Query String: ETOPOSIDE
Etopophos preservative free Etoposide Phosphate BMY-40481 Etopophos BDBM50247889
(5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside TRANS-ETOPOSIDE (-)-etoposide 9-((4,6-O-Ethylidine-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-d)-1,3-dioxol-6(5aH)-one Etoposide (ET) VP-16 etoposide 4-demethylepipodophyllotoxin beta-D-ethylideneglucoside 4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-beta-D-glucopyranoside) BDBM50127140 CHEMBL44657
- Chee, GL; Yalowich, JC; Bodner, A; Wu, X; Hasinoff, BB A diazirine-based photoaffinity etoposide probe for labeling topoisomerase II. Bioorg Med Chem 18: 830-8 (2010)
- Daley, L; Guminski, Y; Demerseman, P; Kruczynski, A; Etiévant, C; Imbert, T; Hill, BT; Monneret, C Synthesis and antitumor activity of new glycosides of epipodophyllotoxin, analogues of etoposide, and NK 611. J Med Chem 41: 4475-85 (1998)
- Kankanala, J; Ribeiro, CJA; Kiselev, E; Ravji, A; Williams, J; Xie, J; Aihara, H; Pommier, Y; Wang, Z Novel Deazaflavin Analogues Potently Inhibited Tyrosyl DNA Phosphodiesterase 2 (TDP2) and Strongly Sensitized Cancer Cells toward Treatment with Topoisomerase II (TOP2) Poison Etoposide. J Med Chem 62: 4669-4682 (2019)
- ChEMBL_1927094 (CHEMBL4430166) Inhibition of AKR1C3 in human HL60 cells assessed as potentiation of etoposide-induced cytotoxicity by measuring etoposide IC50 pre-treated with compound for 24 hrs followed by etoposide exposure for additional 72 hrs by MTS assay (Rvb = 1.16 uM)
- ChEMBL_1927091 (CHEMBL4430163) Inhibition of AKR1C3 in human KG1a cells assessed as potentiation of etoposide-induced cytotoxicity by measuring etoposide IC50 cotreated at 72 hrs by MTS assay (Rvb = 6.70 uM)
- ChEMBL_2112526 (CHEMBL4821376) Inhibition of ABCC1 mediated etoposide resistant in human 2008 cells
- ChEMBL_1927088 (CHEMBL4430160) Inhibition of AKR1C3 in human HL60 cells assessed as potentiation of etoposide-induced cytotoxicity by measuring etoposide IC50 after 24 to 72 hrs by MTS assay (Rvb = 1.16 uM)
- ChEMBL_2332816 Inhibition of ATM kinase in human A549 cells in presence of etoposide by ICW assay
- ChEMBL_1625317 (CHEMBL3867786) Inhibition of human ABCC1 transfected in HEK293 cells assessed as potentiation of etoposide-induced cytotoxicity by measuring etoposide IC50 at 500 nM after 72 hrs by CCK8 assay (Rvb = 38.54 +/- 5.62 nM)
- ChEMBL_1625318 (CHEMBL3867787) Inhibition of human ABCC1 transfected in HEK293 cells assessed as potentiation of etoposide-induced cytotoxicity by measuring etoposide IC50 at 25000 nM after 72 hrs by CCK8 assay (Rvb = 38.54 +/- 5.62 nM)
- ChEMBL_1995477 (CHEMBL4629372) Reversal of human ABCC1-mediated multidrug resistance in HEK293/MRP1 cells assessed as effect on etoposide-induced cytotoxicity by measuring etoposide IC50 at 25 uM after 72 hrs by CCK8 assay (Rvb = 63.34 +/- 7.92 uM)
- ChEMBL_1995625 (CHEMBL4629520) Reversal of human ABCC1-mediated multidrug resistance in HEK293/MRP1 cells assessed as effect on etoposide-induced cytotoxicity by measuring etoposide IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb = 63.34 +/- 7.92 uM)
- ChEMBL_1995626 (CHEMBL4629521) Reversal of human ABCC1-mediated multidrug resistance in HEK293/MRP1 cells assessed as effect on etoposide-induced cytotoxicity by measuring etoposide IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb = 63.34 +/- 7.92 uM)
- ChEMBL_1995627 (CHEMBL4629522) Reversal of human ABCC1-mediated multidrug resistance in HEK293/MRP1 cells assessed as effect on etoposide-induced cytotoxicity by measuring etoposide IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb = 63.34 +/- 7.92 uM)
- ChEMBL_1995628 (CHEMBL4629523) Reversal of human ABCC1-mediated multidrug resistance in HEK293/MRP1 cells assessed as effect on etoposide-induced cytotoxicity by measuring etoposide IC50 at 0.5 uM after 72 hrs by CCK8 assay (Rvb = 63.34 +/- 7.92 uM)
- ChEMBL_2051922 (CHEMBL4706923) Inhibition of CHK1 in human HT-29 cells assessed as abrogation of etoposide-induced G2 checkpoint arrest by ELISA
- ChEMBL_2214616 (CHEMBL5127748) Inhibition of ATM in human MCF7 cells using etoposide as substrate incubated for 1 hr by Cell Western assay
- ChEMBL_2248172 (CHEMBL5162382) Inhibition of ATM in human A549 cells assessed as reduction in etoposide-stimulated KAP1 phosphorylation by In-Cell-Western assay
- ChEMBL_2028067 (CHEMBL4682225) Inhibition of ATM in human MCF7 cells assessed as reduction in etoposide-stimulated KAP1 phosphorylation incubated for 1 hr by ICW assay
- ChEMBL_2114759 (CHEMBL4823700) Inhibition of ATM in human U2OS cells assessed as reduction in etoposide-stimulated KAP1 phosphorylation incubated for 60 mins by immunoreactivity assay
- ChEMBL_608835 (CHEMBL1069054) Inhibition of CHK2 in human HT29 cells assessed as blockade of etoposide-induced DNA damage-activated enzyme phosphorylation by Western bloting
- ChEMBL_887300 (CHEMBL2216279) Inhibition of CHK1 in human HT-29 cells assessed as etoposide-induced G2 check point arrest after 21 hrs by ELISA
- ChEMBL_1477896 (CHEMBL3429175) Inhibition of Cdc25B-mediated entry in to mitosis in etoposide-treated human U2OS cells incubated for 16 hrs in presence of nocodazole by Hoechst 33342 staining based fluorescence microscopy