Query String: DOPAMINE
- dopamine d1
- dopamine d2
- dopamine d3
- dopamine d4
- dopamine d4.4
- dopamine d5
- dopamine receptor
- dopamine transporter
- d1 dopamine receptor
- dopamine d1 low
- dopamine d1 receptor
- dopamine d2 long
- dopamine d2 receptor
- dopamine d2 short
- dopamine d3 receptor
- dopamine d4 receptor
- dopamine d5 receptor
- dopamine receptor d2
- dopamine receptor d3
- dopamine receptor d4
- dopamine transporter (dat)
- d(1a) dopamine receptor
- d(1b) dopamine receptor
- d(2) dopamine receptor
- d(2c) dopamine receptor
- d(3) dopamine receptor
- d(4) dopamine receptor
- dopamine d2 s receptor
- monoamine transporters; norepininephrine & dopamine
- sodium-dependent dopamine transporter
- sodium-dependent dopamine transporter (dat)
- d(1a)/d(2) dopamine receptor
- d(4) dopamine receptor [281-332]
- dopamine d2 receptor and serotonin 1a receptor
- dopamine receptor d2l/neurotensin receptor nts1
- d(2) dopamine receptor/metabotropic glutamate receptor 5
- dopamine d2 receptor/serotonin 2 (5-ht2) receptor
NPA+ (GTP+) Dopamine+ (GTP+) Dopamine+GTP BDBM81874
Oleoyl dopamine cid_5282106 N-oleoyl-dopamine BDBM50215899 CHEMBL250711
Dopamine+ (GTP-) BDBM81995
BDBM50049797 (3,4-dihydroxyphenethyl)ammonium DOPAMINE
Arachidonoyl dopamine N-arachidonoyl-dopamine (NADA) CHEMBL138921 (5Z,8Z,11Z,14Z)-N-[2-(3,4-dihydroxyphenyl)ethyl]icosa-5,8,11,14-tetraenamide BDBM20462
BDBM50028548 5,6-dihydroxyindole Dopamine lutine CHEMBL92636 1H-indole-5,6-diol
- Gogarnoiu, ES; Vogt, CD; Sanchez, J; Bonifazi, A; Saab, E; Shaik, AB; Soler-Cedeño, O; Bi, GH; Klein, B; Xi, ZX; Lane, JR; Newman, AH Dopamine D J Med Chem 66: 1809-1834 (2023)
- Tropmann, K; Bresinsky, M; Forster, L; Mönnich, D; Buschauer, A; Wittmann, HJ; Hübner, H; Gmeiner, P; Pockes, S; Strasser, A Abolishing Dopamine D J Med Chem 64: 8684-8709 (2021)
- Ziu, I; Rettig, I; Luo, D; Dutta, A; McCormick, TM; Wu, C; Martic, S The multifunctional dopamine D Bioorg Med Chem 28: (2020)
- Liu, R; Qi, J; Wang, H; Fan, L; Zhang, P; Yu, J; Tan, L; Wang, S; Cheng, J Transformation of a Dopamine D J Med Chem 66: 6274-6287 (2023)
- Chen, H; Liu, M; Su, Q; Raisinghani, M Sydnonimines-specific dopamine reuptake inhibitors and their use in treating dopamine related disorders US Patent US9604945 (2017)
- Sunahara, RK; Guan, HC; O'Dowd, BF; Seeman, P; Laurier, LG; Ng, G; George, SR; Torchia, J; Van Tol, HH; Niznik, HB Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. Nature 350: 614-9 (1991)
- Enzensperger, C; Lehmann, J Dopamine/serotonin receptor ligands. 13: Homologization of a benzindoloazecine-type dopamine receptor antagonist modulates the affinities for dopamine D(1)-D(5) receptors. J Med Chem 49: 6408-11 (2006)
- Holson, E; Fevrier, F; Weiwer, M; Scolnick, E; Palmer, M; Lewis, MC; Pan, JQ; Zhang, Y; Xu, Q Dopamine D2 receptor ligands US Patent US10752588 (2020)
- Cremonesi, S; Micheli, F; Semerano, T; Tarsi, L Dopamine D3 receptor antagonists US Patent US10239870 (2019)
- Reilly, SW; Griffin, S; Taylor, M; Sahlholm, K; Weng, CC; Xu, K; Jacome, DA; Luedtke, RR; Mach, RH Highly Selective Dopamine D J Med Chem 60: 9905-9910 (2017)
- Luo, D; Sharma, H; Yedlapudi, D; Antonio, T; Reith, MEA; Dutta, AK Novel multifunctional dopamine D Bioorg Med Chem 24: 5088-5102 (2016)
- Pretze, M; Pallavi, P; Roscher, M; Klotz, S; Caballero, J; Binzen, U; Greffrath, W; Treede, RD; Harmsen, MC; Hafner, M; Yard, B; Wängler, C; Wängler, B Radiofluorinated N-Octanoyl Dopamine ([ J Med Chem 59: 9855-9865 (2016)
- Dong, ZX; Shen, Y; Kim, SH Somatostatin-dopamine chimeric analogs US Patent US8952128 (2015)
- Hansch, C; Verma, RP; Kurup, A; Mekapati, SB The role of QSAR in dopamine interactions. Bioorg Med Chem Lett 15: 2149-57 (2005)
- Lahti, RA; Evans, DL; Stratman, NC; Figur, LM Dopamine D4 versus D2 receptor selectivity of dopamine receptor antagonists: possible therapeutic implications. Eur J Pharmacol 236: 483-6 (1993)
- Jaen, JC; Caprathe, BW; Wise, LD; Smith, SJ; Pugsley, TA; Heffner, TG; Meltzer, LT Novel 4,5,6,7-tetrahydrobenzothiazole dopamine agonists display very low stereoselectivity in their interaction with dopamine receptors. Bioorg Med Chem Lett 1: 189-192 (1991)
- Burt, DR; Creese, I; Snyder, SH Properties of [3H]haloperidol and [3H]dopamine binding associated with dopamine receptors in calf brain membranes. Mol Pharmacol 12: 800-12 (1976)
- Ramsby, S; Neumeyer, JL; Grigoriadis, D; Seeman, P 2-Haloaporphines as potent dopamine agonists. J Med Chem 32: 1198-201 (1989)
- Yan, W; Fan, L; Yu, J; Liu, R; Wang, H; Tan, L; Wang, S; Cheng, J 2-Phenylcyclopropylmethylamine Derivatives as Dopamine D J Med Chem 64: 17239-17258 (2021)
- Vendrell, M; Molero, A; González, S; Pérez-Capote, K; Lluis, C; McCormick, PJ; Franco, R; Cortés, A; Casadó, V; Albericio, F; Royo, M Biotin ergopeptide probes for dopamine receptors. J Med Chem 54: 1080-90 (2011)
- Harrold, MW; Chang, YA; Wallace, RA; Farooqui, T; Wallace, LJ; Uretsky, N; Miller, DD Charged analogues of chlorpromazine as dopamine antagonists. J Med Chem 30: 1631-5 (1987)
- Qian, M; Ricarte, A; Wouters, E; Dalton, JAR; Risseeuw, MDP; Giraldo, J; Van Calenbergh, S Discovery of a true bivalent dopamine D Eur J Med Chem 212: (2021)
- Pavleti?, P; Semeano, A; Yano, H; Bonifazi, A; Giorgioni, G; Piergentili, A; Quaglia, W; Sabbieti, MG; Agas, D; Santoni, G; Pallini, R; Ricci-Vitiani, L; Sabato, E; Vistoli, G; Del Bello, F Highly Potent and Selective Dopamine D J Med Chem 65: 12124-12139 (2022)
- Sokoloff, P; Giros, B; Martres, MP; Andrieux, M; Besancon, R; Pilon, C; Bouthenet, ML; Souil, E; Schwartz, JC Localization and function of the D3 dopamine receptor. Arzneimittelforschung 42: 224-30 (1992)
- Hall, A; Provins, L; Valade, A Novel Strategies To Activate the Dopamine D J Med Chem 62: 128-140 (2019)
- Mallo-Abreu, A; Reyes-Resina, I; Azuaje, J; Franco, R; García-Rey, A; Majellaro, M; Miranda-Pastoriza, D; García-Mera, X; Jespers, W; Gutiérrez-de-Terán, H; Navarro, G; Sotelo, E Potent and Subtype-Selective Dopamine D J Med Chem 64: 8710-8726 (2021)
- Robaa, D; Enzensperger, C; Abul Azm, Sel D; El Khawass, el S; El Sayed, O; Lehmann, J Dopamine receptor ligands. Part 18: (1) modification of the structural skeleton of indolobenzazecine-type dopamine receptor antagonists. J Med Chem 53: 2646-50 (2010)
- Mottola, DM; Kilts, JD; Lewis, MM; Connery, HS; Walker, QD; Jones, SR; Booth, RG; Hyslop, DK; Piercey, M; Wightman, RM; Lawler, CP; Nichols, DE; Mailman, RB Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase. J Pharmacol Exp Ther 301: 1166-78 (2002)
- Reinart-Okugbeni, R; Vonk, A; Uustare, A; Gyulai, Z; Sipos, A; Rinken, A 1-substituted apomorphines as potent dopamine agonists. Bioorg Med Chem 21: 4143-50 (2013)
- Blough, BE; Landavazo, A; Partilla, JS; Decker, AM; Page, KM; Baumann, MH; Rothman, RB Alpha-ethyltryptamines as dual dopamine-serotonin releasers. Bioorg Med Chem Lett 24: 4754-8 (2014)
- Schaus, JM; Titus, RD; Foreman, MM; Mason, NR; Truex, LL Aporphines as antagonists of dopamine D-1 receptors. J Med Chem 33: 600-7 (1990)
- Elek, M; Dubiel, M; Mayer, L; Zivkovic, A; Müller, TJJ; Stark, H BOPPY-based novel fluorescent dopamine D Bioorg Med Chem Lett 59: (2022)
- Kühhorn, J; Götz, A; Hübner, H; Thompson, D; Whistler, J; Gmeiner, P Development of a bivalent dopamine D2 receptor agonist. J Med Chem 54: 7911-9 (2011)
- Stößel, A; Brox, R; Purkayastha, N; Hübner, H; Hocke, C; Prante, O; Gmeiner, P Development of molecular tools based on the dopamine D Bioorg Med Chem 25: 3491-3499 (2017)
- Hilliard, DW; Hao, J; Coates, DA Dopamine D1 receptor positive allosteric modulators US Patent US10611751 (2020)
- Jin, J; Roth, B; Frye, S Functionally selective ligands of dopamine D2 receptors US Patent US9156822 (2015)
- Gray, DL; Davoren, JE; Dounay, AB; Efremov, IV; Mente, SR; Subramanyam, C Heteroaromatic compounds and their use as dopamine D1 ligands US Patent US9856263 (2018)
- Gray, DL; Zhang, L; Brodney, MA; Davoren, JE; Efremov, IV; Green, ME; O Neil, SV; Rogers, BN Heterocyclic compounds and their use as dopamine D1 ligands US Patent US9745317 (2017)
- Capet, M; Calmels, T; Levoin, N; Danvy, D; Berrebi-Bertrand, I; Stark, H; Schwartz, JC; Lecomte, JM Improving selectivity of dopamine D3 receptor ligands. Bioorg Med Chem Lett 26: 885-8 (2016)
- Neve, KA Regulation of dopamine D2 receptors by sodium and pH. Mol Pharmacol 39: 570-8 (1991)
- Gray, DL; Zhang, L; Brodney, MA; Green, ME; Subramanyam, C Substituted 1,7-naphthyridines as dopamine D1 ligands US Patent US9540352 (2017)
- Qian, M; Wouters, E; Dalton, JAR; Risseeuw, MDP; Crans, RAJ; Stove, C; Giraldo, J; Van Craenenbroeck, K; Van Calenbergh, S Synthesis toward Bivalent Ligands for the Dopamine D J Med Chem 61: 8212-8225 (2018)
- Gadhiya, S; Madapa, S; Kurtzman, T; Alberts, IL; Ramsey, S; Pillarsetty, NK; Kalidindi, T; Harding, WW Tetrahydroprotoberberine alkaloids with dopamine ands receptor affinity. Bioorg Med Chem 24: 2060-71 (2016)
- Neumeyer, JL; Gao, YG; Kula, NS; Baldessarini, RJ Synthesis and dopamine receptor affinity of (R)-(-)-2-fluoro-N-n-propylnorapomorphine: a highly potent and selective dopamine D2 agonist. J Med Chem 33: 3122-4 (1991)
- Simoni, D; Rossi, M; Bertolasi, V; Roberti, M; Pizzirani, D; Rondanin, R; Baruchello, R; Invidiata, FP; Tolomeo, M; Grimaudo, S; Merighi, S; Varani, K; Gessi, S; Borea, PA; Marino, S; Cavallini, S; Bianchi, C; Siniscalchi, A Synthesis and pharmacology of 6-substituted benztropines: discovery of novel dopamine uptake inhibitors possessing low binding affinity to the dopamine transporter. J Med Chem 48: 3337-43 (2005)
- Xu, L; Kelkar, SV; Lomenzo, SA; Izenwasser, S; Katz, JL; Kline, RH; Trudell, ML Synthesis, dopamine transporter affinity, dopamine uptake inhibition, and locomotor stimulant activity of 2-substituted 3 beta-phenyltropane derivatives. J Med Chem 40: 858-63 (1997)
- Dinda, B; Das, B; Biswas, S; Sharma, H; Armstrong, C; Yedlapudi, D; Antonio, T; Reith, M; Dutta, AK Bivalent dopamine agonists with co-operative binding and functional activities at dopamine D2 receptors, modulate aggregation and toxicity of alpha synuclein protein. Bioorg Med Chem 78: (2023)
- Lomenzo, SA; Izenwasser, S; Katz, JL; Terry, PD; Zhu, N; Klein, CL; Trudell, ML Synthesis, structure, dopamine transporter affinity, and dopamine uptake inhibition of 6-alkyl-3-benzyl-2-[(methoxycarbonyl)methyl]tropane derivatives. J Med Chem 40: 4406-14 (1998)
- Lapinsky, DJ; Aggarwal, S; Huang, Y; Surratt, CK; Lever, JR; Foster, JD; Vaughan, RA A novel photoaffinity ligand for the dopamine transporter based on pyrovalerone. Bioorg Med Chem 17: 3770-4 (2009)
- Wustrow, D; Belliotti, T; Glase, S; Kesten, SR; Johnson, D; Colbry, N; Rubin, R; Blackburn, A; Akunne, H; Corbin, A; Davis, MD; Georgic, L; Whetzel, S; Zoski, K; Heffner, T; Pugsley, T; Wise, L Aminopyrimidines with high affinity for both serotonin and dopamine receptors. J Med Chem 41: 760-71 (1998)
- Jung, JY; Jung, SH; Koh, HY Asymmetric synthesis of chiral piperazinylpropylisoxazoline ligands for dopamine receptors. Eur J Med Chem 42: 1044-8 (2007)
- Warawa, EJ; Migler, BM; Ohnmacht, CJ; Needles, AL; Gatos, GC; McLaren, FM; Nelson, CL; Kirkland, KM Behavioral approach to nondyskinetic dopamine antagonists: identification of seroquel. J Med Chem 44: 372-89 (2001)
- Farrington, GK; Kumar, A; Villafranca, JJ Benzofurans as mechanism-based inhibitors of dopamine beta-hydroxylase. J Med Chem 32: 735-7 (1989)
- Huber, D; Löber, S; Hübner, H; Gmeiner, P Bivalent molecular probes for dopamine D2-like receptors. Bioorg Med Chem 20: 455-66 (2011)
- Motel, WC; Healy, JR; Viard, E; Pouw, B; Martin, K; Matsumoto, RR; Coop, A Chlorophenylpiperazine analogues as high affinity dopamine transporter ligands. Bioorg Med Chem Lett 23: 6920-6922 (2013)
- Grandy, DK; Marchionni, MA; Makam, H; Stofko, RE; Alfano, M; Frothingham, L; Fischer, JB; Burke-Howie, KJ; Bunzow, JR; Server, AC Cloning of the cDNA and gene for a human D2 dopamine receptor. Proc Natl Acad Sci U S A 86: 9762-6 (1989)
- Zhu, Z; Sun, ZY; Ye, Y; McKittrick, B; Greenlee, W; Czarniecki, M; Fawzi, A; Zhang, H; Lachowicz, JE Design and discovery of 1,3-benzodiazepines as novel dopamine antagonists. Bioorg Med Chem Lett 19: 5218-21 (2009)
