Compound (127)
Article Title (6)
Assay (8)
Wright, WC; Chenge, J; Wang, J; Girvan, HM; Yang, L; Chai, SC; Huber, AD; Wu, J; Oladimeji, PO; Munro, AW; Chen, T Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5. J Med Chem 63: 1415 -1433 (2020) Kang, S; Tang, W; Li, H; Chreifi, G; Martásek, P; Roman, LJ; Poulos, TL; Silverman, RB Nitric oxide synthase inhibitors that interact with both heme propionate and tetrahydrobiopterin show high isoform selectivity. J Med Chem 57: 4382 -96 (2014) Zimmermann, TJ; Niesen, FH; Pilka, ES; Knapp, S; Oppermann, U; Maier, ME Discovery of a potent and selective inhibitor for human carbonyl reductase 1 from propionate scanning applied to the macrolide zearalenone. Bioorg Med Chem 17: 530 -6 (2009) Shimizu-Sasamata, M; Kawasaki-Yatsugi, S; Okada, M; Sakamoto, S; Yatsugi, S; Togami, J; Hatanaka, K; Ohmori, J; Koshiya, K; Usuda, S; Murase, K YM90K: pharmacological characterization as a selective and potent alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor antagonist. J Pharmacol Exp Ther 276: 84 -92 (1996) Ohmori, J; Kubota, H; Shimizu-Sasamata, M; Okada, M; Sakamoto, S Novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor antagonists: synthesis and structure-activity relationships of 6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-pyrido[2,3-b]pyrazinedione and related compounds. J Med Chem 39: 1331 -8 (1996) Badorc, A; Bordes, MF; de Cointet, P; Savi, P; Bernat, A; Lalé, A; Petitou, M; Maffrand, JP; Herbert, JM New orally active non-peptide fibrinogen receptor (GpIIb-IIIa) antagonists: identification of ethyl 3-[N-[4-[4-[amino[(ethoxycarbonyl) imino]methyl]phenyl]-1,3-thiazol-2-yl]-N-[1-[(ethoxycarbonyl)methyl]pip erid -4-yl]amino]propionate (SR 121787) as a potent and long-acting antithrombotic agent. J Med Chem 40: 3393 -401 (1997)
ChEMBL_862370 (CHEMBL2173314) Inhibition of NHE1 in rat platelet rich plasma assessed as reduction of propionate medium induced platelet swelling measured every 6 secs for 5 mins ChEMBL_862404 (CHEMBL2173434) Inhibition of NHE1 in human platelet rich plasma assessed as reduction of propionate medium induced platelet swelling measured every 6 secs for 5 mins ChEBML_1653456 Inhibition of platelet NHE1 in human platelet rich plasma assessed as decrease in platelet swelling preincubated for 3 mins followed by sodium propionate addition measured after 4 mins by spectrophotometric method ChEMBL_1653456 (CHEMBL4002822) Inhibition of platelet NHE1 in human platelet rich plasma assessed as decrease in platelet swelling preincubated for 3 mins followed by sodium propionate addition measured after 4 mins by spectrophotometric method ChEMBL_1902642 (CHEMBL4404864) Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assay GTPγS Assay The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membrane-expressing hGPR43, 250 μg of wheatgerm agglutinin beads (Amersham, ref: RPNQ001), a range concentration of compounds of the invention (from 30 μM to 1 nM) in a final volume of 100 μl for 30 min at room temperature. The SCFA propionate was used at 1 mM final concentration as positive control. The plates were then centrifuged for 10 minutes at 2000 rpm, incubated for 2 hours at room temperature and counted for 1 min in a scintillation counter (TopCount, PerkinElmer). The results of the tested compounds are reported as the concentration of the compound required to reach 50% (EC50) of the maximum level of the activation induced by these compounds. GTPγS Assay The assay was used to determine the activity of the compounds of the invention.The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membrane-expressing hGPR43, 250 μg of wheatgerm agglutinin beads (Amersham, ref: RPNQ001), a range concentration of compounds of the invention (from 30 μM to 1 nM) in a final volume of 100 μl for 30 min at room temperature. The SCFA propionate was used at 1 mM final concentration as positive control. The plates were then centrifuged for 10 minutes at 2000 rpm, incubated for 2 hours at room temperature and counted for 1 min in a scintillation counter (TopCount, PerkinElmer). The results of the tested compounds are reported as the concentration of the compound required to reach 50% (EC50) of the maximum level of the activation induced by these compounds GTPγS Binding Assay The assay was used to determine the activity of the compounds of the invention. The [35S]GTPγS assay was incubated in 20 mM HEPES pH7.4, 100 mM NaCl, 10 μg/ml saponin, 30 mM of MgCl2, 10 μM of GDP, 5 μg membrane-expressing hGPR43, 250 μg of wheatgerm agglutinin beads (Amersham, ref: RPNQ001), a range concentration of compounds of the invention (from 30 μM to 1 nM) in a final volume of 100 μl for 30 min at room temperature. The SCFA propionate was used at 1 mM final concentration as positive control. The plates were then centrifuged for 10 minutes at 2000 rpm, incubated for 2 hours at room temperature and counted for 1 min in a scintillation counter (TopCount, PerkinElmer). The results of the tested compounds are reported as the concentration of the compound required to reach 50% (EC50) of the maximum level of the activation induced by these compounds.
