CHEBI:83326 TEDIZOLID PHOSPHATE BDBM50017198 TR-701-FA
BDBM50491954 Torezolid TR-700 Sivextro CHEBI:82717 Tedizolid
Carbamyl phosphate BDBM50162819 CHEMBL369105 carbamoyl phosphate carbamic phosphoric monoanhydride monocarbamoyl phosphate aminocarbonyl dihydrogen phosphate carbamoyl dihydrogen phosphate
CYCLODEXTRIN PHOSPHATE BDBM50229336 Cyclodextrin Phosphate
4-Nitrophenyl phosphate disodium salt hexahydrate 4-nitrophenyl phosphate (pNPP) para-nitrophenyl phosphate (pNPP) BDBM13466 disodium (4-nitrophenyl) phosphate
Na2HPO4 disodium monohydrogen phosphate disodium hydrogen phosphate Disodium phosphate disodium acid orthophosphate BDBM50080995 disodium hydrogenphosphate Dibasic sodium phosphate CHEMBL1060
BDBM50422306 TRICIRIBINE PHOSPHATE Triciribine Phosphate Salt Of Tricyclic Nucleoside
Riboflavin 5''-Phosphate BDBM50421345 RIBOFLAVIN 5'-PHOSPHATE E101a
sodium dihydrogen phosphate NaH2PO4 monosodium phosphate CHEMBL1368 BDBM50155534 sodium phosphate, monobasic sodium dihydrogenphosphate sodium phosphate monobasic anhydrous phosphoric acid, monosodium salt
Photrexa Riboflavin 5''-phosphate sodium RIBOFLAVIN 5'-PHOSPHATE SODIUM Phosphated riboflavin Riboflavin sodium phosphate BDBM50523758
BDBM50292724 arabinouridine 3'-phosphate CHEMBL460901 URACIL ARABINOSE-3'-PHOSPHATE
2-amino-ethanol dihydrogen phosphate O-phosphocolamine ethanolamine O-phosphate OPE phosphonoethanolamine monoaminoethyl phosphate colaminphosphoric acid 2-amino-ethanol phosphate PEA colamine phosphate mono(2-aminoethyl) phosphate colamine phosphoric acid 2-aminoethyl dihydrogen phosphate phosphoric acid 2-aminoethyl phenyl ester CHEMBL146972 BDBM50281572 EAP ethanolamine acid phosphate pEtN O-phosphoethanolamine
BDBM241975 Clindamycin phosphate
Homoserine phosphate BDBM92999
p-nitrophenyl phosphate BDBM24514 CHEMBL24231 4-nitrophenyl phosphate 4-nitrophenoxyphosphonic acid
4-Methylumbelliferyl phosphate BDBM213237
BDBM235670 Dexamethasone sodium phosphate
CHEMBL1756 BDBM50333645 Estramustine phosphate
Estradiol phosphate BDBM50333647 CHEMBL1642763
Phosphate analogue, 6 BDBM84557
Phosphate analogue, 9 BDBM84558
mannose 6-phosphate BDBM50275807
sodium phosphate, tribasic tertiaeres Natriumphosphat(V) tribasic sodium orthophosphate sodium orthophosphate CHEMBL363100 phosphoric acid trisodium salt sodium phosphate tertiary sodium phosphate tribasic sodium phosphate BDBM50155537 Na3PO4 Trinatriumphosphat
BDBM50118216 pyridoxal 5'-phosphate CHEMBL82202 (4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate pyridoxal 5'-(dihydrogen phosphate)
BDBM197174 Glucose-6-phosphate (G6P)
BDBM231698 p-Nitrophenyl phosphate (pNPP)
BDBM84559 Phosphate analogue, (s)-14
BDBM84560 Phosphate analogue, (S)-21
para-nitrophenyl phosphate (pNPP) BDBM26100
BDBM50304360 BENZENE-1,2,3,4-TETRAYL TETRAKIS[DIHYDROGEN (PHOSPHATE)] benzene-1,2,3,4-tetrayl tetrakis(hydrogen phosphate) CHEMBL595349
phosphacol p-nitrophenyl diethyl phosphate diethyl p-nitrophenyl phosphate O,O-diethyl O-p-nitrophenyl phosphate CHEMBL23838 diethyl 4-nitrophenyl phosphate diethyl paraoxon paraoxon BDBM50240416 ethyl paraoxon phosphoric acid diethyl 4-nitrophenyl ester
2S,3R-dihydroxybutyramide 4-phosphate BDBM50153711
CHEBI:63036 BDBM50004328 POTASSIUM PHOSPHATE, MONOBASIC
CHEMBL186043 BDBM50155535 Carbamoyl phosphate; di sodium
CHLOROQUINE DIPHOSPHATE CHLOROQUINE PHOSPHATE BDBM50411863 ARALEN
Cytidine 2,3-cyclic phosphate, 6 BDBM31909
Fragment 1 Phosphate phosphoric acid BDBM14671
RUXOLITINIB PHOSPHATE BDBM50391992 INCB018424 SALT Jakafi
4-{hydroxy[(phosphonooxy)acetyl]amino}butyl dihydrogen phosphate N-(4-hydroxybutyl)-glycolohydroxamicacid bis-phosphate CHEMBL1236228 BDBM50330433
BDBM16190 [3-(2-cyanoacetyl)phenyl] diethyl phosphate 3-(2-Cyanoacetyl)phenyl Diethyl Phosphate beta-ketonitrile 5h
US10676467, Compound S1P (2S,3R,4E)-2-amino-4-octadecene-1,3-diol 1-(dihydrogen phosphate) (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate BDBM50158348 CHEMBL225155 sphingosine-1-phosphate sphingosine 1-phosphate
DDVP CHEMBL167911 2,2-Dichloroethenyl dimethyl phosphate Dimethyl-2,2-dichlorovinyl phosphate Phosphoric acid, 2,2-dichloroethenyl dimethyl ester Dimethyl 2,2-dichlorovinyl phosphate BDBM50286926 Phosphoric acid, 2,2-dichlorovinyl dimethyl ester
AMP adenosine 5'-phosphate group [5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate BDBM92538
1-deoxy-L-ribulose 5-phosphate BDBM50153712
4S-hydroxypentan-2-one 5-phosphate BDBM50153714
BDBM50153710 3S-hydroxypentan-2-one 5-phosphate
BDBM92531 DiFMUP (6,8-Difluoro-4-methylumbelliferyl phosphate)
CHEMBL1230617 8-Bromo-Adenosine Mono Phosphate BDBM50222467
CHEMBL1275924 Phenyl-N-(4-aminopiperidine)phosphate BDBM50330376
CHEMBL1775011 8-phenyl-Adenosine Mono Phosphate BDBM50343897
sphingosine-1-phosphate, 33P labeled {[(4Z)-2-amino-3-hydroxyoctadec-4-en-1-yl]oxy}phosphonic acid S1P [32P]S1P [33P]S1P BDBM22202 sphingosine-1-phosphate sphingosine-1-phosphate, 32P labeled
2-(methylsulfonamido)-2-oxoethyl dihydrogen phosphate BDBM50175714 CHEMBL370845
BDBM50300123 2-(4-Formylphenoxy)ethyl dimethyl phosphate CHEMBL574442
BDBM50300582 CHEMBL573979 Dibutyl 2,2,2-trifluoro-1-phenylethyl phosphate
CHEMBL575281 Dimethyl 2,2,2-trifluoro-1-phenylethyl phosphate BDBM50300580
CHEMBL575301 Diethyl 2,2,2-trifluoro-1-phenylethyl phosphate BDBM50300581
CHEMBL606220 CHEMBL1230617 BDBM50367001 8-Bromo-Adenosine Mono Phosphate
Fludarabine Phosphate Fludarabine Fludara BDBM50248004 CHEBI:63599 Oforta
Hexadecyl[2-(N-Methylpiperidinio)ethyl]phosphate hexadecyl 2-(1-methylpiperidinium-1-yl)ethyl phosphate BDBM50051816 (N-methylpiperidino)ethanol hexadecyl phosphonate CHEMBL89618
1,2-dideoxy-L-threo-3-hexulose 6-phosphate BDBM50153715
2-Methoxy-4-(nonanamidomethyl)phenyl dihydrogen phosphate (3b) BDBM165191
BDBM165193 4-(Nonanamidomethyl)-1,2-phenylene bis(dihydrogen phosphate) (6b)
BDBM50175712 CHEMBL199843 2-oxo-2-(phenylsulfonamido)ethyl dihydrogen phosphate
CHEMBL202243 BDBM50176400 (R)-2,3-bis(octyloxy)propyl dihydrogen phosphate
Etopophos preservative free Etoposide Phosphate BMY-40481 Etopophos BDBM50247889
TCP CAS_78-30-8 BDBM82063 TRI-O-CRESYL PHOSPHATE
beta-nicotinamide adenine dinucleotide phosphate, oxidized form NADP+ BDBM11939
Di-Sodium salt of Phosphoric acid mono-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenyl} ester Disodium Phosphoric acid mono-{2-methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenyl} ester combretastatin A-4 sodium phosphate BDBM50064259 Phosphoric acid mono-{2-methoxy-5-[(Z)-2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenyl} ester; disodium salt sodium(Z)-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl phosphate combretastatin A-4 phosphate Combretastatin A4 phosphate disodium 2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)vinyl]phenyl phosphate CHEMBL289351 sodium (Z)-5-(3,4,5-trimethoxystyryl)-2-methoxyphenyl phosphate disodium mono(Z)-5-(3,4,5-trimethoxystyryl)-2-methoxyphenyl phosphate
2-[(3-bromophenyl)carbamoyl]-5-chlorophenyl diethyl phosphate (20) BDBM150740
2-[(4-bromophenyl)carbamoyl]-5-chlorophenyl diethyl phosphate (23) BDBM150743
BDBM50032981 Phosphate analogue, 8 (3-Amino-propyl)-phosphonic acid CHEMBL286077
BDBM50247086 Chlorphrifos oxon diethyl 3,5,6-trichloropyridin-2-yl phosphate CHEMBL444970
CHEMBL1235276 BDBM50330438 3-{hydroxy[(phosphonooxy)acetyl]amino}propyl dihydrogen phosphate
Phosphoglycolohydroxamic Acid BDBM50167777 2-(hydroxyamino)-2-oxoethyl dihydrogen phosphate CHEMBL371668
2-amino-4,5-dihydronaphtho[1,2-d][1,3]thiazol-8-yl dihydrogen phosphate 2-amino-4,5-dihydronaphtho[1,2-d]thiazol-8-yl dihydrogen phosphate BDBM50302495 CHEMBL565809
cori ester glucose-1-phosphate alpha-glucose-1-phosphate BDBM23188 {[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phosphonic acid
2-(hydroxy(3-hydroxypropyl)amino)-2-oxoethyl hydrogen phosphate BDBM50330436 CHEMBL1276292
2-Methoxy-4-((8-methylnonanamido)methyl)phenyl dihydrogen phosphate (3a) BDBM165190
3-Nitro-1-(beta-D-ribofuranosyl)pyrrole 5'-phosphate BDBM50247810 CHEMBL538120
4-Nitro-1-(-beta-D-ribofuranosyl)pyrazole 5'-phosphate BDBM50247822 CHEMBL538121
5-chloro-2-[(3-chlorophenyl)carbamoyl]phenyl diethyl phosphate (19) BDBM150739
5-chloro-2-[(3-fluorophenyl)carbamoyl]phenyl diethyl phosphate (21) BDBM150741
5-chloro-2-[(4-fluorophenyl)carbamoyl]phenyl diethyl phosphate (22) BDBM150742
5-formyl-6-hydroxy-2-naphthyl di-sodium phosphate BDBM50183272 CHEMBL382634
BDBM150744 5-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl diethyl phosphate (24)
BDBM150745 5-chloro-2-[(3,4-dichlorophenyl)carbamoyl]phenyl diethyl phosphate (25)
BDBM165192 4-((8-Methylnonanamido)methyl)-1,2-phenylene bis(dihydrogen phosphate) (6a)
BDBM50247808 CHEMBL538119 3-Nitro-1-(beta-D-ribofuranosyl)imidazole 5'-phosphate
[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate;triethylazanium SMR000718807 [5-(6-aminopurin-9-yl)-3,4-dihydroxy-2-oxolanyl]methyl hydrogen phosphate;triethylammonium (5-adenin-9-yl-3,4-dihydroxy-tetrahydrofuran-2-yl)methyl hydrogen phosphate;triethylammonium BDBM61258 cid_16396156 MLS001306424 [5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate;triethylazanium
(R)-2-amino-3-(4-octylphenylamino)-3-oxopropyl dihydrogen phosphate CHEMBL227371 BDBM50198840
2-formylphenoxyphosphonic acid BDBM14680 2-formylphenyl dihydrogen phosphate RU78262 CHEMBL286678 Fragment 10
2-hydrazinyl-2-oxoethyl hydrogen phosphate BDBM50167772 Phosphoric acid monohydrazinocarbonylmethyl ester CHEMBL195520
5-Amino-1-(beta-D-ribofuranosyl)-4-nitropyrazole 5'-phosphate CHEMBL554752 BDBM50247824
5-Amino-1-(beta-D-ribofuranosyl)pyrazole-4-carboxylate 5'-phosphate BDBM50247823
5-chloro-2-{[3-(trifluoromethyl)phenyl]carbamoyl}phenyl diethyl phosphate (26) BDBM150746
5-chloro-2-{[4-(trifluoromethyl)phenyl]carbamoyl}phenyl diethyl phosphate (27) BDBM150747
BDBM50198833 CHEMBL228102 (R)-2-amino-3-(3-octylphenylamino)-3-oxopropyl dihydrogen phosphate
BDBM50247809 5-Amino-1-(beta-D-ribofuranosyl)imidazole-4-carboxaldehyde 5'-phosphate
BDBM50312665 Sodium 2-(2-Fluorophenyl)-6,7-methylenedioxyquinolin-4-yl hydrogen phosphate CHEMBL1088572
BDBM50343853 2-(2-(Benzylamino)-6-nitroquinazolin-4-ylamino)ethyl dihydrogen phosphate CHEMBL1774786
CHEMBL1765479 BDBM50342010 5'-phospho-2'-deoxyuridine-3'-pyrophosphate(P'->5')adenosine3'-phosphate
(S)-2-amino-4-(4-(heptyloxy)phenyl)-2-methylbutyl dihydrogen phosphate BDBM50313499 CHEMBL1084929
2-(2-Oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamido)ethyldihydrogen phosphate BDBM50316579 CHEMBL1095991
2-amino-4,5-dihydronaphtho[1,2-d]thiazol-7-yl dihydrogen phosphate CHEMBL566049 BDBM50302494
2-amino-4,5-dihydronaphtho[1,2-d]thiazol-9-yl dihydrogen phosphate BDBM50302496 CHEMBL576125
2-amino-8H-indeno[1,2-d]thiazol-4-yl dihydrogen phosphate CHEMBL578134 BDBM50302493
2-amino-8H-indeno[1,2-d]thiazol-5-yl dihydrogen phosphate BDBM50302492 CHEMBL568771
2-amino-8H-indeno[1,2-d]thiazol-6-yl dihydrogen phosphate BDBM50302491 CHEMBL566670
3-(4,5,6,7-Tetrabromo-2H-1,2,3-benzotriazol-2-yl)propyl dihydrogen phosphate BDBM50276680 CHEMBL459343
5-Amino-1-(beta-D-ribofuranosyl)-1,2,3-triazole-4-carboxylate 5'-phosphate BDBM50247825
BDBM150734 2‐[(4‐bromophenyl)carbamoyl]‐4‐chlorophenyl diethyl phosphate (14)
BDBM150736 2‐[(3‐bromophenyl)carbamoyl]‐4‐chlorophenyl diethyl phosphate (16)
BDBM50316580 6-(2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamido)hexyldihydrogen phosphate CHEMBL1095867
CHEMBL1097477 4-(2-Oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamido)-butyldihydrogen phosphate BDBM50316577
CHEMBL1097478 BDBM50316581 5-(2-Oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamido)-pentyldihydrogen phosphate
CHEMBL455775 BDBM50292713 5'-phospho-2'-deoxyuridine 3-pyrophosphate (P'->5') adenosine 3'-phosphate
CHEMBL88487 Hexadecyl[2-(N-Methylmorpholinio)ethyl]phosphate BDBM50051809 (N-methylmorpholino)ethanol hexadecyl phosphonate
Phosphoric Acid Dimethyl Ester 4-Nitro-Phenyl Ester DIMETHYL 4-NITROPHENYL PHOSPHATE BDBM50487989
O-phosphoryl-4-hydroxy-N,N-dimethyltryptamine 4-phosphoryloxy-N,N-dimethyltryptamine BDBM50171269 Indocybin psilocybin 3-[2-(dimethylamino)ethyl]-1H-indol-4-yl dihydrogen phosphate psilocin phosphate ester Psilocybine CHEMBL194378
(3R,4S,5R)-4,5-dihydroxy-3-phosphonooxycyclohexene-1-carboxylic acid Shikimate-3-phosphate BDBM100283
(benzyloxy)(2-formylphenoxy)phosphinic acid PASBN BDBM14688 benzyl 2-formylphenyl hydrogen phosphate Fragment 18
1-(4-Methoxyphenylsulfonamido)-3-morpholinopropan-2-yl dihydrogen phosphate HEA derivative, 7a BDBM50248217 CHEMBL473552
1D-myo-inositol 1,3,4,5-tetrakis(dihydrogen phosphate) CHEMBL23552 BDBM50075651 1D-myo-inositol 1,3,4,5-tetrakisphosphate
1D-myo-inositol 1,4,5,6-tetrakisphosphate BDBM50075649 CHEMBL282059 1D-myo-inositol 1,4,5,6-tetrakis(dihydrogen phosphate)
1D-myo-inositol 4,5-bisphosphate BDBM50284584 CHEMBL21825 1D-myo-inositol 4,5-bis(dihydrogen phosphate)
2-(6-Nitro-2-(4-phenoxyphenylamino)quinazolin-4-ylamino)ethyl dihydrogen phosphate BDBM50343852 CHEMBL1774785
3-(2-Oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamido)propyl dihydrogen phosphate BDBM50316578 CHEMBL1097476
4‐bromo‐2‐[(3‐fluorophenyl)carbamoyl]phenyl diethyl phosphate (1) BDBM150721
4‐bromo‐2‐[(4‐bromophenyl)carbamoyl]phenyl diethyl phosphate (8) BDBM150728
4‐bromo‐2‐[(4‐chlorophenyl)carbamoyl]phenyl diethyl phosphate (3) BDBM150723
4‐chloro‐2‐[(3‐chlorophenyl)carbamoyl]phenyl diethyl phosphate (10) BDBM150730
4‐chloro‐2‐[(3‐fluorophenyl)carbamoyl]phenyl diethyl phosphate (12) BDBM150732
4‐chloro‐2‐[(4‐chlorophenyl)carbamoyl]phenyl diethyl phosphate (11) BDBM150731
BDBM150722 4‐bromo‐2‐[(3‐chlorophenyl)carbamoyl]phenyl diethyl phosphate (2)
BDBM150724 4‐bromo‐2‐[(3,4‐dichlorophenyl)carbamoyl]phenyl diethyl phosphate (4)
BDBM150727 4‐bromo‐2‐[(3‐bromophenyl)carbamoyl]phenyl diethyl phosphate (7)
BDBM150729 4‐bromo‐2‐[(4‐fluorophenyl)carbamoyl]phenyl diethyl phosphate (9)
BDBM150733 4‐chloro‐2‐[(4‐fluorophenyl)carbamoyl]phenyl diethyl phosphate (13)
BDBM150735 4‐chloro‐2‐[(3,4‐dichlorophenyl)carbamoyl]phenyl diethyl phosphate (15)
BDBM50287679 CHEMBL61555 Sodium; benzyl 3,4,5-trihydroxy-6-methyltetrahydro-2H-thiopyran-2-yl hydrogen phosphate
BDBM50315803 2-amino-4-(2-fluoro-4-pentylphenyl)-2-(hydroxymethyl)butyl dihydrogen phosphate CHEMBL1095889
BDBM50315805 2-amino-4-(4'-butoxybiphenyl-4-yl)-2-(hydroxymethyl)butyl dihydrogen phosphate CHEMBL1096211
HEA derivative, 7b BDBM50248218 CHEMBL473752 1-(4-Fluorophenylsulfonamido)-3-morpholinopropan-2-yl dihydrogen phosphate
4-THIOURIDINE-5'-MONOPHOSPHATE 4-THIOURIDINE-5'-PHOSPHATE BDBM50341895 ((2R,3S,4R,5R)-3,4-dihydroxy-5-(2-oxo-4-thioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl dihydrogen phosphate CHEMBL1230331
dihydrogen phosphate;2-[2-(4-fluorophenyl)sulfanylethyl]pyridin-1-ium BDBM45710 2-[2-(4-Fluoro-phenylsulfanyl)-ethyl]-pyridinium dihydrogen phosphate;2-[2-[(4-fluorophenyl)thio]ethyl]pyridin-1-ium cid_16682387 MLS000767112 SMR000429527
(2S)-2-amino-3-(phosphonooxy)propanoic acid BDBM17664 CHEMBL284377 L-serine O-phosphate L-SOP
4‐chloro‐2‐{[3‐ (trifluoromethyl)phenyl]carbamoyl}phenyl diethyl phosphate (17) BDBM150737
BDBM150725 4‐bromo‐2‐{[3‐ (trifluoromethyl)phenyl]carbamoyl}phenyl diethyl phosphate (5)
BDBM150726 4‐bromo‐2‐{[4‐ (trifluoromethyl)phenyl]carbamoyl}phenyl diethyl phosphate (6)
BDBM150738 4‐chloro‐2‐{[4‐ (trifluoromethyl)phenyl]carbamoyl}phenyl diethyl phosphate (18)
BDBM50110800 P,P'-Bis {[4-(guanine-9-yl)cyclopent-2-enyl]oxy-methylphosphonyl}phosphate CHEMBL23886
CHEMBL277903 P,P'-Bis {[4-(adenine-9-yl)cyclopent-2-enyl]oxy-methylphosphonyl}phosphate BDBM50110798
CHEMBL475495 (S)-2-amino-2-methyl-3-(4-(octyloxy)phenylamino)-3-oxopropyl dihydrogen phosphate BDBM50277148
PAS219 (cyclohexylmethoxy)(2-formylphenoxy)phosphinic acid BDBM14685 CHEMBL24811 Fragment 15 cyclohexylmethyl 2-formylphenyl hydrogen phosphate