- Salmi, P; Isacson, R; Kull, B Dihydrexidine--the first full dopamine D1 receptor agonist. CNS Drug Rev 10: 230-42 (2004)
- Sanna, F; Ortner, B; Hübner, H; Löber, S; Tschammer, N; Gmeiner, P Discovery of dopamine D4 receptor antagonists with planar chirality. Bioorg Med Chem 21: 1680-4 (2013)
- Cremonesi, S; Micheli, F; Semeraro, T; Tarsi, L Dopamine D3 receptor antagonists having a morpholine moiety US Patent US10577361 (2020)
- Freedman, SB; Patel, S; Marwood, R; Emms, F; Seabrook, GR; Knowles, MR; McAllister, G Expression and pharmacological characterization of the human D3 dopamine receptor. J Pharmacol Exp Ther 268: 417-26 (1994)
- Karki, A; Juarez, R; Namballa, HK; Alberts, I; Harding, WW Identification of C10 nitrogen-containing aporphines with dopamine D Bioorg Med Chem Lett 30: (2020)
- Sampson, D; Zhu, XY; Eyunni, SV; Etukala, JR; Ofori, E; Bricker, B; Lamango, NS; Setola, V; Roth, BL; Ablordeppey, SY Identification of a new selective dopamine D4 receptor ligand. Bioorg Med Chem 22: 3105-14 (2014)
- Belliotti, TR; Brink, WA; Kesten, SR; Rubin, JR; Wustrow, DJ; Zoski, KT; Whetzel, SZ; Corbin, AE; Pugsley, TA; Heffner, TG; Wise, LD Isoindolinone enantiomers having affinity for the dopamine D4 receptor. Bioorg Med Chem Lett 8: 1499-502 (1999)
- Weichert, D; Banerjee, A; Hiller, C; Kling, RC; Hübner, H; Gmeiner, P Molecular determinants of biased agonism at the dopamine D2 receptor. J Med Chem 58: 2703-17 (2015)
- Newman, AH; Beuming, T; Banala, AK; Donthamsetti, P; Pongetti, K; LaBounty, A; Levy, B; Cao, J; Michino, M; Luedtke, RR; Javitch, JA; Shi, L Molecular determinants of selectivity and efficacy at the dopamine D3 receptor. J Med Chem 55: 6689-99 (2012)
- Vendrell, M; Angulo, E; Casadó, V; Lluis, C; Franco, R; Albericio, F; Royo, M Novel ergopeptides as dual ligands for adenosine and dopamine receptors. J Med Chem 50: 3062-9 (2007)
- Zou, MF; Kopajtic, T; Katz, JL; Wirtz, S; Justice, JB; Newman, AH Novel tropane-based irreversible ligands for the dopamine transporter. J Med Chem 44: 4453-61 (2001)
- Giorgioni, G; Del Bello, F; Pavleti?, P; Quaglia, W; Botticelli, L; Cifani, C; Micioni Di Bonaventura, E; Micioni Di Bonaventura, MV; Piergentili, A Recent findings leading to the discovery of selective dopamine D Eur J Med Chem 212: (2021)
- Arlt, M; Böttcher, H; Riethmüller, A; Schneider, G; Bartoszyk, GD; Greiner, H; Seyfried, CA SAR of novel biarylmethylamine dopamine D4 receptor ligands. Bioorg Med Chem Lett 8: 2033-8 (1999)
- Sibley, DR; Moritz, AE; Free, RB; Steiner, JP; Southall, NT; Ferrer, M; Hu, X; Weiner, WS; Aubé, J; Frankowski, K Selective D3 dopamine receptor agonists and methods of their use US Patent US11634404 (2023)
- Omran, A; Eslamimehr, S; Crider, AM; Neumann, WL Synthesis of 3-(3-hydroxyphenyl)pyrrolidine dopamine D Bioorg Med Chem Lett 28: 1897-1902 (2018)
- Chemel, BR; Roth, BL; Armbruster, B; Watts, VJ; Nichols, DE WAY-100635 is a potent dopamine D4 receptor agonist. Psychopharmacology (Berl) 188: 244-51 (2006)
- Wittig, TW; Decker, M; Lehmann, J Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 receptor selectivity. J Med Chem 47: 4155-8 (2004)
- Enzensperger, C; Kilian, S; Ackermann, M; Koch, A; Kelch, K; Lehmann, J Dopamine/serotonin receptor ligands. Part 15: Oxygenation of the benz-indolo-azecine LE 300 leads to novel subnanomolar dopamine D1/D5 antagonists. Bioorg Med Chem Lett 17: 1399-402 (2007)
- Sit, SY; Xie, K; Jacutin-Porte, S; Taber, MT; Gulwadi, AG; Korpinen, CD; Burris, KD; Molski, TF; Ryan, E; Xu, C; Wong, H; Zhu, J; Krishnananthan, S; Gao, Q; Verdoorn, T; Johnson, G (+)-Dinapsoline: an efficient synthesis and pharmacological profile of a novel dopamine agonist. J Med Chem 45: 3660-8 (2002)
- Pechulis, AD; Beck, JP; Curry, MA; Wolf, MA; Harms, AE; Xi, N; Opalka, C; Sweet, MP; Yang, Z; Vellekoop, AS; Klos, AM; Crocker, PJ; Hassler, C; Laws, M; Kitchen, DB; Smith, MA; Olson, RE; Liu, S; Molino, BF 4-Phenyl tetrahydroisoquinolines as dual norepinephrine and dopamine reuptake inhibitors. Bioorg Med Chem Lett 22: 7219-22 (2012)
- Shonberg, J; Herenbrink, CK; López, L; Christopoulos, A; Scammells, PJ; Capuano, B; Lane, JR A structure-activity analysis of biased agonism at the dopamine D2 receptor. J Med Chem 56: 9199-221 (2013)
- Maryanoff, BE; McComsey, DF; Martin, GE; Shank, RP Azepinoindole derivatives with high affinity for brain dopamine and serotonin receptors. Bioorg Med Chem Lett 8: 983-8 (1999)
- Kühhorn, J; Hübner, H; Gmeiner, P Bivalent dopamine D2 receptor ligands: synthesis and binding properties. J Med Chem 54: 4896-903 (2011)
- Cannon, JG; Perez, JA; Bhatnagar, RK; Long, JP; Sharabi, FM Conformationally restricted congeners of dopamine derived from 2-aminoindan. J Med Chem 25: 1442-6 (1982)
- Ichihashi, Y; Inagaki, M; Masuda, K Cyclic compound having dopamine D3 receptor antagonistic effect US Patent US11447484 (2022)
- Luderman, KD; Jain, P; Benjamin Free, R; Conroy, JL; Aubé, J; Sibley, DR; Frankowski, KJ Development of pyrimidone D1 dopamine receptor positive allosteric modulators. Bioorg Med Chem Lett 31: (2021)
- Mottola, DM; Brewster, WK; Cook, LL; Nichols, DE; Mailman, RB Dihydrexidine, a novel full efficacy D1 dopamine receptor agonist. J Pharmacol Exp Ther 262: 383-93 (1992)
- Sampaio-Dias, IE; Reis-Mendes, A; Costa, VM; García-Mera, X; Brea, J; Loza, MI; Pires-Lima, BL; Alcoholado, C; Algarra, M; Rodríguez-Borges, JE Discovery of New Potent Positive Allosteric Modulators of Dopamine D J Med Chem 64: 6209-6220 (2021)
- Levoin, N; Murthy, AVR; Narendar, V; Kumar, NS; Aparna, P; Bhavani, AKD; Reddy, CR; Mosset, P; Grée, R Discovery of potent dual ligands for dopamine D4 and ?1 receptors. Bioorg Med Chem 69: (2022)
- Jaen, JC; Wise, LD; Heffner, TG; Pugsley, TA; Meltzer, LT Dopamine autoreceptor agonists as potential antipsychotics. 1. (Aminoalkoxy)anilines. J Med Chem 31: 1621-5 (1988)
- Gmeiner, P; Sommer, J; Mierau, J; Hofner, G Dopamine autoreceptor agonists: computational studies, synthesis and biological investigations Bioorg Med Chem Lett 3: 1477-1483 (1993)
- Lapinsky, DJ; Yarravarapu, N; Nolan, TL; Surratt, CK; Lever, JR; Tomlinson, M; Vaughan, RA; Deutsch, HM Evolution of a Compact Photoprobe for the Dopamine Transporter Based on (±)-threo-Methylphenidate. ACS Med Chem Lett 3: 378-382 (2012)
- Möller, D; Kling, RC; Skultety, M; Leuner, K; Hübner, H; Gmeiner, P Functionally selective dopamine D2, D3 receptor partial agonists. J Med Chem 57: 4861-75 (2014)
- Kalaba, P; Aher, NY; Ili?, M; Draga?evi?, V; Wieder, M; Miklosi, AG; Zehl, M; Wackerlig, J; Roller, A; Beryozkina, T; Radoman, B; Saroja, SR; Lindner, W; Gonzalez, EP; Bakulev, V; Leban, JJ; Sitte, HH; Urban, E; Langer, T; Lubec, G Heterocyclic Analogues of Modafinil as Novel, Atypical Dopamine Transporter Inhibitors. J Med Chem 60: 9330-9348 (2017)
- Chen, J; Levant, B; Wang, S High-affinity and selective dopamine D3 receptor full agonists. Bioorg Med Chem Lett 22: 5612-7 (2012)
- Kongsamut, S; Roehr, JE; Cai, J; Hartman, HB; Weissensee, P; Kerman, LL; Tang, L; Sandrasagra, A Iloperidone binding to human and rat dopamine and 5-HT receptors. Eur J Pharmacol 317: 417-23 (1996)
- Bonifazi, A; Battiti, FO; Sanchez, J; Zaidi, SA; Bow, E; Makarova, M; Cao, J; Shaik, AB; Sulima, A; Rice, KC; Katritch, V; Canals, M; Lane, JR; Newman, AH Novel Dual-Target ?-Opioid Receptor and Dopamine D J Med Chem 64: 7778-7808 (2021)
- Bonifazi, A; Saab, E; Sanchez, J; Nazarova, AL; Zaidi, SA; Jahan, K; Katritch, V; Canals, M; Lane, JR; Newman, AH Pharmacological and Physicochemical Properties Optimization for Dual-Target Dopamine D J Med Chem 66: 10304-10341 (2023)
- Schwalbe, T; Kaindl, J; Hübner, H; Gmeiner, P Potent haloperidol derivatives covalently binding to the dopamine D2 receptor. Bioorg Med Chem 25: 5084-5094 (2017)
- Carroll, FI; Gao, Y; Abraham, P; Lewin, AH; Lew, R; Patel, A; Boja, JW; Kuhar, MJ Probes for the cocaine receptor. Potentially irreversible ligands for the dopamine transporter. J Med Chem 35: 1813-7 (1992)
- Neumeyer, JL; Kula, NS; Bergman, J; Baldessarini, RJ Receptor affinities of dopamine D1 receptor-selective novel phenylbenzazepines. Eur J Pharmacol 474: 137-40 (2003)
- Shaik, AB; Boateng, CA; Battiti, FO; Bonifazi, A; Cao, J; Chen, L; Chitsazi, R; Ravi, S; Lee, KH; Shi, L; Newman, AH Structure Activity Relationships for a Series of Eticlopride-Based Dopamine D J Med Chem 64: 15313-15333 (2021)
- Fyfe, TJ; Kellam, B; Sykes, DA; Capuano, B; Scammells, PJ; Lane, JR; Charlton, SJ; Mistry, SN Structure-Kinetic Profiling of Haloperidol Analogues at the Human Dopamine D J Med Chem 62: 9488-9520 (2019)
- Risgaard, R; Jensen, M; Jørgensen, M; Bang-Andersen, B; Christoffersen, CT; Jensen, KG; Kristensen, JL; Püschl, A Synthesis and SAR study of a novel series of dopamine receptor agonists. Bioorg Med Chem 22: 381-92 (2013)
- Cabedo, N; Protais, P; Cassels, BK; Cortes, D Synthesis and dopamine receptor selectivity of the benzyltetrahydroisoquinoline, (R)-(+)-nor-roefractine. J Nat Prod 61: 709-12 (1998)
- Jean, M; Renault, J; Levoin, N; Danvy, D; Calmels, T; Berrebi-Bertrand, I; Robert, P; Schwartz, JC; Lecomte, JM; Uriac, P; Capet, M Synthesis and evaluation of amides surrogates of dopamine D3 receptor ligands. Bioorg Med Chem Lett 20: 5376-9 (2010)
- Hocke, C; Prante, O; Löber, S; Hübner, H; Gmeiner, P; Kuwert, T Synthesis and radioiodination of selective ligands for the dopamine D3 receptor subtype. Bioorg Med Chem Lett 14: 3963-6 (2004)
- Andersen, PH The dopamine inhibitor GBR 12909: selectivity and molecular mechanism of action. Eur J Pharmacol 166: 493-504 (1989)
- Michino, M; Boateng, CA; Donthamsetti, P; Yano, H; Bakare, OM; Bonifazi, A; Ellenberger, MP; Keck, TM; Kumar, V; Zhu, C; Verma, R; Deschamps, JR; Javitch, JA; Newman, AH; Shi, L Toward Understanding the Structural Basis of Partial Agonism at the Dopamine D J Med Chem 60: 580-593 (2017)
- Banister, SD; Moussa, IA; Beinat, C; Reynolds, AJ; Schiavini, P; Jorgensen, WT; Kassiou, M Trishomocubane as a scaffold for the development of selective dopamine transporter (DAT) ligands. Bioorg Med Chem Lett 21: 38-41 (2010)
- Newman, AH; Zou, MF; Ferrer, JV; Javitch, JA [3H]MFZ 2-12: a novel radioligand for the dopamine transporter. Bioorg Med Chem Lett 11: 1659-61 (2001)
- Ukairo, OT; Bondi, CD; Newman, AH; Kulkarni, SS; Kozikowski, AP; Pan, S; Surratt, CK Recognition of benztropine by the dopamine transporter (DAT) differs from that of the classical dopamine uptake inhibitors cocaine, methylphenidate, and mazindol as a function of a DAT transmembrane 1 aspartic acid residue. J Pharmacol Exp Ther 314: 575-83 (2005)
- Carlier, PR; Lo, MM; Lo, PC; Richelson, E; Tatsumi, M; Reynolds, IJ; Sharma, TA Synthesis of a potent wide-spectrum serotonin-, norepinephrine-, dopamine-reuptake inhibitor (SNDRI) and a species-selective dopamine-reuptake inhibitor based on the gamma-amino alcohol functional group. Bioorg Med Chem Lett 8: 487-92 (1999)
- Shah, JH; Izenwasser, S; Geter-Douglass, B; Witkin, JM; Newman, AH (+/-)-(N-alkylamino)benzazepine analogs: novel dopamine D1 receptor antagonists. J Med Chem 38: 4284-93 (1995)
- Stjernlöf, P; Lin, CH; Sonesson, C; Svensson, K; Smith, MW (Dipropylamino)-tetrahydronaphthofurans: centrally acting serotonin agonists and dopamine agonists-antagonists Bioorg Med Chem Lett 7: 2759-2764 (1997)
- Grundt, P; Husband, SL; Luedtke, RR; Taylor, M; Newman, AH Analogues of the dopamine D2 receptor antagonist L741,626: Binding, function, and SAR. Bioorg Med Chem Lett 17: 745-9 (2007)
- Brown, DG; Bernstein, PR; Wu, Y; Urbanek, RA; Becker, CW; Throner, SR; Dembofsky, BT; Steelman, GB; Lazor, LA; Scott, CW; Wood, MW; Wesolowski, SS; Nugiel, DA; Koch, S; Yu, J; Pivonka, DE; Li, S; Thompson, C; Zacco, A; Elmore, CS; Schroeder, P; Liu, J; Hurley, CA; Ward, S; Hunt, HJ; Williams, K; McLaughlin, J; Hoesch, V; Sydserff, S; Maier, D; Aharony, D Azepines and piperidines with dual norepinephrine dopamine uptake inhibition and antidepressant activity. ACS Med Chem Lett 4: 46-51 (2013)
- Meltzer, PC; Blundell, P; Chen, Z; Yong, YF; Madras, BK Bicyclo[3.2.1]octanes: synthesis and inhibition of binding at the dopamine and serotonin transporters. Bioorg Med Chem Lett 9: 857-62 (1999)
- Battiti, FO; Zaidi, SA; Katritch, V; Newman, AH; Bonifazi, A Chiral Cyclic Aliphatic Linkers as Building Blocks for Selective Dopamine D J Med Chem 64: 16088-16105 (2021)
