US9138393, Diltiazem BDBM181128
Acetic acid 5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester (diltiazem) diltiazem;Acetic acid 5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester Acetic acid (S)-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester Acetic acid 5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester(cis-(+)-Diltiazem) Teczem Acetic acid 5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester DILTIAZEM Cardizem BDBM50004704 8-Chloro-1-methyl-6-phenyl-4H-2,3,5,10b-tetraaza-benzo[e]azulene CHEMBL23 Diltzac cis-Acetic acid 5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester Tiamate 5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester(Diltiazem)Acetic acid Dilt-CD (+)-cis-Diltiazem (2S,3S)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate Tiazac Acetic acid (2S,3S)-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester Acetic acid 5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester; hydrochloride
- Carosati, E; Budriesi, R; Ioan, P; Ugenti, MP; Frosini, M; Fusi, F; Corda, G; Cosimelli, B; Spinelli, D; Chiarini, A; Cruciani, G Discovery of novel and cardioselective diltiazem-like calcium channel blockers via virtual screening. J Med Chem 51: 5552-65 (2008)
- Zhou, Y; Song, M; Xie, D; Yan, S; Yu, S; Xie, S; Cai, M; Li, H; Shang, L; Jiang, L; Yuan, C; Huang, M; Li, J; Xu, P Structural Dynamics-Driven Discovery of Anticancer and Antimetastatic Effects of Diltiazem and Glibenclamide Targeting Urokinase Receptor. J Med Chem 66: 5415-5426 (2023)
- Corelli, F; Manetti, F; Tafi, A; Campiani, G; Nacci, V; Botta, M Diltiazem-like calcium entry blockers: a hypothesis of the receptor-binding site based on a comparative molecular field analysis model. J Med Chem 40: 125-31 (1997)
- Budriesi, R; Cosimelli, B; Ioan, P; Ugenti, MP; Carosati, E; Frosini, M; Fusi, F; Spisani, R; Saponara, S; Cruciani, G; Novellino, E; Spinelli, D; Chiarini, A L-Type calcium channel blockers: from diltiazem to 1,2,4-oxadiazol-5-ones via thiazinooxadiazol-3-one derivatives. J Med Chem 52: 2352-62 (2009)
- Carosati, E; Budriesi, R; Ioan, P; Cruciani, G; Fusi, F; Frosini, M; Saponara, S; Gasparrini, F; Ciogli, A; Villani, C; Stephens, PJ; Devlin, FJ; Spinelli, D; Chiarini, A Stereoselective behavior of the functional diltiazem analogue 1-[(4-chlorophenyl)sulfonyl]-2-(2-thienyl)pyrrolidine, a new L-type calcium channel blocker. J Med Chem 52: 6637-48 (2009)