MLS001306420 SMR000718790 [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate;hydrate cid_6419976 BDBM70140 [(2R,3S,4R,5R)-5-adenin-9-yl-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate;hydrate [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate;hydrate [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-2-oxolanyl]methyl dihydrogen phosphate;hydrate
(1R,3S,4R,6R)-4,5,6-trihydroxy-2-methyl-2,3-bis(phosphonooxy)cyclohexyl dihydrogen phosphate BDBM50075648 CHEMBL281132
(R)-2-amino-2-((R)-6-octyl-1,2,3,4-tetrahydronaphthalen-2-yl)propyl dihydrogen phosphate BDBM50314403 CHEMBL1089004
(S)-2-amino-2-((R)-6-octyl-1,2,3,4-tetrahydronaphthalen-2-yl)propyl dihydrogen phosphate BDBM50314404 CHEMBL1089005
(S)-2-amino-2-((S)-6-octyl-1,2,3,4-tetrahydronaphthalen-2-yl)propyl dihydrogen phosphate CHEMBL1090758 BDBM50314405
(S)-2-amino-3-(4-(4-cyclohexylbutoxy)phenylamino)-2-methyl-3-oxopropyl dihydrogen phosphate BDBM50249153 CHEMBL473562
1,2,3,4-tetrahydroquinolin-8-yl dihydrogen phosphate (1,2,3,4-tetrahydroquinolin-8-yloxy)phosphonic acid Fragment 12 RU79073 BDBM14682
BDBM14681 RU78299 CHEMBL421138 Fragment 11 2,6-diformyl-4-methylphenoxyphosphonic acid 2,6-diformyl-4-methylphenyl dihydrogen phosphate
BDBM50314402 (R)-2-amino-2-((S)-6-octyl-1,2,3,4-tetrahydronaphthalen-2-yl)propyl dihydrogen phosphate CHEMBL1093686
BDBM50315804 2-amino-4-(3-chloro-4'-pentylbiphenyl-4-yl)-2-(hydroxymethyl)butyl dihydrogen phosphate CHEMBL1096210
CHEMBL195976 Phosphoric acid mono-(N-hydroxycarbamimidoylmethyl) ester BDBM50167775 (Z)-2-amino-2-(hydroxyimino)ethyl hydrogen phosphate
CHEMBL25186 RU78300 2-formyl-6-methoxyphenoxyphosphonic acid 2-formyl-6-methoxyphenyl dihydrogen phosphate BDBM14679 Fragment 9
CHEMBL611046 BDBM50304359 (2R,3S,5S,6S)-6-(hydrogen phosphonato)-3,5-dihydroxycyclohexane-1,2,4-triyl tris(hydrogen phosphate)
US10233190, Example 1434 BDBM370515 sodium 1-cyclohexyl-2-(5H-imidazo[5,1- a]isoindol-5-yl)ethyl phosphate
US11046646, Example 14 BDBM506618 (3-amino-1-(4-octylbenzyl)-2-oxopyrrolidin-3-yl)methyl dihydrogen phosphate
6-hydroxy-UMP 1-beta-D-ribofuranosyl(3H)pyrimidine-2,4,6-trione 5'-monophosphate 6-HYDROXYURIDINE-5'-PHOSPHATE 3,4-dihydroxy-5-(6-oxido-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl phosphate BDBM50199178 CHEMBL383923
(2R,3R,4S)-2,3,4-trihydroxy-5-(hydroxyamino)-5-oxopentyl phosphate BDBM50342610 5-PHOSPHO-D-ARABINOHYDROXAMIC ACID CHEMBL1235136
(R)-2-amino-2-(4-(4-(octyloxy)phenyl)-1H-imidazol-2-yl)propyl dihydrogen phosphate BDBM50277186 CHEMBL474689
(S)-2-amino-3-(2-fluoro-4-(octyloxy)phenylamino)-2-methyl-3-oxopropyl dihydrogen phosphate CHEMBL474688 BDBM50277185
2,3,4-trihydroxy-5-oxohexane-1,6-diyl bis(dihydrogen phosphate) BDBM50330437 1,6-di-O-phosphono-D-fructose CHEMBL1235112
2-[hydroxy(4-hydroxybutyl)amino]-2-oxoethyl dihydrogen phosphate BDBM50330439 CHEMBL1236227 N-(4-hydroxybutyl)-phospho-glycolohydroxamic acid
2-amino-3-hydroxy-2-((R)-6-octyl-1,2,3,4-tetrahydronaphthalen-2-yl)propyl dihydrogen phosphate CHEMBL1091103 BDBM50314401
BDBM50080321 ZMP [5-(5-amino-4-carbamoyl-1H-imidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate
BDBM50249114 CHEMBL473156 (S)-2-amino-2-methyl-3-oxo-3-(4-(5-phenylpentyloxy)phenylamino)propyl dihydrogen phosphate
BDBM50249154 CHEMBL473563 (S)-2-amino-3-(4-(biphenyl-4-ylmethoxy)phenylamino)-2-methyl-3-oxopropyl dihydrogen phosphate
BDBM50277149 CHEMBL515921 (S)-2-amino-3-(3-fluoro-4-(octyloxy)phenylamino)-2-methyl-3-oxopropyl dihydrogen phosphate
CHEMBL1089558 BDBM50315807 2-amino-4-(4'-butoxy-2',5'-difluorobiphenyl-4-yl)-2-(hydroxymethyl)butyl dihydrogen phosphate
CHEMBL1683319 5-O-phosphate-1-N-(4'-(4''-methoxyhenyl))-[1',2',3']-triazol-beta-D-ribofuranoside BDBM50338502
CHEMBL514302 BDBM50249113 (S)-2-amino-2-methyl-3-oxo-3-(4-(4-phenylbutoxy)phenylamino)propyl dihydrogen phosphate
CHEMBL515603 (S)-2-amino-3-(4-(biphenyl-4-yloxy)phenylamino)-2-methyl-3-oxopropyl dihydrogen phosphate BDBM50249238
[(2-cyanoquinolin-8-yl)oxy]phosphonic acid RU79072 Fragment 14 BDBM14684 2-cyanoquinolin-8-yl dihydrogen phosphate
(3-amino-1-(4-(1-(phenethoxyimino)ethyl)benzoyl)pyrrolidin-3-yl)methyl Dihydrogen Phosphate US11059784, Example 55 BDBM511446
(S)-2-amino-3-(4-(4-(4-methoxyphenyl)butoxy)phenylamino)-2-methyl-3-oxopropyl dihydrogen phosphate CHEMBL516035 BDBM50249151
BDBM25105 [3-(2,4-diamino-6-{3-[(diethoxyphosphoryl)oxy]phenyl}pteridin-7-yl)phenyl] diethyl phosphate diaminopteridine derivative, 28
BDBM50199187 CHEMBL217370 6-propyl-3-beta-D-ribofuranosyl(1H)pyrimidine-2,4-dione 2',3'-(cyclic phosphate) 5'-triphosphate
BDBM50249294 CHEMBL470511 (R)-2-amino-2-(4-(4-(5-phenylpentyloxy)phenyl)-1H-imidazol-2-yl)propyl dihydrogen phosphate
BDBM50272891 (4-(4-(trifluoromethyl)phenylamino)-7-(3-(trifluoromethyl)pyridin-2-yl)quinazolin-2-yl)methyl dihydrogen phosphate CHEMBL456982
CHEMBL179992 CHEMBL182645 BDBM50150613 [(1R,4S,7aR)-1-(1,5-dimethylhexyl)-4,7a-dimethyloctahydro-1H-inden-4-yl]methyl dihydrogen phosphate
CHEMBL515917 (R)-2-amino-2-(4-(4-(4-phenylbutoxy)phenyl)-1H-imidazol-2-yl)propyl dihydrogen phosphate BDBM50249293
FTY720-phosphate, rac-2 {2-amino-3-hydroxy-2-[2-(4-octylphenyl)ethyl]propoxy}phosphonic acid BDBM23163 CHEMBL114606
Fragment compound, 1 4-trifluoromethylcoumarin phosphate {[2-oxo-4-(trifluoromethyl)-2H-chromen-7-yl]oxy}phosphonic acid BDBM22598
US9707205, 19 BDBM255780 4-(4-(3-(3-(2,2,2-trifluoroacetyl)-1H-indol-1-yl)propyl)phenyl)butyl-dihydrogen phosphate
- Roberts, E; Rosen, H; Brown, S; Guerrero, MA; Peng, X; Poddutoori, R Modulators of sphingosine phosphate receptors US Patent US10544136 (2020)
- Swenson, RE Sphingosine 1-phosphate receptor antagonists US Patent US9663511 (2017)
- Dyckman, AJ Modulators of Sphingosine-1-phosphate Pathway Biology: Recent Advances of Sphingosine-1-phosphate Receptor 1 (S1P J Med Chem 60: 5267-5289 (2017)
- Miller, MJ; Anderson, KS; Braccolino, DS; Cleary, DG; Gruys, KJ; Han, CY; Lin, KC; Pansegrau, PD; Ream, JE; Sammons, RD; Sikorski, JA EPSP synthase inhibitor design II. The importance of the 3-phosphate group for ligand binding at the shikimate-3-phosphate site & the identification of 3-malonate ethers as novel 3-phosphate mimics. Bioorg Med Chem Lett 3: 1435-1440 (1993)
- Pettit, GR; Toki, B; Herald, DL; Verdier-Pinard, P; Boyd, MR; Hamel, E; Pettit, RK Antineoplastic agents. 379. Synthesis of phenstatin phosphate. J Med Chem 41: 1688-95 (1998)
- Urbano, M; Guerrero, M; Rosen, H; Roberts, E Modulators of the Sphingosine 1-phosphate receptor 1. Bioorg Med Chem Lett 23: 6377-89 (2013)
- Rosse, G Novel Pyridyloxadiazole Agonists of Sphingosin-1-phosphate. ACS Med Chem Lett 6: 102-3 (2015)
- PubChem, PC Human Glucose-6-Phosphate Dehydrogenase Dose Response Selectivity Assay for Inhibitors of Plasmodium falciparum Glucose-6-Phosphate Dehydrogenase PubChem Bioassay (2011)
- Marciniak, A; Camp, SM; Garcia, JGN; Polt, R An update on sphingosine-1-phosphate receptor 1 modulators. Bioorg Med Chem Lett 28: 3585-3591 (2018)
- Carreras, C; Charmot, D; Jacobs, JW; Labonte, E; Lewis, JG NHE3-binding compounds and methods for inhibiting phosphate transport US Patent US10272079 (2019)
- Fonvielle, M; Mariano, S; Therisod, M New inhibitors of rabbit muscle triose-phosphate isomerase. Bioorg Med Chem Lett 15: 2906-9 (2005)
- Hamilton, NM; Dawson, M; Fairweather, EE; Hamilton, NS; Hitchin, JR; James, DI; Jones, SD; Jordan, AM; Lyons, AJ; Small, HF; Thomson, GJ; Waddell, ID; Ogilvie, DJ Novel steroid inhibitors of glucose 6-phosphate dehydrogenase. J Med Chem 55: 4431-45 (2012)
- Högenauer, K; Hinterding, K; Nussbaumer, P S1P receptor mediated activity of FTY720 phosphate mimics. Bioorg Med Chem Lett 20: 1485-7 (2010)
- Noble, NJ; Dubreuil, D; Potter, B Total synthesis of myo-inositol-1-phosphate-4,5-pyrophosphate, a novel second messenger analogue, via myo-inositol-1-phosphate-4,5-bisphosphorothioate Bioorg Med Chem Lett 2: 471-476 (1992)
- Zhang, Y; Jumppanen, M; Maksimainen, MM; Auno, S; Awol, Z; Ghemtio, L; Venkannagari, H; Lehti?, L; Yli-Kauhaluoma, J; Xhaard, H; Boije Af Genn?s, G Adenosine analogs bearing phosphate isosteres as human MDO1 ligands. Bioorg Med Chem 26: 1588-1597 (2018)
- Kung, PP; Fan, C; Gukasyan, HJ; Huang, B; Kephart, S; Kraus, M; Lee, JH; Sutton, SC; Yamazaki, S; Zehnder, L Design and Characterization of a Pyridone-Containing EZH2 Inhibitor Phosphate Prodrug. J Med Chem 64: 1725-1732 (2021)
- Bagdanoff, JT; Donoviel, MS; Nouraldeen, A; Tarver, J; Fu, Q; Carlsen, M; Jessop, TC; Zhang, H; Hazelwood, J; Nguyen, H; Baugh, SD; Gardyan, M; Terranova, KM; Barbosa, J; Yan, J; Bednarz, M; Layek, S; Courtney, LF; Taylor, J; Digeorge-Foushee, AM; Gopinathan, S; Bruce, D; Smith, T; Moran, L; O'Neill, E; Kramer, J; Lai, Z; Kimball, SD; Liu, Q; Sun, W; Yu, S; Swaffield, J; Wilson, A; Main, A; Carson, KG; Oravecz, T; Augeri, DJ Inhibition of sphingosine-1-phosphate lyase for the treatment of autoimmune disorders. J Med Chem 52: 3941-53 (2009)
- Horan, JC; Sanyal, S; Choi, Y; Hill-Drzewi, M; Patnaude, L; Anderson, S; Fogal, S; Mao, C; Cook, BN; Gueneva-Boucheva, K; Fisher, MB; Hickey, E; Pack, E; Bannen, LC; Chan, DS; Mac, MB; Ng, SM; Wang, Y; Xu, W; Modis, LK; Lemieux, RM Piperazinyl-oxadiazoles as selective sphingosine-1-phosphate receptor agonists. Bioorg Med Chem Lett 24: 4807-11 (2014)
- Liu, C; Dunaway-Mariano, D; Mariano, PS Rational design of reversible inhibitors for trehalose 6-phosphate phosphatases. Eur J Med Chem 128: 274-286 (2017)
- Roberts, E; Rosen, H; Urbano, M; Guerrero, M Sphinogosine-1 -phosphate receptor modulators for treatment of cardiopulmonary disorders US Patent US11034691 (2021)
- Roberts, E; Rosen, H; Urbano, M; Guerrero, MA Sphinogosine-1-phosphate receptor modulators for treatment of cardiopulmonary disorders US Patent US10323029 (2019)
- Green, OM; McKenzie, AR; Shapiro, AB; Otterbein, L; Ni, H; Patten, A; Stokes, S; Albert, R; Kawatkar, S; Breed, J Inhibitors of acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU). Part 1: Hit to lead evaluation of a novel arylsulfonamide series. Bioorg Med Chem Lett 22: 1510-9 (2012)
- Kwon, YU; Im, J; Choi, G; Kim, YS; Choi, KY; Chung, SK Synthesis of three enantiomeric pairs of scyllo-inositol phosphate and molecular interactions between all possible regioisomers of scyllo-inositol phosphate and inositol 1,4,5-trisphosphate 3-kinase. Bioorg Med Chem Lett 13: 2981-4 (2003)
- Pettit, GR; Grealish, MP; Jung, MK; Hamel, E; Pettit, RK; Chapuis, JC; Schmidt, JM Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate. J Med Chem 45: 2534-42 (2002)
- Kiuchi, M; Adachi, K; Tomatsu, A; Chino, M; Takeda, S; Tanaka, Y; Maeda, Y; Sato, N; Mitsutomi, N; Sugahara, K; Chiba, K Asymmetric synthesis and biological evaluation of the enantiomeric isomers of the immunosuppressive FTY720-phosphate. Bioorg Med Chem 13: 425-32 (2005)
- Fredo Naciuk, F; do Nascimento Faria, J; Gon?alves Eufr?sio, A; Torres Cordeiro, A; Bruder, M Development of Selective Steroid Inhibitors for the Glucose-6-phosphate Dehydrogenase from ACS Med Chem Lett 11: 1250-1256 (2020)
- Freitas, RF; Prokopczyk, IM; Zottis, A; Oliva, G; Andricopulo, AD; Trevisan, MT; Vilegas, W; Silva, MG; Montanari, CA Discovery of novel Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase inhibitors. Bioorg Med Chem 17: 2476-82 (2009)
- Tritsch, D; Zingl?, C; Rohmer, M; Grosdemange-Billiard, C Flavonoids: true or promiscuous inhibitors of enzyme? The case of deoxyxylulose phosphate reductoisomerase. Bioorg Chem 59: 140-4 (2015)
- Fu, J; Lou, Y; He, Y Fused tricyclic ring derivatives as Src homology-2 phosphate inhibitors US Patent US11518772 (2022)
- Xiao, HY; Watterson, SH; Langevine, CM; Srivastava, AS; Ko, SS; Zhang, Y; Cherney, RJ; Guo, WW; Gilmore, JL; Sheppeck, JE; Wu, DR; Li, P; Ramasamy, D; Arunachalam, P; Mathur, A; Taylor, TL; Shuster, DJ; McIntyre, KW; Shen, DR; Yarde, M; Cvijic, ME; Marino, AM; Balimane, PV; Yang, Z; Banas, DM; Cornelius, G; D'Arienzo, CJ; Warrack, BM; Lehman-McKeeman, L; Salter-Cid, LM; Xie, J; Barrish, JC; Carter, PH; Dyckman, AJ; Dhar, TG Identification of Tricyclic Agonists of Sphingosine-1-phosphate Receptor 1 (S1P J Med Chem 59: 9837-9854 (2016)
- Kasprzak, AA; Villafranca, JJ Interactive binding between the substrate and allosteric sites of carbamoyl-phosphate synthetase. Biochemistry 27: 8050-6 (1988)
- Mabiala-Bassiloua, CG; Arthus-Cartier, G; Hannaert, V; Th?risod, H; Sygusch, J; Th?risod, M Mannitol Bis-phosphate Based Inhibitors of Fructose 1,6-Bisphosphate Aldolases. ACS Med Chem Lett 2: 804-808 (2011)
- Chong, KT; Ruwart, MJ; Hinshaw, RR; Wilkinson, KF; Rush, BD; Yancey, MF; Strohbach, JW; Thaisrivongs, S Peptidomimetic HIV protease inhibitors: phosphate prodrugs with improved biological activities. J Med Chem 36: 2575-7 (1993)
- Leitão, A; Andricopulo, AD; Oliva, G; Pupo, MT; de Marchi, AA; Vieira, PC; da Silva, MF; Ferreira, VF; de Souza, MC; Sá, MM; Moraes, VR; Montanari, CA Structure-activity relationships of novel inhibitors of glyceraldehyde-3-phosphate dehydrogenase. Bioorg Med Chem Lett 14: 2199-204 (2004)
- Jain, HV; Rasheed, R; Kalman, TI The role of phosphate in the action of thymidine phosphorylase inhibitors: Implications for the catalytic mechanism. Bioorg Med Chem Lett 20: 1648-51 (2010)
- Kennedy, KJ; Bressi, JC; Gelb, MH A disubstituted NAD+ analogue is a nanomolar inhibitor of trypanosomal glyceraldehyde-3-phosphate dehydrogenase. Bioorg Med Chem Lett 11: 95-8 (2001)
- Shimazawa, R; Gochomori, M; Shirai, R Design and synthesis of novel Cdc25A-inhibitors having phosphate group as a hydrophilic residue. Bioorg Med Chem Lett 14: 4339-42 (2004)
- Filipski, KJ; Sammons, MF; Bhattacharya, SK; Panteleev, J; Brown, JA; Loria, PM; Boehm, M; Smith, AC; Shavnya, A; Conn, EL; Song, K; Weng, Y; Facemire, C; J?ppner, H; Clerin, V Discovery of Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1). ACS Med Chem Lett 9: 440-445 (2018)
- Hennessy, EJ; Grewal, G; Byth, K; Kamhi, VM; Li, D; Lyne, P; Oza, V; Ronco, L; Rooney, MT; Saeh, JC; Su, Q Discovery of heterocyclic sulfonamides as sphingosine 1-phosphate receptor 1 (S1P1) antagonists. Bioorg Med Chem Lett 25: 2041-5 (2015)
- Bell, M; Foley, D; Naylor, C; Robinson, C; Riley, J; Epemolu, O; Scullion, P; Shishikura, Y; Katz, E; McLean, WHI; Wyatt, P; Read, KD; Woodland, A Discovery of super soft-drug modulators of sphingosine-1-phosphate receptor 1. Bioorg Med Chem Lett 28: 3255-3259 (2018)
- Kim, H; Deng, L; Xiong, X; Hunter, WD; Long, MC; Pirrung, MC Glyceraldehyde 3-phosphate dehydrogenase is a cellular target of the insulin mimic demethylasterriquinone B1. J Med Chem 50: 3423-6 (2007)
- Vachal, P; Toth, LM; Hale, JJ; Yan, L; Mills, SG; Chrebet, GL; Koehane, CA; Hajdu, R; Milligan, JA; Rosenbach, MJ; Mandala, S Highly selective and potent agonists of sphingosine-1-phosphate 1 (S1P1) receptor. Bioorg Med Chem Lett 16: 3684-7 (2006)
- Dinges, J; Harris, CM; Wallace, GA; Argiriadi, MA; Queeney, KL; Perron, DC; Dominguez, E; Kebede, T; Desino, KE; Patel, H; Vasudevan, A Hit-to-lead evaluation of a novel class of sphingosine 1-phosphate lyase inhibitors. Bioorg Med Chem Lett 26: 2297-302 (2016)
- Bigham, EC; Gragg, CE; Hall, WR; Kelsey, JE; Mallory, WR; Richardson, DC; Benedict, C; Ray, PH Inhibition of arabinose 5-phosphate isomerase. An approach to the inhibition of bacterial lipopolysaccharide biosynthesis. J Med Chem 27: 717-26 (1984)
- Kotoris, CC; Chen, MJ; Taylor, SD Novel phosphate mimetics for the design of non-peptidyl inhibitors of protein tyrosine phosphatases. Bioorg Med Chem Lett 8: 3275-80 (1999)
- Rankin, GM; Vullo, D; Supuran, CT; Poulsen, SA Phosphate Chemical Probes Designed for Location Specific Inhibition of Intracellular Carbonic Anhydrases. J Med Chem 58: 7580-90 (2015)
- Yao, ZJ; King, CR; Cao, T; Kelley, J; Milne, GW; Voigt, JH; Burke, TR Potent inhibition of Grb2 SH2 domain binding by non-phosphate-containing ligands. J Med Chem 42: 25-35 (1999)
