CHEMBL1672355 (S)-Modafinil BDBM50336893
(R)-Modafinil ARMODAFINIL CHEMBL1201192 BDBM50336892 Nuvigil
US9862679, Compound (+-)-modafinil Provigil 2-(benzhydrylsulfinyl)acetamide 2-[(diphenylmethyl)sulfinyl]acetamide CRL-40476 US10913711, Compound (+-)-modafinilb CEP-1538 CHEMBL1373 2-(Diphenyl-methanesulfinyl)-acetamide BDBM50156055 MODAFINIL Ambrisentan
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- Uptake Assays The uptake assays were carried out 2 days after transfection. Prior to the experiment, the cells were washed once in 500 ul of uptake buffer (25 mM 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), 130 mM NaCl, 5.4 mM KCl, 1.2 mM CaCl2, 1.2 mM MgSO4, 1 mM L-ascorbic acid, 5 mM D-glucose, and 1 uM of the catechol-O-methyltransferase inhibitor Ro 41-0960 (Sigma), pH 7.4) at room temperature (RT). The unlabeled ligand (e.g. modafinil [(+-)-1] or analogues) was added to the cells in 10 concentrations from 1 nM to 0.1 mM equally distributed around the expected IC50 value, and uptake was initiated by addition of ˜10 nM radioligand in a final volume of 500 uL.