- BDBM23516 [5, 6-3H]-niacin
- BDBM23515 Nicotinic Acid pyridine-3-carboxylic acid wampocap CHEMBL573 Niacin [5, 6-3H]-niacin
- Schmidt, D; Smenton, A; Raghavan, S; Shen, H; Ding, FX; Carballo-Jane, E; Luell, S; Ciecko, T; Holt, TG; Wolff, M; Taggart, A; Wilsie, L; Krsmanovic, M; Ren, N; Blom, D; Cheng, K; McCann, PE; Waters, MG; Tata, J; Colletti, S Anthranilic acid replacements in a niacin receptor agonist. Bioorg Med Chem Lett 20: 3426-30 (2010)
- Schmidt, D; Smenton, A; Raghavan, S; Carballo-Jane, E; Lubell, S; Ciecko, T; Holt, TG; Wolff, M; Taggart, A; Wilsie, L; Krsmanovic, M; Ren, N; Blom, D; Cheng, K; McCann, PE; Gerard Waters, M; Tata, J; Colletti, S Pyrazole acids as niacin receptor agonists for the treatment of dyslipidemia. Bioorg Med Chem Lett 19: 4768-72 (2009)
- Gharbaoui, T; Skinner, PJ; Shin, YJ; Averbuj, C; Jung, JK; Johnson, BR; Duong, T; Decaire, M; Uy, J; Cherrier, MC; Webb, PJ; Tamura, SY; Zou, N; Rodriguez, N; Boatman, PD; Sage, CR; Lindstrom, A; Xu, J; Schrader, TO; Smith, BM; Chen, R; Richman, JG; Connolly, DT; Colletti, SL; Tata, JR; Semple, G Agonist lead identification for the high affinity niacin receptor GPR109a. Bioorg Med Chem Lett 17: 4914-9 (2007)
- Vu, CB; Bemis, JE; Benson, E; Bista, P; Carney, D; Fahrner, R; Lee, D; Liu, F; Lonkar, P; Milne, JC; Nichols, AJ; Picarella, D; Shoelson, A; Smith, J; Ting, A; Wensley, A; Yeager, M; Zimmer, M; Jirousek, MR Synthesis and Characterization of Fatty Acid Conjugates of Niacin and Salicylic Acid. J Med Chem 59: 1217-31 (2016)
- Shen, HC; Ding, FX; Luell, S; Forrest, MJ; Carballo-Jane, E; Wu, KK; Wu, TJ; Cheng, K; Wilsie, LC; Krsmanovic, ML; Taggart, AK; Ren, N; Cai, TQ; Deng, Q; Chen, Q; Wang, J; Wolff, MS; Tong, X; Holt, TG; Waters, MG; Hammond, ML; Tata, JR; Colletti, SL Discovery of biaryl anthranilides as full agonists for the high affinity niacin receptor. J Med Chem 50: 6303-6 (2007)
- Miyazawa, Y; Yamaguchi, T; Yamaguchi, M; Tago, K; Tamura, A; Sugiyama, D; Aburatani, T; Nishizawa, T; Kurikawa, N; Kono, K Discovery of novel pyrrole derivatives as potent agonists for the niacin receptor GPR109A. Bioorg Med Chem Lett 30: (2020)
- Skinner, PJ; Cherrier, MC; Webb, PJ; Shin, YJ; Gharbaoui, T; Lindstrom, A; Hong, V; Tamura, SY; Dang, HT; Pride, CC; Chen, R; Richman, JG; Connolly, DT; Semple, G Fluorinated pyrazole acids are agonists of the high affinity niacin receptor GPR109a. Bioorg Med Chem Lett 17: 5620-3 (2007)
- Jung, JK; Johnson, BR; Duong, T; Decaire, M; Uy, J; Gharbaoui, T; Boatman, PD; Sage, CR; Chen, R; Richman, JG; Connolly, DT; Semple, G Analogues of acifran: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b. J Med Chem 50: 1445-8 (2007)
- Shen, HC; Szymonifka, MJ; Kharbanda, D; Deng, Q; Carballo-Jane, E; Wu, KK; Wu, TJ; Cheng, K; Ren, N; Cai, TQ; Taggart, AK; Wang, J; Tong, X; Waters, MG; Hammond, ML; Tata, JR; Colletti, SL Discovery of orally bioavailable and novel urea agonists of the high affinity niacin receptor GPR109A. Bioorg Med Chem Lett 17: 6723-8 (2008)
- Singh, LR; Kumar, A; Upadhyay, A; Gupta, S; Palanati, GR; Sikka, K; Siddiqi, MI; Yadav, PN; Sashidhara, KV Discovery of coumarin-dihydroquinazolinone analogs as niacin receptor 1 agonist with in-vivo anti-obesity efficacy. Eur J Med Chem 152: 208-222 (2018)
- Ding, FX; Shen, HC; Wilsie, LC; Krsmanovic, ML; Taggart, AK; Ren, N; Cai, TQ; Wang, J; Tong, X; Holt, TG; Chen, Q; Waters, MG; Hammond, ML; Tata, JR; Colletti, SL Discovery of pyrazolyl propionyl cyclohexenamide derivatives as full agonists for the high affinity niacin receptor GPR109A. Bioorg Med Chem Lett 20: 3372-5 (2010)
- Peters, JU; Kühne, H; Dehmlow, H; Grether, U; Conte, A; Hainzl, D; Hertel, C; Kratochwil, NA; Otteneder, M; Narquizian, R; Panousis, CG; Ricklin, F; Röver, S Pyrido pyrimidinones as selective agonists of the high affinity niacin receptor GPR109A: optimization of in vitro activity. Bioorg Med Chem Lett 20: 5426-30 (2010)
- Raghavan, S; Tria, GS; Shen, HC; Ding, FX; Taggart, AK; Ren, N; Wilsie, LC; Krsmanovic, ML; Holt, TG; Wolff, MS; Waters, MG; Hammond, ML; Tata, JR; Colletti, SL Tetrahydro anthranilic acid as a surrogate for anthranilic acid: application to the discovery of potent niacin receptor agonists. Bioorg Med Chem Lett 18: 3163-7 (2008)
- Shen, HC; Ding, FX; Deng, Q; Wilsie, LC; Krsmanovic, ML; Taggart, AK; Carballo-Jane, E; Ren, N; Cai, TQ; Wu, TJ; Wu, KK; Cheng, K; Chen, Q; Wolff, MS; Tong, X; Holt, TG; Waters, MG; Hammond, ML; Tata, JR; Colletti, SL Discovery of novel tricyclic full agonists for the G-protein-coupled niacin receptor 109A with minimized flushing in rats. J Med Chem 52: 2587-602 (2009)
- Shen, HC; Ding, FX; Raghavan, S; Deng, Q; Luell, S; Forrest, MJ; Carballo-Jane, E; Wilsie, LC; Krsmanovic, ML; Taggart, AK; Wu, KK; Wu, TJ; Cheng, K; Ren, N; Cai, TQ; Chen, Q; Wang, J; Wolff, MS; Tong, X; Holt, TG; Waters, MG; Hammond, ML; Tata, JR; Colletti, SL Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate. J Med Chem 53: 2666-70 (2010)