_TRANSPORTER: inhibition of Daunorubicin transepithelial transport (basal to apical) (Daunorubicin: 0.035 uM) in MDR1-expressing LLC-PK1 cells
- ChEMBL_836271 (CHEMBL2076284) TP_TRANSPORTER: inhibition of Daunorubicin transepithelial transport (basal to apical) (Daunorubicin: 0.035 uM) in MDR1-expressing LLC-PK1 cells
- ChEMBL_837190 (CHEMBL2076734) TP_TRANSPORTER: inhibition of Daunorubicin transepithelial transport (basal to apical) (Daunorubicin: 0.1 uM) in MDR1-expressing LLC-PK1 cells
- ChEMBL_474395 (CHEMBL939118) Inhibition of Pgp by daunorubicin accumulation assay
- ChEMBL_836754 (CHEMBL2075176) TP_TRANSPORTER: inhibition of Daunorubicin transepithelial transport (basal to apical), (-)-efonidipine (Daunorubicin: 0.035 uM) in MDR1-expressing LLC-PK1 cells
- ChEMBL_836755 (CHEMBL2075177) TP_TRANSPORTER: inhibition of Daunorubicin transepithelial transport (basal to apical), (+)-efonidipine (Daunorubicin: 0.035 uM) in MDR1-expressing LLC-PK1 cells
- ChEMBL_836602 (CHEMBL2077343) TP_TRANSPORTER: inhibition of Daunorubicin transport in G185 cells
- ChEMBL_836603 (CHEMBL2077344) TP_TRANSPORTER: inhibition of Daunorubicin transport in 3T3-G185 cells
- ChEMBL_838270 (CHEMBL2076218) TP_TRANSPORTER: inhibition of Daunorubicin efflux in NIH-3T3-G185 cells
- ChEMBL_838292 (CHEMBL2076240) TP_TRANSPORTER: inhibition of Daunorubicin efflux in NIH-3T3-G185 cells
- ChEMBL_592351 (CHEMBL1048477) Modulation of P-gp overexpressed in human A2780 cells assessed as daunorubicin accumulation preincubated 15 mins prior to daunorubicin addition measured after 180 mins by fluorescence assay
- ChEMBL_836873 (CHEMBL2075511) TP_TRANSPORTER: increase in Daunorubicn intracellular accumulation (Daunorubicin: uM) in NIH-G185 cells
- ChEMBL_1506699 (CHEMBL3598715) Inhibition of human P-gp expressed in mouse T-cell lymphoma assessed as potentiation of daunorubicin-induced cellular toxicity by measuring daunorubicin IC50 at 10 uM by MTT assay (Rvb = 8.26 +/- 0.62 uM)
- ChEMBL_1506700 (CHEMBL3598716) Inhibition of human P-gp expressed in mouse T-cell lymphoma assessed as potentiation of daunorubicin-induced cellular toxicity by measuring daunorubicin IC50 at 5 uM by MTT assay (Rvb = 8.26 +/- 0.62 uM)
- ChEMBL_429163 (CHEMBL914418) Inhibition of P-glycoprotein expressed in MDR CCRF vcr1000 cells by daunorubicin efflux assay
- ChEMBL_607771 (CHEMBL1068742) Displacement of daunorubicin from human recombinant CBR expressed in Escherichia coli BL21 (DE3)
- ChEMBL_2336465 Inhibition of ABCB1 in multi-drug resistance human HL-60 cells assessed as increase in daunorubicin accumulation
- ChEMBL_474396 (CHEMBL939121) Inhibition of mouse Pgp in EMT6/AR1.0 cells after 1 hr by daunorubicin accumulation assay
- ChEMBL_2302426 Inhibition of MRP1 in human NCI-H69AR cells incubated for 180 mins in presence of daunorubicin by flow cytometry analysis
- ChEMBL_493332 (CHEMBL952395) Inhibition of human MDR1 overexpressed in mouse NIH/3T3 cells assessed as daunorubicin accumulation by flow cytometry
- ChEMBL_2308030 Inhibition of ABCB1 in human A2780 ADR cells incubated for 180 mins by daunorubicin based fluorescence flow cytometric analysis
- ChEMBL_2308031 Inhibition of ABCC1 in human NCI-H69AR cells incubated for 180 mins by daunorubicin based fluorescence flow cytometric analysis
- ChEMBL_2336466 Inhibition of ABCG2 efflux pump in multi-drug resistance human HL-60 cells assessed as reversal of daunorubicin sensitivity
- ChEMBL_1576618 (CHEMBL3807536) Inhibition of MRP1 in human H69AR cells assessed as daunorubicin accumulation preincubated for 15 mins measured after 180 mins by flow cytometry
- ChEMBL_1920434 (CHEMBL4423279) Inhibition of ABCB1 in human A2780/ADR cells assessed as potentiation of daunorubicin-induced cytotoxicity measured after 72 hrs by MTT assay
- ChEMBL_2116815 (CHEMBL4825881) Inhibition of ABCC1 (unknown origin) expressed in H69AR cells assessed as reduction in daunorubicin accumulation after 180 mins by flow cytometry analysis
- ChEMBL_1335029 (CHEMBL3239460) Inhibition of P-gp-mediated daunorubicin efflux in human CCRF-CEM/VCR1000 cells measured within 1 hr by FACS flow cytometry
- ChEMBL_1850558 (CHEMBL4351182) Reversal of ABCC1-mediated multidrug resistance in human H69AR cells assessed as potentiation of daunorubicin-induced cytotoxicity incubated for 72 hrs by MTT assay
- ChEMBL_1850594 (CHEMBL4351218) Reversal of ABCB1-mediated multidrug resistance in human A2780/ADR cells assessed as potentiation of daunorubicin-induced cytotoxicity incubated for 72 hrs by MTT assay
- ChEMBL_829666 (CHEMBL2061056) Inhibition of P-glycoprotein-mediated daunorubicin efflux from human CCRF-CEM/VCR1000 cells after 240 secs by FACS flow cytometric analysis
- ChEMBL_1850596 (CHEMBL4351220) Reversal of ABCG2-mediated multidrug resistance in human MCF-7/MX cells assessed as potentiation of daunorubicin-induced cytotoxicity incubated for 72 hrs by MTT assay
- ChEMBL_2058573 (CHEMBL4713574) Inhibition of ABCB1 (unknown origin) expressed in human A2780 ADR cells assessed as potentiation of daunorubicin-induced cytotoxicity measured after 72 hrs by MTT assay
- ChEMBL_1540748 (CHEMBL3745362) Inhibition of recombinant human N-terminal His6-tagged AKR1B10 expressed in Escherichia coli BL21 cells using daunorubicin as substrate incubated for 20 mins by UHPLC method
- ChEMBL_1850559 (CHEMBL4351183) Reversal of ABCC1 (unknown origin)-mediated multidrug resistance in MDCK2 cells co-expressing MRP1 (unknown origin) assessed as potentiation of daunorubicin-induced cytotoxicity incubated for 72 hrs by MTT assay
- ChEMBL_1850595 (CHEMBL4351219) Reversal of ABCB1 (unknown origin)-mediated multidrug resistance in MDCK2 cells co-expressing MDR1 (unknown origin) assessed as potentiation of daunorubicin-induced cytotoxicity incubated for 72 hrs by MTT assay