CHEMBL36 BDBM18512 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine cid_4993 US11530198, Example Pyrimethamine Pyrimethamine (Pyr)
Tindurine US9884860, Example 16jw Daraprim BDBM218512 Malocide pyrimethamine US9284333, 16jw Chloridin
- Saepua, S; Sadorn, K; Vanichtanankul, J; Anukunwithaya, T; Rattanajak, R; Vitsupakorn, D; Kamchonwongpaisan, S; Yuthavong, Y; Thongpanchang, C 6-Hydrophobic aromatic substituent pyrimethamine analogues as potential antimalarials for pyrimethamine-resistant Plasmodium falciparum. Bioorg Med Chem 27: (2019)
- Wagner, CR; Benkovic, SJ Probing the molecular basis of resistance to pyrimethamine by site-directed mutagenesis. J Med Chem 35: 2912-5 (1992)
- Tropak, MB; Zhang, J; Yonekawa, S; Rigat, BA; Aulakh, VS; Smith, MR; Hwang, HJ; Ciufolini, MA; Mahuran, DJ Pyrimethamine Derivatives: Insight into Binding Mechanism and Improved Enhancement of Mutantß-N-acetylhexosaminidase Activity. J Med Chem 58: 4483-93 (2015)
- McKie, JH; Douglas, KT; Chan, C; Roser, SA; Yates, R; Read, M; Hyde, JE; Dascombe, MJ; Yuthavong, Y; Sirawaraporn, W Rational drug design approach for overcoming drug resistance: application to pyrimethamine resistance in malaria. J Med Chem 41: 1367-70 (1998)
- Japrung, D; Leartsakulpanich, U; Chusacultanachai, S; Yuthavong, Y Conflicting requirements of Plasmodium falciparum dihydrofolate reductase mutations conferring resistance to pyrimethamine-WR99210 combination. Antimicrob Agents Chemother 51: 4356-60 (2007)
- Wu, B; Fathi, S; Mortley, S; Mohiuddin, M; Jang, YC; Oyelere, AK Pyrimethamine conjugated histone deacetylase inhibitors: Design, synthesis and evidence for triple negative breast cancer selective cytotoxicity. Bioorg Med Chem 28: (2020)
- Stevens, MF; Phillip, KS; Rathbone, DL; O'Shea, DM; Queener, SF; Schwalbe, CH; Lambert, PA Structural studies on bioactive compounds. 28. Selective activity of triazenyl-substituted pyrimethamine derivatives against Pneumocystis carinii dihydrofolate reductase. J Med Chem 40: 1886-93 (1997)
- Tarnchompoo, B; Sirichaiwat, C; Phupong, W; Intaraudom, C; Sirawaraporn, W; Kamchonwongpaisan, S; Vanichtanankul, J; Thebtaranonth, Y; Yuthavong, Y Development of 2,4-diaminopyrimidines as antimalarials based on inhibition of the S108N and C59R+S108N mutants of dihydrofolate reductase from pyrimethamine-resistant Plasmodium falciparum. J Med Chem 45: 1244-52 (2002)
- Chan, DC; Laughton, CA; Queener, SF; Stevens, MF Structural studies on bioactive compounds. 34. Design, synthesis, and biological evaluation of triazenyl-substituted pyrimethamine inhibitors of Pneumocystis carinii dihydrofolate reductase. J Med Chem 44: 2555-64 (2001)
- Bunyarataphan, S; Leartsakulpanich, U; Taweechai, S; Tarnchompoo, B; Kamchonwongpaisan, S; Yuthavong, Y Evaluation of the activities of pyrimethamine analogs against Plasmodium vivax and Plasmodium falciparum dihydrofolate reductase-thymidylate synthase using in vitro enzyme inhibition and bacterial complementation assays. Antimicrob Agents Chemother 50: 3631-7 (2006)