BDBM589230 US11554172, Compound Fluticasone-Propionate
CCI-18781 Flonase Flovent diskus 50 FLUTICASONE PROPIONATE BDBM50354849 US10869929, Compound FLUTICASONE PROPIONATE Flovent hfa Flovent diskus 250 Cutivate Fluticasone Flovent Flovent diskus 100
Veramyst FLUTICASONE FUROATE BDBM50354851
BDBM50257201 CHEMBL500826 sodium propionate
cid_32798 SMR000058745 MLS000028708 CLOBETASOL PROPIONATE BDBM39347
Isosorbide-2-benzylcarbamate-5-propionate BDBM50252783 CHEMBL493672
Ethyl-3-borono-2-(carbamylamino)propionate BDBM50010600 CHEMBL168878
SODIUM LACTATE CHEMBL1357 Sodium; 2-hydroxy-propionate BDBM50159794
3-(2-hydroxyphenyl)propionic acid 3-(2-Hydroxyphenyl)propionate BDBM36128
3-(2-hydroxyphenyl)propionic acid 3-(2-Hydroxyphenyl)propionate BDBM36144
3-(4-hydroxyphenyl)propionic acid 3-(4-Hydroxyphenyl)propionate BDBM36143
BDBM36129 3-(4-hydroxyphenyl)propionic acid 3-(4-Hydroxyphenyl)propionate
sodium;2-(2-quinolinylthio)propanoate Sodium; 2-(quinolin-2-ylsulfanyl)-propionate cid_23663723 BDBM114319 sodium;2-(2-quinolylthio)propionate MLS000555430 sodium;2-quinolin-2-ylsulfanylpropanoate SMR000147147
4-(2-(6-phenylpicolinamido)acetyl)piperazin-1-yl propionate BDBM50298124 CHEMBL549307
BDBM50298122 CHEMBL549797 4-(2-(4,6-diphenylpicolinamido)acetyl)piperazin-1-yl propionate
BDBM50022201 Sodium; 3-{hydroxy-[3-(naphthalen-2-ylmethoxy)-phenyl]-carbamoyl}-propionate CHEMBL34676
BDBM50023537 Sodium; 3-{bis-[4-(2,2-dimethyl-propionyloxy)-phenyl]-methoxycarbonyl}-propionate CHEMBL10148
CHEMBL1169703 BDBM50322032 2-Methylisoindole-1,3-dione-5-yl 3-(4-aminophenyl)propionate
BDBM50075091 CHEMBL131894 Sodium; 3-{2-[(4-chloro-benzenesulfonylamino)-methyl]-indan-5-yl}-propionate
loxoprofen sodium CHEMBL66552 BDBM50330853 Sodium; 2-[4-(2-oxo-cyclopentylmethyl)-phenyl]-propionate; hydrate
CHEMBL1171655 2-Methylisoindole-1,3-dione-5-yl 3-(6-aminopyridin-3-yl)propionate BDBM50322033
2-(4-Cyanophenyl)isoindole-1,3-dione-5-yl(E)-3-(4-aminophenyl)propionate CHEMBL1172717 BDBM50322034
dilithium; 3-((2-carboxy-ethylsulfanyl)-{3-[(quinoline-2-carbonyl)-amino]-phenyl}-methylsulfanyl)-propionate CHEMBL338166 BDBM50001295
BDBM50265314 CHEMBL497586 3-(4-(3-(bis(4-fluorophenyl)amino)propyl)piperazin-1-yl)-1-phenylpropyl propionate
CHEMBL15481 Sodium; 3-{1-[3-(7-chloro-quinolin-2-ylmethoxy)-phenyl]-3-phenyl-propylsulfanyl}-propionate BDBM50280700
CHEMBL343392 Sodium; 3-[3-hydroxycarbamoyl-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinolin-7-ylcarbamoyl]-propionate BDBM50082478
Propionic acid (8R,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester BDBM50215709 testosteron propionate Propionic acid 10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester(Testosterone Propionate) CHEMBL1170 Propionic acid 10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester TESTOSTERONE PROPIONATE
BDBM50025453 CHEMBL3349127 Sodium; 2-(4a,6a-dimethyl-2-oxo-hexadecahydro-indeno[5,4-f]quinolin-7-yl)-propionate
BDBM50077371 Sodium; 3-[(R)-3-hydroxycarbamoyl-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinolin-7-ylcarbamoyl]-propionate CHEMBL56965