- Tobinaga, H; Masuda, K Condensed ring compounds having dopamine D3 receptor antagonistic effect US Patent US11578084 (2023)
- Boyfield, I; Brown, TH; Coldwell, MC; Cooper, DG; Hadley, MS; Hagan, JJ; Healy, MA; Johns, A; King, RJ; Middlemiss, DN; Nash, DJ; Riley, GJ; Scott, EE; Smith, SA; Stemp, G Design and synthesis of 2-naphthoate esters as selective dopamine D4 antagonists. J Med Chem 39: 1946-8 (1996)
- Cha, MY; Choi, BC; Kang, KH; Pae, AN; Choi, KI; Cho, YS; Koh, HY; Lee, HY; Jung, D; Kong, JY Design and synthesis of a piperazinylalkylisoxazole library for subtype selective dopamine receptor ligands. Bioorg Med Chem Lett 12: 1327-30 (2002)
- Stoelwinder, J; Roberti, M; Kozikowski, AP; Johnson, KM; Bergmann, JS Differential binding and dopamine uptake activity of cocaine analogues modified at nitrogen Bioorg Med Chem Lett 4: 303-308 (1994)
- Tolentino, KT; Mashinson, V; Vadukoot, AK; Hopkins, CR Discovery and characterization of benzyloxy piperidine based dopamine 4 receptor antagonists. Bioorg Med Chem Lett 61: (2022)
- Xiao, J; Free, RB; Barnaeva, E; Conroy, JL; Doyle, T; Miller, B; Bryant-Genevier, M; Taylor, MK; Hu, X; Dulcey, AE; Southall, N; Ferrer, M; Titus, S; Zheng, W; Sibley, DR; Marugan, JJ Discovery, optimization, and characterization of novel D2 dopamine receptor selective antagonists. J Med Chem 57: 3450-63 (2014)
- Newman, AH; Kumar, V; Shaik, AB Dopamine D3 receptor selective antagonists/partial agonists and uses thereof US Patent US11337971 (2022)
- Creese, I; Burt, DR; Snyder, SH Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs. J Neuropsychiatry Clin Neurosci 8: 223-6 (1996)
- Battiti, FO; Newman, AH; Bonifazi, A Exception That Proves the Rule: Investigation of Privileged Stereochemistry in Designing Dopamine D ACS Med Chem Lett 11: 1956-1964 (2020)
- Zhai, H; Miller, J; Sammis, G First enantioselective syntheses of the dopamine D1 and D2 receptor modulators, (+)- and (-)-govadine. Bioorg Med Chem Lett 22: 1557-9 (2012)
- Chumpradit, S; Kung, MP; Billings, J; Mach, R; Kung, HF Fluorinated and iodinated dopamine agents: D2 imaging agents for PET and SPECT. J Med Chem 36: 221-8 (1993)
- Avenell, KY; Boyfield, I; Coldwell, MC; Hadley, MS; Healy, MA; Jeffrey, PM; Johnson, CN; Nash, DJ; Riley, GJ; Scott, EE; Smith, SA; Stacey, R; Stemp, G; Thewlis, KM Fused aminotetralins: novel antagonists with high selectivity for the dopamine D3 receptor. Bioorg Med Chem Lett 8: 2859-64 (1998)
- Reilly, SW; Riad, AA; Hsieh, CJ; Sahlholm, K; Jacome, DA; Griffin, S; Taylor, M; Weng, CC; Xu, K; Kirschner, N; Luedtke, RR; Parry, C; Malhotra, S; Karanicolas, J; Mach, RH Leveraging a Low-Affinity Diazaspiro Orthosteric Fragment to Reduce Dopamine D J Med Chem 62: 5132-5147 (2019)
- Houlihan, WJ; Kelly, L; Pankuch, J; Koletar, J; Brand, L; Janowsky, A; Kopajtic, TA Mazindol analogues as potential inhibitors of the cocaine binding site at the dopamine transporter. J Med Chem 45: 4097-109 (2002)
- Sokoloff, P; Giros, B; Martres, MP; Bouthenet, ML; Schwartz, JC Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics. Nature 347: 146-51 (1990)
- Stormann, TM; Gdula, DC; Weiner, DM; Brann, MR Molecular cloning and expression of a dopamine D2 receptor from human retina. Mol Pharmacol 37: 1-6 (1990)
- Vass, M; Agai-Csongor, E; Horti, F; Keseru, GM Multiple fragment docking and linking in primary and secondary pockets of dopamine receptors. ACS Med Chem Lett 5: 1010-4 (2014)
- Grundt, P; Kopajtic, TA; Katz, JL; Newman, AH N-8-Substituted benztropinamine analogs as selective dopamine transporter ligands. Bioorg Med Chem Lett 15: 5419-23 (2005)
- Bøgesø, KP Neuroleptic activity and dopamine-uptake inhibition in 1-piperazino-3-phenylindans. J Med Chem 26: 935-47 (1983)
- Austin, NE; Avenell, KY; Boyfield, I; Branch, CL; Coldwell, MC; Hadley, MS; Jeffrey, P; Johns, A; Johnson, CN; Nash, DJ; Riley, GJ; Smith, SA; Stacey, RC; Stemp, G; Thewlis, KM; Vong, AK Novel 1,2,3,4-tetrahydroisoquinolines with high affinity and selectivity for the dopamine D3 receptor. Bioorg Med Chem Lett 9: 179-84 (1999)
- Bonifazi, A; Yano, H; Ellenberger, MP; Muller, L; Kumar, V; Zou, MF; Cai, NS; Guerrero, AM; Woods, AS; Shi, L; Newman, AH Novel Bivalent Ligands Based on the Sumanirole Pharmacophore Reveal Dopamine D J Med Chem 60: 2890-2907 (2017)
- Rosse, G Novel Pyrazolyl-dihydroisoquinolines as Positive Allosteric Modulator of the Dopamine D1 Receptor. ACS Med Chem Lett 11: (2020)
- Belliotti, TR; Kesten, SR; Rubin, JR; Wustrow, DJ; Georgic, LM; Zoski, KT; Akunne, HC; Wise, LD Novel cyclohexyl amides as potent and selective D3 dopamine receptor ligands Bioorg Med Chem Lett 7: 2403-2408 (1997)
- Micheli, F; Cremonesi, S; Semeraro, T; Tarsi, L; Tomelleri, S; Cavanni, P; Oliosi, B; Perdonà, E; Sava, A; Zonzini, L; Feriani, A; Braggio, S; Heidbreder, C Novel morpholine scaffolds as selective dopamine (DA) D3 receptor antagonists. Bioorg Med Chem Lett 26: 1329-32 (2016)
- Merchant, KM; Gill, GS; Harris, DW; Huff, RM; Eaton, MJ; Lookingland, K; Lutzke, BS; Mccall, RB; Piercey, MF; Schreur, PJ; Sethy, VH; Smith, MW; Svensson, KA; Tang, AH; Vonvoigtlander, PF; Tenbrink, RE Pharmacological characterization of U-101387, a dopamine D4 receptor selective antagonist. J Pharmacol Exp Ther 279: 1392-403 (1996)
- Enyedy, IJ; Sakamuri, S; Zaman, WA; Johnson, KM; Wang, S Pharmacophore-based discovery of substituted pyridines as novel dopamine transporter inhibitors. Bioorg Med Chem Lett 13: 513-7 (2003)
- Einsiedel, J; Thomas, C; Hübner, H; Gmeiner, P Phenyloxazoles and phenylthiazoles as benzamide bioisosteres: synthesis and dopamine receptor binding profiles. Bioorg Med Chem Lett 10: 2041-4 (2001)
- Mavel, S; Mincheva, Z; Méheux, N; Carcenac, Y; Guilloteau, D; Abarbri, M; Emond, P QSAR study and synthesis of new phenyltropanes as ligands of the dopamine transporter (DAT). Bioorg Med Chem 20: 1388-95 (2012)
- Meegalla, SK; Plössl, K; Kung, MP; Stevenson, DA; Mu, M; Kushner, S; Liable-Sands, LM; Rheingold, AL; Kung, HF Specificity of diastereomers of [99mTc]TRODAT-1 as dopamine transporter imaging agents. J Med Chem 41: 428-36 (1998)
- Weichert, D; Stanek, M; Hübner, H; Gmeiner, P Structure-guided development of dualß2 adrenergic/dopamine D2 receptor agonists. Bioorg Med Chem 24: 2641-53 (2016)
- Wustrow, DJ; Wise, LD; Cody, DM; MacKenzie, RG; Georgic, LM; Pugsley, TA; Heffner, TG Studies of the active conformation of a novel series of benzamide dopamine D2 agonists. J Med Chem 37: 4251-7 (1995)
- Sonesson, C; Waters, N; Svensson, K; Carlsson, A; Smith, MW; Piercey, MF; Meier, E; Wikström, H Substituted 3-phenylpiperidines: new centrally acting dopamine autoreceptor antagonists. J Med Chem 36: 3188-96 (1993)
- Glase, SA; Akunne, HC; Georgic, LM; Heffner, TG; MacKenzie, RG; Manley, PJ; Pugsley, TA; Wise, LD Substituted [(4-phenylpiperazinyl)-methyl]benzamides: selective dopamine D4 agonists. J Med Chem 40: 1771-2 (1997)
- Bezuglov, V; Bobrov, M; Gretskaya, N; Gonchar, A; Zinchenko, G; Melck, D; Bisogno, T; Di Marzo, V; Kuklev, D; Rossi, JC; Vidal, JP; Durand, T Synthesis and biological evaluation of novel amides of polyunsaturated fatty acids with dopamine. Bioorg Med Chem Lett 11: 447-9 (2001)
- Aksu, K; Nar, M; Tanc, M; Vullo, D; Gülçin, I; Göksu, S; Tümer, F; Supuran, CT Synthesis and carbonic anhydrase inhibitory properties of sulfamides structurally related to dopamine. Bioorg Med Chem 21: 2925-31 (2013)
- Madapa, S; Gadhiya, S; Kurtzman, T; Alberts, IL; Ramsey, S; Reith, M; Harding, WW Synthesis and evaluation of C9 alkoxy analogues of (-)-stepholidine as dopamine receptor ligands. Eur J Med Chem 125: 255-268 (2017)
- Kotić, S; Šoskić, V; Joksimović, J Synthesis and evaluation of several cathechol bioisosteres as potential dopamine receptor ligands Bioorg Med Chem Lett 1: 403-406 (1991)
- Tu, Z; Li, S; Cui, J; Xu, J; Taylor, M; Ho, D; Luedtke, RR; Mach, RH Synthesis and pharmacological evaluation of fluorine-containing D3 dopamine receptor ligands. J Med Chem 54: 1555-64 (2011)
- Jaen, JC; Caprathe, BW; Wise, LD; Meltzer, LT; Pugsley, TA; Huffner, TG Synthesis and pharmacological evaluation of the enantiomers of the dopamine autoreceptor agonist PD 135385 Bioorg Med Chem Lett 3: 639-644 (1993)
- Huang, Y; Luedtke, RR; Freeman, RA; Wu, L; Mach, RH Synthesis and structure-activity relationships of naphthamides as dopamine D3 receptor ligands. J Med Chem 44: 1815-26 (2001)
- Kline, RH; Wright, J; Fox, KM; Eldefrawi, ME Synthesis of 3-arylecgonine analogues as inhibitors of cocaine binding and dopamine uptake. J Med Chem 33: 2024-7 (1990)
- Ellefson, CR; Prodan, KA; Brougham, LR; Miller, A Synthesis of 8-aryltetrahydroisoquinolines as dopamine antagonists and evaluation for potential neuroleptic activity. J Med Chem 23: 977-80 (1980)
- Eydoux, F; Chlenov, MA; Réglier, M Synthesis of indane derivatives as mechanism-based inhibitors of dopamine β-hydroxylase Bioorg Med Chem Lett 5: 941-944 (1995)
- Davies, HM; Hopper, DW; Hansen, T; Liu, Q; Childers, SR Synthesis of methylphenidate analogues and their binding affinities at dopamine and serotonin transport sites. Bioorg Med Chem Lett 14: 1799-802 (2004)
- Huang, Y; Kegeles, LS; Bae, S; Hwang, D; Roth, BL; Savage, JE; Laruelle, M Synthesis of potent and selective dopamine D(4) antagonists as candidate radioligands. Bioorg Med Chem Lett 11: 1375-7 (2001)
- Lomenzo, SA; Izenwasser, S; Gerdes, RM; Katz, JL; Kopajtic, T; Trudell, ML Synthesis, dopamine and serotonin transporter binding affinities of novel analogues of meperidine. Bioorg Med Chem Lett 9: 3273-6 (2000)
- Hoepping, A; Reisgys, M; Brust, P; Seifert, S; Spies, H; Alberto, R; Johannsen, B TROTEC-1: a new high-affinity ligand for labeling of the dopamine transporter. J Med Chem 41: 4429-32 (1998)
- Lapa, GB; Byrd, GD; Lapa, AA; Budygin, EA; Childers, SR; Jones, SR; Harp, JJ The synthesis and biological evaluation of dopamine transporter inhibiting activity of substituted diphenylmethoxypiperidines. Bioorg Med Chem Lett 15: 4915-8 (2005)
- Bagli, J; Bogri, T; Voith, K; Lee, D Troponoids. 7. Chemistry and dopamine agonist activity of ciladopa and related aralkyltroponylpiperazines. J Med Chem 29: 186-93 (1986)
- Enzensperger, C; Müller, FK; Schmalwasser, B; Wiecha, P; Traber, H; Lehmann, J Dopamine/serotonin receptor ligands. 16.(1) Expanding dibenz[d,g]azecines to 11- and 12-membered homologues. Interaction with dopamine D(1)-D(5) receptors. J Med Chem 50: 4528-33 (2007)
- ChEMBL_62801 (CHEMBL674114) Inhibition of dopamine uptake at dopamine transporter.
- ChEBML_61651 Ability to inhibit the reuptake of dopamine at human dopamine transporter
- ChEMBL_405516 (CHEMBL869861) Inhibition of [3H]dopamine uptake at dopamine transporter
- ChEMBL_582830 (CHEMBL1061666) Inhibition of [3H]dopamine reuptake at dopamine transporter
- ChEMBL_62170 (CHEMBL675167) Inhibition of [3H]dopamine uptake at the dopamine transporter.
- ChEMBL_62182 (CHEMBL672121) Inhibition of [3H]-dopamine uptake at dopamine transporter.
- ChEMBL_62183 (CHEMBL884454) Inhibition of [3H]dopamine uptake at dopamine transporter.
- ChEMBL_62798 (CHEMBL674111) Inhibition of [3H]dopamine uptake at the dopamine transporter.
- ChEMBL_62800 (CHEMBL674113) Inhibition of [3H]dopamine uptake at dopamine transporter.
- ChEMBL_351280 (CHEMBL870733) Inhibition of dopamine reuptake at human recombinant dopamine transporter
- ChEMBL_62972 (CHEMBL677462) Inhibition of dopamine uptake from dopamine uptake site
- ChEBML_62638 Inhibition of [3H]dopamine uptake at striatal nerve endings by dopamine transporter
- ChEMBL_62636 (CHEMBL676682) Inhibition of [3H]dopamine uptake via rat dopamine receptor.
- ChEBML_60524 Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase
- ChEBML_58796 The binding affinity was measured on dopamine receptor D1 using [3H]- dopamine as radioligand.
- ChEBML_60499 In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1
- ChEBML_61514 Inhibition of [3H]dopamine uptake in HEK cells expressing human Dopamine transporter
- ChEBML_62496 Ability to inhibit reuptake of dopamine ([3H]DA) at dopamine transporter of rat striatum
- ChEBML_62899 The binding affinity was measured on dopamine receptor D3 using [3H]- dopamine as radioligand.
