Simple Search Results

Query String: MICONAZOLE

CHEMBL91 cid_4189 US9138393, Miconazole Nitrate Dactarin Miconazole BDBM31772 US9144538, Miconazole Nitrate Brentan 1-[2-(2,4-dichlorobenzyl)oxy-2-(2,4-dichlorophenyl)ethyl]imidazole;nitric acid
1-[(R)-2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole MICONAZOLE BDBM50139811 CHEMBL368348
BDBM50139808 MICONAZOLE CHEMBL173038 1-[(S)-2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole
cid_68553 SMR000058733 MICONAZOLE NITRATE MLS000028674 BDBM59256 1-[2-(2,4-dichlorobenzyl)oxy-2-(2,4-dichlorophenyl)ethyl]imidazole;nitric acid 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole;nitric acid

Lu, X; He, SY; Li, Q; Yang, H; Jiang, X; Lin, H; Chen, Y; Qu, W; Feng, F; Bian, Y; Zhou, Y; Sun, H Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease. Bioorg Med Chem 26: 1665-1674 (2018)

P450 Inhibition Assay A range of concentrations of each compound in a 96-well plate were preincubated in buffer containing recombinant human CYP450 microsomal protein and the substrate. Following preincubation, NADPH generating system (glucose-6-phosphate, NADP, and glucose 6-phosphate dehydrogenase) was added to each well to start the reaction. Production of fluorescent metabolite was measured using Cytofluor (Perkin-Elmer, US) plate reader. The rate of metabolite production (AFU/min) was determined for each concentration of compound and converted to a percentage of the mean control rates using Cytofluor software. The inhibitory potential (IC50) of each compound was determined from the slope of the plot using GraFit v5.08 (Erithacus software, UK). Miconazole was included as a positive control for each isozyme.