Sodium; 2-(1,4a,6a-trimethyl-2-oxo-hexadecahydro-indeno[5,4-f]quinolin-7-yl)-propionate BDBM50025401 CHEMBL3085568
3-(trifluoromethyl)-5-(4-((1R,2R)-2-(4-(trifluoromethyl)phenyl)cyclopropanecarbonyl)piperazin-1-ylsulfonyl)phenyl propionate BDBM50267616 CHEMBL488932
BDBM50280715 Sodium; 3-[1-[3-(7-chloro-quinolin-2-ylmethoxy)-phenyl]-3-(2-dimethylcarbamoyl-phenyl)-propylsulfanyl]-propionate CHEMBL15513
CHEMBL15292 BDBM50280694 Sodium; 3-[1-[3-(7-chloro-quinolin-2-ylmethoxy)-phenyl]-3-(2-sulfamoyl-phenyl)-propylsulfanyl]-propionate
CHEMBL563301 methyl 3-(3-(3(3-fluoro-4hydroxyphenyl)-4,5-dihydroisoxazole-5-yl)-1,2,4-oxadiazol-5-yl)propionate BDBM50298011
Erythromycin Estolate Erythromycin Propionate Lauryl Sulfate CHEBI:4846 BDBM50237591 Ilosone Erythromycin Lauryl Sulfate, Propionyl Propionyl Erythromycin Lauryl Sulfate
Erythromycin Estolate Erythromycin Propionate Lauryl Sulfate CHEBI:4846 Ilosone Erythromycin Lauryl Sulfate, Propionyl Propionyl Erythromycin Lauryl Sulfate BDBM50103515
Sodium; 3-[1-[3-(7-chloro-quinolin-2-ylmethoxy)-phenyl]-3-(2-methanesulfonylamino-phenyl)-propylsulfanyl]-propionate CHEMBL274049 BDBM50280698
[2-[(5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]methoxy]methyl propionate (14b) BDBM234289
Sodium; 3-[3-tert-butylsulfanyl-1-(4-chloro-benzyl)-5-isopropyl-1H-indol-2-yl]-2,2-dimethyl-propionate(Takeda AA 861) CHEMBL416657 Sodium; 3-[3-tert-butylsulfanyl-1-(4-chloro-benzyl)-5-isopropyl-1H-indol-2-yl]-2,2-dimethyl-propionate BDBM50000838
3-phenyl-2-(trimethylazaniumyl)propanoate MLS000863632 3-phenyl-2-(trimethylammonio)propionate cid_16745393 BDBM76196 SMR000440709 3-phenyl-2-(trimethylammonio)propanoate
BDBM50264743 (S)-1-(4-(3-(bis(4-fluorophenyl)amino)propyl)piperazin-1-yl)-3-phenylpropan-2-yl propionate CHEMBL490424
US10836743, Compound A7 Methyl 3-(4-fluoro-4-(((trans-2-phenylcyclo- propyl)amino)methyl)piperidin-1- yl)-propionate BDBM472868
Sodium;3-[(R)-{3-[(E)-2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-(2-dimethylcarbamoyl-ethylsulfanyl)-methylsulfanyl]-propionate MK-679 BDBM50052029 Sodium; 3-[(R)-{3-[(E)-2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-(2-dimethylcarbamoyl-ethylsulfanyl)-methylsulfanyl]-propionate L-668019 CHEMBL89340
(S)-3-(4-(7-chloro-3,3-dimethyl-2-oxoindoline-1-yl)phenyl)-2-(triphenylamino)methyl propionate BDBM672842 US20240150287, Example 10
4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl) BDBM50019951
BDBM561980 methyl 3-[6-[(Z)-2-(aminomethyl)-3-fluoro-allyloxy]-1-oxo-3,4-dihydro isoquinolin-2-yl]propionate US11396495, No. 57
CHEMBL15419 BDBM50280692 Sodium; 3-[1-[3-(7-chloro-quinolin-2-ylmethoxy)-phenyl]-3-(2-isopropyl-phenyl)-propylsulfanyl]-2-methyl-propionate
CHEMBL278411 Sodium; 3-{1-[3-(7-chloro-quinolin-2-ylmethoxy)-phenyl]-3-[2-(piperidine-1-carbonyl)-phenyl]-propylsulfanyl}-propionate BDBM50280689
Sodium; 3-[1-[3-(7-chloro-quinolin-2-ylmethoxy)-phenyl]-3-(2-nitro-phenyl)-propylsulfanyl]-2-methyl-propionate CHEMBL15370 BDBM50280693
methyl 3-[6-[(E)-2-(aminomethyl)-3-fluoro-allyloxy]-1-oxo-3,4-dihydro isoquinolin-2-yl]propionate BDBM561979 US11396495, No. 56