- ChEMBL_216109 (CHEMBL816032) Inhibition of [3H]dopamine binding to dopamine receptor of rat corpus striatum
- ChEMBL_216110 (CHEMBL816033) Inhibition of [3H]dopamine binding to dopamine receptor of rat corpus striatum
- ChEMBL_2261975 (CHEMBL5216986) Inhibition of dopamine transporter (unknown origin) assessed as inhibition of dopamine reuptake
- ChEMBL_59592 (CHEMBL672941) Inhibition of [3H]dopamine binding to Dopamine receptor in calf caudate nuclei.
- ChEMBL_61987 (CHEMBL670592) Inhibition of [3H]dopamine uptake at the dopamine transporter in rat striatal tissue
- ChEMBL_62476 (CHEMBL677368) Inhibition of [3H]dopamine binding to rat striatal synaptosome dopamine transporter
- ChEMBL_62638 (CHEMBL676683) Inhibition of [3H]dopamine uptake at striatal nerve endings by dopamine transporter
- ChEMBL_654116 (CHEMBL1228922) Inhibition of dopamine reuptake at human dopamine transporter expressed in CHO cells
- ChEBML_177229 Inhibition of dopamine uptake in synaptosomal preparation in rat corpus striatum, using [3H]dopamine
- ChEMBL_1615836 (CHEMBL3857905) Inhibition of dopamine transporter (unknown origin) assessed as suppression of synaptosomal uptake of dopamine
- ChEMBL_306589 (CHEMBL832936) Inhibition of [3H]dopamine uptake in HEK293 cells expressing human dopamine transporter
- ChEMBL_339939 (CHEMBL862305) Inhibition of dopamine re-uptake at human dopamine transporter expressed in HEK293 cells
- ChEMBL_463819 (CHEMBL948898) Inhibition of [3H]dopamine uptake at human dopamine transporter expressed in HEK293 cells
- ChEMBL_58796 (CHEMBL667038) The binding affinity was measured on dopamine receptor D1 using [3H]- dopamine as radioligand.
- ChEMBL_608505 (CHEMBL1065164) Inhibition of [3H]dopamine reuptake at rat brain frontal cortex dopamine transporter
- ChEMBL_61503 (CHEMBL672997) Inhibition of dopamine uptake in HEK cells expressing human dopamine transporter (hDAT)
- ChEMBL_61511 (CHEMBL670828) Inhibition of [3H]dopamine reuptake in HEK293 cells expressing human dopamine transporter
- ChEMBL_61512 (CHEMBL671432) Inhibition of dopamine (DA) reuptake using cloned human dopamine transporter was determined
- ChEMBL_61514 (CHEMBL671434) Inhibition of [3H]dopamine uptake in HEK cells expressing human Dopamine transporter
- ChEMBL_62302 (CHEMBL675224) Inhibition of dopamine uptake into rat striatal tissue, using [3H]- dopamine as the radioligand.
- ChEMBL_62496 (CHEMBL677553) Ability to inhibit reuptake of dopamine ([3H]DA) at dopamine transporter of rat striatum
- ChEMBL_62899 (CHEMBL676138) The binding affinity was measured on dopamine receptor D3 using [3H]- dopamine as radioligand.
- ChEMBL_839139 (CHEMBL2077810) TP_TRANSPORTER: inhibition of Dopamine uptake (Dopamine: 200 uM) in Xenopus laevis oocytes
- ChEMBL_177229 (CHEMBL783703) Inhibition of dopamine uptake in synaptosomal preparation in rat corpus striatum, using [3H]dopamine
- ChEMBL_59582 (CHEMBL672933) Evaluated for the inhibition of binding of [3H]DA (dopamine) to dopamine receptor in calf striatal homogenate
- ChEMBL_60008 (CHEMBL675833) Evaluated for the inhibition of binding of [3H]DA (dopamine) to dopamine receptor in rat brain homogenate
- ChEMBL_61854 (CHEMBL670041) Compound was tested for Inhibition of [3H]dopamine uptake at the dopamine transporter in rat strial tissue
- ChEMBL_61986 (CHEMBL670591) Compound was tested for inhibition of [3H]dopamine uptake at the dopamine transporter in rat strial tissue
- ChEBML_305233 Inhibition of dopamine D3 receptor
- ChEBML_305234 Inhibition of dopamine D4 receptor
- ChEBML_58646 Affinity for Dopamine receptor D1
- ChEBML_59102 Inhibition of Dopamine beta hydroxylase.
- ChEBML_62390 Affinity for Dopamine receptor D2
- ChEMBL_761552 (CHEMBL1817432) Inhibition of dopamine transporter
- ChEMBL_59586 (CHEMBL672937) In vitro inhibitory activity was evaluated against [3H]dopamine (DA) calf caudate dopamine receptor
- ChEMBL_59588 (CHEMBL672939) In vitro inhibitory activity was evaluated against,[3H]dopamine (DA),calf caudate dopamine receptor
- ChEBML_58154 Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes. Partial agonist, maximum effect 60% of dopamine maximum effect.
- ChEMBL_58154 (CHEMBL672898) Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes. Partial agonist, maximum effect 60% of dopamine maximum effect.
- ChEMBL_60526 (CHEMBL674937) Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes. Partial agonist, maximum effect 59% of dopamine maximum effect
- ChEBML_61990 Compound was tested for its ability to inhibit the neurotransmitter dopamine-DA reuptake system using [3H]dopamine as radioligand
- ChEMBL_571436 (CHEMBL1032747) Inhibition of [3H]dopamine uptake at human dopamine transporter expressed in mouse N2A cells by scintillation counting
- ChEMBL_58663 (CHEMBL670437) Dopamine receptor D1 antagonistic activity as ability to block dopamine-stimulated adenylate cyclase in rat caudate
- ChEMBL_59584 (CHEMBL672935) In vitro inhibitory activity against dopamine receptor from calf caudate using [3H]dopamine as radioligand
- ChEMBL_60523 (CHEMBL674934) Dopamine D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes
- ChEMBL_61686 (CHEMBL671771) Inhibitory activity against [3H]-Dopamine uptake from Dopamine transporter in rat caudate putamen tissue
- ChEMBL_61690 (CHEMBL671774) Inhibitory activity against [3H]dopamine uptake from Dopamine transporter in rat caudate putamen tissue
- ChEMBL_62144 (CHEMBL675900) Inhibition of high-affinity uptake of [3H]dopamine at dopamine transporter into rat striatal nerve endings (synaptosomes)
- ChEMBL_62174 (CHEMBL672113) Reuptake inhibition at the dopamine transporter labeled with radioligand [3H]dopamine on synaptosomes obtained from rat caudate.
- ChEBML_1688592 Inhibition of human dopamine D1 receptor
- ChEBML_1688593 Inhibition of human dopamine D2 receptor
- ChEBML_1688594 Inhibition of human dopamine D3 receptor
- ChEBML_1688595 Inhibition of human dopamine D5 receptor
- ChEBML_302616 Binding affinity for dopamine D2 receptor
- ChEBML_302618 Binding affinity for dopamine D4 receptor
- ChEBML_305085 Inhibition of rat dopamine D3 receptor
- ChEBML_305086 Inhibition of rat dopamine D4 receptor
- ChEBML_58660 Binding affinity for dopamine receptor D1
- ChEBML_59436 Inhibitory activity against the dopamine decarboxylase
- ChEBML_62245 Binding affinity to dopamine receptor D2
- ChEBML_62472 Binding affinity for dopamine transporter (DAT)
- ChEBML_62576 Binding affinity for dopamine receptor D2
- ChEMBL_1554623 (CHEMBL3768719) Inhibition of human dopamine transporter
- ChEMBL_2268437 Inhibition of dopamine transporter (unknown origin)
- ChEMBL_2286669 Inhibition of dopamine transporter (unknown origin)
- ChEMBL_2336075 Inhibition of dopamine receptor (unknown origin)
- ChEMBL_447510 (CHEMBL896533) Inhibition of dopamine D2 receptor
- ChEMBL_447511 (CHEMBL896534) Inhibition of dopamine D3 receptor
- ChEMBL_458979 (CHEMBL925073) Inhibition of dopamine D2 receptor
- ChEMBL_458981 (CHEMBL925075) Binding affinity to dopamine transporter
- ChEMBL_476019 (CHEMBL927099) Inhibition of dopamine D1 receptor
- ChEMBL_476020 (CHEMBL927100) Inhibition of dopamine D2 receptor
- ChEMBL_514038 (CHEMBL979061) Inhibition of dopamine D2 receptor
- ChEMBL_520034 (CHEMBL939873) Binding affinity to dopamine transporter
- ChEMBL_532090 (CHEMBL993303) Inhibition of dopamine uptake at DAT
- ChEMBL_536127 (CHEMBL983581) Inhibition of dopamine D2 receptor
- ChEMBL_539365 (CHEMBL1027249) Binding affinity to dopamine transporter
- ChEMBL_579693 (CHEMBL1053207) Inhibition of human dopamine transporter
- ChEMBL_59102 (CHEMBL667895) Inhibition of Dopamine beta hydroxylase.
- ChEMBL_592332 (CHEMBL1046707) Inhibition of dopamine D1 receptor
- ChEMBL_592333 (CHEMBL1046708) Inhibition of dopamine D2 receptor
- ChEMBL_592334 (CHEMBL1046709) Inhibition of dopamine D3 receptor
- ChEMBL_59302 (CHEMBL669437) Inhibition of dopamine beta hydroxylase
- ChEMBL_601708 (CHEMBL1050443) Inhibition of dopamine D1 receptor
- ChEMBL_601709 (CHEMBL1050444) Inhibition of dopamine D2 receptor
- ChEMBL_601710 (CHEMBL1050445) Inhibition of dopamine D5 receptor
- ChEMBL_615841 (CHEMBL1101951) Inhibition of dopamine D2 receptor
- ChEMBL_615842 (CHEMBL1101952) Inhibition of dopamine D3 receptor
- ChEMBL_617090 (CHEMBL1101348) Inhibition of dopamine D2 receptor
- ChEMBL_617091 (CHEMBL1101349) Inhibition of dopamine D3 receptor
- ChEMBL_617092 (CHEMBL1101350) Inhibition of dopamine D4 receptor
- ChEMBL_61988 (CHEMBL670593) Inhibition of dopamine DA reuptake
- ChEMBL_622531 (CHEMBL1116589) Inhibition of human dopamine transporter
- ChEMBL_624451 (CHEMBL1108779) Inhibition of dopamine D2 (receptor)
- ChEMBL_624452 (CHEMBL1108780) Inhibition of dopamine D3 (receptor)
- ChEMBL_624453 (CHEMBL1108781) Inhibition of dopamine D4 (receptor)
- ChEMBL_62478 (CHEMBL677370) Binding affinity for dopamine transporter
- ChEMBL_62951 (CHEMBL675535) Concentration inhibiting Dopamine transporter
- ChEMBL_630143 (CHEMBL1113734) Inhibition of dopamine D1 receptor
- ChEMBL_630144 (CHEMBL1113735) Inhibition of dopamine D2 receptor
- ChEMBL_630145 (CHEMBL1113736) Inhibition of dopamine D3 receptor
- ChEMBL_649503 (CHEMBL1219201) Inhibition of dopamine D2 receptor
- ChEMBL_649646 (CHEMBL1219344) Binding affinity to dopamine D2
- ChEMBL_685495 (CHEMBL1285526) Binding affinity to dopamine D1
- ChEMBL_685496 (CHEMBL1285527) Binding affinity to dopamine D2
- ChEMBL_700864 (CHEMBL1646423) Inhibition of dopamine D3 receptor
- ChEMBL_700868 (CHEMBL1646427) Inhibition of dopamine D5 receptor
- ChEMBL_714780 (CHEMBL1663586) Inhibition of human dopamine transporter
- ChEMBL_747461 (CHEMBL1776961) Inhibition of dopamine D4 receptor
- ChEMBL_795936 (CHEMBL1936809) Inhibition of dopamine D2 receptor
- ChEMBL_820281 (CHEMBL2033368) Inhibition of D2 dopamine receptor
- ChEMBL_820282 (CHEMBL2033369) Inhibition of D3 dopamine receptor
- ChEMBL_820284 (CHEMBL2033371) Inhibition of D5 dopamine receptor
- ChEMBL_875717 (CHEMBL2185769) Binding affinity to dopamine transporter
- ChEMBL_946917 (CHEMBL2346458) Inhibition of human dopamine transporter
- ChEBML_61501 Ability to inhibit human dopamine uptake by the human dopamine transporter in EM4 cells stably infected with Flag HA-hDAT
- ChEBML_61991 Compound was tested for its ability to inhibit the uptake of [3H]dopamine in DAT (dopamine transporter system) expressing cell line
- ChEMBL_507938 (CHEMBL952559) Inhibition of dopamine transporter-mediated [3H]dopamine uptake in Wistar rat striatal synaptosomes by liquid scintillation spectrometry
- ChEMBL_596936 (CHEMBL1048877) Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation counting
- ChEMBL_61990 (CHEMBL670595) Compound was tested for its ability to inhibit the neurotransmitter dopamine-DA reuptake system using [3H]dopamine as radioligand
- ChEMBL_60062 (CHEMBL671376) Antagonism of dopamine-stimulated [35S]GTP-gamma-S binding against human Dopamine receptor D2 in CHO cells
- ChEMBL_60659 (CHEMBL671696) Antagonism of dopamine-stimulated [35S]GTP-gamma-S binding against human Dopamine receptor D4 in CHO cells
- ChEBML_176345 Inhibition of dopamine uptake in rat synaptosomal fraction
- ChEBML_31418 In vitro inhibition of dopamine stimulated adenylate cyclase
- ChEBML_52581 Percent inhibition towards dopamine D2 receptor
- ChEBML_52597 Percent inhibition towards dopamine D3 receptor
- ChEBML_52724 Percent inhibition towards dopamine D4 receptor
- ChEBML_58202 Binding affinity towards Dopamine receptor D2
- ChEBML_58459 Binding affinity against dopamine D2 receptor
- ChEBML_58645 Binding affinity towards Dopamine receptor D1
- ChEBML_58971 Compound was evaluated for Dopamine receptor D1 binding
- ChEBML_59144 Binding affinity against dopamine receptor D1A
- ChEBML_59303 Inhibitory activity against the dopamine beta hydroxylase
- ChEBML_59636 Binding affinity towards Dopamine receptor D2
- ChEBML_60059 Affinity towards human dopamine receptor D2
- ChEBML_60490 Affinity towards human Dopamine receptor D1
- ChEBML_60810 Binding affinity for rat Dopamine receptor D2
- ChEBML_60811 Binding affinity for rat Dopamine receptor D2
- ChEBML_60843 Binding affinity against Dopamine receptor D4
- ChEBML_60988 Binding affinity to Dopamine receptor D4 was determined
- ChEBML_61114 Inhibitory concentration against Dopamine receptor D2
- ChEBML_61121 Binding affinity to Dopamine receptor D2 was determined
- ChEBML_61127 Compound was evaluated for Dopamine receptor D2 binding
- ChEBML_61144 Binding affinity towards dopamine receptor D2
- ChEBML_61273 Binding affinity of compound to Dopamine receptor D2
- ChEBML_61332 Affinity towards human dopamine receptor D5
- ChEBML_61647 Binding affinity against Dopamine receptor D2L
- ChEBML_62002 Effect on synaptosomal uptake inhibition of Dopamine transporter
- ChEBML_62114 Affinity towards human dopamine receptor D3
- ChEBML_62171 Inhibition of [3H]mazindol binding to the dopamine transporter.
