- CHEMBL255863 AMN107 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide BDBM50237710 US11649218, Example Nilotinib AMN 107 NILOTINIB
- Pan, X; Wang, F; Zhang, Y; Gao, H; Hu, Z; Wang, S; Zhang, J Design, synthesis and biological activities of Nilotinib derivates as antitumor agents. Bioorg Med Chem 21: 2527-34 (2013)
- Manley, PW; Stiefl, N; Cowan-Jacob, SW; Kaufman, S; Mestan, J; Wartmann, M; Wiesmann, M; Woodman, R; Gallagher, N Structural resemblances and comparisons of the relative pharmacological properties of imatinib and nilotinib. Bioorg Med Chem 18: 6977-86 (2010)
- Duveau, DY; Hu, X; Walsh, MJ; Shukla, S; Skoumbourdis, AP; Boxer, MB; Ambudkar, SV; Shen, M; Thomas, CJ Synthesis and biological evaluation of analogues of the kinase inhibitor nilotinib as Abl and Kit inhibitors. Bioorg Med Chem Lett 23: 682-6 (2013)
- Parkkila, S; Innocenti, A; Kallio, H; Hilvo, M; Scozzafava, A; Supuran, CT The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian alpha-carbonic anhydrase isoforms. Bioorg Med Chem Lett 19: 4102-6 (2009)
- Marín-Rubio, JL; Peltier-Heap, RE; Dueñas, ME; Heunis, T; Dannoura, A; Inns, J; Scott, J; Simpson, AJ; Blair, HJ; Heidenreich, O; Allan, JM; Watt, JE; Martin, MP; Saxty, B; Trost, M A Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Assay Identifies Nilotinib as an Inhibitor of Inflammation in Acute Myeloid Leukemia. J Med Chem 65: 12014-12030 (2022)
- Ghosh, AK; Mishevich, JL; Kovela, S; Shaktah, R; Ghosh, AK; Johnson, M; Wang, YF; Wong-Sam, A; Agniswamy, J; Amano, M; Takamatsu, Y; Hattori, SI; Weber, IT; Mitsuya, H Exploration of imatinib and nilotinib-derived templates as the P2-Ligand for HIV-1 protease inhibitors: Design, synthesis, protein X-ray structural studies, and biological evaluation. Eur J Med Chem 255: (2023)