(S)-3-(4-(2′-oxospiro[cyclopropane-1,3′-indoline]-1′-yl)phenyl)-2-(triphenylamino)methyl propionate BDBM672838 US20240150287, Example 6
BDBM50106099 CHEMBL321739 Lithium; (S)-3-[2-((3-methyl-butyl)-{2-[4-(3-o-tolyl-ureido)-phenyl]-acetyl}-amino)-acetylamino]-3-phenyl-propionate
CHEMBL14819 Sodium; 3-{1-[3-(7-chloro-quinolin-2-ylmethoxy)-phenyl]-3-[2-(2H-[1,2,4]triazol-3-yl)-phenyl]-propylsulfanyl}-propionate BDBM50280712
BDBM50096894 Sodium; 3-cyclohexyl-2-{2,3,5-trihydroxy-6-[2-(3,4,5-trihydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-cyclohexyloxy]-tetrahydro-pyran-4-yloxy}-propionate CHEMBL3215408 Sodium; (R)-3-cyclohexyl-2-{3,5-dihydroxy-2-hydroxymethyl-6-[2-(3,4,5-trihydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-cyclohexyloxy]-tetrahydro-pyran-4-yloxy}-propionate
(3R,5S)-5-((4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-3-yl propionate BDBM50293258 CHEMBL500381
BDBM50025427 CHEMBL3349153 Sodium; 2-(1,4a,6a-trimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinolin-7-yl)-propionate
CHEMBL3349157 BDBM50025422 Sodium; 2-(4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinolin-7-yl)-propionate
Sodium; 2-(1,4a,6a-trimethyl-2-oxo-2,3,4,4a,4b,5,6,6a,7,8,9,9a,9b,10-tetradecahydro-1H-indeno[5,4-f]quinolin-7-yl)-propionate BDBM50025352 CHEMBL3349083
(RS)-2-amino-3-(1-hydroxy-1,2,3-triazol-5-yl)propionate BDBM50107950 CHEMBL321164 2-Amino-3-(3-hydroxy-3H-[1,2,3]triazol-4-yl)-propionic acid
(S)-3-(4-(5′-(dimethylamino)-2′-oxospiro[cyclopropane-1,3′-indoline]-1′-yl)phenyl)-2-(triphenylamino)methyl propionate BDBM672844 US20240150287, Example 12
(S)-3-(4-(7′-chloro-2′-oxospiro[cyclopropane-1,3′-indolinyl]-1′-yl)phenyl)-2-(tritylamino)methyl propionate BDBM672834 US20240150287, Example 2
(S)-3-(4-(7′-methoxy-2′-oxospiro[cyclopropane-1,3′-indoline]-1′-yl)phenyl)-2-(triphenylamino)methyl propionate BDBM672835 US20240150287, Example 3
BDBM50096895 CHEMBL3215404 Sodium; (S)-3-phenyl-2-{2,3,5-trihydroxy-6-[2-(3,4,5-trihydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-cyclohexyloxy]-tetrahydro-pyran-4-yloxy}-propionate
Methyl (R)-3-((5-(1-amino-8-azaspiro[4.5]decan-8-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)thio)propionate US11498930, Compound 1.2.24 BDBM580319
US20240150287, Example 9 (S)-3-(4-(5′-fluoro-2′-oxospiro[cyclopropane-1,3′-indoline]-1′-yl)phenyl)-2-(triphenylamino)methyl propionate BDBM672841
(S)-3-(4-(3-cyclopropyl-7-fluoro-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)phenyl)-2-(triphenylmethylamino)methyl propionate BDBM672858 US20240150287, Example 27
(S)-3-(4-(4,5-difluoro-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)phenyl)-2-(triphenylmethylamino)methyl propionate BDBM672865 US20240150287, Example 34
(S)-3-(4-(5-chloro-3-cyclopropyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)phenyl)-2-(triphenylmethylamino)methyl propionate BDBM672854 US20240150287, Example 23
(S)-3-(4-(6,7-difluoro-3-methyl-2-oxo-2,3-dihydro-H-benzo[d]imidazol-1-yl)phenyl)-2-(triphenylmethylamino)methyl propionate BDBM672864 US20240150287, Example 33