- Miran, SG; Chang, SH; Raushel, FM Role of the four conserved histidine residues in the amidotransferase domain of carbamoyl phosphate synthetase. Biochemistry 30: 7901-7 (1991)
- Abdel-Magid, AF Sphingosine-1-phosphate (S1P) Receptor Modulators Provide Potential for Diverse Treatments. ACS Med Chem Lett 4: 1014-5 (2013)
- Phaosiri, C; Proteau, PJ Substrate analogs for the investigation of deoxyxylulose 5-phosphate reductoisomerase inhibition: synthesis and evaluation. Bioorg Med Chem Lett 14: 5309-12 (2004)
- PubChem, PC Late-stage fluorescence-based dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Sphingosine 1-Phosphate Receptor 1 (S1P1) counterscreen assay PubChem Bioassay (2010)
- PubChem, PC Late-stage fluorescence-based dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Sphingosine 1-Phosphate Receptor 2 (S1P2) counterscreen assay PubChem Bioassay (2010)
- PubChem, PC Late-stage fluorescence-based dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Sphingosine 1-Phosphate Receptor 3 (S1P3) counterscreen assay PubChem Bioassay (2010)
- PubChem, PC Late-stage fluorescence-based dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Sphingosine 1-Phosphate Receptor 5 (S1P5) counterscreen assay PubChem Bioassay (2010)
- Chang, CT; Edwards, MW; Torrence, PF; Mertes, MP 5-Cyano-2'-deoxyuridine 5'-phosphate: a potent competitive inhibitor of thymidylate synthetase. J Med Chem 22: 1137-9 (1979)
- Alphey, MS; Pirrie, L; Torrie, LS; Boulkeroua, WA; Gardiner, M; Sarkar, A; Maringer, M; Oehlmann, W; Brenk, R; Scherman, MS; McNeil, M; Rejzek, M; Field, RA; Singh, M; Gray, D; Westwood, NJ; Naismith, JH Allosteric competitive inhibitors of the glucose-1-phosphate thymidylyltransferase (RmlA) from Pseudomonas aeruginosa. ACS Chem Biol 8: 387-96 (2013)
- Pereira, JM; Severino, RP; Vieira, PC; Fernandes, JB; da Silva, MF; Zottis, A; Andricopulo, AD; Oliva, G; Corrêa, AG Anacardic acid derivatives as inhibitors of glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma cruzi. Bioorg Med Chem 16: 8889-95 (2008)
- Schweitzer, BA; Loida, PJ; Thompson-Mize, RL; CaJacob, CA; Hegde, SG Design and synthesis of beta-carboxamido phosphonates as potent inhibitors of imidazole glycerol phosphate dehydratase. Bioorg Med Chem Lett 9: 2053-8 (1999)
- Schweitzer, BA; Loida, PJ; CaJacob, CA; Chott, RC; Collantes, EM; Hegde, SG; Mosier, PD; Profeta, S Discovery of imidazole glycerol phosphate dehydratase inhibitors through 3-D database searching. Bioorg Med Chem Lett 12: 1743-6 (2002)
- Akkemik, E; Budak, H; Ciftci, M Effects of some drugs on human erythrocyte glucose 6-phosphate dehydrogenase: an in vitro study. J Enzyme Inhib Med Chem 25: 871-5 (2010)
- Nakanishi, W; Kikuchi, K; Inoue, T; Hirose, K; Iino, M; Nagano, T Hydrophobic modifications at 1-phosphate of inositol 1,4,5-trisphosphate analogues enhance receptor binding. Bioorg Med Chem Lett 12: 911-3 (2002)
- PubChem, PC SAR assay for compounds activating TNAP in the absence of phosphate acceptor performed in a luminescent assay PubChem Bioassay (2010)
- PubChem, PC SAR assay for compounds inhibiting TNAP in the absence of phosphate acceptor performed in a luminescent assay PubChem Bioassay (2010)
- Scott, LM; Chen, L; Daniel, KG; Brooks, WH; Guida, WC; Lawrence, HR; Sebti, SM; Lawrence, NJ; Wu, J Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs. Bioorg Med Chem Lett 21: 730-3 (2011)
- Kim, YC; Brown, SG; Harden, TK; Boyer, JL; Dubyak, G; King, BF; Burnstock, G; Jacobson, KA Structure-activity relationships of pyridoxal phosphate derivatives as potent and selective antagonists of P2X1 receptors. J Med Chem 44: 340-9 (2001)
- Guida, WC; Elliott, RD; Thomas, HJ; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Ealick, SE; Montgomery, JA Structure-based design of inhibitors of purine nucleoside phosphorylase. 4. A study of phosphate mimics. J Med Chem 37: 1109-14 (1994)
- Deng, L; Endo, K; Kato, M; Cheng, G; Yajima, S; Song, Y Structures of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase/Lipophilic Phosphonate Complexes. ACS Med Chem Lett 2: 165-170 (2011)
- Kim, D; Kowalchick, JE; Edmondson, SD; Mastracchio, A; Xu, J; Eiermann, GJ; Leiting, B; Wu, JK; Pryor, KD; Patel, RA; He, H; Lyons, KA; Thornberry, NA; Weber, AE Triazolopiperazine-amides as dipeptidyl peptidase IV inhibitors: close analogs of JANUVIA (sitagliptin phosphate). Bioorg Med Chem Lett 17: 3373-7 (2007)
- PubChem, PC uHTS identification of compounds activating TNAP in the absence of phosphate acceptor performed in luminescent assay PubChem Bioassay (2009)
- Mercklé, L; de Andrés-Gómez, A; Dick, B; Cox, RJ; Godfrey, CR A fragment-based approach to understanding inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase. Chembiochem 6: 1866-74 (2005)
- Sanlleh?, P; Abad, JL; Casas, J; Bujons, J; Delgado, A Bacterial versus human sphingosine-1-phosphate lyase (S1PL) in the design of potential S1PL inhibitors. Bioorg Med Chem 24: 4381-4389 (2016)
- Zingl?, C; Tritsch, D; Grosdemange-Billiard, C; Rohmer, M Catechol-rhodanine derivatives: Specific and promiscuous inhibitors of Escherichia coli deoxyxylulose phosphate reductoisomerase (DXR). Bioorg Med Chem 22: 3713-9 (2014)
- Hanessian, S; Charron, G; Billich, A; Guerini, D Constrained azacyclic analogues of the immunomodulatory agent FTY720 as molecular probes for sphingosine 1-phosphate receptors. Bioorg Med Chem Lett 17: 491-4 (2007)
- Buzard, DJ; Kim, SH; Lopez, L; Kawasaki, A; Zhu, X; Moody, J; Thoresen, L; Calderon, I; Ullman, B; Han, S; Lehmann, J; Gharbaoui, T; Sengupta, D; Calvano, L; Montalban, AG; Ma, YA; Sage, C; Gao, Y; Semple, G; Edwards, J; Barden, J; Morgan, M; Chen, W; Usmani, K; Chen, C; Sadeque, A; Christopher, RJ; Thatte, J; Fu, L; Solomon, M; Mills, D; Whelan, K; Al-Shamma, H; Gatlin, J; Le, M; Gaidarov, I; Anthony, T; Unett, DJ; Blackburn, A; Rueter, J; Stirn, S; Behan, DP; Jones, RM Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 Receptor. ACS Med Chem Lett 5: 1313-7 (2014)
- Bell, M; Foley, D; Naylor, C; Wood, G; Robinson, C; Riley, J; Epemolu, O; Ellis, L; Scullion, P; Shishikura, Y; Osuna-Cabello, M; Ferguson, L; Pinto, E; Fletcher, D; Katz, E; McLean, WHI; Wyatt, P; Read, KD; Woodland, A Discovery of Soft-Drug Topical Tool Modulators of Sphingosine-1-phosphate Receptor 1 (S1PR1). ACS Med Chem Lett 10: 341-347 (2019)
- Ibrahim, MA; Johnson, HW; Jeong, JW; Lewis, GL; Shi, X; Noguchi, RT; Williams, M; Leahy, JW; Nuss, JM; Woolfrey, J; Banica, M; Bentzien, F; Chou, YC; Gibson, A; Heald, N; Lamb, P; Mattheakis, L; Matthews, D; Shipway, A; Wu, X; Zhang, W; Zhou, S; Shankar, G Discovery of a novel class of potent and orally bioavailable sphingosine 1-phosphate receptor 1 antagonists. J Med Chem 55: 1368-81 (2012)
- Yep, A; Sorenson, RJ; Wilson, MR; Showalter, HD; Larsen, SD; Keller, PR; Woodard, RW Enediol mimics as inhibitors of the D-arabinose 5-phosphate isomerase (KdsD) from Francisella tularensis. Bioorg Med Chem Lett 21: 2679-82 (2011)
- Jedrzejczak, R; Wojciechowski, M; Andruszkiewicz, R; Sowinski, P; Kot-Wasik, A; Milewski, S Inactivation of glucosamine-6-phosphate synthase by N3-oxoacyl derivatives of L-2,3-diaminopropanoic acid. Chembiochem 13: 85-96 (2012)
- Milewski, S; Hoffmann, M; Andruszkiewicz, R; Borowski, E Investigation of Mechanism of Nitrogen Transfer in Glucosamine 6-Phosphate Synthase with the Use of Transition State Analogs Bioorg Chem 25: 283-296 (1997)
- Innocenti, A; Supuran, CT Paraoxon, 4-nitrophenyl phosphate and acetate are substrates ofa- but not ofß-,¿- and¿-carbonic anhydrases. Bioorg Med Chem Lett 20: 6208-12 (2010)
- Fossetta, J; Deno, G; Gonsiorek, W; Fan, X; Lavey, B; Das, P; Lunn, C; Zavodny, PJ; Lundell, D; Hipkin, RW Pharmacological characterization of human S1P4 using a novel radioligand, [4,5-3H]-dihydrosphingosine-1-phosphate. Br J Pharmacol 142: 851-60 (2004)
- Zobel, K; Koehler, MF; Beresini, MH; Caris, LD; Combs, D Phosphate ester serum albumin affinity tags greatly improve peptide half-life in vivo. Bioorg Med Chem Lett 13: 1513-5 (2003)
- Gosein, V; Miller, GJ Roles of phosphate recognition in inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IPK1) substrate binding and activation. J Biol Chem 288: 26908-13 (2013)
- Smith, JM; Vierling, RJ; Meyers, CF Selective inhibition of E. coli 1-deoxy-D-xylulose-5-phosphate synthase by acetylphosphonates(). Medchemcomm 3: 65-67 (2012)
- Manz, TD; Sivakumaren, SC; Yasgar, A; Hall, MD; Davis, MI; Seo, HS; Card, JD; Ficarro, SB; Shim, H; Marto, JA; Dhe-Paganon, S; Sasaki, AT; Boxer, MB; Simeonov, A; Cantley, LC; Shen, M; Zhang, T; Ferguson, FM; Gray, NS Structure-Activity Relationship Study of Covalent Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors. ACS Med Chem Lett 11: 346-352 (2020)
- Sanlleh?, P; Abad, JL; Bujons, J; Casas, J; Delgado, A Studies on the inhibition of sphingosine-1-phosphate lyase by stabilized reaction intermediates and stereodefined azido phosphates. Eur J Med Chem 123: 905-915 (2016)
- Veleti, SK; Lindenberger, JJ; Ronning, DR; Sucheck, SJ Synthesis of a C-phosphonate mimic of maltose-1-phosphate and inhibition studies on Mycobacterium tuberculosis GlgE. Bioorg Med Chem 22: 1404-11 (2014)
- Jeanjean, A; Gary-Bobo, M; Nirdé, P; Leiris, S; Garcia, M; Morère, A Synthesis of new sulfonate and phosphonate derivatives for cation-independent mannose 6-phosphate receptor targeting. Bioorg Med Chem Lett 18: 6240-3 (2008)
- Colandrea, VJ; Legiec, IE; Huo, P; Yan, L; Hale, JJ; Mills, SG; Bergstrom, J; Card, D; Chebret, G; Hajdu, R; Keohane, CA; Milligan, JA; Rosenbach, MJ; Shei, GJ; Mandala, SM 2,5-Disubstituted pyrrolidine carboxylates as potent, orally active sphingosine-1-phosphate (S1P) receptor agonists. Bioorg Med Chem Lett 16: 2905-8 (2006)
- Maggiora, L; Chang, CT; Hasson, ME; Bigge, CF; Mertes, MP 5-p-benzoquinonyl-2'-deoxyuridine 5'-phosphate: a possible mechanism-based inhibitor of thymidylate synthetase. J Med Chem 26: 1028-36 (1983)
- Jacobson, KA; Kim, YC; Wildman, SS; Mohanram, A; Harden, TK; Boyer, JL; King, BF; Burnstock, G A pyridoxine cyclic phosphate and its 6-azoaryl derivative selectively potentiate and antagonize activation of P2X1 receptors. J Med Chem 41: 2201-6 (1998)
- Wissner, A; Carroll, ML; Green, KE; Kerwar, SS; Pickett, WC; Schaub, RE; Torley, LW; Wrenn, S; Kohler, CA Analogues of platelet activating factor. 6. Mono- and bis-aryl phosphate antagonists of platelet activating factor. J Med Chem 35: 1650-62 (1992)
- Chen, YH; Hsu, HY; Yeh, MT; Chen, CC; Huang, CY; Chung, YH; Chang, ZF; Kuo, WC; Chan, NL; Weng, JH; Chung, BC; Chen, YJ; Jian, CB; Shen, CC; Tai, HC; Sheu, SY; Fang, JM Chemical Inhibition of Human Thymidylate Kinase and Structural Insights into the Phosphate Binding Loop and Ligand-Induced Degradation. J Med Chem 59: 9906-9918 (2016)
- Tu, Z; Rosenberg, A; Liu, H; Han, J Compositions for binding sphingosine-1-phosphate receptor 1 (S1P1), imaging of S1P1, and methods of use thereof US Patent US10676467 (2020)
- Luo, Z; Liu, H; Klein, RS; Tu, Z Design, synthesis, and in vitro bioactivity evaluation of fluorine-containing analogues for sphingosine-1-phosphate 2 receptor. Bioorg Med Chem 27: 3619-3631 (2019)
- Luo, Z; Du, D; Liu, Y; Lu, T; Liu, L; Jiang, H; Chen, K; Shan, C; Luo, C Discovery and characterization of a novel glucose-6-phosphate dehydrogenase (G6PD) inhibitor via high-throughput screening. Bioorg Med Chem Lett 40: (2021)
- Qian, Y; Ahmad, M; Chen, S; Gillespie, P; Le, N; Mennona, F; Mischke, S; So, SS; Wang, H; Burghardt, C; Tannu, S; Conde-Knape, K; Kochan, J; Bolin, D Discovery of 1-arylcarbonyl-6,7-dimethoxyisoquinoline derivatives as glutamine fructose-6-phosphate amidotransferase (GFAT) inhibitors. Bioorg Med Chem Lett 21: 6264-9 (2011)
- Xu, H; Zhang, H; Luan, L; Xu, Y; Li, C; Wang, Y; Han, F; Yang, T; Ren, F; Xiang, JN; Elliott, JD; Zhao, Y; Guo, TB; Lu, H; Zhang, W; Hirst, D; Lindon, M; Lin, X Discovery of thiadiazole amides as potent, S1P3-sparing agonists of sphingosine-1-phosphate 1 (S1P1) receptor. Bioorg Med Chem Lett 22: 2456-9 (2012)
- Golojuch, S; Kopcial, M; Strzelecka, D; Kasprzyk, R; Baran, N; Sikorski, PJ; Kowalska, J; Jemielity, J Exploring tryptamine conjugates as pronucleotides of phosphate-modified 7-methylguanine nucleotides targeting cap-dependent translation. Bioorg Med Chem 28: (2020)
- Guo, J; Watterson, SH; Spergel, SH; Kempson, J; Langevine, CM; Shen, DR; Yarde, M; Cvijic, ME; Banas, D; Liu, R; Suchard, SJ; Gillooly, K; Taylor, T; Rex-Rabe, S; Shuster, DJ; McIntyre, KW; Cornelius, G; D'Arienzo, C; Marino, A; Balimane, P; Salter-Cid, L; McKinnon, M; Barrish, JC; Carter, PH; Pitts, WJ; Xie, J; Dyckman, AJ Identification and synthesis of potent and selective pyridyl-isoxazole based agonists of sphingosine-1-phosphate 1 (S1P1). Bioorg Med Chem Lett 26: 2470-4 (2016)
- Cordeiro, AT; Thiemann, OH; Michels, PA Inhibition of Trypanosoma brucei glucose-6-phosphate dehydrogenase by human steroids and their effects on the viability of cultured parasites. Bioorg Med Chem 17: 2483-9 (2009)
- Morere, A; Da Silva, A; Bouffard, E; El Cheikh, K; Durand, J; Maynadier, M; Basile, I Multi-functionalized polysaccharide compounds and use thereof for targeting the cation-independent mannose 6-phosphate receptor US Patent US10894803 (2021)
- Peterson, ML; Corey, SD; Font, JL; Walker, MC; Sikorski, JA New simplified inhibitors of EPSP synthase: The importance of ring size for recognition at the shikimate 3-phosphate site Bioorg Med Chem Lett 6: 2853-2858 (1996)
- Towell, JF; Erwin, VG; Deitrich, RA Nicotinamide adenine dinucleotide phosphate-decanaldehyde adduct as an inhibitor of beef brain NADP-linked aldehyde reductase. J Med Chem 22: 1011-4 (1979)
- Koide, Y; Uemoto, K; Hasegawa, T; Sada, T; Murakami, A; Takasugi, H; Sakurai, A; Mochizuki, N; Takahashi, A; Nishida, A Pharmacophore-based design of sphingosine 1-phosphate-3 receptor antagonists that include a 3,4-dialkoxybenzophenone scaffold. J Med Chem 50: 442-54 (2007)
- Urbano, M; Guerrero, M; Zhao, J; Velaparthi, S; Schaeffer, MT; Brown, S; Rosen, H; Roberts, E SAR analysis of innovative selective small molecule antagonists of sphingosine-1-phosphate 4 (S1P4) receptor. Bioorg Med Chem Lett 21: 5470-4 (2011)
- Ajmera, S; Bapat, AR; Danenberg, K; Danenberg, PV Synthesis and biological activity of 5-fluoro-2',3'-dideoxy-3'-fluorouridine and its 5'-phosphate. J Med Chem 27: 11-4 (1984)
- Martin, BP; Vasilieva, E; Dupureur, CM; Spilling, CD Synthesis and comparison of the biological activity of monocyclic phosphonate, difluorophosphonate and phosphate analogs of the natural AChE inhibitor cyclophostin. Bioorg Med Chem 23: 7529-34 (2015)
- Walker, SR; Jiao, W; Parker, EJ Synthesis and evaluation of dual site inhibitors of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase. Bioorg Med Chem Lett 21: 5092-7 (2011)
- van Steijn, A; Willems, H; de Boer, T; Geurts, J; van Boeckel, C Synthesis of myo-inositol-1-phosphatase inhibitors in which the phosphate group is replaced by less polar groups Bioorg Med Chem Lett 5: 469-474 (1995)
- Lee, D; Marshall, LA; Bolognese, B; Adams, JL Tetrazole is an effective Sn-3 phosphate replacement in substrate analog inhibitors of 14 kDa phospholipase A2 Bioorg Med Chem Lett 7: 1427-1432 (1997)
- Schmitt, L; Spiess, B; Schlewer, G Synthesis and binding properties of myo-inositol 4,5,6-tris(phosphate) an analogue of myo-inositol 1,4,5-tris(phosphate). Correlation with the ionization state of the molecules Bioorg Med Chem Lett 5: 1225-1230 (1995)
- Yan, L; Budhu, R; Huo, P; Lynch, CL; Hale, JJ; Mills, SG; Hajdu, R; Keohane, CA; Rosenbach, MJ; Milligan, JA; Shei, GJ; Chrebet, G; Bergstrom, J; Card, D; Mandala, SM 2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors. Bioorg Med Chem Lett 16: 3564-8 (2006)
