Query String: ILOPROST
Ventavis BDBM23954 5-[(2E,3aS,4R,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl]-octahydropentalen-2-ylidene]pentanoic acid [3H]-Iloprost CHEMBL494 ILOPROST
- ChEBML_158008 Displacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
- ChEBML_158015 Tested for inhibition of 3[H]-iloprost binding to human IP receptor
- ChEMBL_302597 (CHEMBL838565) Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptor
- ChEMBL_303131 (CHEMBL828948) Inhibition of [3H]iloprost binding to human prostanoid IP receptor
- ChEMBL_303292 (CHEMBL828285) Displacement of [3H]iloprost from human Prostanoid IP receptor
- ChEMBL_400375 (CHEMBL912673) Displacement of [3H]iloprost from cloned human PGI2 receptor
- ChEBML_158007 Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human platelets
- ChEMBL_158008 (CHEMBL768434) Displacement of [3H]iloprost from Prostaglandin I2 receptor of human platelets
- ChEMBL_158464 (CHEMBL763223) In vitro binding at prostanoid IP receptor using [3H]iloprost as radioligand
- ChEBML_158010 IC50 value was evaluated by measuring the displacement of [3H]iloprost from Prostaglandin I2 receptor
- ChEMBL_302783 (CHEMBL839468) Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
- ChEMBL_716962 (CHEMBL1670990) Displacement of [3H]iloprost from IP receptor in human 293 cell membrane
- ChEMBL_1559787 (CHEMBL3779740) Displacement of [3H]iloprost from human recombinant Prostanoid IP receptor expressed in HEK293 cells
- ChEMBL_580963 (CHEMBL1054928) Displacement of [3H]iloprost from human prostacyclin receptor expressed in human 293 cell membrane
- ChEMBL_596850 (CHEMBL1045309) Displacement of [3H]iloprost from human IP receptor after 1 hr by liquid scintillation counting
- ChEMBL_610069 (CHEMBL1072478) Displacement of [3H]iloprost from human IP receptor expressed in HEK293-EBNA cells by scintillation counting
- ChEMBL_788537 (CHEMBL1918376) Displacement of [3H]-iloprost from human prostanoid IP receptor expressed in human 293T cells membranes
- ChEMBL_157784 (CHEMBL857865) Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand
- ChEBML_157657 Compound was tested for prostacyclin (PGI-2) binding by displacement of [3H]iloprost from human platelets using conventional ligand binding assay
- ChEMBL_761110 (CHEMBL1815364) Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
- ChEBML_158014 In vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptor
- ChEMBL_634911 (CHEMBL1117651) Displacement of [3H]iloprost from human prostanoid IP receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting
- ChEMBL_764674 (CHEMBL1821226) Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
- ChEMBL_788407 (CHEMBL1918135) Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting
- ChEBML_158009 Compound was tested for its binding affinity against Prostaglandin I2 receptor using conventional ligand assay by the displacement of [3H]-iloprost from human platelets
- ChEMBL_1633595 (CHEMBL3876387) Displacement of [3H]iloprost from human recombinant IP receptor expressed in HEK293 cells measured after 60 mins by scintillation counting method
- ChEMBL_1655810 (CHEMBL4005280) Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
- ChEMBL_1655816 (CHEMBL4005286) Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation counting method
- IP Receptor Filter Binding Assay and cAMP Assay IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. Raw data were fit to the Michaelis-Menten equation to calculate IC50 values. EC50/IC50 values were obtained from functional antagonism assay by measuring the inhibition of cAMP production induced by Iloprost in human erythroleukemia (HEL) cells using a Perkin-Elmer LANCETM cAMP detection kit.