(S)-3-(4-(6-chloro-3-cyclopropyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)phenyl)-2-(triphenylmethylamino)methyl propionate BDBM672855 US20240150287, Example 24
(S)-3-(4-(7-chloro-3-cyclopropyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)phenyl)-2-(triphenylmethylamino)methyl propionate US20240150287, Example 25 BDBM672856
BDBM50096893 CHEMBL356673 Sodium; 2-{2-benzoylamino-3,5-dihydroxy-6-[2-(3,4,5-trihydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-cyclohexyloxy]-tetrahydro-pyran-4-yloxy}-3-phenyl-propionate
BDBM50128264 (R,S)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionate CHEMBL72366 2-Amino-3-(4-chloro-3-hydroxy-isoxazol-5-yl)-propionic acid
BDBM50280705 CHEMBL15306 Sodium; (S)-3-{(R)-1-[3-(7-chloro-quinolin-2-ylmethoxy)-phenyl]-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanyl}-2-methyl-propionate
BDBM672849 (S)-3-(4-(7′-chloro-2′-oxospiro[cyclopropane-1,3′-indoline]-1′-yl)phenyl)-2-(2,4,6-trichlorobenzoylamino)methyl propionate US20240150287, Example 17
BDBM672853 US20240150287, Example 22 (S)-3-(4-(7-chloro-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)phenyl)-2-(triphenylmethylamino)methyl propionate
BDBM672857 US20240150287, Example 26 (S)-3-(4-(7-chloro-3-methyl-2-thio-2,3-dihydro-1H-benzo[d]imidazol-1-yl)phenyl)-2-(triphenylmethylamino)methyl propionate
BDBM672861 US20240150287, Example 30 (S)-3-(4-(7-fluoro-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)phenyl)-2-(triphenylmethylamino)methyl propionate
BDBM672868 US20240150287, Example 37 (S)-3-(4-(5-(dimethylamino)-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)phenyl)-2-(triphenylmethylamino)methyl propionate
CHEMBL275357 Sodium; (R)-3-{(R)-1-[3-(7-chloro-quinolin-2-ylmethoxy)-phenyl]-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanyl}-2-methyl-propionate BDBM50280701
CHEMBL277533 BDBM50280706 Sodium; (R)-3-{(S)-1-[3-(7-chloro-quinolin-2-ylmethoxy)-phenyl]-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanyl}-2-methyl-propionate
Sodium; (S)-3-{(S)-1-[3-(7-chloro-quinolin-2-ylmethoxy)-phenyl]-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanyl}-2-methyl-propionate BDBM50280696 CHEMBL274913
Sodium; 2-{2-acetylamino-3,5-dihydroxy-6-[2-(3,4,5-trihydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-cyclohexyloxy]-tetrahydro-pyran-4-yloxy}-3-phenyl-propionate CHEMBL336473 BDBM50096888
Sodium; 2-{2-carbamoyl-3,5-dihydroxy-6-[2-(3,4,5-trihydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-cyclohexyloxy]-tetrahydro-pyran-4-yloxy}-3-cyclohexyl-propionate CHEMBL140314 BDBM50096889
US20240150287, Example 31 (S)-3-(4-(5,7-difluoro-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)phenyl)-2-(triphenylmethylamino)methyl propionate BDBM672862
US20240150287, Example 32 (S)-3-(4-(5,6-dichloro-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)phenyl)-2-(triphenylmethylamino)methyl propionate BDBM672863
US20240150287, Example 36 BDBM672867 (S)-3-(4-(6-(dimethylamino)-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)phenyl)-2-(triphenylmethylamino)methyl propionate