- Bressi, JC; Verlinde, CL; Aronov, AM; Shaw, ML; Shin, SS; Nguyen, LN; Suresh, S; Buckner, FS; Van Voorhis, WC; Kuntz, ID; Hol, WG; Gelb, MH Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design. J Med Chem 44: 2080-93 (2001)
- Shin, ES; Park, J; Shin, JM; Cho, D; Cho, SY; Shin, DW; Ham, M; Kim, JB; Lee, TR Catechin gallates are NADP+-competitive inhibitors of glucose-6-phosphate dehydrogenase and other enzymes that employ NADP+ as a coenzyme. Bioorg Med Chem 16: 3580-6 (2008)
- Marzabadi, MR; Font, JL; Gruys, KJ; Pansegrau, PD; Sikorski, JA Design & synthesis of a novel EPSP synthase inhibitor based on its ternary complex with shikimate-3-phosphate and glyphosate Bioorg Med Chem Lett 2: 1435-1440 (1992)
- Nahum, V; Tulapurkar, M; Lévesque, SA; Sévigny, J; Reiser, G; Fischer, B Diadenosine and diuridine poly(borano)phosphate analogues: synthesis, chemical and enzymatic stability, and activity at P2Y1 and P2Y2 receptors. J Med Chem 49: 1980-90 (2006)
- Guerrero, M; Urbano, M; Zhao, J; Crisp, M; Chase, P; Hodder, P; Schaeffer, MT; Brown, S; Rosen, H; Roberts, E Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P4-R) agonists. Bioorg Med Chem Lett 22: 537-42 (2011)
- Guerrero, M; Urbano, M; Velaparthi, S; Zhao, J; Schaeffer, MT; Brown, S; Rosen, H; Roberts, E Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists. Bioorg Med Chem Lett 21: 3632-6 (2011)
- Anderson, KS; Sikorski, JA; Johnson, KA Evaluation of 5-enolpyruvoylshikimate-3-phosphate synthase substrate and inhibitor binding by stopped-flow and equilibrium fluorescence measurements. Biochemistry 27: 1604-10 (1988)
- Evindar, G; Deng, H; Bernier, SG; Doyle, E; Lorusso, J; Morgan, BA; Westlin, WF Exploring amino acids derivatives as potent, selective, and direct agonists of sphingosine-1-phosphate receptor subtype-1. Bioorg Med Chem Lett 23: 472-5 (2012)
- Lillo, AM; Tetzlaff, CN; Sangari, FJ; Cane, DE Functional expression and characterization of EryA, the erythritol kinase of Brucella abortus, and enzymatic synthesis of L-erythritol-4-phosphate. Bioorg Med Chem Lett 13: 737-9 (2003)
- Ponaire, S; Zinglé, C; Tritsch, D; Grosdemange-Billiard, C; Rohmer, M Growth inhibition of Mycobacterium smegmatis by prodrugs of deoxyxylulose phosphate reducto-isomerase inhibitors, promising anti-mycobacterial agents. Eur J Med Chem 51: 277-85 (2012)
- Bartee, D; Morris, F; Al-Khouja, A; Freel Meyers, CL Hydroxybenzaldoximes Are D-GAP-Competitive Inhibitors of E. coli 1-Deoxy-D-Xylulose-5-Phosphate Synthase. Chembiochem 16: 1771-81 (2015)
- Hennessy, EJ; Oza, V; Adam, A; Byth, K; Castriotta, L; Grewal, G; Hamilton, GA; Kamhi, VM; Lewis, P; Li, D; Lyne, P; ?ster, L; Rooney, MT; Saeh, JC; Sha, L; Su, Q; Wen, S; Xue, Y; Yang, B Identification and Optimization of Benzimidazole Sulfonamides as Orally Bioavailable Sphingosine 1-Phosphate Receptor 1 Antagonists with in Vivo Activity. J Med Chem 58: 7057-75 (2015)
- Deng, L; Diao, J; Chen, P; Pujari, V; Yao, Y; Cheng, G; Crick, DC; Prasad, BV; Song, Y Inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase by lipophilic phosphonates: SAR, QSAR, and crystallographic studies. J Med Chem 54: 4721-34 (2011)
- Beaulieu, PL; Cameron, DR; Ferland, JM; Gauthier, J; Ghiro, E; Gillard, J; Gorys, V; Poirier, M; Rancourt, J; Wernic, D; Llinas-Brunet, M; Betageri, R; Cardozo, M; Hickey, ER; Ingraham, R; Jakes, S; Kabcenell, A; Kirrane, T; Lukas, S; Patel, U; Proudfoot, J; Sharma, R; Tong, L; Moss, N Ligands for the tyrosine kinase p56lck SH2 domain: discovery of potent dipeptide derivatives with monocharged, nonhydrolyzable phosphate replacements. J Med Chem 42: 1757-66 (1999)
- Kalman, TI; Nie, Z; Kamat, A Mechanism-based inactivation of thymidylate synthase by 5-(3-fluoropropyn-1-yl)-2'-deoxyuridine 5'-phosphate. Bioorg Med Chem Lett 10: 391-4 (2000)
- Ziemniak, M; Kowalska, J; Lukaszewicz, M; Zuberek, J; Wnek, K; Darzynkiewicz, E; Jemielity, J Phosphate-modified analogues of m(7)GTP and m(7)Gppppm(7)G-Synthesis and biochemical properties. Bioorg Med Chem 23: 5369-81 (2015)
- Watterson, SH; Guo, J; Spergel, SH; Langevine, CM; Moquin, RV; Shen, DR; Yarde, M; Cvijic, ME; Banas, D; Liu, R; Suchard, SJ; Gillooly, K; Taylor, T; Rex-Rabe, S; Shuster, DJ; McIntyre, KW; Cornelius, G; D'Arienzo, C; Marino, A; Balimane, P; Warrack, B; Salter-Cid, L; McKinnon, M; Barrish, JC; Carter, PH; Pitts, WJ; Xie, J; Dyckman, AJ Potent and Selective Agonists of Sphingosine 1-Phosphate 1 (S1P1): Discovery and SAR of a Novel Isoxazole Based Series. J Med Chem 59: 2820-40 (2016)
- Aronov, AM; Verlinde, CL; Hol, WG; Gelb, MH Selective tight binding inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase via structure-based drug design. J Med Chem 41: 4790-9 (1998)
- Kurata, H; Otsuki, K; Kusumi, K; Kurono, M; Terakado, M; Seko, T; Mizuno, H; Ono, T; Hagiya, H; Minami, M; Nakade, S; Habashita, H Structure-activity relationship studies of sphingosine-1-phosphate receptor agonists with N-cinnamyl-ß-alanine moiety. Bioorg Med Chem Lett 21: 1390-3 (2011)
- Nassir, M; Pelletier, J; Arad, U; Arguin, G; Khazanov, N; Gendron, FP; S?vigny, J; Senderowitz, H; Fischer, B Structure-activity relationship study of NPP1 inhibitors based on uracil-N1-(methoxy)ethyl-?-phosphate scaffold. Eur J Med Chem 184: (2019)
- Mao, J; Eoh, H; He, R; Wang, Y; Wan, B; Franzblau, SG; Crick, DC; Kozikowski, AP Structure-activity relationships of compounds targeting mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate synthase. Bioorg Med Chem Lett 18: 5320-3 (2008)
- Guo, C; Hou, X; Dong, L; Marakovits, J; Greasley, S; Dagostino, E; Ferre, R; Johnson, MC; Humphries, PS; Li, H; Paderes, GD; Piraino, J; Kraynov, E; Murray, BW Structure-based design of novel human Pin1 inhibitors (III): optimizing affinity beyond the phosphate recognition pocket. Bioorg Med Chem Lett 24: 4187-91 (2014)
- Henriksson, LM; Unge, T; Carlsson, J; Aqvist, J; Mowbray, SL; Jones, TA Structures of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase provide new insights into catalysis. J Biol Chem 282: 19905-16 (2007)
- Chofor, R; Sooriyaarachchi, S; Risseeuw, MD; Bergfors, T; Pouyez, J; Johny, C; Haymond, A; Everaert, A; Dowd, CS; Maes, L; Coenye, T; Alex, A; Couch, RD; Jones, TA; Wouters, J; Mowbray, SL; Van Calenbergh, S Synthesis and bioactivity ofß-substituted fosmidomycin analogues targeting 1-deoxy-D-xylulose-5-phosphate reductoisomerase. J Med Chem 58: 2988-3001 (2015)
- Foss, FW; Snyder, AH; Davis, MD; Rouse, M; Okusa, MD; Lynch, KR; Macdonald, TL Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists. Bioorg Med Chem 15: 663-77 (2006)
- Evindar, G; Bernier, SG; Kavarana, MJ; Doyle, E; Lorusso, J; Kelley, MS; Halley, K; Hutchings, A; Wright, AD; Saha, AK; Hannig, G; Morgan, BA; Westlin, WF Synthesis and evaluation of alkoxy-phenylamides and alkoxy-phenylimidazoles as potent sphingosine-1-phosphate receptor subtype-1 agonists. Bioorg Med Chem Lett 19: 369-72 (2008)
- Harrison, AN; Reichau, S; Parker, EJ Synthesis and evaluation of tetrahedral intermediate mimic inhibitors of 3-deoxy-d-manno-octulosonate 8-phosphate synthase. Bioorg Med Chem Lett 22: 907-11 (2012)
- Clemens, JJ; Davis, MD; Lynch, KR; Macdonald, TL Synthesis of benzimidazole based analogues of sphingosine-1-phosphate: discovery of potent, subtype-selective S1P4 receptor agonists. Bioorg Med Chem Lett 14: 4903-6 (2004)
- Clemens, JJ; Davis, MD; Lynch, KR; Macdonald, TL Synthesis of para-alkyl aryl amide analogues of sphingosine-1-phosphate: discovery of potent S1P receptor agonists. Bioorg Med Chem Lett 13: 3401-4 (2003)
- Ballereau, S; Guédat, P; Poirier, SN; Guillemette, G; Spiess, B; Schlewer, G Synthesis, acid-base behavior, and binding properties of 6-modified myo-inositol 1,4,5-tris(phosphate)s. J Med Chem 42: 4824-35 (1999)
- Sauer, R; Maurinsh, J; Reith, U; Fülle, F; Klotz, KN; Müller, CE Water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, A(2A)-selective adenosine receptor antagonists. J Med Chem 43: 440-8 (2000)
- Al-Razzak, LA; Schwepler, D; Decedue, CJ; Balzarini, J; De Clercq, E; Mertes, MP 5-Quinone derivatives of 2'-deoxyuridine 5'-phosphate: inhibition and inactivation of thymidylate synthase, antitumor cell, and antiviral studies. J Med Chem 30: 409-19 (1987)
- Fei, X; Connelly, CM; MacDonald, RG; Berkowitz, DB A set of phosphatase-inert"molecular rulers" to probe for bivalent mannose 6-phosphate ligand-receptor interactions. Bioorg Med Chem Lett 18: 3085-9 (2008)
- Angst, D; Janser, P; Quancard, J; Buehlmayer, P; Berst, F; Oberer, L; Beerli, C; Streiff, M; Pally, C; Hersperger, R; Bruns, C; Bassilana, F; Bollbuck, B An oral sphingosine 1-phosphate receptor 1 (S1P(1)) antagonist prodrug with efficacy in vivo: discovery, synthesis, and evaluation. J Med Chem 55: 9722-34 (2012)
- Rossi, F; Valentina, C; Garavaglia, S; Sathyasaikumar, KV; Schwarcz, R; Kojima, S; Okuwaki, K; Ono, S; Kajii, Y; Rizzi, M Crystal structure-based selective targeting of the pyridoxal 5'-phosphate dependent enzyme kynurenine aminotransferase II for cognitive enhancement. J Med Chem 53: 5684-9 (2010)
- Boffey, HK; Rooney, TPC; Willems, HMG; Edwards, S; Green, C; Howard, T; Ogg, D; Romero, T; Scott, DE; Winpenny, D; Duce, J; Skidmore, J; Clarke, JH; Andrews, SP Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase ? Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode. J Med Chem 65: 3359-3370 (2022)
- Kennedy, AJ; Mathews, TP; Kharel, Y; Field, SD; Moyer, ML; East, JE; Houck, JD; Lynch, KR; Macdonald, TL Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells. J Med Chem 54: 3524-48 (2011)
- Masini, T; Hirsch, AK Development of inhibitors of the 2C-methyl-D-erythritol 4-phosphate (MEP) pathway enzymes as potential anti-infective agents. J Med Chem 57: 9740-63 (2014)
- Gilmore, JL; Sheppeck, JE; Watterson, SH; Haque, L; Mukhopadhyay, P; Tebben, AJ; Galella, MA; Shen, DR; Yarde, M; Cvijic, ME; Borowski, V; Gillooly, K; Taylor, T; McIntyre, KW; Warrack, B; Levesque, PC; Li, JP; Cornelius, G; D'Arienzo, C; Marino, A; Balimane, P; Salter-Cid, L; Barrish, JC; Pitts, WJ; Carter, PH; Xie, J; Dyckman, AJ Discovery and Structure-Activity Relationship (SAR) of a Series of Ethanolamine-Based Direct-Acting Agonists of Sphingosine-1-phosphate (S1P1). J Med Chem 59: 6248-64 (2016)
- Demont, EH; Bailey, JM; Bit, RA; Brown, JA; Campbell, CA; Deeks, N; Dowell, SJ; Eldred, C; Gaskin, P; Gray, JR; Haynes, A; Hirst, DJ; Holmes, DS; Kumar, U; Morse, MA; Osborne, GJ; Renaux, JF; Seal, GA; Smethurst, CA; Taylor, S; Watson, R; Willis, R; Witherington, J Discovery of Tetrahydropyrazolopyridine as Sphingosine 1-Phosphate Receptor 3 (S1P3)-Sparing S1P1 Agonists Active at Low Oral Doses. J Med Chem 59: 1003-20 (2016)
- PubChem, PC Dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 3 (S1P3) PubChem Bioassay (2009)
- Evindar, G; Bernier, SG; Doyle, E; Kavarana, MJ; Satz, AL; Lorusso, J; Blanchette, HS; Saha, AK; Hannig, G; Morgan, BA; Westlin, WF Exploration of amino alcohol derivatives as novel, potent, and highly selective sphingosine-1-phosphate receptor subtype-1 agonists. Bioorg Med Chem Lett 20: 2520-4 (2010)
- Neumann, TS; Span, EA; Kalous, KS; Bongard, R; Gastonguay, A; Lepley, MA; Kutty, RG; Nayak, J; Bohl, C; Lange, RG; Sarker, MI; Talipov, MR; Rathore, R; Ramchandran, R; Sem, DS Identification of inhibitors that target dual-specificity phosphatase 5 provide new insights into the binding requirements for the two phosphate pockets. BMC Biochem 16: 19 (2015)
- Skidmore, J; Heer, J; Johnson, CN; Norton, D; Redshaw, S; Sweeting, J; Hurst, D; Cridland, A; Vesey, D; Wall, I; Ahmed, M; Rivers, D; Myatt, J; Giblin, G; Philpott, K; Kumar, U; Stevens, A; Bit, RA; Haynes, A; Taylor, S; Watson, R; Witherington, J; Demont, E; Heightman, TD Optimization of sphingosine-1-phosphate-1 receptor agonists: effects of acidic, basic, and zwitterionic chemotypes on pharmacokinetic and pharmacodynamic profiles. J Med Chem 57: 10424-42 (2014)
- DeSouza, SR; Olson, MC; Tinucci, SL; Sinner, EK; Flynn, RS; Marshall, QF; Jakubowski, HV; McIntee, EJ SAR of non-hydrolysable analogs of pyridoxal 5'-phosphate against low molecular weight protein tyrosine phosphatase isoforms. Bioorg Med Chem Lett 30: (2020)
- Parker, EN; Odutola, SO; Wang, Y; Strecker, TE; Mukherjee, R; Shi, Z; Chaplin, DJ; Trawick, ML; Pinney, KG Synthesis and biological evaluation of a water-soluble phosphate prodrug salt and structural analogues of KGP94, a lead inhibitor of cathepsin L. Bioorg Med Chem Lett 27: 1304-1310 (2017)
- Evindar, G; Satz, AL; Bernier, SG; Kavarana, MJ; Doyle, E; Lorusso, J; Taghizadeh, N; Halley, K; Hutchings, A; Kelley, MS; Wright, AD; Saha, AK; Hannig, G; Morgan, BA; Westlin, WF Synthesis and evaluation of arylalkoxy- and biarylalkoxy-phenylamide and phenylimidazoles as potent and selective sphingosine-1-phosphate receptor subtype-1 agonists. Bioorg Med Chem Lett 19: 2315-9 (2009)
- Clemens, JJ; Davis, MD; Lynch, KR; Macdonald, TL Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: discovery of potent S1P1 receptor agonists. Bioorg Med Chem Lett 15: 3568-72 (2005)
- Knobloch, G; Jabari, N; Stadlbauer, S; Schindelin, H; K?hn, M; Gohla, A Synthesis of hydrolysis-resistant pyridoxal 5'-phosphate analogs and their biochemical and X-ray crystallographic characterization with the pyridoxal phosphatase chronophin. Bioorg Med Chem 23: 2819-27 (2015)
- Vadnere, MK; Maggiora, L; Mertes, MP Thiol addition to quinones: model reactions for the inactivation of thymidylate synthase by 5-p-benzoquinonyl-2'-deoxyuridine 5'-phosphate. J Med Chem 29: 1714-20 (1986)
- PubChem, PC Confirmation of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay using a high concentration of mannose 6-phosphate. PubChem Bioassay (2009)
- Yan, L; Hale, JJ; Lynch, CL; Budhu, R; Gentry, A; Mills, SG; Hajdu, R; Keohane, CA; Rosenbach, MJ; Milligan, JA; Shei, GJ; Chrebet, G; Bergstrom, J; Card, D; Rosen, H; Mandala, SM Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors. Bioorg Med Chem Lett 14: 4861-6 (2004)
- Hobson, AD; Harris, CM; van der Kam, EL; Turner, SC; Abibi, A; Aguirre, AL; Bousquet, P; Kebede, T; Konopacki, DB; Gintant, G; Kim, Y; Larson, K; Maull, JW; Moore, NS; Shi, D; Shrestha, A; Tang, X; Zhang, P; Sarris, KK Discovery of A-971432, An Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist for the Potential Treatment of Neurodegenerative Disorders. J Med Chem 58: 9154-70 (2015)
- Kurata, H; Kusumi, K; Otsuki, K; Suzuki, R; Kurono, M; Komiya, T; Hagiya, H; Mizuno, H; Shioya, H; Ono, T; Takada, Y; Maeda, T; Matsunaga, N; Kondo, T; Tominaga, S; Nunoya, KI; Kiyoshi, H; Komeno, M; Nakade, S; Habashita, H Discovery of a 1-Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1P J Med Chem 60: 9508-9530 (2017)
- Miller, MJ; Braccolino, DS; Clearly, DG; Ream, JE; Walker, MC; Sikorski, JA EPSP synthase inhibitor design IV. New aromatic substrate analogs and symmetrical inhibitors containing novel 3-phosphate mimics. Bioorg Med Chem Lett 4: 2605-2608 (1994)
- Meng, Q; Zhao, B; Xu, Q; Xu, X; Deng, G; Li, C; Luan, L; Ren, F; Wang, H; Xu, H; Xu, Y; Zhang, H; Xiang, JN; Elliott, JD; Guo, TB; Zhao, Y; Zhang, W; Lu, H; Lin, X Indole-propionic acid derivatives as potent, S1P3-sparing and EAE efficacious sphingosine-1-phosphate 1 (S1P1) receptor agonists. Bioorg Med Chem Lett 22: 2794-7 (2012)
- PubChem, PC Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4) PubChem Bioassay (2010)
- Zécri, FJ; Albert, R; Landrum, G; Hinterding, K; Cooke, NG; Guerini, D; Streiff, M; Bruns, C; Nuesslein-Hildesheim, B Pyrazole derived from (+)-3-carene; a novel potent, selective scaffold for sphingosine-1-phosphate (S1P(1)) receptor agonists. Bioorg Med Chem Lett 20: 35-7 (2010)
- Daher, R; Coinçon, M; Fonvielle, M; Gest, PM; Guerin, ME; Jackson, M; Sygusch, J; Therisod, M Rational design, synthesis, and evaluation of new selective inhibitors of microbial class II (zinc dependent) fructose bis-phosphate aldolases. J Med Chem 53: 7836-42 (2010)
