Query String: KETOTIFEN
HC-20511 fumarate CHEMBL1633 Zaditor Alaway Ketotifen KETOTIFEN FUMARATE BDBM50258516
cid_5282408 10-(1-methyl-4-piperidylidene)-5H-benzo[1,2]cyclohepta[3,4-b]thiophen-4-one;maleate (Z)-2-butenedioate;10-(1-methyl-4-piperidinylidene)-5H-benzo[1,2]cyclohepta[3,4-b]thiophen-4-one Ketotifen Ketotifen fumarate (Z)-but-2-enedioate;10-(1-methylpiperidin-4-ylidene)-5H-benzo[1,2]cyclohepta[3,4-b]thiophen-4-one BDBM94597 cid_45479747 US9333199, KETOTIFEN MLS002222254 SMR001307257 US9138431, KETOTIFEN
Zaditor 4-(1-Methyl-piperidin-4-ylidene)-4,9-dihydro-1-thia-benzo[f]azulen-10-one(Ketotifen hydrogen malate) 4-(1-methyl-piperidin-4-ylidene)-4,9-dihydro-1-thia-benzo[f]azulen-10-one CHEMBL534 BDBM50002087 KETOTIFEN 4-(1-Methyl-piperidin-4-ylidene)-4,9-dihydro-1-thia-benzo[f]azulen-10-one(Ketotifen)
- In Vitro Inhibition Assay Ketotifen, dacarbazine, thiocolchicoside, meloxicam, methotrexate, furosemide, olanzapine, methylprednizolone acetate, paricalcitol, ritodrine hydrochloride, and gadobenate-dimeglumine were used as inhibitors. In the media with inhibitor or without inhibitor, the substrate concentrations were 0.012 mM, 0.030 mM, 0.060 mM, 0.120 mM, and 0.450 mM. Inhibitor solutions were added to the reaction medium, resulting in three different fixed concentrations of inhibitors in 1 ml total reaction volume.
- In Vitro Assay In order to determine the effects of some drugs on human 6PGD, concentrations of ketotifen (0.0018-0.0282 mM), dacarbazine (0.0049-0.054 mM), meloxicam (0.02-0.285 mM), furosemide (0.03-0.6 mM), methotrexate (0.036-0.55 mM), metochloropramide hydrochloride (0.83-8.335 mM), ritodrine hydrochloride (1.54-15.4 mM), and gadopentetic acid (24.99-249.935 mM) were added to the reaction mixture and the enzyme activity was measured. An experiment in the absence of drug was used as control (100% activity)