- ChEBML_62452 Binding affinity against Dopamine receptor D3
- ChEBML_62473 Binding affinity towards dopamine transporter (DAT)
- ChEBML_62807 Displacement of [3H]mazindol from dopamine transporter
- ChEBML_62967 In vitro binding affinity for dopamine uptake site
- ChEBML_63109 Affinity towards human dopamine receptor D4
- ChEMBL_1339957 (CHEMBL3243864) Inhibition of human dopamine D1 receptor
- ChEMBL_1339958 (CHEMBL3243865) Inhibition of human dopamine D4 receptor
- ChEMBL_1439002 (CHEMBL3383109) Inhibition of human dopamine D1 receptor
- ChEMBL_1439003 (CHEMBL3383110) Inhibition of human dopamine D2 receptor
- ChEMBL_1439004 (CHEMBL3383111) Inhibition of human dopamine D3 receptor
- ChEMBL_1439005 (CHEMBL3383112) Inhibition of human dopamine D4 receptor
- ChEMBL_1439009 (CHEMBL3383656) Inhibition of human dopamine D2L receptor
- ChEMBL_1688593 (CHEMBL4039163) Inhibition of human dopamine D2 receptor
- ChEMBL_1688620 (CHEMBL4039190) Inhibition of human dopamine D4 receptor
- ChEMBL_1817364 (CHEMBL4317024) Inhibition of dopamine receptor (unknown origin)
- ChEMBL_1833862 (CHEMBL4333870) Inhibition of dopamine transporter (unknown origin)
- ChEMBL_1859530 (CHEMBL4360386) Inhibition of dopamine transporter (unknown origin)
- ChEMBL_2027265 (CHEMBL4681423) Inhibition of dopamine transporter (unknown origin)
- ChEMBL_216102 (CHEMBL817691) The compound was tested for inhibition of dopamine reuptake
- ChEMBL_2162545 (CHEMBL5047406) Inhibition of dopamine transporter (unknown origin)
- ChEMBL_302368 (CHEMBL829549) Binding affinity for Dopamine receptor D4
- ChEMBL_320747 (CHEMBL881220) Inhibition constant against dopamine transporter
- ChEMBL_320837 (CHEMBL871679) Inhibition of monoamine reuptake at dopamine transporter
- ChEMBL_321258 (CHEMBL881883) Inhibitory concentration against dopamine transporter
- ChEMBL_321339 (CHEMBL880623) Inhibitory concentration against dopamine transporter
- ChEMBL_325915 (CHEMBL869385) Inhibition of human dopamine receptor D1
- ChEMBL_325916 (CHEMBL869386) Inhibition of human dopamine receptor D2
- ChEMBL_325917 (CHEMBL869387) Inhibition of human dopamine receptor D3
- ChEMBL_325918 (CHEMBL869388) Inhibition of human dopamine receptor D4.4
- ChEMBL_328774 (CHEMBL864518) Binding affinity to dopamine D1 receptor
- ChEMBL_328775 (CHEMBL864519) Binding affinity to dopamine D2 receptor
- ChEMBL_329925 (CHEMBL868786) Binding affinity to dopamine D1 receptor
- ChEMBL_329926 (CHEMBL868787) Binding affinity to dopamine D2 receptor
- ChEMBL_329927 (CHEMBL868788) Binding affinity to dopamine D3 receptor
- ChEMBL_329928 (CHEMBL868789) Binding affinity to dopamine D4 receptor
- ChEMBL_329929 (CHEMBL868790) Binding affinity to dopamine D5 receptor
- ChEMBL_332082 (CHEMBL858802) Binding affinity to dopamine receptor D1
- ChEMBL_332083 (CHEMBL858805) Binding affinity to dopamine receptor D2
- ChEMBL_334933 (CHEMBL859253) Inhibitory activity against dopamine D1
- ChEMBL_334934 (CHEMBL859254) Inhibitory activity against dopamine D2
- ChEMBL_334935 (CHEMBL859255) Inhibitory activity against dopamine D3
- ChEMBL_391337 (CHEMBL870473) Binding affinity at dopamine D4 receptor
- ChEMBL_391338 (CHEMBL870474) Binding affinity at dopamine D2 receptor
- ChEMBL_391342 (CHEMBL870479) Binding affinity at dopamine D5 receptor
- ChEMBL_438895 (CHEMBL889238) Binding affinity for dopamine D2 receptor
- ChEMBL_449184 (CHEMBL899449) Activity against human dopamine transporter
- ChEMBL_458722 (CHEMBL942057) Binding affinity to dopamine D1 receptor
- ChEMBL_458723 (CHEMBL942058) Binding affinity to dopamine D5 receptor
- ChEMBL_460797 (CHEMBL944738) Binding affinity to dopamine D1 receptor
- ChEMBL_465424 (CHEMBL946008) Binding affinity to dopamine D2 receptor
- ChEMBL_474646 (CHEMBL920904) Binding affinity at dopamine D2 receptor
- ChEMBL_487760 (CHEMBL1009492) Binding affinity to dopamine D2 receptor
- ChEMBL_491100 (CHEMBL982123) Binding affinity to dopamine D3 receptor
- ChEMBL_491101 (CHEMBL982124) Binding affinity to dopamine D2 receptor
- ChEMBL_492769 (CHEMBL939457) Antagonist activity at dopamine D2 receptor
- ChEMBL_510243 (CHEMBL1005621) Antagonist activity at dopamine D2 receptor
- ChEMBL_514049 (CHEMBL979072) Agonist activity at dopamine D2 receptor
- ChEMBL_537457 (CHEMBL990622) Binding affinity at dopamine D2 receptor
- ChEMBL_538667 (CHEMBL1033065) Antagonist activity at dopamine D2 receptor
- ChEMBL_538668 (CHEMBL1033066) Antagonist activity at dopamine D3 receptor
- ChEMBL_555734 (CHEMBL959090) Binding affinity at dopamine D2 receptor
- ChEMBL_556740 (CHEMBL959803) Binding affinity to dopamine D3 receptor
- ChEMBL_556749 (CHEMBL959812) Binding affinity to dopamine D2 receptor
- ChEMBL_556750 (CHEMBL959813) Binding affinity to dopamine D1 receptor
- ChEMBL_556753 (CHEMBL959816) Binding affinity to dopamine D5 receptor
- ChEMBL_556760 (CHEMBL960611) Binding affinity to dopamine uptake transporter
- ChEMBL_58196 (CHEMBL670364) Inhibition of mouse Dopamine receptor D2
- ChEMBL_582222 (CHEMBL1059882) Antagonist activity at dopamine D4 receptor
- ChEMBL_588078 (CHEMBL1041330) Agonist activity at dopamine D1 receptor
- ChEMBL_58831 (CHEMBL671915) Affinity towards Dopamine receptor D1
- ChEMBL_59913 (CHEMBL671072) Inhibition of human dopamine receptor D2
- ChEMBL_60181 (CHEMBL675880) Binding affinity towards Dopamine receptor
- ChEMBL_60187 (CHEMBL674898) Affinity towards Dopamine receptor D1
- ChEMBL_60374 (CHEMBL672210) Affinity towards Dopamine receptor D2
- ChEMBL_60486 (CHEMBL674242) Inhibition of human dopamine receptor D1
- ChEMBL_608751 (CHEMBL1067764) Antagonist activity at dopamine D4 receptor
- ChEMBL_608752 (CHEMBL1067765) Agonist activity at dopamine D2 receptor
- ChEMBL_609554 (CHEMBL1073807) Binding affinity to dopamine D1 receptor
- ChEMBL_609555 (CHEMBL1073808) Binding affinity to dopamine D5 receptor
- ChEMBL_609556 (CHEMBL1073809) Binding affinity to dopamine D2 receptor
- ChEMBL_609557 (CHEMBL1073810) Binding affinity to dopamine D4 receptor
- ChEMBL_610407 (CHEMBL1073463) Binding affinity to dopamine D2 receptor
- ChEMBL_61172 (CHEMBL670987) Inhibition of human dopamine receptor D4.4
- ChEMBL_61330 (CHEMBL675948) Inhibition of human dopamine receptor D5
- ChEMBL_61840 (CHEMBL673210) Binding affinity for rat Dopamine transporter.
- ChEMBL_61970 (CHEMBL670426) Inhibition of human dopamine receptor D3
- ChEMBL_62125 (CHEMBL673446) Binding affinity at dopamine receptor D3
- ChEMBL_62245 (CHEMBL671577) Binding affinity to dopamine receptor D2
- ChEMBL_62332 (CHEMBL674426) Ability to inhibition uptake of [2H]-Dopamine
- ChEMBL_62471 (CHEMBL679108) Binding affinity towards dopamine transporter
- ChEMBL_62819 (CHEMBL678068) The inhibition of reuptake against dopamine transporter
- ChEMBL_629543 (CHEMBL1120961) Binding affinity to dopamine D3 receptor
- ChEMBL_629557 (CHEMBL1120975) Binding affinity to dopamine D4 receptor
- ChEMBL_62968 (CHEMBL873582) Binding affinity against dopamine transporter
- ChEMBL_644064 (CHEMBL1211963) Binding affinity to dopamine D1 receptor
- ChEMBL_644065 (CHEMBL1211964) Binding affinity to dopamine D2 receptor
- ChEMBL_644069 (CHEMBL1211968) Binding affinity to dopamine D4 receptor
- ChEMBL_652385 (CHEMBL1225588) Binding affinity to dopamine D1 receptor
- ChEMBL_652386 (CHEMBL1225589) Binding affinity to dopamine D2 receptor
- ChEMBL_652387 (CHEMBL1225590) Binding affinity to dopamine D3 receptor
- ChEMBL_652388 (CHEMBL1225591) Binding affinity to dopamine D4 receptor
- ChEMBL_652389 (CHEMBL1225592) Binding affinity to dopamine D5 receptor
- ChEMBL_684873 (CHEMBL1286197) Inhibition of human dopamine D2 receptor
- ChEMBL_685575 (CHEMBL1285353) Antagonist activity at dopamine D2 receptor
- ChEMBL_697200 (CHEMBL1640620) Binding affinity to dopamine receptor D1
- ChEMBL_697201 (CHEMBL1640621) Binding affinity to dopamine receptor D2
- ChEMBL_697202 (CHEMBL1640622) Binding affinity to dopamine receptor D3
- ChEMBL_697203 (CHEMBL1640623) Binding affinity to dopamine receptor D4
- ChEMBL_697204 (CHEMBL1640624) Binding affinity to dopamine receptor D5
- ChEMBL_699288 (CHEMBL1647108) Binding affinity to dopamine D2 receptor
- ChEMBL_699575 (CHEMBL1647933) Inhibition of human recombinant dopamine transporter
- ChEMBL_714776 (CHEMBL1663582) Inhibition of human dopamine D1 receptor
- ChEMBL_714777 (CHEMBL1663583) Inhibition of human dopamine D2 receptor
- ChEMBL_714778 (CHEMBL1663584) Inhibition of human dopamine D3 receptor
- ChEMBL_718155 (CHEMBL1679201) Binding affinity to dopamine D4 receptor
- ChEMBL_718156 (CHEMBL1679202) Binding affinity to dopamine D5 receptor
- ChEMBL_718872 (CHEMBL1681366) Binding affinity to dopamine D1 receptor
- ChEMBL_718873 (CHEMBL1681367) Binding affinity to dopamine D2 receptor
- ChEMBL_718874 (CHEMBL1681368) Binding affinity to dopamine D3 receptor
- ChEMBL_726928 (CHEMBL1686717) Inhibition of human recombinant dopamine transporter
- ChEMBL_744202 (CHEMBL1771959) Binding affinity to dopamine D3 receptor
- ChEMBL_759383 (CHEMBL1810621) Binding affinity to dopamine 2 receptor
- ChEMBL_761642 (CHEMBL1816546) Inhibition of recombinant human dopamine transporter
- ChEMBL_771226 (CHEMBL1839308) Inhibition of human dopamine D2 receptor
- ChEMBL_788043 (CHEMBL1919022) Antagonist activity at dopamine D2 receptor
- ChEMBL_794948 (CHEMBL1936227) Binding affinity to dopamine D1 receptor
- ChEMBL_794949 (CHEMBL1936228) Binding affinity to dopamine D2 receptor
- ChEMBL_804288 (CHEMBL1954433) Antagonist activity at dopamine D1 receptor
- ChEMBL_804289 (CHEMBL1954434) Antagonist activity at dopamine D2 receptor
- ChEMBL_818582 (CHEMBL2032869) Binding affinity to dopamine D1 receptor
- ChEMBL_818583 (CHEMBL2032870) Binding affinity to dopamine D2 receptor
- ChEMBL_849495 (CHEMBL2149602) Binding affinity to dopamine D2 receptor
- ChEMBL_849496 (CHEMBL2149603) Binding affinity to dopamine D3 receptor
- ChEMBL_875721 (CHEMBL2185773) Binding affinity to dopamine D2 receptor
- ChEMBL_879204 (CHEMBL2208517) Antagonist activity at dopamine D1 receptor
- ChEMBL_879321 (CHEMBL2208719) Inhibition of human dopamine D5 receptor
- ChEMBL_879322 (CHEMBL2208720) Inhibition of human dopamine D4 receptor
- ChEMBL_879323 (CHEMBL2208721) Inhibition of human dopamine D2 receptor
- ChEMBL_879324 (CHEMBL2208722) Inhibition of human dopamine D3 receptor
- ChEMBL_879325 (CHEMBL2208723) Inhibition of human dopamine D1 receptor
- ChEMBL_884312 (CHEMBL2210345) Binding affinity to D3 dopamine receptor
- ChEMBL_884318 (CHEMBL2210351) Binding affinity to D1 dopamine receptor
- ChEMBL_884319 (CHEMBL2210352) Binding affinity to D2 dopamine receptor
- ChEMBL_884320 (CHEMBL2210353) Binding affinity to D4 dopamine receptor
- ChEMBL_884321 (CHEMBL2210354) Binding affinity to D5 dopamine receptor
- ChEBML_58170 Affinity of the Compound for Dopamine D1 receptor in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]SCH-23390 as ligand.
- ChEMBL_1356560 (CHEMBL3286059) Inhibition of [3H]dopamine uptake at dopamine transporter expressed in rat striatal homogenate after 5 mins by scintillation counting analysis
- ChEMBL_52731 (CHEMBL663149) Reuptake inhibition was determined at the dopamine transporter labeled with radioligand [3H]dopamine in nonstandard conditions on brain membranes obtained from rat
- ChEMBL_62173 (CHEMBL675170) Reuptake inhibition was determined at the dopamine transporter labeled with radioligand [3H]dopamine in nonstandard conditions on brain membranes obtained from rat
- ChEMBL_1804344 (CHEMBL4276636) Antagonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as inhibition of dopamine-induced cAMP accumulation preincubated for 15 mins followed by dopamine induction and measured after 30 mins by HTRF assay
- ChEMBL_1878790 (CHEMBL4380184) Inhibition of wild type human dopamine transporter expressed in HEK293 cells assessed as inhibition of [3H]dopamine reuptake preincubated for 5 mins followed by [3H]dopamine addition and measured after 1 min by liquid scintillation analysis
- ChEMBL_1621627 (CHEMBL3863910) Inhibition of human dopamine transporter expressed in HEK293 cells assessed as inhibition of dopamine uptake measured after 30 mins by fluorescence analysis
- ChEMBL_58170 (CHEMBL669678) Affinity of the Compound for Dopamine D1 receptor in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]SCH-23390 as ligand.
- ChEMBL_60023 (CHEMBL675848) Relative affinity for dopamine receptor by displacement of [3H]spiroperidol (2.2 nM) from (in vitro) dopamine binding sites in rat caudate nuclei
- ChEMBL_1561633 (CHEMBL3776848) Antagonist activity at human dopamine D2L receptor expressed in CHO cells assessed as inhibition of dopamine-mediated Ca+2 stimulation pretreated for 10 mins followed by addition of dopamine by fluo-4 AM dye-based FLIPR assay
- ChEMBL_1613480 (CHEMBL3855280) Antagonist activity at human dopamine D2L receptor expressed in CHO cells coexpressing Galpha16 assessed as inhibition of dopamine-induced Ca2+ stimulation pre-incubated for 10 mins followed by dopamine challenge by Fluo-4AM based fluorometric analysis
- ChEMBL_2325145 Antagonist activity at human dopamine D3 receptor expressed in HEK-T cells assessed as inhibition of dopamine-induced cAMP production preincubated for 5 followed by dopamine and NKH-477 addition and measured after 30 mins by fluorescence based analysis
- ChEBML_131451 Tested in vitro for dopamine(DA) neuronal uptake inhibition
- ChEBML_1554004 Binding affinity to dopamine D1 receptor (unknown origin)
- ChEBML_1554005 Binding affinity to dopamine D4 receptor (unknown origin)
- ChEBML_178952 Inhibition of uptake of dopamine (DA) rat brain striatum
- ChEBML_184435 Inhibition of dopamine (DA) uptake into rat brain synaptosomes
- ChEBML_193333 Inhibition of the uptake of tritiated dopamine (DA) in rat synaptosomes
- ChEBML_58478 Compound was tested for its effect on dopamine saturation analysis
- ChEBML_58513 Ancillary Binding affinity to rat Dopamine receptor D1
- ChEBML_58603 Displacement of [3H]-spiperone from dopamine D2 receptor
- ChEBML_58991 Tested for binding affinity against dopamine receptor D1
- ChEBML_60493 Binding affinity towards Dopamine receptor D1 was determined
- ChEBML_60812 In vitro binding affinity to human Dopamine receptor D4
- ChEBML_60840 Binding affinity for human cloned Dopamine receptor D4
- ChEBML_60841 Binding affinity for human cloned Dopamine receptor D4
- ChEBML_61111 Compound was selective with respect to binding at the Dopamine receptor D2
- ChEBML_61306 Tested for binding affinity against dopamine receptor D2
- ChEBML_61645 Binding affinity for human cloned Dopamine receptor D2L
- ChEBML_61646 Binding affinity for human cloned Dopamine receptor D2L
- ChEBML_61997 In vivo inhibition of DA uptake at dopamine uptake site
- ChEBML_62229 Binding affinity against rat Dopamine receptor D2.
