BDBM50053711 OLANZAPINE
2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine olanzapine CHEMBL715 Zyprexa US8802672, Olanzapine Olansek BDBM35254
USRE49340, Rank 2 NSC_4585 CAS_132539-06-1 OLANZAPINE BDBM82479
4-Desmethylolanzapine CHEMBL1125 desmethylolanzapine olanzapine, N-desmethyl BDBM50240701 2-Methyl-10-piperazin-1-yl-4H-3-thia-4,9-diaza-benzo[f]azulene
- Bymaster, FP; Calligaro, DO; Falcone, JF; Marsh, RD; Moore, NA; Tye, NC; Seeman, P; Wong, DT Radioreceptor binding profile of the atypical antipsychotic olanzapine. Neuropsychopharmacology 14: 87-96 (1996)
- Selent, J; Marti-Solano, M; Rodr?guez, J; Atanes, P; Brea, J; Castro, M; Sanz, F; Loza, MI; Pastor, M Novel insights on the structural determinants of clozapine and olanzapine multi-target binding profiles. Eur J Med Chem 77: 91-5 (2014)
- Calligaro, DO; Fairhurst, J; Hotten, TM; Moore, NA; Tupper, DE The synthesis and biological activity of some known and putative metabolites of the atypical antipsychotic agent olanzapine (LY170053) Bioorg Med Chem Lett 7: 25-30 (1997)
- Gao, M; Shi, Z; Wang, M; Zheng, QH [11C]olanzapine, radiosynthesis and lipophilicity of a new potential PET 5-HT2 and D2 receptor radioligand. Bioorg Med Chem Lett 23: 1953-6 (2013)
- Bymaster, FP; Nelson, DL; DeLapp, NW; Falcone, JF; Eckols, K; Truex, LL; Foreman, MM; Lucaites, VL; Calligaro, DO Antagonism by olanzapine of dopamine D1, serotonin2, muscarinic, histamine H1 and alpha 1-adrenergic receptors in vitro. Schizophr Res 37: 107-22 (1999)
- Bymaster, FP; Falcone, JF Decreased binding affinity of olanzapine and clozapine for human muscarinic receptors in intact clonal cells in physiological medium. Eur J Pharmacol 390: 245-8 (2000)
- Hunt, HJ; Ray, NC; Hynd, G; Sutton, J; Sajad, M; O'Connor, E; Ahmed, S; Lockey, P; Daly, S; Buckley, G; Clark, RD; Roe, R; Blasey, C; Belanoff, J Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat. Bioorg Med Chem Lett 22: 7376-80 (2012)
- In Vitro Inhibition Assay Ketotifen, dacarbazine, thiocolchicoside, meloxicam, methotrexate, furosemide, olanzapine, methylprednizolone acetate, paricalcitol, ritodrine hydrochloride, and gadobenate-dimeglumine were used as inhibitors. In the media with inhibitor or without inhibitor, the substrate concentrations were 0.012 mM, 0.030 mM, 0.060 mM, 0.120 mM, and 0.450 mM. Inhibitor solutions were added to the reaction medium, resulting in three different fixed concentrations of inhibitors in 1 ml total reaction volume.