rac-(1R,2S)-2- (cyano(phenyl)(1-((1-(4- (pyridin-4- ylsulfonyl)phenyl)azetidin-3- yl)methyl)piperidin-4- yl)methylcyclopentyl propionate BDBM480136 US10899738, Cpd. No 196
Sodium; 3-[{3-[(E)-2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-(2-dimethylcarbamoyl-ethylsulfanyl)-methylsulfanyl]-propionate L-660771 BDBM50052019 Sodium;3-[{3-[(E)-2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-(2-dimethylcarbamoyl-ethylsulfanyl)-methylsulfanyl]-propionate CHEMBL89768 MK-571 sodium (E)-3-((3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)(3-(dimethylamino)-3-oxopropylthio)methylthio)propanoate
(S)-3-(4-(5′,6′-difluoro-2′-oxospiro[cyclopropane-1,3′-indoline]-1′-yl)phenyl)-2-(triphenylamino)methyl propionate BDBM672833 US20240150287, Example 1
(S)-3-(4-(6′,7′-difluoro-2′-oxospiro[cyclopropane-1,3′-indoline]-1′-yl)phenyl)-2-(triphenylamino)methyl propionate BDBM672847 US20240150287, Example 15
(Step 1) (S)-3-(4-(6′-fluoro-2′-oxospiro [cyclopropane-1,3′-indoline]-1′-yl)phenyl)-2-(triphenylamino)methyl propionate BDBM672845 US20240150287, Example 13
(Step 1) (S)-3-(4-(7′-fluoro-2′-oxospiro [cyclopropane-1,3′-indoline]-1′-yl)phenyl)-2-(triphenylamino)methyl propionate BDBM672846 US20240150287, Example 14
BDBM480135 US10899738, Cpd. No 195 rac-(1S,2R)-2- (cyano(phenyl)(1-((1-(4- (pyridin-4- ylsulfonyl)phenyl)azetidin-3- yl)methyl)piperidin-4- yl)methyl)cyclopentyl propionate
BDBM672866 (S)-3-(4-(7-methoxy-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)phenyl)-2-(triphenyl methylamino)methyl propionate US20240150287, Example 35
BDBM672869 US20240150287, Example 38 (S)-3-(4-(7-chloro-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)phenyl)-2-(2,4,6-trichlorobenzamido)methyl propionate
(S)-3-(4-(6′-(dimethylamino)-5′-fluoro-2′-oxospiro[cyclopropane-1,3′-indoline]-1′-yl)phenyl)-2-(triphenylamino)methyl propionate BDBM672843 US20240150287, Example 11
(S)-3-(4-(6′-chloro-5′-fluoro-2′-oxospiro[cyclopropane-1,3′-indoline]-1′-yl)phenyl)-2-(triphenylamino)methyl propionate US20240150287, Example 8 BDBM672840
(S)-3-(4-(6′-fluoro-2′-oxospiro[cyclopropane-1,3′-indoline]-1′-yl)phenyl)-2-(triphenylamino)methyl propionate BDBM672836 US20240150287, Example 13 US20240150287, Example 4
BDBM54704 cid_23681059 sodium;(2S)-2-(6-methoxynaphthalen-2-yl)propanoate UNM-0000306098 sodium;(2S)-2-(6-methoxy-2-naphthyl)propionate sodium;(2S)-2-(6-methoxy-2-naphthalenyl)propanoate
BDBM672848 (S)-3-(4-(2′-oxospiro[cyclopropane-1,3′-pyrrolo[2,3-b]pyridine]-1′(2′H)-yl)phenyl)-2-(triphenylamino)methyl propionate US20240150287, Example 16
BDBM672850 US20240150287, Example 19 (S)-3-(4-(7′-chloro-2′-oxospiro[cyclopropane-1,3′-indoline]-1′-yl)phenyl)-2-(2,6-dichloro-4-morpholinoylbenzoylamino)methyl propionate
CHEMBL81732 BDBM50080294 Sodium; (S)-3-(1H-indol-3-yl)-2-[(S)-4-methyl-2-(3,4,5-trihydroxy-6-methyl-2-oxo-2lambda*5*-[1,2]oxaphosphinan-2-ylamino)-pentanoylamino]-propionate
cid_23675324 sodium;(2R)-2-(6-methoxy-2-naphthyl)propionate sodium;(2R)-2-(6-methoxynaphthalen-2-yl)propanoate BDBM54693 UNM-0000305812 sodium;(2R)-2-(6-methoxy-2-naphthalenyl)propanoate