- ChEBML_62450 Binding affinity for human cloned Dopamine receptor D3
- ChEBML_62451 Binding affinity for human cloned Dopamine receptor D3
- ChEBML_62643 Reuptake inhibitory activity against dopamine DA transporter
- ChEBML_62872 Displacement of [3H]spiperone from dopamine receptor D2
- ChEBML_62950 Displacement of [3H]WIN-35428 from Dopamine transporter
- ChEMBL_1367803 Inhibition of DAT-mediated dopamine uptake in rat synaptosomes
- ChEMBL_1367804 Induction of DAT-mediated dopamine release in rat synaptosomes
- ChEMBL_1367904 Inhibition of DAT (unknown origin)-mediated dopamine reuptake
- ChEMBL_1445391 (CHEMBL3379090) Inhibition of dopamine D2 receptor (unknown origin)
- ChEMBL_1469013 (CHEMBL3412829) Inhibition of dopamine D1 receptor (unknown origin)
- ChEMBL_1502293 (CHEMBL3591527) Binding affinity to human dopamine D2 receptor
- ChEMBL_1502686 (CHEMBL3593060) Inhibition of dopamine beta-oxygenase (unknown origin)
- ChEMBL_1525544 (CHEMBL3637051) Binding affinity to dopamine receptor (unknown origin)
- ChEMBL_1569998 (CHEMBL3789146) Binding affinity to dopamine receptor (unknown origin)
- ChEMBL_1613487 (CHEMBL3855287) Activity at dopamine D1 receptor (unknown origin)
- ChEMBL_1613488 (CHEMBL3855288) Activity at dopamine D4 receptor (unknown origin)
- ChEMBL_1688623 (CHEMBL4039193) Inhibition of human dopamine D2 (short) receptor
- ChEMBL_1722529 (CHEMBL4137529) Inhibition of dopamine D1 receptor (unknown origin)
- ChEMBL_176345 (CHEMBL783267) Inhibition of dopamine uptake in rat synaptosomal fraction
- ChEMBL_1771297 (CHEMBL4223409) Binding affinity to human dopamine D2 receptor
- ChEMBL_1771298 (CHEMBL4223410) Binding affinity to human dopamine D3 receptor
- ChEMBL_2017999 (CHEMBL4671577) Binding affinity to human dopamine D2 receptor
- ChEMBL_2018000 (CHEMBL4671578) Binding affinity to human dopamine D1 receptor
- ChEMBL_2033536 (CHEMBL4687694) Inhibition of D1 dopamine receptor (unknown origin)
- ChEMBL_2063344 (CHEMBL4718597) Binding affinity to human dopamine D2 receptor
- ChEMBL_2109658 (CHEMBL4818333) Inhibition of dopamine D5 receptor (unknown origin)
- ChEMBL_2109662 (CHEMBL4818337) Inhibition of dopamine D3 receptor (unknown origin)
- ChEMBL_2109663 (CHEMBL4818338) Inhibition of dopamine D1 receptor (unknown origin)
- ChEMBL_2134932 (CHEMBL4844542) Binding affinity to human dopamine D3 receptor
- ChEMBL_2163944 (CHEMBL5048805) Inhibition of dopamine D2 receptor (unknown origin)
- ChEMBL_2194570 (CHEMBL5106930) Binding affinity to human D3 dopamine receptor
- ChEMBL_2207729 (CHEMBL5120437) Inhibition of dopamine D2 receptor (unknown origin)
- ChEMBL_2265222 Binding affinity to dopamine 3 receptor (unknown origin)
- ChEMBL_2265223 Binding affinity to dopamine 5 receptor (unknown origin)
- ChEMBL_302418 (CHEMBL828822) Inhibitory constant for Dopamine receptor D1-like
- ChEMBL_302443 (CHEMBL827140) Binding affinity for human dopamine D2 receptor
- ChEMBL_302444 (CHEMBL827141) Binding affinity for human dopamine receptor D3
- ChEMBL_302448 (CHEMBL827144) Binding affinity for rat Dopamine receptor D3
- ChEMBL_302474 (CHEMBL826339) Binding affinity for human Dopamine receptor D2
- ChEMBL_302580 (CHEMBL875219) Binding affinity for human dopamine D4 receptor
- ChEMBL_302694 (CHEMBL839567) Inhibitory constant against Dopamine receptor D2
- ChEMBL_302707 (CHEMBL839579) Binding affinity for human dopamine receptor D3
- ChEMBL_302736 (CHEMBL838683) Binding affinity for human dopamine D2 receptor
- ChEMBL_302737 (CHEMBL838684) Binding affinity for human dopamine D3 receptor
- ChEMBL_302843 (CHEMBL827888) Binding affinity for human dopamine D3 receptor
- ChEMBL_304000 (CHEMBL838639) Binding affinity for human dopamine receptor D2
- ChEMBL_304001 (CHEMBL838640) Binding affinity for human dopamine receptor D3
- ChEMBL_304002 (CHEMBL838641) Binding affinity for human dopamine receptor D4
- ChEMBL_320746 (CHEMBL881219) Inhibition constant against dopamine receptor D2
- ChEMBL_320765 (CHEMBL884720) Affinity towards cloned Dopamine receptor D1
- ChEMBL_320766 (CHEMBL884721) Affinity towards cloned Dopamine receptor D2
- ChEMBL_320767 (CHEMBL884722) Affinity towards cloned Dopamine receptor D3
- ChEMBL_320768 (CHEMBL884723) Affinity towards cloned Dopamine receptor D4
- ChEMBL_320769 (CHEMBL884724) Affinity towards cloned Dopamine receptor D5
- ChEMBL_320771 (CHEMBL884726) Ligand efficacy towards dopamine D3 receptor
- ChEMBL_320794 (CHEMBL884749) Binding inhibition towards human dopamine transporter
- ChEMBL_321093 (CHEMBL883696) Effective concentration against dopamine D3 receptor
- ChEMBL_321094 (CHEMBL882064) Effective concentration against dopamine D3 receptor
- ChEMBL_321165 (CHEMBL872218) Inhibitory concentration against dopamine receptor D4
- ChEMBL_321256 (CHEMBL881881) Inhibitory concentration against dopamine receptor D1
- ChEMBL_321257 (CHEMBL881882) Inhibitory concentration against dopamine receptor D3
- ChEMBL_326580 (CHEMBL863369) Inhibitory activity against dopamine D3 receptor
- ChEMBL_333001 (CHEMBL853600) Inhibitory activity against dopamine D1 receptor
- ChEMBL_333003 (CHEMBL853603) Inhibitory activity against dopamine D5 receptor
- ChEMBL_384221 (CHEMBL866700) Binding affinity to human dopamine D3 receptor
- ChEMBL_384500 (CHEMBL866718) Binding affinity to human dopamine D5 receptor
- ChEMBL_444279 (CHEMBL894519) Binding affinity to human dopamine D2 receptor
- ChEMBL_456086 (CHEMBL888095) Binding affinity to human dopamine D4 receptor
- ChEMBL_461996 (CHEMBL944839) Binding affinity to human dopamine D2 receptor
- ChEMBL_461997 (CHEMBL944840) Binding affinity to human dopamine D4 receptor
- ChEMBL_491873 (CHEMBL946403) Inhibition of dopamine uptake at human cloned DAT
- ChEMBL_512428 (CHEMBL980769) Displacement of radioligand from dopamine D1 receptor
- ChEMBL_512429 (CHEMBL980770) Displacement of radioligand from dopamine D2S receptor
- ChEMBL_512430 (CHEMBL980771) Displacement of radioligand from dopamine D3 receptor
- ChEMBL_552743 (CHEMBL965249) Binding affinity to human dopamine D2 receptor
- ChEMBL_58226 (CHEMBL669953) Binding affinity against dopamine D2 receptor
- ChEMBL_58312 (CHEMBL672706) Binding affinity against Dopamine D1 receptor
- ChEMBL_58313 (CHEMBL672707) Binding affinity against Dopamine D1 receptor
- ChEMBL_58468 (CHEMBL670399) Binding affinity towards dopamine D2 receptor
- ChEMBL_58622 (CHEMBL666192) Binding affinity towards dopamine D2 receptor
- ChEMBL_58625 (CHEMBL663737) Tested for binding affinity for Dopamine D2 receptor
- ChEMBL_58626 (CHEMBL663738) Tested for binding affinity for Dopamine D2 receptors
- ChEMBL_58630 (CHEMBL857790) Binding affinity against Dopamine D2 receptor
- ChEMBL_588133 (CHEMBL1044859) Binding affinity to pig dopamine D1 receptor
- ChEMBL_58945 (CHEMBL671259) Binding affinity towards Dopamine D4 receptor
- ChEMBL_58984 (CHEMBL668649) Binding affinities towards Dopamine receptor D1
- ChEMBL_58985 (CHEMBL668650) Binding affinity against Dopamine receptor D1
- ChEMBL_58988 (CHEMBL668653) Binding affinity against Dopamine receptor D1
- ChEMBL_58989 (CHEMBL668654) Binding affinity towards Dopamine receptor D1
- ChEMBL_58998 (CHEMBL671820) Binding affinity against dopamine receptor D1
- ChEMBL_59428 (CHEMBL671831) Inhibition of dopamine beta-hydroxylase (DbetaH) enzyme
- ChEMBL_60071 (CHEMBL671385) Binding affinity at human dopamine receptor D2
- ChEMBL_60178 (CHEMBL675878) Effect on synaptosomal uptake inhibition of Dopamine receptor
- ChEMBL_60492 (CHEMBL674248) Binding affinity against dopamine receptor D1
- ChEMBL_60518 (CHEMBL858025) Binding affinity against dopamine receptor D1
- ChEMBL_60665 (CHEMBL671701) Binding affinity at human dopamine receptor D4
- ChEMBL_60843 (CHEMBL675985) Binding affinity against Dopamine receptor D4
- ChEMBL_60989 (CHEMBL671607) In vitro binding affinity for Dopamine receptor D4
- ChEMBL_60992 (CHEMBL872502) Binding affinity against Dopamine receptor D4
- ChEMBL_61119 (CHEMBL672309) Binding affinity towards Dopamine receptor D2
- ChEMBL_61132 (CHEMBL670745) In vitro binding affinity for Dopamine receptor D2
- ChEMBL_61142 (CHEMBL670679) Binding affinity for Dopamine receptor D2 was determined
- ChEMBL_61144 (CHEMBL670681) Binding affinity towards dopamine receptor D2
- ChEMBL_61147 (CHEMBL670684) In vitro binding affinity for Dopamine receptor D2
- ChEMBL_61284 (CHEMBL670781) Binding affinity against Dopamine receptor D2
- ChEMBL_61287 (CHEMBL670784) Binding affinity against Dopamine receptor D2
- ChEMBL_61290 (CHEMBL671484) Binding affinity towards Dopamine receptor D2
- ChEMBL_61315 (CHEMBL670090) Binding affinity against dopamine D2 receptor
- ChEMBL_61340 (CHEMBL675957) Binding affinity against Dopamine receptor D5
- ChEMBL_61341 (CHEMBL675958) Binding affinity towards Dopamine receptor D5
- ChEMBL_61350 (CHEMBL858396) Binding affinity against dopamine D4 receptor
- ChEMBL_61647 (CHEMBL672502) Binding affinity against Dopamine receptor D2L
- ChEMBL_61667 (CHEMBL879871) In vitro binding affinity on cloned Dopamine transporter
- ChEMBL_61763 (CHEMBL671129) Binding affinity against dopamine receptor D2
- ChEMBL_61803 (CHEMBL670556) Binding Affinity of Compound of Dopamine receptor D2S
- ChEMBL_61943 (CHEMBL675130) Effective concentration for Dopamine receptor D3 was determined
- ChEMBL_61945 (CHEMBL675132) Effective concentration for Dopamine receptor D3 was determined
- ChEMBL_62002 (CHEMBL670185) Effect on synaptosomal uptake inhibition of Dopamine transporter
- ChEMBL_62163 (CHEMBL675006) Inhibition of [3H]BTCP binding to the dopamine transporter.
- ChEMBL_62164 (CHEMBL675007) Inhibition of [3H]BTCP binding to the dopamine transporter.
- ChEMBL_62169 (CHEMBL675166) Inhibition of [3H]cocaine binding to the dopamine transporter.
- ChEMBL_62171 (CHEMBL675168) Inhibition of [3H]mazindol binding to the dopamine transporter.
- ChEMBL_62386 (CHEMBL672339) Binding affinity towards Dopamine receptor D2
- ChEMBL_62452 (CHEMBL679224) Binding affinity against Dopamine receptor D3
- ChEMBL_62621 (CHEMBL678244) Evaluated for the Competitive inhibition of uptake of dopamine transporter
- ChEMBL_62792 (CHEMBL673942) Inhibition of [3H]BTCP binding to the dopamine transporter.
- ChEMBL_62797 (CHEMBL674110) Inhibition of [3H]cocaine binding to the dopamine transporter.
- ChEMBL_62799 (CHEMBL674112) Inhibition of [3H]mazindol binding to the dopamine transporter.
