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Query String: DIGITOXIN

cid_441207 MLS000069787 US10668094, Compound Digitoxin BDBM46356 DIGITOXIN SMR000058529
BDBM435723 US10610539, Compound digitoxin

The inhibition of HCMV replication by digitoxin The effect of digitoxin analogs on HCMV replication was tested. HFFs were infected with pp28-luciferase HCMV and treated with the compounds (Table 2, FIG. 2A). EC50, CC50 and selectivity index (SI) calculated as CC50/EC50 were determined for each compound. The L-isomers had an improved anti-HCMV activity compared to the D-isomers. Within each stereoisomer, there was an inverse correlation between the sugar length and anti-HCMV activity; the longer the oligosaccharide chain, the less effective the compound was against HCMV replication. There was also decreased cytotoxicity in HFFs as the sugar length increased; however, the anti-HCMV activity was not a result of cytotoxicity as reflected by the selectivity index (SI). The compounds with the best SI were α-L rhamnose, α-L amicetose and mannose. Virus yield was determined for selected compounds (FIG. 2B), and a dose dependent effect on virus DNA yield was observed.