propanoic acid [4-(2-quinoxalinyl)phenyl] ester (4-quinoxalin-2-ylphenyl) propanoate cid_768876 propionic acid (4-quinoxalin-2-ylphenyl) ester MLS000579684 4-(2-quinoxalinyl)phenyl propionate BDBM49530 SMR000186414
BDBM672859 (S)-3-(4-(7-chloro-2-oxo-3-(tetrahydro-2H-pyran-4-yl)-2,3-dihydro-1H-benzo[d]imidazol-1-phenyl)-2-(triphenylamino)methyl propionate US20240150287, Example 28
BDBM672860 (S)-3-(4-(7-chloro-3-(1-methylpiperidin-4-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)phenyl)-2-(triphenylamino)methyl propionate US20240150287, Example 29
BDBM672870 (S)-3-(4-(7-chloro-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)phenyl)-2-(2,6-dichloro-4-morpholinylbenzoylamino)methyl propionate US20240150287, Example 39
(Step 1) (S)-3-(4-(7′-fluoro-2′-oxospiro [cyclopropane-1,3′-indoline]-1′-yl)phenyl)-2-(triphenylamino)methyl propionate BDBM672837 US20240150287, Example 14 US20240150287, Example 5
BDBM288124 US10087178, Example S65 7'-(3-chloro-2- fluorobenzylcarbamoyl)-cis- 3-methoxy-2'-methyl-1',8'- dioxo-1',2',3',8'- tetrahydrospiro[cyclobutane- 1,4'-pyrido[1,2-a]pyrazin]- 9'-yl propionate
BDBM50000561 CHEMBL290454 Sodium; 2-{2-[2-({2-[(azepane-1-carbonyl)-amino]-4-methyl-pentanoyl}-methyl-amino)-3-(1H-indol-3-yl)-propionylamino]-3-pyridin-2-yl-propionylamino}-3-phenyl-propionate
US10087178, Example S67 7'-(3-chloro-2- fluorobenzylcarbamoyl)-cis- 3-(methoxymethyl)-2'-methyl- 1',8'-dioxo-1',2',3',8'- tetrahydrospiro[cyclobutane- 1,4'-pyrido[1,2-a]pyrazin]- 9'-yl propionate BDBM288126
(S)-3-(4-(7′-chloro-2′-oxospiro[cyclopropane-1,3′-indoline]-1-yl)phenyl)-2-(2,6-dichloro-4-(4-morpholinopiperidin-1-yl)benzoylamino)methyl propionate US20240150287, Example 21 BDBM672852
BDBM672839 (S)-3-(4-(7-chloro-2-oxo-2′,3′,5′,6′-tetrahydrospiro[indoline-3,4′-pyran]-1-yl)phenyl)-2-(triphenylamino)methyl propionate US20240150287, Example 7
CHEMBL3215450 Sodium; (R)-3-cyclohexyl-2-{3,5-dihydroxy-2-hydroxymethyl-6-[2-hydroxymethyl-3-(3,4,5-trihydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-4-yloxy]-tetrahydro-pyran-4-yloxy}-propionate BDBM50098171
ethyl (S)-2-amino-3-(4- (4-((R)-1-(4-chloro-2- (3-methyl-1H-pyrazole- 1-yl)phenyl)-2,2,2- trifluoroethoxy)thieno [3,2-d]pyrimidine-7- yl)phenyl)propionate hydrochloride US11407763, Example 22 BDBM563490
(2S)-2-(4-(2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-2,6-dichlorobenzamido)-3-(4-(7′-chloro-2′-oxospiro[cyclopropane-1,3′-indoline]-1′-yl)phenyl)methyl propionate US20240150287, Example 20 BDBM672851
Propionic acid (R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)-4-methyl-pent-3-enyl ester (R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-enyl propionate CHEMBL8951 BDBM50033725
sodium;3-[(4-methoxyphenyl)carbonylamino]-3-phenyl-propanoate KUC105717AM sodium;3-(p-anisoylamino)-3-phenyl-propionate BDBM61984 cid_23678497 sodium;3-[(4-methoxybenzoyl)amino]-3-phenylpropanoate sodium;3-[[(4-methoxyphenyl)-oxomethyl]amino]-3-phenylpropanoate KSC-09-176C
CHEMBL545608 4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl) 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one BDBM21398 Haloperidol CHEMBL54 Haloperidol, 1