- ChEMBL_62802 (CHEMBL674115) Inhibition constant of high-affinity dopamine uptake
- ChEMBL_62807 (CHEMBL674120) Displacement of [3H]mazindol from dopamine transporter
- ChEMBL_62814 (CHEMBL674126) Compound was tested for the inhibition of dopamine (DA) reuptake
- ChEMBL_62817 (CHEMBL674129) Inhibitory concentration against [3H]dopamine uptake
- ChEMBL_62926 (CHEMBL673832) Binding affinity for Dopamine receptor D3 was determined
- ChEMBL_62929 (CHEMBL673834) Binding affinity against Dopamine receptor D3
- ChEMBL_62930 (CHEMBL673835) Binding affinity against Dopamine receptor D3
- ChEMBL_62931 (CHEMBL673836) Binding affinity towards Dopamine receptor D3
- ChEMBL_62939 (CHEMBL881939) Binding affinity against dopamine D3 receptor
- ChEMBL_658549 (CHEMBL1247882) Binding affinity to human recombinant dopamine transporter
- ChEMBL_664950 (CHEMBL1259907) Binding affinity to rat dopamine D1 receptor
- ChEMBL_664951 (CHEMBL1259908) Binding affinity to rat dopamine D2 receptor
- ChEMBL_664952 (CHEMBL1259909) Binding affinity to rat dopamine D3 receptor
- ChEMBL_664953 (CHEMBL1259910) Binding affinity to rat dopamine D4 receptor
- ChEMBL_664954 (CHEMBL1259911) Binding affinity to human dopamine D5 receptor
- ChEMBL_767224 (CHEMBL1826470) Inhibition of D1 dopamine receptor by NIMH PDSP
- ChEMBL_807237 (CHEMBL1960167) Inhibition of rat DAT-mediated dopamine reuptake
- ChEMBL_816869 (CHEMBL2026140) Binding affinity to human dopamine D3 receptor
- ChEMBL_816870 (CHEMBL2026141) Binding affinity to human dopamine D2L receptor
- ChEMBL_816871 (CHEMBL2026142) Binding affinity to human dopamine D2S receptor
- ChEMBL_816874 (CHEMBL2026145) Binding affinity to rat dopamine D1 receptor
- ChEMBL_816875 (CHEMBL2026146) Binding affinity to human dopamine D1 receptor
- ChEMBL_816877 (CHEMBL2026148) Binding affinity to human dopamine D5 receptor
- ChEMBL_821614 (CHEMBL2038569) Binding affinity to human dopamine D5 receptor
- ChEMBL_824329 (CHEMBL2044471) Inhibition of rat DAT-mediated dopamine reuptake
- ChEMBL_942037 (CHEMBL2330406) Inhibition of dopamine receptor D2 (unknown origin)
- ChEMBL_2024048 (CHEMBL4677861) Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)
- ChEMBL_1437794 (CHEMBL3383591) Antagonist activity at human dopamine D3 receptor expressed in CHO-K1 cells assessed as reduction in dopamine-induced response by [35S]GTPgammaS binding assay
- ChEMBL_1450571 (CHEMBL3372149) Antagonist activity against human D3R expressed in CHO cells assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by dopamine potency shift assay
- ChEMBL_1450572 (CHEMBL3372150) Antagonist activity against human D2LR expressed in CHO cells assessed as inhibition of dopamine-induced [35S]GTPgammaS binding by dopamine potency shift assay
- ChEMBL_63075 (CHEMBL673642) Agonist activation of human dopamine receptor stimulating mitogenesis in Dopamine receptor D4-transfected CHO pro-5 cells using [3H]thymidine as radioligand
- ChEMBL_2024044 (CHEMBL4677857) Positive allosteric modulator activity at human dopamine D5 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 81.7 nM)
- ChEMBL_2024046 (CHEMBL4677859) Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)
- ChEMBL_2325143 Antagonist activity at N-terminal Flag epitope tagged human dopamine D1 receptor expressed in HTLA cells assessed as inhibition of dopamine-induced beta-arrestin translocation activity preincubated for 30 mins followed by dopamine addition by luminescence based GPCR-TANGO assay
- ChEMBL_2325147 Antagonist activity at human dopamine D3 receptor expressed in pathHunter cells assessed as inhibition of dopamine-induced beta-arrestin translocation activity preincubated for 30 mins followed by dopamine addition and measured after 90 to 180 min by pathHunter microplate based TANGO assay
- ChEBML_58311 Compound was tested for inhibitory activity against Dopamine D1 receptor
- ChEBML_58516 Binding affinity against Dopamine receptor D1 in rat radioligand
- ChEBML_59142 Compound was evaluated for the ability to bind to dopamine beta-hydroxylase of bovine
- ChEBML_60189 Formation of cAMP on Dopamine receptor D1 in vitro in carp retina
- ChEBML_60201 Binding affinity towards cloned human Dopamine receptor D2
- ChEBML_60939 Antagonistic affinity against rat striatum Dopamine receptor D2
- ChEBML_61120 Binding affinity for Dopamine receptor D2 by displacement of [3H]-spiperone
- ChEBML_61513 Inhibitory activity against human dopamine transporter at 10 uM
- ChEBML_62005 In vitro inhibition of [3H]dopamine uptake in rat brain synaptosomes
- ChEBML_62094 Ancillary Binding affinity towards rat Dopamine receptor D2
- ChEBML_62149 Inhibitory activity against dopamine transporter in rat striatal membranes
- ChEBML_62342 Displacement of [3H]WIN-35428 from dopamine transporter (DAT)
- ChEBML_62479 Binding affinity to dopamine transporter (DAT) in rat forebrain tissue
- ChEBML_62491 Inhibition of [3H]DA reuptake at dopamine transporter in rat striatum
- ChEBML_62632 Inhibition of [3H]DA uptake at Dopamine transporter in rat cortex.
- ChEBML_62775 Tested for inhibition of the binding of [125I]NCQ298 to dopamine receptor D3
- ChEMBL_1279266 (CHEMBL3095674) Binding affinity to dopamine D2 receptor (unknown origin)
- ChEMBL_1282075 (CHEMBL3101864) Binding affinity to dopamine D2 receptor (unknown origin)
- ChEMBL_1295491 (CHEMBL3131489) Agonist activity at dopamine D2 receptor (unknown origin)
- ChEMBL_131451 (CHEMBL740206) Tested in vitro for dopamine(DA) neuronal uptake inhibition
- ChEMBL_1352906 (CHEMBL3269423) Binding affinity to dopamine D3 receptor (unknown origin)
- ChEMBL_1353324 (CHEMBL3267826) Agonist activity at dopamine D1 receptor (unknown origin)
- ChEMBL_1353325 (CHEMBL3267827) Antagonist activity at dopamine D1 receptor (unknown origin)
- ChEMBL_1353326 (CHEMBL3267828) Antagonist activity at dopamine D5 receptor (unknown origin)
- ChEMBL_1437144 (CHEMBL3381713) Binding affinity to dopamine D2 receptor (unknown origin)
- ChEMBL_1437145 (CHEMBL3381714) Binding affinity to dopamine D3 receptor (unknown origin)
- ChEMBL_1440706 (CHEMBL3381341) Binding affinity to dopamine D2 receptor (unknown origin)
- ChEMBL_1447545 (CHEMBL3373152) Binding affinity to dopamine D2 receptor (unknown origin)
- ChEMBL_1473029 (CHEMBL3420910) Binding affinity to dopamine D3 receptor (unknown origin)
- ChEMBL_1506471 (CHEMBL3599870) Binding affinity to dopamine D3 receptor (unknown origin)
- ChEMBL_1506472 (CHEMBL3599871) Binding affinity to dopamine D2 receptor (unknown origin)
- ChEMBL_1561663 (CHEMBL3776878) Binding affinity to dopamine D4 receptor (unknown origin)
- ChEMBL_1586233 (CHEMBL3820051) Binding affinity to dopamine D3 receptor (unknown origin)
- ChEMBL_1586234 (CHEMBL3820052) Binding affinity to dopamine D4 receptor (unknown origin)
- ChEMBL_1615911 (CHEMBL3857980) Binding affinity to dopamine D2 receptor (unknown origin)
- ChEMBL_1682172 (CHEMBL4032449) Binding affinity to dopamine D4 receptor (unknown origin)
- ChEMBL_177781 (CHEMBL785239) Reuptake inhibition of [3H]-labeled dopamine (DA) in rat.
- ChEMBL_177956 (CHEMBL785171) Inhibition of [3H]dopamine uptake in rat caudate putamen.
- ChEMBL_1789232 (CHEMBL4260966) Agonist activity at dopamine D2 receptor (unknown origin)
- ChEMBL_1789233 (CHEMBL4260967) Agonist activity at dopamine D5 receptor (unknown origin)
- ChEMBL_1803920 (CHEMBL4276212) Inhibition of [3H]dopamine uptake at DAT (unknown origin)
- ChEMBL_184435 (CHEMBL789207) Inhibition of dopamine (DA) uptake into rat brain synaptosomes
- ChEMBL_1912575 (CHEMBL4415158) Agonist activity at dopamine D4 receptor (unknown origin)
- ChEMBL_1926106 (CHEMBL4429178) Binding affinity to dopamine D3 receptor (unknown origin)
- ChEMBL_1926107 (CHEMBL4429179) Binding affinity to dopamine D2 receptor (unknown origin)
- ChEMBL_193333 (CHEMBL802527) Inhibition of the uptake of tritiated dopamine (DA) in rat synaptosomes
- ChEMBL_193486 (CHEMBL802636) [3H]-Dopamine uptake inhibition in rat caudate putamen
- ChEMBL_1979076 (CHEMBL4612211) Binding affinity to dopamine D1 receptor (unknown origin)
- ChEMBL_1979077 (CHEMBL4612212) Binding affinity to dopamine D2 receptor (unknown origin)
- ChEMBL_1979078 (CHEMBL4612213) Binding affinity to dopamine D3 receptor (unknown origin)
- ChEMBL_1979079 (CHEMBL4612214) Binding affinity to dopamine D4 receptor (unknown origin)
- ChEMBL_1979080 (CHEMBL4612215) Binding affinity to dopamine D5 receptor (unknown origin)
- ChEMBL_1988754 (CHEMBL4622301) Binding affinity to dopamine D5 receptor (unknown origin)
- ChEMBL_1991500 (CHEMBL4625235) Antagonist activity at dopamine D1 receptor (unknown origin)
- ChEMBL_1991501 (CHEMBL4625236) Antagonist activity at dopamine D5 receptor (unknown origin)
- ChEMBL_1991502 (CHEMBL4625237) Agonist activity at dopamine D1 receptor (unknown origin)
- ChEMBL_1991503 (CHEMBL4625238) Agonist activity at dopamine D5 receptor (unknown origin)
- ChEMBL_2068264 (CHEMBL4723517) Antagonist activity at dopamine D2 receptor (unknown origin)
- ChEMBL_2112202 (CHEMBL4821052) Binding affinity to dopamine D2 receptor (unknown origin)
- ChEMBL_2112203 (CHEMBL4821053) Binding affinity to dopamine D3 receptor (unknown origin)
- ChEMBL_2215488 (CHEMBL5128620) Agonist activity at dopamine D2 receptor (unknown origin)
- ChEMBL_2215489 (CHEMBL5128621) Agonist activity at dopamine D3 receptor (unknown origin)
- ChEMBL_2215490 (CHEMBL5128622) Agonist activity at dopamine D1 receptor (unknown origin)
- ChEMBL_2232737 (CHEMBL5146509) Binding affinity to dopamine D2 receptor (unknown origin)
- ChEMBL_302285 (CHEMBL830303) Binding affinity against human Dopamine receptor D2
- ChEMBL_302583 (CHEMBL839543) Binding affinity for human recombinant dopamine D2 receptor
- ChEMBL_302584 (CHEMBL839544) Binding affinity for human recombinant dopamine receptor D1
- ChEMBL_302585 (CHEMBL839545) Binding affinity for human recombinant dopamine receptor D3
- ChEMBL_302586 (CHEMBL839546) Binding affinity for human recombinant dopamine receptor D5
- ChEMBL_302602 (CHEMBL838569) Binding affinity for human recombinant dopamine receptor D2L
- ChEMBL_302619 (CHEMBL838817) Binding affinity for human recombinant dopamine receptor D4.2
- ChEMBL_302620 (CHEMBL876688) Binding affinity for human recombinant dopamine receptor D4.4
- ChEMBL_302793 (CHEMBL839477) Binding affinity for human dopamine receptor D2 long
- ChEMBL_303308 (CHEMBL840034) Inhibition of [3H]spiperone binding to Dopamine receptor D2
- ChEMBL_303309 (CHEMBL840035) Inhibition of [3H]spiperone binding to Dopamine receptor D4
- ChEMBL_303376 (CHEMBL839694) Inhibition of [125I]-iodosulpiride binding to Dopamine receptor D3
- ChEMBL_307366 (CHEMBL835264) Ability of compound to inhibit dopamine uptake of receptor was determined
- ChEMBL_311949 (CHEMBL834316) Partial agonist intrinsic activity at dopamine D3 receptor
- ChEMBL_326581 (CHEMBL863370) Inhibitory activity against dopamine D2(long) receptor
- ChEMBL_331690 (CHEMBL862890) Binding affinity to human cloned dopamine D3 receptor
- ChEMBL_331691 (CHEMBL865866) Binding affinity to human cloned dopamine D2 receptor
- ChEMBL_332996 (CHEMBL853593) Binding affinity to human cloned dopamine D3 receptor
- ChEMBL_332997 (CHEMBL853595) Binding affinity to human cloned dopamine D2 receptor
- ChEMBL_337502 (CHEMBL861435) Displacement of [3H]spiperone from D2L dopamine receptor
- ChEMBL_346082 (CHEMBL862318) Binding affinity to cloned human dopamine D3 receptor
- ChEMBL_346083 (CHEMBL862319) Binding affinity to cloned human dopamine D2 receptor
- ChEMBL_357782 (CHEMBL859039) Binding affinity to dopamine receptor by radioligand binding assay
- ChEMBL_357807 (CHEMBL862271) Binding affinity to dopamine transporter by radioligand binding assay
- ChEMBL_410547 (CHEMBL912417) Binding affinity to human cloned dopamine D1 receptor
- ChEMBL_410548 (CHEMBL912418) Binding affinity to human cloned dopamine D2 receptor
- ChEMBL_410549 (CHEMBL912419) Binding affinity to human cloned dopamine D3 receptor
- ChEMBL_410550 (CHEMBL912420) Binding affinity to human cloned dopamine D4 receptor
- ChEMBL_410554 (CHEMBL855594) Binding affinity to human cloned dopamine D5 receptor
- ChEMBL_450225 (CHEMBL900500) Binding affinity to human cloned dopamine D2 receptor
- ChEMBL_454685 (CHEMBL886705) Displacement of [3H]spiperone from dopamine D2 receptor
- ChEMBL_460878 (CHEMBL944817) Blockade of N-arachidonoyl-dopamine-induced activation of TRPV1
- ChEMBL_466543 (CHEMBL928141) Displacement of [3H]spiperone from dopamine D2 receptor
- ChEMBL_466544 (CHEMBL935636) Displacement of [3H]spiperone from dopamine D3 receptor
- ChEMBL_466546 (CHEMBL935638) Displacement of [3H]SCH23390 from dopamine D5 receptor
- ChEMBL_468370 (CHEMBL931954) Binding affinity to human dopamine D2 long receptor
- ChEMBL_472677 (CHEMBL922844) Inhibition of [3H]dopamine uptake in DAT in rat striatum
- ChEMBL_485923 (CHEMBL1013926) Displacement of [3H]SCH23390 from dopamine D1 receptor
- ChEMBL_485924 (CHEMBL1013927) Displacement of [3H]sulpiride from dopamine D2 receptor
- ChEMBL_490804 (CHEMBL992741) Binding affinity to human cloned dopamine D1 receptor
- ChEMBL_490806 (CHEMBL992743) Binding affinity to human cloned dopamine D2 receptor
- ChEMBL_490807 (CHEMBL992744) Binding affinity to human cloned dopamine D3 receptor
- ChEMBL_490808 (CHEMBL992745) Binding affinity to human cloned dopamine D4 receptor
- ChEMBL_537766 (CHEMBL994219) Displacement of [3H]spiperone from dopamine D2 receptor
- ChEMBL_538665 (CHEMBL1033063) Displacement of [3H]SCH23390 from dopamine D1 receptor
- ChEMBL_556593 (CHEMBL958092) Displacement of [3H]WIN-35428 from dopamine transporter
- ChEMBL_58478 (CHEMBL670409) Compound was tested for its effect on dopamine saturation analysis
- ChEMBL_58672 (CHEMBL670446) In vitro binding affinity towards Dopamine receptor D1
- ChEMBL_58981 (CHEMBL668646) Inhibition of SCH 23390 binding to Dopamine receptor D1
- ChEMBL_59479 (CHEMBL671439) Compound was evaluated for the binding affinity at Dopamine receptor D2
- ChEMBL_59905 (CHEMBL671064) Inhibition of [3H]thymidine uptake by Dopamine receptor D2
- ChEMBL_59916 (CHEMBL671075) Binding affinity towards human Dopamine receptor D2
- ChEMBL_60038 (CHEMBL672134) Compound was tested for its effect on dopamine saturation analysis
- ChEMBL_60063 (CHEMBL671377) Binding ability of compound to human Dopamine receptor D2
- ChEMBL_60177 (CHEMBL675877) Effect of compound on synaptosomal uptake inhibition of Dopamine (DA)
- ChEMBL_60206 (CHEMBL672168) Binding affinity towards human Dopamine receptor D2
- ChEMBL_60207 (CHEMBL672169) Binding affinity towards human Dopamine receptor D2
- ChEMBL_60217 (CHEMBL672179) Binding affinity towards human D2 dopamine receptor.