- Aronov, AM; Gelb, MH Synthesis and structure-activity relationships of adenosine analogs as inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase. Modifications at positions 5' and 8. Bioorg Med Chem Lett 8: 3505-10 (1999)
- Beard, RL; Yuan, H; Donello, JE; Liu, X; Duong, T 6-substituted indole-3-carboxylic acid amide compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity US Patent US8524917 (2013)
- Rusconi, S; Innocenti, A; Vullo, D; Mastrolorenzo, A; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral drug foscarnet. Bioorg Med Chem Lett 14: 5763-7 (2004)
- A M Subbaiah, M; Mandlekar, S; Desikan, S; Ramar, T; Subramani, L; Annadurai, M; Desai, SD; Sinha, S; Jenkins, SM; Krystal, MR; Subramanian, M; Sridhar, S; Padmanabhan, S; Bhutani, P; Arla, R; Singh, S; Sinha, J; Thakur, M; Kadow, JF; Meanwell, NA Design, Synthesis, and Pharmacokinetic Evaluation of Phosphate and Amino Acid Ester Prodrugs for Improving the Oral Bioavailability of the HIV-1 Protease Inhibitor Atazanavir. J Med Chem 62: 3553-3574 (2019)
- Kim, SH; Constantine, KL; Duke, GJ; Goldfarb, V; Hunt, JT; Johnson, S; Kish, K; Klei, HE; McDonnell, PA; Metzler, WJ; Mueller, L; Poss, MA; Fairchild, CR; Bhide, RS Design, synthesis, functional and structural characterization of an inhibitor of N-acetylneuraminate-9-phosphate phosphatase: observation of extensive dynamics in an enzyme/inhibitor complex. Bioorg Med Chem Lett 23: 4107-11 (2013)
- Ren, F; Deng, G; Wang, H; Luan, L; Meng, Q; Xu, Q; Xu, H; Xu, X; Zhang, H; Zhao, B; Li, C; Guo, TB; Yang, J; Zhang, W; Zhao, Y; Jia, Q; Lu, H; Xiang, JN; Elliott, JD; Lin, X Discovery of novel 1,2,4-thiadiazole derivatives as potent, orally active agonists of sphingosine 1-phosphate receptor subtype 1 (S1P(1)). J Med Chem 55: 4286-96 (2012)
- PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assay PubChem Bioassay (2011)
- PubChem, PC HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay using a high concentration of mannose 6-phosphate PubChem Bioassay (2009)
- Hoffman, HE; Jirásková, J; Cígler, P; Sanda, M; Schraml, J; Konvalinka, J Hydroxamic acids as a novel family of serine racemase inhibitors: mechanistic analysis reveals different modes of interaction with the pyridoxal-5'-phosphate cofactor. J Med Chem 52: 6032-41 (2009)
- Gao, Y; Luo, J; Yao, ZJ; Guo, R; Zou, H; Kelley, J; Voigt, JH; Yang, D; Burke, TR Inhibition of Grb2 SH2 domain binding by non-phosphate-containing ligands. 2. 4-(2-Malonyl)phenylalanine as a potent phosphotyrosyl mimetic. J Med Chem 43: 911-20 (2000)
- Singh, B; Bacon, ER; Lesher, GY; Robinson, S; Pennock, PO; Bode, DC; Pagani, ED; Bentley, RG; Connell, MJ; Hamel, LT Novel and potent adenosine 3',5'-cyclic phosphate phosphodiesterase III inhibitors: thiazolo[4,5-b][1,6]naphthyridin-2-ones. J Med Chem 38: 2546-50 (1995)
- Yan, L; Huo, P; Hale, JJ; Mills, SG; Hajdu, R; Keohane, CA; Rosenbach, MJ; Milligan, JA; Shei, GJ; Chrebet, G; Bergstrom, J; Card, D; Mandala, SM SAR studies of 3-arylpropionic acids as potent and selective agonists of sphingosine-1-phosphate receptor-1 (S1P1) with enhanced pharmacokinetic properties. Bioorg Med Chem Lett 17: 828-31 (2007)
- Verlinde, CL; Callens, M; Van Calenbergh, S; Van Aerschot, A; Herdewijn, P; Hannaert, V; Michels, PA; Opperdoes, FR; Hol, WG Selective inhibition of trypanosomal glyceraldehyde-3-phosphate dehydrogenase by protein structure-based design: toward new drugs for the treatment of sleeping sickness. J Med Chem 37: 3605-13 (1994)
- Sasaki, S; Ehara, T; Alam, MR; Fujino, Y; Harada, N; Kimura, J; Nakamura, H; Maeda, M Solid-Phase synthesis of a library constructed of aromatic phosphate, long alkyl chains and tryptophane components, and identification of potent dipeptide telomerase inhibitors. Bioorg Med Chem Lett 11: 2581-4 (2001)
- Hai, TT; Picker, D; Abo, M; Hampton, A Species- or isozyme-specific enzyme inhibitors. 7. Selective effects in inhibitions of rat adenylate kinase isozymes by adenosine 5'-phosphate derivatives. J Med Chem 25: 806-12 (1982)
- Hikishima, S; Hashimoto, M; Magnowska, L; Bzowska, A; Yokomatsu, T Structural-based design and synthesis of novel 9-deazaguanine derivatives having a phosphate mimic as multi-substrate analogue inhibitors for mammalian PNPs. Bioorg Med Chem 18: 2275-84 (2010)
- Bombrun, A; Schwarz, M; Crosignani, S; Covini, D; Marin, D 6-amino-pyrimidine-4-carboxamide derivatives and related compounds which bind to the sphingosine 1-phosphate (S1P) receptor for the treatment of multiple sclerosis US Patent US9150519 (2015)
- Uliassi, E; Fiorani, G; Krauth-Siegel, RL; Bergamini, C; Fato, R; Bianchini, G; Carlos Men?ndez, J; Molina, MT; L?pez-Montero, E; Falchi, F; Cavalli, A; Gul, S; Kuzikov, M; Ellinger, B; Witt, G; Moraes, CB; Freitas-Junior, LH; Borsari, C; Costi, MP; Bolognesi, ML Crassiflorone derivatives that inhibit Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) and Trypanosoma cruzi trypanothione reductase (TcTR) and display trypanocidal activity. Eur J Med Chem 141: 138-148 (2017)
- Lanman, BA; Cee, VJ; Cheruku, SR; Frohn, M; Golden, J; Lin, J; Lobera, M; Marantz, Y; Muller, KM; Neira, SC; Pickrell, AJ; Rivenzon-Segal, D; Schutz, N; Sharadendu, A; Yu, X; Zhang, Z; Buys, J; Fiorino, M; Gore, A; Horner, M; Itano, A; McElvain, M; Middleton, S; Schrag, M; Vargas, HM; Xu, H; Xu, Y; Zhang, X; Siu, J Discovery of a Potent, S1P3-Sparing Benzothiazole Agonist of Sphingosine-1-Phosphate Receptor 1 (S1P1) ACS Med Chem Lett 2: 102-106 (2011)
- Li, Z; Chen, W; Hale, JJ; Lynch, CL; Mills, SG; Hajdu, R; Keohane, CA; Rosenbach, MJ; Milligan, JA; Shei, GJ; Chrebet, G; Parent, SA; Bergstrom, J; Card, D; Forrest, M; Quackenbush, EJ; Wickham, LA; Vargas, H; Evans, RM; Rosen, H; Mandala, S Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3. J Med Chem 48: 6169-73 (2005)
- Alencar, N; Sola, I; Linares, M; Ju?rez-Jim?nez, J; Pont, C; Viayna, A; V?lchez, D; Sampedro, C; Abad, P; P?rez-Benavente, S; Lameira, J; Bautista, JM; Mu?oz-Torrero, D; Luque, FJ First homology model of Plasmodium falciparum glucose-6-phosphate dehydrogenase: Discovery of selective substrate analog-based inhibitors as novel antimalarial agents. Eur J Med Chem 146: 108-122 (2018)
- Oyugi, MA; Bashiri, G; Baker, EN; Johnson-Winters, K Investigating the Reaction Mechanism of F420-Dependent Glucose-6-phosphate Dehydrogenase from Mycobacterium tuberculosis: Kinetic Analysis of the Wild-Type and Mutant Enzymes. Biochemistry 55: 5566-5577 (2016)
- PubChem, PC Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized analogues PubChem Bioassay (2010)
- PubChem, PC Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds PubChem Bioassay (2010)
- G?nther, M; Lategahn, J; Juchum, M; D?ring, E; Keul, M; Engel, J; Tumbrink, HL; Rauh, D; Laufer, S Trisubstituted Pyridinylimidazoles as Potent Inhibitors of the Clinically Resistant L858R/T790M/C797S EGFR Mutant: Targeting of Both Hydrophobic Regions and the Phosphate Binding Site. J Med Chem 60: 5613-5637 (2017)
- ChEMBL_556521 Inhibition of rabbit muscle glycogen phosphorylase assessed as release of phosphate from glucose 1 phosphate
- ChEMBL_1558648 Inhibition of rabbit muscle glycogen phosphorylase-a assessed as formation of inorganic phosphate from glucose-1-phosphate by colorimetry
- ChEMBL_595113 Inhibition of rabbit muscle glycogen phosphorylase A assessed as release of phosphate from glucose-1-phosphate after 25 mins
- ChEMBL_620083 Inhibition of rabbit muscle glycogen phosphorylase assessed as release of phosphate from glucose-1-phosphate after 25 mins
- ChEMBL_762684 Inhibition of rabbit muscle glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins
- ChEMBL_762685 Inhibition of human liver glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins
- ChEMBL_447975 Inhibition of glucose 6 phosphate translocase 1
- ChEMBL_664344 Inhibition of human recombinant renin in phosphate buffer
- ChEMBL_743385 Inhibition of mTOR by radiometric phosphate incorporation assay
- ChEMBL_1360672 Non-competitive inhibition of pyridoxine phosphate oxidase (unknown origin) assessed as oxidation of pyridoxol 5'-phosphate by Lineweaver-Burk plot analysis
- ChEMBL_1460187 Inhibition of rabbit muscle glycogen phosphorylase a assessed as inhibition of release of phosphate from glucose-1-phosphate after 30 mins by spectrophotometry
- ChEMBL_1630551 Inhibition of rabbit muscle glycogen phosphorylase-b assessed as release of inorganic phosphate from glucose-1-phosphate in presence of AMP and glycogen
- ChEMBL_99040 In vitro inhibitory activity against recombinant human liver glycogen phosphorylase a (rHLGPa) catalyzed release of phosphate from glucose-1-phosphate.
- ChEMBL_1733215 Inhibition of rabbit muscle glycogen phosphorylase-a assessed as release of inorganic phosphate using glucose-1-phosphate as substrate in presence of glycogen by spectrophotometric method
- ChEMBL_1733216 Inhibition of human liver glycogen phosphorylase-a assessed as release of inorganic phosphate using glucose-1-phosphate as substrate in presence of glycogen by spectrophotometric method
- Inhibition Activity Assay Human liver glycogen phsphorylase (HLGP) activity was measured in the direction of glycogen synthesis by the release of phosphate from glucose-1-phosphate.
- ChEMBL_1670145 Competitive inhibition of human liver glycogen phosphorylase-a assessed as release of inorganic phosphate using varying levels of glucose-1-phosphate and constant concentration of AMP and glycogen preincubated for 15 mins with AMP and glycogen followed by glucose-1-phosphate addition
- ChEMBL_36028 Inhibitory activity against Arabinose-5-phosphate isomerase
- ChEMBL_447602 Inhibition of human PNP in presence of 1 mM phosphate
- ChEMBL_447603 Inhibition of human PNP in presence of 0.025 mM phosphate
- ChEMBL_447604 Inhibition of calf PNP in presence of 1 mM phosphate
- ChEMBL_447605 Inhibition of calf PNP in presence of 0.025 mM phosphate
- ChEMBL_72881 TInhibition of glyceraldehyde-3-phosphate dehydrogenase in Leishmania mexicana
- ChEMBL_72891 Inhibition of glyceraldehyde-3-phosphate dehydrogenase in Trypanosoma brucei
- ChEMBL_72903 Inhibition of Glyceraldehyde-3-phosphate dehydrogenase in human erythrocytes.
- ChEMBL_765397 Inhibition of PTP1B using p-nitrophenyl phosphate as substrate
- ChEMBL_775058 Noncompetitive inhibition of GFAT in presence of fructose-6-phosphate
- ChEMBL_882108 Inhibition of TCPTP by para-nitrophenyl phosphate release assay
- ChEMBL_882109 Inhibition of PTP1B by para-nitrophenyl phosphate release assay
- ChEMBL_1619029 Inhibition of rabbit skeletal muscle glycogen phosphorylase b assessed as reduction in inorganic phosphate release using glucose-1-phosphate as substrate at pH 6.8
- ChEMBL_753234 Inhibition of rabbit muscle glycogen phosphorylase A assessed as release of phosphate from glucose-1-phosphate after 25 mins by microplate reader based method
- ChEMBL_797827 Inhibition of rabbit muscle glycogen phosphorylase a assessed as release of phosphate from glucose-1-phosphate after 25 mins using malachite green staining
- ChEMBL_1619018 Inhibition of rabbit skeletal muscle glycogen phosphorylase b assessed as inorganic phosphate release using glucose-1-phosphate as substrate by double-reciprocal plot analysis
- ChEMBL_1733214 Inhibition of rabbit muscle glycogen phosphorylase-b assessed as release of inorganic phosphate using glucose-1-phosphate as substrate in presence of AMP and glycogen by spectrophotometric method
- ChEMBL_1455461 Stimulation of ATPase activity of human MRP2 assessed as inorganic phosphate
- ChEMBL_1455462 Inhibition of ATPase activity of human MRP2 assessed as inorganic phosphate
- ChEMBL_1455463 Stimulation of ATPase activity of rat Mrp2 assessed as inorganic phosphate
- ChEMBL_1455464 Inhibition of ATPase activity of rat Mrp2 assessed as inorganic phosphate
- ChEMBL_302548 Binding affinity against rabbit muscle triose-phosphate isomerase
- ChEMBL_305228 Inhibitory concentration against rabbit muscle triose-phosphate isomerase
- ChEMBL_555945 Activity at human GnRH receptor by inositol phosphate functional assay
- ChEMBL_775079 Inhibition of GFAT using N-acetylglucosamine 6-phosphate as substrate
- ChEMBL_835427 Agonist activity at mouse GPR142 assessed as inositol phosphate accumulation
- ChEMBL_882103 Competitive inhibition of PTP1B by para-nitrophenyl phosphate release assay
- ChEMBL_2106081 Inhibition of Fam20C (unknown origin) assessed as reduction in inorganic phosphate release in presence of ATP measured by Malachite green phosphate staining based micro plate reader assay
- ChEMBL_764140 Competitive inhibition of rabbit muscle glycogen phosphorylase b assessed as inorganic phosphate release using alphaD glucose-1-phosphate as substrate at pH 6.8 by spectrophotometric analysis
- Fluorescent Coupled Assay The binding affinities to FtsZ were determined by a fluorescent coupled assay for phosphate relase. In this GTPase studies, phosphate liberated during GTP hydrolysis is a substrate of purine nucleoside phosphorylase, which converts 7-methylguanosine to 7-methylguanin and ribose-1-phosphate, resulting in a decrease of fluorescence.
- ChEMBL_1649508 Inhibition of rat muscle glycogen phosphorylase A assessed as release of inorganic phosphate from glucose-1- phosphate in presence of glycogen after 30 mins by malachite green based assay
- ChEMBL_907777 Inhibition of Escherichia coli imidazoleglycerol phosphate dehydratase using imidazole glycerol phosphate as substrate incubated for 30 min prior to substrate addition measured for 16 min by spectrophotometric analysis
- ChEMBL_1581173 Inhibition of recombinant human PTP1B assessed as hydrolysis of p-nitrophenyl phosphate
- ChEMBL_162205 Binding affinity against phosphate binding site of Purine nucleoside Phosphorylase
- ChEMBL_303122 Inhibitory activity against Escherichia coli deoxyxylulose 5-phosphate reductoisomerase
- ChEMBL_466588 Displacement of pentamannosyl phosphate bovine serum albumin from M6P/IGF2R
- ChEMBL_499713 Displacement of [33P]sphingosine-1-phosphate from human S1P1 receptor
- ChEMBL_499714 Displacement of [33P]sphingosine-1-phosphate from human S1P3 receptor
- ChEMBL_499715 Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
- ChEMBL_499716 Displacement of [33P]sphingosine-1-phosphate from human S1P5 receptor
- ChEMBL_519984 Inhibition of sphingosine-1-phosphate lyase in mouse spleen by scintillation counting
- ChEMBL_540418 Displacement of [33P]sphingosine-1-phosphate from human S1P1 receptor
- ChEMBL_540419 Displacement of [33P]sphingosine-1-phosphate from human S1P3 receptor
- ChEMBL_540420 Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor
- ChEMBL_540421 Displacement of [33P]sphingosine-1-phosphate from human S1P5 receptor
- ChEMBL_555946 Activity at rhesus monkey GnRH receptor by inositol phosphate functional assay
- ChEMBL_606269 Agonist activity against 5HT2B receptor assessed as inositol phosphate accumulation
- ChEMBL_70744 Inhibition of rat brain farnesyltransferase in 30 mM potassium phosphate buffer
- ChEMBL_72894 Inhibitory concentration of compound against glyceraldehyde-3-phosphate dehydrogenase was determined
- ChEMBL_72896 Inhibitory activity was measured for Glyceraldehyde-3-phosphate dehydrogenase in Trypanosoma brucei
- ChEMBL_72898 Inhibitory activity was measured for Glyceraldehyde-3-phosphate dehydrogenase in Trypanosoma cruzi.
- ChEMBL_72900 Inhibitory activity was measured for Glyceraldehyde-3-phosphate dehydrogenase in human(erythrocytes)
- ChEMBL_741887 Inhibition of Itk after 40 mins by radiometric phosphate incorporation assay
- ChEMBL_743384 Inhibition of DNAPK after 2 hrs by radiometric phosphate incorporation assay
- ChEMBL_986855 Inhibition of PTP1B (unknown origin) using p-nitrophenyl phosphate as substrate
- Inhibition Assay Inhibition assay using glucose-1-phosphate thymidylyltransferase (RmlA).
- Inhibition Assay Inhibition assay using sphingosine-1-phosphate receptor 3.
