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Query String: MACITENTAN

MACITENTAN ACT-064992 BDBM50395626

Boss, C; Bolli, MH; Gatfield, J From bosentan (Tracleer�) to macitentan (Opsumit�): The medicinal chemistry perspective. Bioorg Med Chem Lett 26: 3381-94 (2016)
Bolli, MH; Boss, C; Binkert, C; Buchmann, S; Bur, D; Hess, P; Iglarz, M; Meyer, S; Rein, J; Rey, M; Treiber, A; Clozel, M; Fischli, W; Weller, T The discovery of N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide (Macitentan), an orally active, potent dual endothelin receptor antagonist. J Med Chem 55: 7849-61 (2012)