- ChEMBL_60222 (CHEMBL672183) Displacement of [3H]quinpirole from Dopamine receptor D2
- ChEMBL_60223 (CHEMBL672184) Inhibition of [3H]raclopride binding to Dopamine receptor D2
- ChEMBL_60224 (CHEMBL672794) Inhibition of [3H]raclopride binding to Dopamine receptor D2
- ChEMBL_60494 (CHEMBL674250) Binding affinity towards human Dopamine receptor D1
- ChEMBL_60673 (CHEMBL674044) Binding affinity of compound was tested for Dopamine receptor D4
- ChEMBL_60679 (CHEMBL674050) Binding affinity to recombinant human dopamine receptor D4
- ChEMBL_60684 (CHEMBL675946) Binding affinity towards human dopamine receptor D4
- ChEMBL_60994 (CHEMBL671610) Binding affinity towards human Dopamine receptor D4
- ChEMBL_61111 (CHEMBL672301) Compound was selective with respect to binding at the Dopamine receptor D2
- ChEMBL_61316 (CHEMBL670091) The compound's binding affinity against Dopamine receptor D2
- ChEMBL_61484 (CHEMBL672386) Binding affinity of compound was tested for Dopamine receptor D2L
- ChEMBL_61606 (CHEMBL675928) Inhibition of spiropiperidone binding at dopamine receptor D2 of rat.
- ChEMBL_61655 (CHEMBL670789) Inhibition of [125I]RTI-55 binding to dopamine transporter
- ChEMBL_61759 (CHEMBL670521) Displacement of [3H]spiroperidol from D2 dopamine receptor
- ChEMBL_61848 (CHEMBL670035) Inhibition of [3H]WIN-35428 binding to Dopamine transporter
- ChEMBL_61851 (CHEMBL670038) Inhibition of [3H]WIN-35428l binding to Dopamine transporter
- ChEMBL_61946 (CHEMBL675133) Effective concentration for Dopamine receptor D3 was determined in monkeys
- ChEMBL_61972 (CHEMBL670577) Binding affinity towards human Dopamine receptor D3
- ChEMBL_62009 (CHEMBL671631) In vitro potency for inhibiting [3H]- dopamine uptake was determined
- ChEMBL_62018 (CHEMBL671639) Inhibition of [3H]dopamine uptake in rat striatal synaptosomes
- ChEMBL_62165 (CHEMBL675008) Inhibition of [3H]GBR-12935 binding to the dopamine transporter.
- ChEMBL_62167 (CHEMBL675010) Inhibition of [3H]WIN-35428 binding to the dopamine transporter.
- ChEMBL_62262 (CHEMBL675664) Binding affinity towards human Dopamine receptor D3
- ChEMBL_62268 (CHEMBL675670) Binding affinity towards human dopamine receptor D3
- ChEMBL_62275 (CHEMBL674410) Displacement of [3H]raclopride from Dopamine receptor D3
- ChEMBL_62317 (CHEMBL677519) The potency of the [125I]RTI-55 for Dopamine transporter site
- ChEMBL_62402 (CHEMBL675727) Binding constant against dopamine receptor D2 (in vitro)
- ChEMBL_62403 (CHEMBL675728) Binding constant against dopamine receptor D2 (in vivo)
- ChEMBL_62487 (CHEMBL677379) Inhibition of reuptake of [3H]DA at Dopamine transporter (DAT)
- ChEMBL_62567 (CHEMBL671498) Binding affinity against rat Dopamine receptor D2.
- ChEMBL_62643 (CHEMBL676688) Reuptake inhibitory activity against dopamine DA transporter
- ChEMBL_62647 (CHEMBL872894) Binding affinity for dopamine transporters in rat brain tissue.
- ChEMBL_62748 (CHEMBL674589) Tested for binding affinity against dopamine receptor D3
- ChEMBL_62753 (CHEMBL872899) Binding affinity of compound was tested for Dopamine receptor D3
- ChEMBL_62793 (CHEMBL673943) Inhibition of [3H]GBR-12935 binding to the dopamine transporter.
- ChEMBL_62795 (CHEMBL674108) Inhibition of [3H]WIN-35428 binding to the dopamine transporter.
- ChEMBL_62796 (CHEMBL674109) Inhibition of [3H]WIN-35428 binding to the dopamine transporter
- ChEMBL_62805 (CHEMBL674118) Ability to displace [3H]-Mazindol from dopamine receptor
- ChEMBL_62806 (CHEMBL674119) Ability to displace [3H]mazindol from dopamine transporter
- ChEMBL_62879 (CHEMBL878289) In vitro binding affinity towards Dopamine receptor D2
- ChEMBL_62932 (CHEMBL673837) Binding affinity towards human Dopamine receptor D3
- ChEMBL_62950 (CHEMBL675534) Displacement of [3H]WIN-35428 from Dopamine transporter
- ChEMBL_62952 (CHEMBL675536) Inhibition of [3H]DA uptake evaluated at the dopamine transporter
- ChEMBL_63063 (CHEMBL673630) Displacement of [3H]spiperone from dopamine receptor D2
- ChEMBL_63078 (CHEMBL673645) Effective concentration against human Dopamine receptor D4
- ChEMBL_658545 (CHEMBL1247747) Binding affinity to human recombinant dopamine D1 receptor
- ChEMBL_658546 (CHEMBL1247748) Binding affinity to human recombinant dopamine D2 receptor
- ChEMBL_658547 (CHEMBL1247880) Binding affinity to human recombinant dopamine D3 receptor
- ChEMBL_766799 (CHEMBL1827739) Inhibition of dopamine D2 receptor by competition binding assay
- ChEMBL_766800 (CHEMBL1827740) Inhibition of dopamine D3 receptor by competition binding assay
- ChEMBL_766801 (CHEMBL1827741) inhibition of dopamine D4 receptor by competition binding assay
- ChEMBL_818823 (CHEMBL2033609) Binding affinity to human recombinant Dopamine D1 receptor
- ChEMBL_818824 (CHEMBL2033610) Binding affinity to human recombinant Dopamine D2 receptor
- ChEMBL_818825 (CHEMBL2033611) Binding affinity to human recombinant Dopamine D3 receptor
- ChEMBL_818826 (CHEMBL2033612) Binding affinity to human recombinant Dopamine D4 receptor
- ChEMBL_818827 (CHEMBL2033613) Binding affinity to human recombinant Dopamine D5 receptor
- ChEMBL_827294 (CHEMBL2050797) Displacement of [3H]SCH23390 from dopamine D1 receptor
- ChEMBL_875982 (CHEMBL2188488) Inhibition of radioligand binding to human dopamine D1 receptor
- ChEMBL_932187 (CHEMBL3073105) Binding affinity to dopamine D2 receptor (unknown origin)
- ChEMBL_932188 (CHEMBL3073106) Binding affinity to dopamine D3 receptor (unknown origin)
- ChEMBL_932189 (CHEMBL3073107) Binding affinity to dopamine D1 receptor (unknown origin)
- ChEMBL_934615 (CHEMBL2317821) Inhibition of DAT (unknown origin) assessed as dopamine reuptake
- ChEMBL_963021 (CHEMBL2390029) Binding affinity to dopamine D2 receptor (unknown origin)
- ChEMBL_977143 (CHEMBL2416736) Binding affinity to dopamine 2 receptor (unknown origin)
- ChEBML_58539 Affinity of the Compound for Dopamine receptor D2 in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]spiperone as ligand; Value ranges from (270-500)
- ChEMBL_1290765 (CHEMBL3117964) Antagonist activity at dopamine D2 receptor (unknown origin) expressed in HEK cells co-expressing Gqi5 assessed as inhibition of dopamine-induced effect by FLIPR assay
- ChEMBL_1698014 (CHEMBL4048904) Antagonist activity at human SP/Myc epitope-tagged dopamine D4 receptor expressed in HEK293T cells assessed as inhibition of dopamine-induced RLuc8-fused Galphai1 activation preincubated for 15 mins followed by dopamine induction measured after 2 mins by BRET assay
- ChEMBL_1698016 (CHEMBL4048906) Antagonist activity at human SP/Myc epitope-tagged dopamine D4 receptor expressed in HEK293T cells assessed as inhibition of dopamine-induced mVenus-fused beta-arrestin2 recruitment preincubated for 15 mins followed by dopamine induction measured after 2 mins by BRET assay
- ChEMBL_1751568 (CHEMBL4186328) Inhibition of [3H]dopamine uptake at dopamine transporter in rat striatal synaptosomes preincubated for 5 mins followed by radioligand addition measured after 10 mins by scintillation spectrometry
- ChEMBL_58537 (CHEMBL667473) Affinity of the Compound for Dopamine receptor D2 in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]spiperone as ligand; Value ranges from (124-550)
- ChEMBL_58538 (CHEMBL667474) Affinity of the Compound for Dopamine receptor D2 in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]-spiperone as ligand; Value ranges from (20-29)
- ChEMBL_58539 (CHEMBL667475) Affinity of the Compound for Dopamine receptor D2 in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]spiperone as ligand; Value ranges from (270-500)
- ChEMBL_58540 (CHEMBL667476) Affinity of the Compound for Dopamine receptor D2 in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]spiperone as ligand; Value ranges from (580-1050)
- ChEBML_58332 Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 was determined
- ChEBML_58529 Displacement of [3H]haloperidol from Dopamine receptor D2 in rat brain
- ChEBML_59422 Inhibitory activity was determined against bovine dopamine beta-hydroxylase (DBH)
- ChEBML_60934 Inhibition of [3H](-)-sulpiride binding to rat striatum dopamine receptor D2
- ChEBML_61140 Binding affinity towards Dopamine receptor D2 by displacement of [3H]-Raclopride.
- ChEBML_61742 Inhibitory concentration required against Dopamine receptor D2 in rat striatum
- ChEBML_61756 Tested in vitro for inhibition of [3H]spiperone binding to dopamine receptor D2
- ChEBML_63037 Displacement of [3H]-Spiperone from Dopamine receptor D2 in rat striatum
- ChEBML_63062 Binding affinity towards Dopamine receptor D2 by displacing [3H]spiperone
- ChEMBL_166352 (CHEMBL775439) Inhibition of high affinity dopamine uptake at concentration of 1 uM
- ChEMBL_1724719 (CHEMBL4139997) Displacement of [3H]-spiperone from rat caudate dopamine receptor
- ChEMBL_1724720 (CHEMBL4139998) Displacement of [3H]apomorphine from rat caudate dopamine receptor
- ChEMBL_201668 (CHEMBL803042) Ratio of IC50 value against Serotonin transporter to that of dopamine transporter
- ChEMBL_202133 (CHEMBL808122) Ratio of Ki value towards Serotonin transporter to that of dopamine transporter
- ChEMBL_302722 (CHEMBL839593) Inhibition of [3H]WIN-35428 binding to rat dopamine transporter
- ChEMBL_302723 (CHEMBL876353) Inhibition of [3H]WIN-35428 binding to rat dopamine transporter
- ChEMBL_303119 (CHEMBL829628) Inhibition of rat brain dopamine transporter as accumulation of [3H]DA
- ChEMBL_303165 (CHEMBL829977) Inhibition of [18F]PET binding to dopamine transporter of human brain
- ChEMBL_303244 (CHEMBL827209) Inhibition of [125I]iodosulpiride binding to human Dopamine receptor D3
- ChEMBL_303446 (CHEMBL839706) Binding affinity for dopamine transporter expressed in LCK PK1 cells
- ChEMBL_307370 (CHEMBL835385) Binding affinity towards human dopamine receptor D4 was determined
- ChEMBL_31571 (CHEMBL644534) Inhibitory concentration against Dopamine sensitive adenylate cyclase in rats
- ChEMBL_31583 (CHEMBL646377) Inhibitory activity against Dopamine sensitive adenylate cyclase in rats
- ChEMBL_447582 (CHEMBL896595) Displacement of [3H]nemonapride from rat dopamine D2 receptor
- ChEMBL_461138 (CHEMBL944161) Displacement of [3H]raclopride from rat dopamine D2 receptor
- ChEMBL_469572 (CHEMBL932301) Inhibition of dopamine uptake at VMAT in bovine chromaffin granule ghosts
- ChEMBL_491607 (CHEMBL945183) Inhibition of dopamine uptake at human DAT in human HEK293 cells
- ChEMBL_491870 (CHEMBL946207) Inhibition of dopamine uptake at cloned DAT in rat brain synaptosome
- ChEMBL_523087 (CHEMBL1004117) Inhibition of dopamine uptake at human DAT expressed in HEK293 cells
- ChEMBL_538666 (CHEMBL1033064) Displacement of [125I]IABN from human dopamine D4 receptor
- ChEMBL_539628 (CHEMBL1025633) Displacement of [3H]N-methylspiperone from dopamine D4 receptor
- ChEMBL_556326 (CHEMBL954061) Displacement of radioligand from human cloned dopamine D2 receptor
- ChEMBL_558435 (CHEMBL963841) Inhibition of dopamine uptake at human DAT transfected in HEK cells
- ChEMBL_578982 (CHEMBL1061431) Displacement of [3H]SCH23390 from bovine dopamine D1 receptor
- ChEMBL_58169 (CHEMBL669075) Affinity for displacement of [3H]clonidine labeled Dopamine receptor D1
- ChEMBL_58682 (CHEMBL670246) Binding affinity towards Dopamine receptor D2 in rat was evaluated
- ChEMBL_59268 (CHEMBL668983) Compound was evaluated for the inhibition of Dopamine beta hydroxylase at pH 4.5
- ChEMBL_59269 (CHEMBL872495) Compound was evaluated for the inhibition of Dopamine beta hydroxylase at pH 6.6
- ChEMBL_59771 (CHEMBL671053) Binding affinity of [3H]-NPA to striatal Dopamine receptor D2
- ChEMBL_59780 (CHEMBL671061) Binding affinity of [3H]NPA to striatal Dopamine receptor D2
- ChEMBL_60018 (CHEMBL675843) Inhibitory activity against dopamine receptor in rat striatal membranes
- ChEMBL_60677 (CHEMBL674048) Binding affinity towards cloned human Dopamine receptor D4
- ChEMBL_61001 (CHEMBL675193) Effective dose was measured by the stimulation of mitogenesis at Dopamine receptor D4.2
- ChEMBL_61110 (CHEMBL672300) In vitro receptor binding affinity against Dopamine receptor D2
- ChEMBL_61453 (CHEMBL670880) Displacement of [3H]raclopride from human Dopamine receptor D2A
- ChEMBL_61673 (CHEMBL670051) Inhibition of reuptake of [3H]DA (20 nM) by dopamine transporter
- ChEMBL_61838 (CHEMBL673208) Inhibition of [3H]cocaine binding to rat forebrain dopamine receptor
- ChEMBL_61849 (CHEMBL670036) Inhibition of [3H]dopamine uptake in rat caudate putamen tissue.
- ChEMBL_62005 (CHEMBL670188) In vitro inhibition of [3H]dopamine uptake in rat brain synaptosomes
- ChEMBL_62014 (CHEMBL671635) Inhibition of [3H]WIN-35428 binding at dopamine transporter was determined
- ChEMBL_62149 (CHEMBL675905) Inhibitory activity against dopamine transporter in rat striatal membranes
- ChEMBL_62250 (CHEMBL675477) Binding affinity towards Dopamine receptor D2 in rat was evaluated
- ChEMBL_62327 (CHEMBL674266) Ability to inhibit [3H]dopamine uptake into rat striatal synaptosomes
- ChEMBL_62468 (CHEMBL678933) Binding affinity for dopamine transporter was determined in rat striatal membrane
- ChEMBL_62469 (CHEMBL679106) Binding affinity for dopamine transporter was determined in rat striatal membrane.
- ChEMBL_62637 (CHEMBL872892) Inhibition of [3H]DA uptake by rat striatal dopamine transporter
- ChEMBL_63038 (CHEMBL678341) Affinity against the dopamine receptor D2 using [3H]spiperinone.
- ChEMBL_659509 (CHEMBL1248562) Binding affinity to human dopamine transporter by radioligand displacement assay
- ChEMBL_746271 (CHEMBL1775933) Inhibition of DAT in rat striatum assessed as [3H]dopamine accumulation
- ChEMBL_836778 (CHEMBL2075303) TP_TRANSPORTER: inhibition of Dopamine uptake in OCT2-expressing HEK293 cells
- ChEMBL_932175 (CHEMBL3073886) Binding affinity to Homo sapiens (human) dopamine D4.4 receptor
- ChEMBL_932176 (CHEMBL3073887) Binding affinity to Homo sapiens (human) dopamine D3 receptor
- ChEMBL_932177 (CHEMBL3073888) Binding affinity to Homo sapiens (human) dopamine D2S receptor
- ChEMBL_977647 (CHEMBL2423805) Displacement of [3H]spiperone from human dopamine D2 receptor
- ChEMBL_985425 (CHEMBL2432454) Inhibition of dopamine D2 receptor (unknown origin) by PDSP assay