- ChEMBL_1878663 Inhibition of human recombinant CYP1B1 using 7-ethoxyresorufin as substrate in presence of glucose-6-phosphate, glucose-6-phosphate dehydrogenase and NADPH-generating system incubated for 35 mins by fluorometry
- ChEMBL_1878664 Inhibition of human recombinant CYP1A1 using 7-ethoxyresorufin as substrate in presence of glucose-6-phosphate, glucose-6-phosphate dehydrogenase and NADPH-generating system incubated for 15 mins by fluorometry
- ChEMBL_1878665 Inhibition of human recombinant CYP1A2 using 7-ethoxyresorufin as substrate in presence of glucose-6-phosphate, glucose-6-phosphate dehydrogenase and NADPH-generating system incubated for 50 mins by fluorometry
- ChEMBL_506139 Inhibition of Mycobacterium tuberculosis DXR assessed as NADPH-dependent conversion of 1-deoxy-D-xylulose 5-phosphate to 2-C-methyl-D-erythritol 4-phosphate by spectrophotometric method
- ChEBML_158626 Inhibition of human prostatic acid phosphatase was determined as inhibition of the hydrolysis of tyrosine phosphate
- ChEBML_52541 Inhibition of 2-C-methyl-d-erythritol-4-phosphate cytidyltransferase (YgbP)
- ChEBML_69909 Inhibitory concentration against Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
- ChEBML_71454 Inhibition of gonadotropin-releasing hormone receptor-stimulated [3H]inositol phosphate hydrolysis
- ChEBML_72905 Compound was tested for the inhibition of Leishmania mexicana GAPDH(glyceraldehyde-3-phosphate dehydrogenase)
- ChEMBL_1286129 Competitive inhibition of PFKFB3 (unknown origin) using fructose 6-phosphate as substrate
- ChEMBL_1455848 Inhibition of rat DNPH1 assessed as 2-deoxyribose 5-phosphate production by spectrophotometrically
- ChEMBL_1455849 Inhibition of human DNPH1 assessed as 2-deoxyribose 5-phosphate production by spectrophotometrically
- ChEMBL_1467560 Competitive inhibition of PTP1B (unknown origin) using p-nitrophenyl phosphate as substrate
- ChEMBL_147577 Accumulation of inositol phosphate in 1321N1 astrocytoma cells expressing human P2Y1 purinoceptor
- ChEMBL_1500296 Inverse agonist activity at rat ghrelin receptor by inositol phosphate turnover assay
- ChEMBL_1506090 Inhibition of human placental alkaline phosphatase using p-nitrophenyl phosphate substrate
- ChEMBL_153320 Inhibition of purine nucleoside phosphorylase from calf spleen in 50 mM phosphate
- ChEMBL_162032 Inhibition of calf spleen PNP (purine nucleoside phosphorylase) in 1 mM phosphate
- ChEMBL_162033 Inhibition of calf spleen PNP (purine nucleoside phosphorylase) in 50 mM phosphate
- ChEMBL_162190 Inhibition of human erythrocytic PNP (purine nucleoside phosphorylase) in 1 mM phosphate
- ChEMBL_1888918 Inhibition of Mycobacterium tuberculosis H37Ra PTPB using p-nitrophenyl phosphate as substrate
- ChEMBL_1990679 Inhibition of HSP90 ATPase activity (unknown origin) malachite-green phosphate assay
- ChEMBL_306074 Inhibition of human GnRH receptor stimulated inositol phosphate accumulation in RBL cells
- ChEMBL_312533 Inhibition of PGD2-induced inositol phosphate formation at human Prostaglandin D2 receptor
- ChEMBL_399838 Inhibition of non-phosphorylated form of rabbit muscle glycogen phosphorylase in presence of phosphate
- ChEMBL_463125 Inhibition of human carbonic anhydrase 1 assessed as 4-nitrophenyl phosphate hydrolysis
- ChEMBL_463126 Inhibition of human carbonic anhydrase 2 assessed as 4-nitrophenyl phosphate hydrolysis
- ChEMBL_463127 Inhibition of mouse carbonic anhydrase 13 assessed as 4-nitrophenyl phosphate hydrolysis
- ChEMBL_504639 Inhibition of DNA polymerase beta lyase activity by deoxyribose phosphate excision assay
- ChEMBL_516599 Inhibition of fructose-1,6-bisphosphatase in mouse liver homogenates by colorimetric phosphate assay
- ChEMBL_566013 Inhibition of ATPase activity of SCV helicase assessed as phosphate release by colorimetric assay
- ChEMBL_598030 Inhibition of Streptococcus pneumoniae SP-3 gyrB by enzyme coupled phosphate assay
- ChEMBL_69909 Inhibitory concentration against Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
- ChEMBL_69910 Inhibitory concentration against Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
- ChEMBL_69911 Inhibitory concentration against Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
- ChEMBL_69912 Inhibitory concentration against Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
- ChEMBL_69913 Inhibitory concentration against Trypanosoma mexicana glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
- ChEMBL_69915 Inhibitory concentration against rabbit muscle glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
- ChEMBL_69916 Inhibitory concentration against rabbit muscle glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
- ChEMBL_71454 Inhibition of gonadotropin-releasing hormone receptor-stimulated [3H]inositol phosphate hydrolysis
- ChEMBL_72770 Inhibitory activity measured for Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in Leishmania. mexicana
- ChEMBL_72772 Inhibitory activity was measured for Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in Leishmania. mexicana.
- ChEMBL_72905 Compound was tested for the inhibition of Leishmania mexicana GAPDH(glyceraldehyde-3-phosphate dehydrogenase)
- ChEMBL_741888 Inhibition of c-Kit after 45 mins by radiometric phosphate incorporation assay
- ChEMBL_831739 Inhibition of KHKC in human HepG2 cells assessed as level of fructose-1-phosphate
- ChEMBL_1632373 Inhibition of PI3Kbeta in HUVEC assessed as reduction in sphingosine-1-phosphate stimulated akt phosphorylation at Ser473 residue preincubated for 15 mins followed by sphingosine-1-phosphate stimulation for 5 mins by HTRF assay
- ChEMBL_604866 Inhibition of Escherichia coli type I phosphomannose isomerase assessed as D-mannose 6-phosphate to D-fructose 6-phosphate isomerization at pH 7.1 by PGI/G6PDH coupled enzyme spectrophotometric assay
- ChEMBL_604867 Inhibition of Saccharomyces cerevisiae type I phosphomannose isomerase assessed as D-mannose 6-phosphate to D-fructose 6-phosphate isomerization at pH 7.1 by PGI/G6PDH coupled enzyme spectrophotometric assay
- ChEMBL_1670147 Competitive inhibition of 6xHis-tagged human liver glycogen phosphorylase-a expressed in Escherichia coli BL21 Gold (DE3) assessed as release of inorganic phosphate using varying levels of glucose-1-phosphate and constant concentration of AMP and glycogen preincubated for 15 mins with AMP and glycogen followed by glucose-1-phosphate addition by Lineweaver-Burk plot method
- ChEBML_153319 In vitro inhibition of purine nucleoside phosphorylase from calf spleen in 1 mM phosphate
- ChEBML_65103 Competitive inhibitory activity with respect to EPSP (5-enolpyruvyl-shikimate- 3-phosphate) synthase
- ChEBML_72895 Inhibitory concentration against glyceraldehyde-3-phosphate dehydrogenase was determined as log 1/IC50
- ChEBML_90659 Inhibitory concentration against imidazole glycerol phosphate dehydratase (IGPD) from Cryptococcus neoformans
- ChEMBL_1449753 Inhibition of rabbit skeletal muscle glycogen phosphorylase b assessed as inorganic phosphate release
- ChEMBL_1458320 Inhibition of SHP2 (unknown origin) using p-nitrophenyl phosphate substrate by microplate spectrophotometry
- ChEMBL_1462478 Inhibition of STEP (unknown origin) in absence of GSH by p-nitrophenyl phosphate hydrolysis assay
- ChEMBL_153319 In vitro inhibition of purine nucleoside phosphorylase from calf spleen in 1 mM phosphate
- ChEMBL_1548347 Inhibition of human recombinant PTP1B using p-nitrophenyl phosphate as substrate by spectrophotometric analysis
- ChEMBL_1554435 Competitive inhibition of rabbit muscle glycogen phosphorylase b in presence of glucose 1-phosphate
- ChEMBL_1586214 Inhibition of PTP1B (unknown origin) using p-nitrophenyl phosphate as substrate by colorimetric method
- ChEMBL_1586215 Inhibition of TCPTP (unknown origin) using p-nitrophenyl phosphate as substrate by colorimetric method
- ChEMBL_1752096 Agonist activity at P2Y2 receptor (unknown origin) assessed as reduction in inositol phosphate accumulation
- ChEMBL_312848 Inhibition of U-46,619-induced inositol phosphate accumulation at human Thromboxane A2 receptor
- ChEMBL_322135 Effective concentration against US28-mediated inositol phosphate production in COS-7 cells
- ChEMBL_424478 Activity at human NK3 receptor assessed as stimulation of inositol phosphate generation in CHO cells
- ChEMBL_48586 Inhibition of inositol phosphate production induced by Cholecystokinin type B receptor (0.5 nM)
- ChEMBL_542431 Inhibition of human G6PDH using glucose-6-phosphate as substrate by Lineweaver-Burke plot
- ChEMBL_64950 Tested for the inhibition against Escherichia coli 5-enolpyruvyl-shikimate-3-phosphate synthase
- ChEMBL_72895 Inhibitory concentration against glyceraldehyde-3-phosphate dehydrogenase was determined as log 1/IC50
- ChEMBL_860252 Agonist activity at mouse GPR142 expressed in HEK293 cells by inositol phosphate accumulation assay
- ChEMBL_90659 Inhibitory concentration against imidazole glycerol phosphate dehydratase (IGPD) from Cryptococcus neoformans
- ChEMBL_90660 Binding affinity imidazole glycerol phosphate dehydratase (IGPD) obtained from Cryptococcus neoformans
- ChEMBL_1619019 Inhibition of human recombinant liver glycogen phosphorylase A expressed in baculovirus infected Sf9 insect cells assessed as release of phosphate from glucose-1- phosphate in presence of 7.5 mM glucose by malachite green based assay
- ChEMBL_1630550 Competitive inhibition of rabbit muscle glycogen phosphorylase-a assessed as release of inorganic phosphate using varying levels of glucose-1-phosphate and constant concentration of AMP and glycogen measured after 1 min by Dixon plot method
- ChEMBL_1924594 Activation of human recombinant glucokinase using 5 mM glucose monitored over 5 mins in presence of NAD+ and glucose 6-phosphate 4% human serum albumin by glucose 6-phosphate dehydrogenase coupled assay
- ChEMBL_767067 Inhibition of Mycobacterium tuberculosis DXR assessed as reduction of 1-deoxy-D-xylulose 5-phosphate into 2-C-methyl-D-erythritol-4-phosphate measured for every 5 secs upto 500 secs by spectrophotometry analysis
- Enzyme Inhibition Assay The activity of the compounds is determined by measuring the inhibitory effect of the compounds in the direction of glycogen synthesis, the conversion of glucose-1-phosphate into glycogen with the release of inorganic phosphate, which was monitored using microplate reader (BIO-RAD). The phosphate absorbance was measured at 655 nm. The IC50 values were estimated by fitting the inhibition data to a dose dependent curve using a logistic derivative equation.
- ChEBML_162111 Inhibitory potency for the protein tyrosine phosphatase (PTP 1B)-catalyzed hydrolysis of p-nitrophenol phosphate
- ChEBML_1685483 Inhibition of recombinant human PTP1B using p-nitrophenyl phosphate as substrate after 30 mins
- ChEBML_64958 Dissociation constant was calculated for Escherichia coli EPSP(5-enolpyruvyl-shikimate-3-phosphate) Synthase
- ChEBML_65094 The compound was tested for the inhibition of Escherichia coli 5-enolpyruvyl-shikimate-3-phosphate synthase (EPSP).
- ChEMBL_1335408 Inhibition of PTP1B (unknown origin) using nitrophenyl phosphate as substrate after 30 mins by spectrophotometry
- ChEMBL_1362995 Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assay
- ChEMBL_1367645 Inhibition of CDK1 (unknown origin) assessed as inhibition of phosphate incorporation into substrate in presence of radiolabeled ATP
- ChEMBL_1367646 Inhibition of CDK5 (unknown origin) assessed as inhibition of phosphate incorporation into substrate in presence of radiolabeled ATP
- ChEMBL_1367647 Inhibition of DYRK1A (unknown origin) assessed as inhibition of phosphate incorporation into substrate in presence of radiolabeled ATP
- ChEMBL_1367652 Inhibition of CLK1 (unknown origin) assessed as inhibition of phosphate incorporation into substrate in presence of radiolabeled ATP
- ChEMBL_1449543 Inhibition of rabbit muscle glycogen phosphorylase b at pH 6.8 assessed as inorganic phosphate release
- ChEMBL_1461022 Inhibition of PRL3 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylation
- ChEMBL_1461023 Inhibition of PRL2 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylation
- ChEMBL_1461024 Inhibition of PRL1 (unknown origin) using DiFMUP as fluorogenic phosphate substrate assessed as DiFMUP dephosphorylation
- ChEMBL_1476393 Inhibition of recombinant human PTP1B using p-nitrophenyl phosphate as substrate after 40 mins
- ChEMBL_1497576 Inhibition of PTP1B (unknown origin) using p-nitrophenyl phosphate as substrate after 30 mins
- ChEMBL_153321 Inhibition of purine nucleoside phosphorylase against the enzyme from calf spleen in 1 mM phosphate
- ChEMBL_1575591 Inhibition of human sphingosine 1-phosphate lyase after 22 hrs by umbelliferone fluorescence analysis
- ChEMBL_1586209 Inhibition of human TCPTP using p-nitrophenyl phosphate as substrate by micro plate reader method
- ChEMBL_1705037 Inhibition of PTP1B (unknown origin) using p-nitrophenyl phosphate substrate incubated for 30 mins
- ChEMBL_1705038 Inhibition of SHP2 (unknown origin) using p-nitrophenyl phosphate substrate incubated for 30 mins
- ChEMBL_1705039 Inhibition of PTPLAR (unknown origin) using p-nitrophenyl phosphate substrate incubated for 30 mins
- ChEMBL_1705040 Inhibition of TCPTP (unknown origin) using p-nitrophenyl phosphate substrate incubated for 30 mins
- ChEMBL_1746765 Inhibition of SHP2 (unknown origin) using 3-o-methylfluorescein phosphate as substrate by fluorescence assay
- ChEMBL_1746770 Inhibition of SHP1 (unknown origin) using 3-o-methylfluorescein phosphate as substrate by fluorescence assay
- ChEMBL_1844001 Binding affinity to bovine beta-trypsin in phosphate/HEPES/Tricine/Tris buffer by ITC method
- ChEMBL_1844002 Binding affinity to human alpha-thrombin in phosphate/HEPES/Tricine/Tris buffer by ITC method
- ChEMBL_1986994 Inhibition of SHP2 (unknown origin) using 3-o-methylfluorescein phosphate as substrate by fluorescence assay
- ChEMBL_1986997 Inhibition of SHP1 (unknown origin) using 3-o-methylfluorescein phosphate as substrate by fluorescence assay
- ChEMBL_2015157 Inhibition of human CD73 using AMP as substrate by Malachite green phosphate reagent-based assay
- ChEMBL_208010 Inhibition of HSV-1 thymidine kinase, 1 uM [3H]thymidine and ATP as phosphate donor
- ChEMBL_208029 Inhibition of HSV-2 thymidine kinase, 2 uM [3H]thymidine and ATP as phosphate donor
- ChEMBL_303534 In vitro inhibitory concentration against Protein-tyrosine phosphatase 1B hydrolysis of p-nitrophenol phosphate
- ChEMBL_306715 Inhibitory concentration against human glutathione reductase in the absence of glucose-6-phosphate dehydrogenase (G6PDH)
- ChEMBL_306877 Inhibition of CCK-Induced inositol phosphate production in Cos-7 cells expressing human CCK1R
- ChEMBL_317580 Inhibition of CCK-Induced inositol phosphate in Cos-7 cells expressing mutant CCK1R (I352A)
- ChEMBL_317584 Inhibition of CCK-induced inositol phosphate in Cos-7 cells expressing mutant CCK1R (F107A)
- ChEMBL_317585 Inhibition of CCK-induced inositol phosphate in Cos-7 cells expressing mutant CCK1R (I329A)
- ChEMBL_317586 Inhibition of CCK-Induced inositol phosphate in Cos-7 cells expressing mutant CCK1R (I329F)
- ChEMBL_317587 Inhibition of CCK-Induced inositol phosphate in Cos-7 cells expressing mutant CCK1R (I352A)
- ChEMBL_317588 Inhibition of CCK-Induced inositol phosphate in Cos-7 cells expressing mutant CCK1R (M195L)
- ChEMBL_317589 Inhibition of CCK-Induced inositol phosphate in Cos-7 cells expressing mutant CCK1R (R197M)
- ChEMBL_317590 Inhibition of CCK-Induced inositol phosphate in Cos-7 cells expressing mutant CCK1R (R336M)
- ChEMBL_317591 Inhibition of CCK-Induced inositol phosphate in Cos-7 cells expressing mutant CCK1R (S342A)
- ChEMBL_317592 Inhibition of CCK-Induced inositol phosphate in Cos-7 cells expressing mutant CCK1R (S348A)
- ChEMBL_317593 Inhibition of CCK-Induced inositol phosphate in Cos-7 cells expressing mutant CCK1R (T117A)
- ChEMBL_382561 Inhibition of kinesin ATPase activity by enzyme-linked inorganic phosphate detection assay without preincubation
- ChEMBL_424431 Activity at human NK3 receptor expressed in CHO cells assessed as increase in inositol phosphate generation
- ChEMBL_430293 Displacement of [33P]sphingosine 1 phosphate from human S1P1 receptor expressed in CHO cells
- ChEMBL_430294 Displacement of [33P]sphingosine 1 phosphate from human S1P2 receptor expressed in CHO cells
- ChEMBL_430295 Displacement of [33P]sphingosine 1 phosphate from human S1P3 receptor expressed in CHO cells
- ChEMBL_430296 Displacement of [33P]sphingosine 1 phosphate from human S1P4 receptor expressed in CHO cells
- ChEMBL_430297 Displacement of [33P]sphingosine 1 phosphate from human S1P5 receptor expressed in CHO cells
- ChEMBL_542429 Inhibition of Trypanosoma brucei G6PDH using glucose-6-phosphate as substrate by Lineweaver-Burke plot
- ChEMBL_581483 Inhibition of ATPase activity of SARS coronavirus helicase assessed as phosphate release by malachite green assay
- ChEMBL_590794 Agonist activity at human NK3 receptor expressed in cells assessed as accumulation of [3H]inositol phosphate
- ChEMBL_598343 Inhibition of recombinant human PTP1B assessed as hydrolysis of p-nitrophenyl phosphate after 30 mins
- ChEMBL_602838 Antagonist activity at human mGluR5 assessed as inhibition of quisqualate-induced intracellular inositol phosphate accumulation
- ChEMBL_63499 Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.
- ChEMBL_64958 Dissociation constant was calculated for Escherichia coli EPSP(5-enolpyruvyl-shikimate-3-phosphate) Synthase
- ChEMBL_64961 Tested for the dissociation constant against Escherichia coli 5-enolpyruvyl-shikimate-3-phosphate synthase
- ChEMBL_64963 The compound was tested for the inhibition of Escherichia coli 5-enolpyruvyl-shikimate-3-phosphate synthase (EPSP).
- ChEMBL_65087 Binding affinity against Escherichia coli EPSP(5-enolpyruvyl-shikimate-3-phosphate) synthase
- ChEMBL_65094 The compound was tested for the inhibition of Escherichia coli 5-enolpyruvyl-shikimate-3-phosphate synthase (EPSP).
- ChEMBL_65099 Tested for the dissociation rate against Escherichia coli 5-enolpyruvyl-shikimate-3-phosphate synthase
- ChEMBL_65101 Tested for the rate of association against Escherichia coli 5-enolpyruvyl-shikimate-3-phosphate synthase
- ChEMBL_70746 Inhibition of rat brain farnesyltransferase in 5 mM potassium phosphate and 50 mM HEPES buffer
- ChEMBL_72880 Tested for the inhibitory activity against Glycosomal glyceraldehyde 3-phosphate dehydrogenase (gGAPDH) of Leishmania mexicana
- ChEMBL_72889 Tested for the inhibitory activity against Glycosomal glyceraldehyd 3-phosphate dehydrogenase (gGAPDH) of Trypanosoma brucei
- ChEMBL_72890 Tested for the inhibitory activity against Glycosomal glyceraldehyde 3-phosphate dehydrogenase (gGAPDH) of Trypanosoma brucei
- ChEMBL_72902 Tested for the inhibitory activity against Glycosomal glyceraldehyde 3-phosphate dehydrogenase (gGAPDH) of human erythrocyte
- ChEMBL_743338 Inhibition of full length recombinant ATR after 24 hrs by radiometric phosphate incorporation assay
- ChEMBL_743383 Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assay
- ChEMBL_744737 Agonist activity at human 5HT2C receptor expressed in HEK293 cells by inositol phosphate accumulation assay
- ChEMBL_744739 Agonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assay
- ChEMBL_748961 Inhibition of recombinant human PTP1B using p-nitrophenyl phosphate as substrate after 30 mins
- ChEMBL_753876 Inhibition of Calmodulin-dependent PDE1 activity assessed as inorganic phosphate release after 30 min
- ChEMBL_802298 Inhibition of rabbit muscle glycogen phosphorylase b assessed as inorganic phosphate release at pH 6.8
- ChEMBL_839558 Agonist activity at P2Y6 receptor expressed in human 1321N1 cells assessed as inositol phosphate accumulation
- ChEMBL_856703 Inhibition of human recombinant PTP1B using p-nitrophenyl phosphate as substrate after 30 mins
- ChEMBL_862643 Inhibition of human glucose-6-phosphate dehydrogenase after 90 mins by resazurin/diaphorasecoupled assay
- ChEMBL_862644 Inhibition of Plasmodium falciparum glucose-6-phosphate dehydrogenase after 45 mins by orthogonal assay
- Enzyme Assay The rate of carbamoyl phosphate synthesis was determined by use of a coupled enzyme assay with ornithine transcarbamoylase.