3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid Sodium; 3-[3-tert-butylsulfanyl-1-(4-chloro-benzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionate MK-591 BDBM50052018 CHEMBL313489
propan-2-yl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate FENOFIBRATE Fenofibric acid CHEMBL672 Procetofen Finofibrate Lipantil (TN) 2-(4-(4-Chlorobenzoyl)phenoxy)-2-methylpropanoic acid 1-methylethyl ester BDBM50085042 Isopropyl (4'-(p-chlorobenzoyl)-2-phenoxy-2-methyl)propionate Isopropyl 2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropionate Tricor (TN) FNF
azanium;2-(dodecanoylamino)-3-(4-methoxy-3-nitro-phenyl)propanoate BDBM90685 azanium;2-(dodecanoylamino)-3-(4-methoxy-3-nitrophenyl)propanoate cid_16682307 SMR000429460 2-Dodecanoylamino-3-(4-methoxy-3-nitro-phenyl)-propionic acid anion ammonium;3-(4-methoxy-3-nitrophenyl)-2-(1-oxododecylamino)propanoate ammonium;2-(lauroylamino)-3-(4-methoxy-3-nitro-phenyl)propionate MLS000767130
sodium;(2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate 3,3',5-TRIIODO-L-THYRONINE SODIUM SALT sodium;(2S)-2-amino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3,5-diiodo-phenyl]propionate SMR000059206 sodium;(2S)-2-azanyl-3-[3,5-bis(iodanyl)-4-(3-iodanyl-4-oxidanyl-phenoxy)phenyl]propanoate BDBM50007 Triiodothyronine cid_23666110 MLS000028648
propionic acid 2-[[7-(1H-benzimidazol-2-ylthio)-4-nitro-benzofurazan-5-yl]amino]ethyl ester 2-[[7-(1H-benzimidazol-2-ylsulfanyl)-4-nitro-2,1,3-benzoxadiazol-5-yl]amino]ethyl propanoate BDBM33121 2-{[7-(1H-benzimidazol-2-ylthio)-4-nitro-2,1,3-benzoxadiazol-5-yl]amino}ethyl propionate MLS000584446 propanoic acid 2-[[7-(1H-benzimidazol-2-ylthio)-4-nitro-2,1,3-benzoxadiazol-5-yl]amino]ethyl ester SMR000207032 cid_12005314
2-[[7-(1-methylimidazol-2-yl)sulfanyl-4-nitro-2,1,3-benzoxadiazol-5-yl]amino]ethyl propanoate propanoic acid 2-[[7-[(1-methyl-2-imidazolyl)thio]-4-nitro-2,1,3-benzoxadiazol-5-yl]amino]ethyl ester BDBM33119 cid_12005273 MLS000584447 2-({7-[(1-methyl-1H-imidazol-2-yl)thio]-4-nitro-2,1,3-benzoxadiazol-5-yl}amino)ethyl propionate SMR000207033 propionic acid 2-[[7-[(1-methylimidazol-2-yl)thio]-4-nitro-benzofurazan-5-yl]amino]ethyl ester
MLS000550586 sodium;(2R)-2-[(2R,5S,6R)-6-[(3E,5E)-6-[(3aR,4S,5S,7aS)-4-(1H-pyrrole-2-carbonyl)-2,3,3a,4,5,7a-hexahydro-1H-inden-5-yl]hexa-3,5-dien-3-yl]-5-methyloxan-2-yl]propanoate sodium;(2R)-2-[(2R,5S,6R)-6-[(3E,5E)-6-[(3aR,4S,5S,7aS)-4-[oxo(1H-pyrrol-2-yl)methyl]-2,3,3a,4,5,7a-hexahydro-1H-inden-5-yl]hexa-3,5-dien-3-yl]-5-methyl-2-oxanyl]propanoate SMR000114418 sodium;(2R)-2-[(2R,5S,6R)-6-[(1E,3E)-4-[(3aR,4S,5S,7aS)-4-(1H-pyrrole-2-carbonyl)-2,3,3a,4,5,7a-hexahydro-1H-inden-5-yl]-1-ethyl-buta-1,3-dienyl]-5-methyl-tetrahydropyran-2-yl]propionate 2-(6-{1-ethyl-4-[4-(1H-pyrrol-2-ylcarbonyl)-2,3,3a,4,5,7a-hexahydro-1H-inden-5-yl]-1,3-butadienyl}-5-methyltetrahydro-2H-pyran-2-yl)propanoate cid_23670524 sodium;(2R)-2-[(2R,5S,6R)-6-[(3E,5E)-6-[(3aR,4S,5S,7aS)-4-(1H-pyrrol-2-ylcarbonyl)-2,3,3a,4,5,7a-hexahydro-1H-inden-5-yl]hexa-3,5-dien-3-yl]-5-methyl-oxan-2-yl]propanoate BDBM52222