- ChEMBL_1670149 Competitive inhibition of rabbit muscle glycogen phosphorylase-a in presence of varying levels of glucose-1-phosphate and constant concentration of glycogen and AMP preincubated for 15 mins with AMP and glycogen followed by glucose-1-phosphate addition by Lineweaver-Burk plot method
- ChEBML_153324 Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from calf spleen in 50 mM phosphate
- ChEBML_153325 Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphate
- ChEBML_1651766 Inhibition of recombinant human ATX using bisP-nitrophenyl phosphate as substrate measured after 30 mins
- ChEBML_1717872 Inhibition of PTP1B (unknown origin) using p-nitrophenyl phosphate as substrate measured after 30 mins
- ChEBML_64947 Compound was tested for inhibitory activity against EPSP(5-enolpyruvylshikimate 3-phosphate) synthase in Escherichia coli.
- ChEBML_65093 Tested for the inhibition against Escherichia coli 5-enolpyruvyl-shikimate-3-phosphate synthase versus phosphoenolpyruvate
- ChEBML_70678 KI for pyridoxal 5'-phosphate (PLP)-dependent Gamma-amino-N-butyrate transaminase at pH 7.4
- ChEMBL_1288272 Inhibition of mouse EAP using p-nitrophenyl phosphate as substrate after 30 mins by chemiluminescence assay
- ChEMBL_1500295 Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by inositol phosphate turnover assay
- ChEMBL_1520498 Binding affinity to Grb7-SH2 domain (unknown origin) without using phosphate buffer by SPR analysis
- ChEMBL_153322 Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from calf spleen in 50 mM phosphate
- ChEMBL_153323 Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from calf spleen in 1 mM phosphate
- ChEMBL_153324 Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from calf spleen in 50 mM phosphate
- ChEMBL_1538843 Inhibition of GPAT1 (unknown origin) by CPM assay using glycerol-3-phosphate and oleoyl-CoA as substrate
- ChEMBL_1546979 Binding affinity to Salmonella typhi glucose-1-phosphate cytidylyl-transferase assessed as dissociation constant by spectrophotometry
- ChEMBL_1619017 Inhibition of rabbit muscle glycogen phosphorylase b using alpha-D-glucose-1-phosphate as substrate
- ChEMBL_1651766 Inhibition of recombinant human ATX using bisP-nitrophenyl phosphate as substrate measured after 30 mins
- ChEMBL_1767106 Inhibition of recombinant human GST-tagged PTP1B catalytic domain using para-nitrophenyl phosphate as substrate
- ChEMBL_2168507 Inhibition of human SHIP2 (419 to 732 residues) expressed in Escherichia coli by malachite green phosphate assay
- ChEMBL_216946 Inhibitory potency for brewer's yeast alpha-glucosidase in 0.1 M sodium phosphate buffer at pH 6.55.
- ChEMBL_29964 50% inhibition of human placental alkaline phosphatase in the presence of 10 mM p-nitrophenyl phosphate as substrate
- ChEMBL_361236 Antagonist activity at human recombinant GnRH receptor assessed as inhibition of GnRH-stimulated inositol phosphate accumulation
- ChEMBL_361237 Antagonist activity at rat pituitary GnRH receptor assessed as inhibition of GnRH-stimulated inositol phosphate accumulation
- ChEMBL_399839 Inhibition of non-phosphorylated form of rabbit muscle glycogen phosphorylase in presence of glycogen and 45 mM phosphate
- ChEMBL_399840 Inhibition of non-phosphorylated form of rabbit muscle glycogen phosphorylase in presence of 6.17 mM glycogen and phosphate
- ChEMBL_424432 Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of inositol phosphate generation
- ChEMBL_424463 Activity at human NK3 receptor assessed as inhibition of senktide-stimulated inositol phosphate generation in CHO cells
- ChEMBL_440404 Agonist activity at mGlu4 receptor expressed in HEK 293 cells assessed as effect on inositol phosphate production
- ChEMBL_440405 Agonist activity at mGlu6 receptor expressed in HEK 293 cells assessed as effect on inositol phosphate production
- ChEMBL_440406 Agonist activity at mGlu7 receptor expressed in HEK 293 cells assessed as effect on inositol phosphate production
- ChEMBL_440407 Agonist activity at mGlu8 receptor expressed in HEK 293 cells assessed as effect on inositol phosphate production
- ChEMBL_445954 Agonist activity at rat mGluR4 receptor expressed HEK293 cells assessed as effect on inositol phosphate production
- ChEMBL_445955 Agonist activity at rat mGluR6 receptor expressed HEK293 cells assessed as effect on inositol phosphate production
- ChEMBL_445956 Agonist activity at rat mGluR7 receptor expressed HEK293 cells assessed as effect on inositol phosphate production
- ChEMBL_445957 Agonist activity at rat mGluR8 receptor expressed HEK293 cells assessed as effect on inositol phosphate production
- ChEMBL_457690 Antagonist activity at human CRTH2 receptor assessed as inhibition of PGD2-induced signaling by inositol-phosphate assay
- ChEMBL_460661 Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphate
- ChEMBL_590795 Agonist activity at guinea pig NK3 receptor expressed in cells assessed as accumulation of [3H]inositol phosphate
- ChEMBL_64947 Compound was tested for inhibitory activity against EPSP(5-enolpyruvylshikimate 3-phosphate) synthase in Escherichia coli.
- ChEMBL_64955 Compound was tested for inhibitory activity against EPSP(5-enolpyruvylshikimate 3-phosphate) synthase in Escherichia coli.
- ChEMBL_64960 Inhibitory activity was evaluated against Escherichia coli EPSP(5-enolpyruvyl-shikimate-3-phosphate) Synthase
- ChEMBL_65086 Compound was tested for inhibitory activity against EPSP(5-enolpyruvylshikimate 3-phosphate) synthase in Escherichia coli.
- ChEMBL_65093 Tested for the inhibition against Escherichia coli 5-enolpyruvyl-shikimate-3-phosphate synthase versus phosphoenolpyruvate
- ChEMBL_65096 Compound was tested for inhibitory activity against EPSP(5-enolpyruvylshikimate 3-phosphate) synthase in Escherichia coli.
- ChEMBL_754327 Inhibition of human recombinant PTP1B assessed as inhibition of para-nitrophenyl phosphate to para-nitrophenol conversion by spectrophotometry
- ChEMBL_798051 Inhibition of PTP1B assessed as para-nitrophenyl phosphate catalyzed hydrolysis of para-nitrophenol by p-NPP assay
- ChEMBL_801146 Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry
- ChEMBL_831490 Inhibition of GST-tagged human recombinant PTP1B using para-nitrophenyl phosphate as substrate by spectrophotometric analysis
- ChEMBL_862647 Inhibition of Plasmodium falciparum glucose-6-phosphate dehydrogenase after 2 hrs by resazurin/diaphorasecoupled assay
- ChEMBL_1670148 Competitive inhibition of rabbit muscle glycogen phosphorylase-b in presence of varying levels of glucose-1-phosphate and constant concentration of glycogen and AMP preincubated for 15 mins with AMP and glycogen followed by glucose-1-phosphate addition by Lineweaver-Burk plot method
- ChEMBL_1630554 Competitive inhibition of rabbit muscle glycogen phosphorylase-b assessed as release of inorganic phosphate using varying levels of glucose-1-phosphate and constant concentration of AMP and glycogen measured at 1 min time interval for 1 to 5 mins by Hill plot method
- ChEMBL_2027541 Inhibition of active recombinant human N-terminal His-tagged 11-betaHSD1 expressed in Escherichia coli using cortisone, NADPH and glucose-6-phosphate incubated for 2 hrs by glucose-6-phosphate dehydrogenase based coupled HTRF immuno-competitive assay
- ChEMBL_1361029 Antagonist activity at human recombinant 5-HT2A receptor assessed as inhibition of serotonin-induced inositol phosphate accumulation
- ChEMBL_1361031 Antagonist activity at human recombinant 5-HT2C receptor assessed as inhibition of serotonin-induced inositol phosphate accumulation
- ChEMBL_1363386 Antagonist activity at human GPR103 receptor assessed as inhibition of inositol-1-phosphate production by cell-based assay
- ChEMBL_1436200 Inhibition of Mycobacterium tuberculosis IspC using 1-deoxy-D-xylulose 5-phosphate as substrate by photometric analysis
- ChEMBL_1448918 Inhibition of PHOSPHO1 phosphoethanolamine activity (unknown origin) assessed as amount of inorganic phosphate release after 30 mins
- ChEMBL_145032 Ability to inhibit OT-induced inositol phosphate accumulation was determined in CHO cells expressing the human OT receptor
- ChEMBL_1476391 Inhibition of recombinant human PTP1B (1 to 299) expressed in Escherichia coli using p-nitrophenyl phosphate as substrate
- ChEMBL_1476723 Agonist activity at rat mGluR2 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay
- ChEMBL_1476724 Agonist activity at rat mGluR4 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay
- ChEMBL_1476726 Agonist activity at rat mGluR6 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay
- ChEMBL_1476727 Agonist activity at rat mGluR7 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay
- ChEMBL_1476728 Agonist activity at rat mGluR8 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay
- ChEMBL_1476729 Agonist activity at rat mGluR1 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay
- ChEMBL_1476730 Agonist activity at rat mGluR5 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay
- ChEMBL_1520499 Binding affinity to Grb7-SH2 domain (unknown origin) using 100 mM phosphate buffer by SPR analysis
- ChEMBL_1566144 Inhibition of recombinant human PTP-1B expressed in Escherichia coli TB1 using p-nitrophenyl phosphate as substrate
- ChEMBL_1586211 Inhibition of human recombinant PTP1B expressed in Escherichia coli using p-nitrophenyl phosphate as substrate by UV spectroscopy
- ChEMBL_162594 Inhibitory effect against protein-tyrosine phosphatase Lar, using p-nitrophenyl phosphate as substrate at pH 5.5.
- ChEMBL_1630545 Competitive inhibition of rabbit muscle glycogen phosphorylase-b in presence of varying glucose-1-phosphate levels and NADP
- ChEMBL_1793242 Competitive inhibition of Mycobacterium tuberculosis PtpA using p-nitrophenyl phosphate as substrate by Michaelis-Menten plot analysis
- ChEMBL_201317 Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 1 expressed on CHO cell membranes
- ChEMBL_201334 Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 3 expressed on CHO cell membranes
- ChEMBL_201335 Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
- ChEMBL_201454 Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 5 expressed on CHO cell membranes
- ChEMBL_2130000 Inhibition of SLK (unknown origin) assessed as transfer of radiolabelled phosphate group from ATP by reaction biology method
- ChEMBL_2130002 Inhibition of CLK2 (unknown origin) assessed as transfer of radiolabelled phosphate group from ATP by reaction biology method
- ChEMBL_2130003 Inhibition of GSK3alpha (unknown origin) assessed as transfer of radiolabelled phosphate group from ATP by reaction biology method
- ChEMBL_2130004 Inhibition of GSK3beta (unknown origin) assessed as transfer of radiolabelled phosphate group from ATP by reaction biology method
- ChEMBL_304296 Effective concentration against sphingosine-1-phosphate receptor 1 determined by a [c-35S]-GTP binding assay
- ChEMBL_304306 Effective concentration against sphingosine 1-phosphate receptor 2 determined by a [c-35S]-GTP binding assay
- ChEMBL_304307 Effective concentration against sphingosine 1-phosphate receptor 3 determined by a [c-35S]-GTP binding assay
- ChEMBL_304308 Effective concentration against sphingosine 1-phosphate receptor 4 determined by a [c-35S]-GTP binding assay
- ChEMBL_304309 Effective concentration against sphingosine 1-phosphate receptor 5 determined by a [c-35S]-GTP binding assay
- ChEMBL_304324 Effective concentration to activate wild-type P2Y1 receptor expressed in COS-7 cells for the accumulation of inositol phosphate
- ChEMBL_306053 Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 1 expressed on CHO cell membranes
- ChEMBL_306054 Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 2 expressed on CHO cell membranes
- ChEMBL_306055 Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 3 expressed on CHO cell membranes
- ChEMBL_306056 Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 4 expressed on CHO cell membranes
- ChEMBL_306057 Inhibition of [33P]-S1P binding to human Sphingosine 1-phosphate receptor 5 expressed on CHO cell membranes
- ChEMBL_313020 Inhibition of PGD2-induced inositol phosphate formation at human chemoattractant receptor-homologous molecule expressed on TH2 cells
- ChEMBL_382280 Activity at rat CaSR in CHO cells assessed as inhibition of calcium ion-induced [3H]inositol phosphate accumulation
- ChEMBL_382560 Inhibition of kinesin ATPase activity by enzyme-linked inorganic phosphate detection assay with 5 mins pre-incubation
- ChEMBL_40068 Inhibitory effect against human CD45 tyrosine phosphatase using p-nitrophenyl phosphate substrate at a pH 7.0
- ChEMBL_447478 Inhibition of human GnRHR expressed in RBL cells assessed as inhibition of GnRH-stimulated [3H]inositol phosphate hydrolysis
- ChEMBL_481449 Inhibition of lyase activity of rat DNA polymerase beta after 30 mins by deoxyribose phosphate excision assay
- ChEMBL_535725 Inhibition of Mycobacterium tuberculosis cloned 1-deoxy-D-xylulose-5-phosphate synthase expressed in Escherichia coli
- ChEMBL_543916 Inhibition of recombinant calmodulin mediated bovine brain PDE1 activation assessed as effect on inorganic phosphate release by spectrophotometry
- ChEMBL_556099 Agonist activity at rat 5HT2A receptor expressed in mouse NIH3T3 cells assessed as stimulation of inositol phosphate accumulation
- ChEMBL_559825 Binding affinity to PSMA in human LNCaP cells assessed as cell surface binding in phosphate-buffered saline buffer
- ChEMBL_559827 Binding affinity to PSMA in human PC3 cells assessed as cell surface binding in phosphate-buffered saline buffer
- ChEMBL_600348 Agonist activity at 5HT2A receptor expressed in HEK cells assessed as inhibition of serotonin-induced inositol phosphate accumulation
- ChEMBL_610374 Inhibition of SHP1 expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry
- ChEMBL_610375 Inhibition of PTP1B expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry
- ChEMBL_610376 Inhibition of HePTP expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry
- ChEMBL_610377 Inhibition of Lyp expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry
- ChEMBL_610378 Inhibition of FAP1 expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry
- ChEMBL_610379 Inhibition of CD45 expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry
- ChEMBL_610380 Inhibition of LAR expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry
- ChEMBL_610381 Inhibition of PTPalpha expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry
- ChEMBL_610382 Inhibition of VHR expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry
- ChEMBL_610383 Inhibition of Cdc14A expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry
- ChEMBL_610384 Inhibition of LMWPTP expressed in Escherichia coli assessed as inhibition of p-nitrophenyl phosphate hydrolysis at pH 7 by spectrophotometry
- ChEMBL_612567 Activity at human 5HT2A receptor expressed in HEK293 cells assessed as [3H]inositol phosphate production by scintillation counting
- ChEMBL_634153 Inverse agonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of inositol phosphate accumulation
- ChEMBL_662795 Antagonist activity at human bradykinin B1 receptor in human MR5 cells assessed as [3H]inositol phosphate accumulation
- ChEMBL_801147 Inhibition of Mycobacterium tuberculosis PTP-B using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry
- ChEMBL_821949 Inhibition of human Tdp1 using 3'-phosphate-(4-methylumbelliferone)-thymidine as substrate after 180 mins by spectrophotometry
- ChEMBL_886806 Inhibition of human recombinant PTP1B using p-nitrophenyl phosphate as substrate after 30 mins by spectrophotometric analysis
- ChEMBL_962306 Inhibition of human recombinant GST-tagged PTP1B using para-nitrophenyl phosphate as substrate after 2 mins
- ChEMBL_972706 Agonist activity at human GPR142 transfected in HEK293 cells after 1 hr by inositol phosphate accumulation assay
- Competitive Inhibition Assay PNPase activity (guanosine to guanine and ribose 1-phosphate) was followed by measuring the decrease in absorbance at 268nm.
- Inhibition Assay Pooled human liver microsome suspension (20 mg/mL) was diluted with phosphate buffer to obtain a 5 mg/mL suspension. A solution of NADPH was prepared in phosphate buffer at a concentration of 5 mM. Separate stock solutions of each substrate were prepared in DMSO:MeCN (50:50 v/v), mixed, and diluted in phosphate buffer to obtain a single solution containing each substrate at five times its experimentally determined Km concentration.
- ChEBML_143203 Agonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphate
- ChEBML_219283 Ability to inhibit yeast glyoxalase I enzyme in 0.05 M phosphate buffer, pH 6.6, 30 degree C
- ChEBML_32781 Dissociation constant in high affinity sites where the binding is in 50 mM phosphate buffer for Alpha-2 adrenergic receptor
- ChEBML_32783 Dissociation constant in low affinity sites where the binding is in 50 mM phosphate buffer for Alpha-2 adrenergic receptor
- ChEMBL_1288117 Competitive inhibition Trypanosoma brucei PFK using fructose-6-phosphate as substrate by Line-weaver Burk plot analysis
- ChEMBL_143203 Agonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphate
- ChEMBL_1458873 Antagonist activity at alphavbeta1 integrin receptor in HEK293 cells after 4 hrs using p-nitrophenyl phosphate by colorimetry
- ChEMBL_1458874 Antagonist activity at alphavbeta3 integrin receptor in HEK293 cells after 4 hrs using p-nitrophenyl phosphate by colorimetry
- ChEMBL_1458875 Antagonist activity at alphavbeta5 integrin receptor in HEK293 cells after 4 hrs using p-nitrophenyl phosphate by colorimetry
- ChEMBL_1458878 Antagonist activity at alpha5beta1 integrin receptor in K562 cells after 4 hrs using p-nitrophenyl phosphate by colorimetry
- ChEMBL_1511315 Inhibition of recombinant human GAPDH assessed as oxidative phosphorylation of D-glyceraldehyde-3-phosphate to 1,3-bisphosphoglycerate by spectrophotometric method
- ChEMBL_1548346 Competitive inhibition of human recombinant PTP1B using p-nitrophenyl phosphate as substrate by spectrophotometry based Lineweaver-Burk plot
- ChEMBL_1554437 Competitive inhibition of rabbit muscle glycogen phosphorylase b by Lineweaver-Burk plot analysis in presence of glucose 1-phosphate
- ChEMBL_1586208 Inhibition of human recombinant PTP1B catalytic domain using p-nitrophenyl phosphate as substrate by micro plate reader method
- ChEMBL_162595 Inhibitory effect against human Protein-tyrosine phosphatase Lar using p-nitrophenyl phosphate substrate at a pH 7.0
- ChEMBL_1793241 Non-competitive inhibition of Mycobacterium tuberculosis PtpA using p-nitrophenyl phosphate as substrate by Michaelis-Menten plot analysis
- ChEMBL_1812157 Binding affinity to recombinant human CA2 in pH 7 sodium phosphate buffer at 37 degC by isothermal titration calorimetry
- ChEMBL_2014923 Inhibition of SHP2 catalytic domain (unknown origin) using p-nitrophenyl phosphate as substrate incubated for 10 to 15 mins
- ChEMBL_216862 In vitro inhibition of the c-src tyrosine kinase activity in A431 membranes using angiotensin II as phosphate acceptor as substrate
- ChEMBL_226175 In vitro inhibition of the v-abl tyrosine kinase activity in A431 membranes using angiotensin II as phosphate acceptor as substrate
- ChEMBL_29963 Concentration required for 50% inhibition of human leukocyte alkaline phosphatase in the presence of 10 mM p-nitrophenyl phosphate as substrate
- ChEMBL_29968 Concentration required for 50% inhibition of human leukocyte alkaline phosphatase in the presence of 10 mM p-nitrophenyl phosphate as substrate
- ChEMBL_304388 Effective concentration required for the activation of wild-type P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate
- ChEMBL_30932 Inhibitory constant against adenosine deaminase in 0.05 M sodium phosphate buffer at pH 7.0 was determined before heating
- ChEMBL_30933 Inhibitory constant against adenosine deaminase in 0.05 M sodium phosphate buffer at pH 7.0, was determined before heating
- ChEMBL_32781 Dissociation constant in high affinity sites where the binding is in 50 mM phosphate buffer for Alpha-2 adrenergic receptor
- ChEMBL_32783 Dissociation constant in low affinity sites where the binding is in 50 mM phosphate buffer for Alpha-2 adrenergic receptor
- ChEMBL_363668 Activity at human B2 receptor transfected in CHO cells assessed as ability to antagonize BK-induced inositol-phosphate accumulation
- ChEMBL_48440 Effective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptor
- ChEMBL_495152 Antagonist activity at human GnRH receptor expressed in RBL1 cells assessed as inhibition of GnRH-stimulated inositol phosphate production
- ChEMBL_565878 Activation of human glucokinase by glucose-6-phosphate dehydrogenase coupled continuous spectrophotometric assay in presence of 2.5 mM glucose
- ChEMBL_565879 Activation of human glucokinase by glucose-6-phosphate dehydrogenase coupled continuous spectrophotometric assay in presence of 10 mM glucose
- ChEMBL_634094 Competitive reversible inhibition of Trypanosoma brucei PFK expressed in Escherichia coli using fructose-6-phosphate by spectrophotometry analysis
- ChEMBL_642245 Inhibition of 6x-histidine-tagged human recombinant ATX expressed in HEK293 cells using bisP-nitrophenyl phosphate as a substrate
- ChEMBL_740875 Inhibition of squalene synthase assessed as conversion of [3H]farnesyl phosphate to [3H]squalene after 10 mins by scintillation counting
- ChEMBL_749305 Inhibition of Trypanosoma cruzi recombinant glycosomal GAPDH expressed in Escherichia coli using GAPDH and D-glyceraldehyde-3-phosphate
- ChEMBL_751030 Non-competitive inhibition of Mycobacterium tuberculosis PTPA using p-nitrophenyl phosphate as substrate by Lineweaver-Burk plot analysis
- ChEMBL_829769 Inhibition of MKP3 using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry
- ChEMBL_829770 Inhibition of PTP1B using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry
- ChEMBL_829772 Inhibition of PTPMT1 using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry
- ChEMBL_885380 Activation of recombinant rat glucokinase assessed measuring rate of glucose 6-phosphate formation using G6PDH/NADP coupling
- ChEMBL_885387 Activation of recombinant human glucokinase assessed measuring rate of glucose 6-phosphate formation using G6PDH/NADP coupling
- ChEMBL_930438 Inhibition of snake venom phosphodiesterase using bis-(para-nitrophenyl)phosphate as substrate after 30 min by spectrophotometric analysis
- ChEMBL_936606 Binding affinity to recombinant Tdp1 (unknown origin) using 3'-phosphate(GATCTAAAAGACTT) as substrate by surface plasmon resonance analysis
- ChEMBL_945952 Binding affinity to GST-tagged human TNF-alpha in 10 mM citrate-phosphate at pH 6.5 by fluorescence assay
- NMR (OBClip) The experimental studies were carried out in 20 mM sodium phosphate buffer at pH7.4, at a temperature of 298 K.
- PKA assay The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.
- UV/VIS The experimental studies were carried out in 20 mM sodium phosphate buffer at pH7.4, at a temperature of 298 K.
- cGPK assay The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.
- ChEMBL_1630548 Competitive inhibition of His6-tagged human liver glycogen phosphorylase-a expressed in Escherichia coli BL21 Gold (DE3) assessed as release of inorganic phosphate using varying levels of glucose-1-phosphate and constant concentration of AMP and glycogen measured after 1 min by Dixon plot method
- ChEBML_201314 Binding affinity to human Sphingosine 1-phosphate receptor 1 expressed in CHO cells was determined by using [33P]-S1P as radioligand
- ChEBML_201315 Binding affinity to human sphingosine 1-phosphate receptor 1 expressed in CHO cells was determined by using [33P]-S1P as radioligand
- ChEBML_201322 Binding affinity to human sphingosine 1-phosphate receptor 2 expressed in CHO cells was determined by using [33P]-S1P as radioligand
- ChEBML_201331 Binding affinity to human sphingosine 1-phosphate receptor 3 expressed in CHO cells was determined by using [33P]-S1P as radioligand
- ChEBML_201448 Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
- ChEBML_201449 Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
- ChEMBL_1283725 Inhibition of Escherichia coli thymidine phosphorylase using thymidine 5' mono phosphate as substrate after 10 mins by spectrophotometric analysis
- ChEMBL_1436199 Inhibition of Escherichia coli M15 recombinant IspC using 1-deoxy-D-xylulose 5-phosphate as substrate by photometric analysis
- ChEMBL_1458876 Antagonist activity at alphavbeta6 integrin receptor in human HT29 cells after 4 hrs using p-nitrophenyl phosphate by colorimetry
- ChEMBL_1462475 Inhibition of STEP (unknown origin) pre-incubated for 10 mins before addition of p-nitrophenyl phosphate substrate in absence of GSH
- ChEMBL_147734 Agonist activity by measuring inositol phosphate accumulation in 1321N1 human astrocytoma cells stably expressing human P2Y purinoceptor 11
- ChEMBL_147744 Agonist activity by measuring inositol phosphate accumulation in 1321N1 human astrocytoma cells stably expressing human P2Y purinoceptor 2
- ChEMBL_1508846 Inhibition of PIP5K1C (unknown origin) using D-myo-phosphatidylinositol 4-phosphate substrate and ATP by ADP-Glo kinase Assay
- ChEMBL_154380 Tested functionally in vitro for inducing 50% of the maximum alkaline phosphate activity (Transactivation) against Peroxisome proliferator activated receptor gamma
- ChEMBL_1548348 Non-competitive inhibition of human recombinant PTP1B using p-nitrophenyl phosphate as substrate by spectrophotometry based Lineweaver-Burk plot
- ChEMBL_162602 Inhibitory effect against human Protein-tyrosine phosphatase alpha (PTPalpha) using p-nitrophenyl phosphate substrate at a pH 7.0
- ChEMBL_162603 Inhibitory effect against human protein-tyrosine phosphatase alpha (PTPalpha), using p-nitrophenyl phosphate substrate at pH 5.5.
- ChEMBL_1821937 Inhibition of HK2 (unknown origin) using glucose-6-phosphate dehydrogenase as substrate preincubated for 10 mins followed by substrate addition
- ChEMBL_201314 Binding affinity to human Sphingosine 1-phosphate receptor 1 expressed in CHO cells was determined by using [33P]-S1P as radioligand
- ChEMBL_201322 Binding affinity to human sphingosine 1-phosphate receptor 2 expressed in CHO cells was determined by using [33P]-S1P as radioligand
- ChEMBL_201323 Binding affinity to human sphingosine 1-phosphate receptor 2 expressed in CHO cells was determined by using [33P]-S1P as radioligand
- ChEMBL_201331 Binding affinity to human sphingosine 1-phosphate receptor 3 expressed in CHO cells was determined by using [33P]-S1P as radioligand
- ChEMBL_201448 Binding affinity to human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
- ChEMBL_201451 Binding affinity to human sphingosine 1-phosphate receptor 5 expressed in CHO cells was determined by using [33P]-S1P as radioligand
- ChEMBL_201452 Binding affinity to human sphingosine 1-phosphate receptor 5 expressed in CHO cells was determined by using [33P]-S1P as radioligand
- ChEMBL_2014921 Inhibition of recombinant His6-fused SHP2 catalytic domain (unknown origin) using p-nitrophenyl phosphate as substrate by spectrophotometric analysis
- ChEMBL_2014922 Inhibition of recombinant His6-fused SHP1 catalytic domain (unknown origin) using p-nitrophenyl phosphate as substrate by spectrophotometric analysis
- ChEMBL_2107526 Competitive inhibition of G6PD (unknown origin) using glucose-6-phosphate and varying concentrations of NADP+ as substrate by Michaelis-Menten analysis
- ChEMBL_2161850 Displacement of sphingosine D-erythro [3-3H] I- phosphate from human S1P2 receptor expressed in CHO cell membrane
- ChEMBL_303616 In vitro binding affinity of compound towards rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay
- ChEMBL_304373 Effective concentration to activate human Y203F mutant strain P2Y1 receptor expressed in COS-7 cells for the accumulation of inositol phosphate
- ChEMBL_304374 Effective concentration to activate human Y273A mutant strain P2Y1 receptor expressed in COS-7 cells for the accumulation of inositol phosphate
- ChEMBL_304375 Effective concentration to activate human Y273F mutant strain P2Y1 receptor expressed in COS-7 cells for the accumulation of inositol phosphate
- ChEMBL_304376 Effective concentration to activate human Y306A mutant strain P2Y1 receptor expressed in COS-7 cells for the accumulation of inositol phosphate
- ChEMBL_304377 Effective concentration to activate human Y306F mutant strain P2Y1 receptor expressed in COS-7 cells for the accumulation of inositol phosphate
- ChEMBL_306712 Concentration required for 50% growth inhibition of rat metabotropic glutamate receptor 5 was determined using inositol phosphate hydrolysis assay
- ChEMBL_310796 Inhibition of (Thr,Nle)-CCK-9 -induced inositol phosphate production in COS-7 cells expressing human CCK2 receptor
- ChEMBL_312857 Inhibition of (Thr,Nle)-CCK-9-induced inositol phosphate production in COS-7 cells expressing human CCK2 receptor
- ChEMBL_49009 Inhibitory activity tested against cell division cycle 25A (assay using p-nitro phenyl phosphate (pNPP) as substrate)
- ChEMBL_584072 Activation of flag-tagged recombinant human liver glucokinase expressed in Escherichia coli assessed as glucose-6-phosphate dehydrogenase by spectrophotometry
- ChEMBL_607910 Inhibition of thymidine phosphorylase in T cell lymphomas of Sprague-Dawley rat in presence of 100 uM thymidine and 200 uM phosphate
- ChEMBL_63519 Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin B receptor of chinese hamster ovary(CHO) cells.
- ChEMBL_727296 Displacement of biotinylated phosphatidylinositol-3,4,5-phosphate from mouse AKT1 PH domain by surface plasmon resonance competitive binding assay
- ChEMBL_751690 Inhibition of Manduca sexta V-ATPase V1/Vo holoenzyme activity assessed as inorganic phosphate production pretreated for 5 mins
- ChEMBL_790928 Inhibition of GST-tagged human recombinant PTP1B assessed as dephosphorylation of para-nitrophenyl phosphate after 10 mins by spectrophotometric analysis
- ChEMBL_829771 Inhibition of human PTEN using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry
- ChEMBL_840475 Inhibition of human recombinant PTP1B using p-nitrophenyl phosphate as substrate assessed as p-nitrophenol release after 30 mins
- ChEMBL_848287 Inhibition of human recombinant LAR expressed in Escherichia coli TB1 using p-nitrophenyl phosphate as substrate after 1 hr
- ChEMBL_848288 Mixed type inhibition of human recombinant PTP-1B expressed in Escherichia coli TB1 using p-nitrophenyl phosphate as substrate
- ChEMBL_848289 Non-competitive inhibition of human recombinant PTP-1B expressed in Escherichia coli TB1 using p-nitrophenyl phosphate as substrate
- ChEMBL_860250 Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting
- ChEMBL_983901 Inhibition of LAR (unknown origin) assessed as p-nitrophenyl phosphate conversion to p-nitrophenol after 10 mins by spectrophotometric analysis
- ChEMBL_983902 Inhibition of SHP2 (unknown origin) assessed as p-nitrophenyl phosphate conversion to p-nitrophenol after 10 mins by spectrophotometric analysis
- ChEMBL_983903 Inhibition of CD45 (unknown origin) assessed as p-nitrophenyl phosphate conversion to p-nitrophenol after 10 mins by spectrophotometric analysis
- ChEMBL_983904 Inhibition of PTPbeta (unknown origin) assessed as p-nitrophenyl phosphate conversion to p-nitrophenol after 10 mins by spectrophotometric analysis
- ChEMBL_983905 Inhibition of TCPTP (unknown origin) assessed as p-nitrophenyl phosphate conversion to p-nitrophenol after 10 mins by spectrophotometric analysis
- Inhibition Assay (piHA-Dm) After kinetic analysis with HPA, piHA-Dm was tested as an inhibitor of ten additional enzymes. The conditions are listed as follows: Agrobacterium faecalis β-glucosidase (2.5 × 10^-4 mg/mL enzyme, 50 mM sodium phosphate pH 7, 4 mM PNP β-gal); Bos taurus β-galactosidase (6.9 × 10^-2 mg/mL enzyme, 50 mM sodium phosphate pH 7, 1 mM PNP β-gal); S. cerevisiae α-glucosidase (5 × 10^-3 mg/mL enzyme, 50 mM sodium phosphate pH 7, 1 mM α-glc); Human maltase-glucoamylase (8.1 × 10^-2 mg/mL enzyme, 50 mM sodium phosphate pH 7, 1 mM α-glc); Mouse maltase-glucoamylase (8.1 × 10^-2 mg/mL enzyme, 50 mM sodium phosphate pH 7, 1 mM α-glc); Butyrivibrio fibrisolvens α-amylase (1.7 × 10^-4 mg/mL enzyme, 50 mM sodium phosphate 100 mM NaCl pH 7, 1 mM CNPG3); Aspergillus oryzae α-amylase (1.9 × 10^-4 mg/mL enzyme, 50 mM sodium phosphate 100 mM NaCl pH 7, 1 mM CNPG3); Porcine pancreatic α-amylase (6.7 × 10^-3 mg/mL enzyme, 50 mM sodium phosphate 100 mM N
- ChEBML_201324 Binding affinity towards human sphingosine 1-phosphate receptor 2 expressed in CHO cells was determined by using [33P]-S1P as radioligand
- ChEBML_201333 Binding affinity towards human sphingosine 1-phosphate receptor 3 expressed in CHO cells was determined by using [33P]-S1P as radioligand
- ChEBML_201450 Binding affinity towards human sphingosine 1-phosphate receptor 4 expressed in CHO cells was determined by using [33P]-S1P as radioligand
- ChEMBL_105574 Agonist activity against Metabotropic glutamate receptor 1 expressed in HEK 293 cells was evaluated by measuring total inositol phosphate accumulation
- ChEMBL_105891 Agonist activity against Metabotropic glutamate receptor 2 expressed in HEK 293 cells was evaluated by measuring total inositol phosphate accumulation
- ChEMBL_106545 Agonist activity against Metabotropic glutamate receptor 4 expressed in HEK 293 cells was evaluated by measuring total inositol phosphate accumulation
- ChEMBL_1288121 Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay
- ChEMBL_1297731 Inhibition of human recombinant FBPase expressed in Escherichia coli BL21(DE3) by phosphoglucose isomerase and glucose-6-phosphate dehydrogenase coupled assay
- ChEMBL_1336827 Inhibition of Staphylococcus aureus DNA gyrase subunit B ATPase activity assessed as consumption of inorganic phosphate by PNP-based absorbance assay
- ChEMBL_152658 Kinetic constant Apparent binding constant (Ki`) for the inhibition of papain conducted in 0.1 M phosphate, pH 6.8, at 30 degree C
- ChEMBL_154381 Compound was tested functionally in vitro for inducing 50% of the maximum alkaline phosphate activity (Transactivation) against Peroxisome proliferator activated receptor gamma
- ChEMBL_1557478 Competitive inhibition of rabbit muscle glycogen phosphorylase-b using alpha-D-glucose-1-phosphate as substrate by Dixon plot analysis
- ChEMBL_1670144 Competitive inhibition of rabbit muscle glycogen phosphorylase b using glucose-1-phosphate as substrate in presence of constant concentrations of glycogen and AMP
- ChEMBL_1844625 Inhibition of recombinant human brain INPP5A expressed in Escherichia coli incubated for 10 mins by malachite green reagent based phosphate assay
- ChEMBL_1992561 Inhibition of Mycobacterium tuberculosis PTPA using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vis spectrophotometric method
- ChEMBL_201316 Binding affinity towards human Sphingosine 1-phosphate receptor 1 expressed in CHO cells was determined by using [33P]-S1P as radioligand
- ChEMBL_201324 Binding affinity towards human sphingosine 1-phosphate receptor 2 expressed in CHO cells was determined by using [33P]-S1P as radioligand
- ChEMBL_201333 Binding affinity towards human sphingosine 1-phosphate receptor 3 expressed in CHO cells was determined by using [33P]-S1P as radioligand
- ChEMBL_201453 Binding affinity towards human sphingosine 1-phosphate receptor 5 expressed in CHO cells was determined by using [33P]-S1P as radioligand
- ChEMBL_2016972 Inhibition of actin-activated bovine heart muscle myosin 2 assessed as phosphate level incubated for 6 to 24 mins by spectrophotometric method
- ChEMBL_2107522 Non-competitive inhibition of G6PD (unknown origin) using glucose-6-phosphate and varying concentrations of NADP+ as substrate by Michaelis-Menten analysis
- ChEMBL_304417 Effective concentration required for the activation of human C296A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate
- ChEMBL_304427 Effective concentration required for the activation of human E209R mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate
- ChEMBL_304439 Effective concentration required for the activation of human R212A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate
- ChEMBL_304441 Effective concentration required for the activation of human R287A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate
- ChEMBL_304442 Effective concentration required for the activation of human R287E mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate
- ChEMBL_304443 Effective concentration required for the activation of human R287K mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate
- ChEMBL_304451 Effective concentration required for the activation of human T221A mutant strain P2Y1 receptors expressed in COS-7 cells for the accumulation of inositol phosphate
- ChEMBL_34910 Inhibitory constant was evaluated against Angiotensin I converting enzyme from rabbit lungs at pH 8 in TRIS phosphate/borate buffer
- ChEMBL_351405 Activity against human adenosine A3 receptor H272E mutant expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assay
- ChEMBL_351407 Activity against human wild type adenosine A3 receptor expressed in COS7 cells as measured by accumulation of inositol phosphate by PLC assay
- ChEMBL_552859 Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity assay
- ChEMBL_552861 Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity assay
- ChEMBL_552863 Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity assay
- ChEMBL_613431 Inhibition of calf spleen PNP assessed as inhibition of 25 uM 7-methylguanosine phosphorolysis by spectrophotometry in presence of 1 mM inorganic phosphate
- ChEMBL_613432 Inhibition of human erythrocyte PNP assessed as inhibition of 25 uM 7-methylguanosine phosphorolysis by spectrophotometry in presence of 1 mM inorganic phosphate
- ChEMBL_627320 Displacement of [33P]sphingosine-1-phosphate from human S1P1 receptor expressed in HEK293T cells after 60 mins by scintillation counting
- ChEMBL_627321 Displacement of [33P]sphingosine-1-phosphate from human S1P3 receptor expressed in HEK293T cells after 60 mins by scintillation counting
- ChEMBL_627322 Displacement of [33P]sphingosine-1-phosphate from human S1P4 receptor expressed in HEK293T cells after 60 mins by scintillation counting
- ChEMBL_627323 Displacement of [33P]sphingosine-1-phosphate from human S1P5 receptor expressed in HEK293T cells after 60 mins by scintillation counting
- ChEMBL_654167 Antagonist activity at human recombinant MCHR1 expressed in CHOK1 cells assessed as reduction in [3H]inositol phosphate levels by scintillation proximity assay
- ChEMBL_685005 Inhibition of human full-length Eg5 ATPase activity expressed in Escherichia coli assessed as release of inorganic phosphate after 30 mins
- ChEMBL_759463 Inhibition of KHK-mediated conversion of D-fructose to fructose-1-phosphate after 60 mins by high throughput mass spectrometry analysis
- ChEMBL_800332 Binding affinity to chicken riboflavin binding protein assessed as dissociation constant at pH 7.4 in phosphate buffer by isothermal titration calorimetric assay
- ChEMBL_801148 Inhibition of human PTP1B expressed in Escherichia coli BL21 DE3 using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry
- ChEMBL_822162 Inhibition of recombinant AKT1 using GSK3 as substrate assessed as inhibition of [33P]Phosphate incorporation into substrate after 80 mins by scintillation counting
- ChEMBL_822166 Inhibition of recombinant PLK1 using RBERCHKtide as substrate assessed as inhibition of [33P]Phosphate incorporation into substrate after 80 mins by scintillation counting
- ChEMBL_829768 Inhibition of PTP-beta receptor using 3-O-Methylfluorescein phosphate as substrate incubated for 10 mins prior to substrate addition by fluorometry
- ChEMBL_848283 Inhibition of human recombinant PTP-1B expressed in Escherichia coli TB1 using p-nitrophenyl phosphate as substrate after 1 hr
- ChEMBL_848284 Inhibition of human recombinant LMW-PTP1 expressed in Escherichia coli TB1 using p-nitrophenyl phosphate as substrate after 1 hr
- ChEMBL_848285 Inhibition of human recombinant LMW-PTP2 expressed in Escherichia coli TB1 using p-nitrophenyl phosphate as substrate after 1 hr